Best Fat Burners and Weight Loss Pills

Of all the supplements out there, fat burners are arguably the ones with the most questionable effectiveness. Despite that, the market is full of products promising to help you finally burn that stubborn fat.

Some products even argue to have scientific evidence backing their claims. This might look quite promising for the regular person but the studies they cite are often sponsored, biased, or cherry-picked.

The terrible truth is that most of the products are not only a complete waste of money, but some can be downright dangerous for your health.

In this article, we decided to take a deeper look at the science of fat burners and reveal what truly works and what doesn’t.

TL; DR: What You Need to Know

  • Some fat-burners work but not in the exact way you expect
  • Most fat-burners are useless and based on cherry-picked studies
  • Some fat-burners can have side-effects
  • A few fat-burners can be even dangerous
  • Our top fat-burner picks

If you’d rather just see our picks, below is a comparison table. Otherwise, you can keep reading to discover why we picked them and why most fat burners do not work.

Disclaimer: The content on and the information included in this article is intended for entertainment and informational purposes only. It is not intended nor implied to be a substitute for professional medical advice. Prior to buying anything, check that it is compliant where you live with your current government laws. Your access is subject to our full Terms of Use.

Do Fat Burners Work?

The short answer is yes – but not in the way one might expect them to work.

There is no magic pill when it comes to fat loss. How much weight you will lose depends only on your energy balance.

That is a basic principle of thermodynamics and it applies to everything, including our bodies.

We have known this fact for decades and there is solid evidence to back it up.[1]

Negative energy balance can be achieved in two ways – increasing the amount of calories burned and reducing the amount of calories consumed.

We expect from fat burners to boost our caloric expenditure, but this strategy is not as effective as restricting the caloric intake.

If you still eat as much as you feel like, without controlling the energy intake, you can easily compensate for the increased caloric expenditure with more food.

Your body is trying to maintain balance (homeostasis) and you will likely feel hungrier once you start burning more calories.

That is why simply eating fewer calories is the better strategy for fat loss and it is well supported by studies.[2]

This is why most fat burners today are blends and focus on appetite and calorie absorption control rather than trying to boost “fat-burning” itself.

How Do Fat Burners Work?

There are 3 main mechanisms through which fat burners can help you stay in a caloric deficit to burn fat:

  • Appetite suppression
  • Decreased calorie absorption from food
  • Increase in resting energy expenditure

People taking fat burners usually expect to benefit from the 3rd mechanism but ironically that is the least successful one for fat loss.

Boosting fat oxidation is another effect that weight loss pills and fat burners claim.

Unfortunately, it is quite useless, because your body can achieve amazing rates of fat oxidation on its own. As long as it is a caloric deficit, of course.

A study has revealed that in athletic individuals maximum fat loss rate can be as high as 1.27g/min during exercise.[3]

Even a study in Korean women with metabolic problems (type 2 diabetes) the maximum fat oxidation could reach 0.38 g/min during exercise.[4] Calculated for a week, that is almost 4kg (8.5 lb) of fat loss.

This shows that your body’s ability to burn fat is not the limiting factor for weight loss. The limiting factor is the amount of energy deficit you can maintain.

Unfortunately, no exercise program or fat burner alone will help you lose weight if you are not eating less energy than you burn.

How Did We Research Fat Burners?

Many ingredients are often labeled “supported by science”. However, biased studies are quite common.

While there might be some evidence supporting their effectiveness, it is important to avoid “cherry-picking” studies. Instead, we looked at all the available research.

As it turns out, plenty of fat burner ingredients are not as well supported by evidence as they claim…


It is a type of soluble fiber that can absorb water and turn into a gel-like substance.

Thus, it creates volume in the stomach and intestines which could aid with fullness and satiation. It is added to fat boosters as an appetite suppressant but some manufacturers claim that it also boosts fat loss.

A study from 2005 is often cited as the largest study on the weight loss effects of glucomannan because it involved 176 participants.[5]

The subjects were randomly assigned to either placebo or glucomannan supplementation. According to the study, everyone had the same caloric deficit but the glucomannan group lost significantly more weight.

Unfortunately, it turns out that the study has a high attrition bias. If you take a deeper look you will discover that only 80 subjects completed the study.

Furthermore, only 50 of those had an eligible food diary to monitor their caloric intake. The dropout rate was highest amongst the glucomannan group because of adverse effects such as gastrointestinal problems.

Considering this huge dropout rate, this study cannot claim to be proof of anything, but let’s look even deeper.

Another major bias is the fact the subjects in the control group were significantly lighter and shorter in height which means they had lower resting energy expenditure. Besides, the glucomannan group was in a higher caloric deficit, which is why it lost just over a kilogram of more weight compared to the control group.

According to a systematic review of 14 studies (one of which is the study with “176 participants”), glucomannan is effective in lowering body weight, blood cholesterol, and blood sugar.[6]

However, another systematic review and meta-analysis of 18 studies didn’t find any statistical relationship between glucomannan and weight loss.[7] Adverse effects such as abdominal discomfort, diarrhea, and constipation were common.

And finally, a recent systematic review confirmed once again, that there was no effect on fat loss after supplementing with glucomannan.[8] [9]

And to make everything worse, Health Canada stated the following: “glucomannan products have a potential for harm if taken without at least 8 ounces of water or other fluid. The risk includes choking and/or blockage of the throat, esophagus, or intestine, according to international adverse reaction case reports. It is also important to note that these products should NOT be taken immediately before going to bed.”

Synephrine (Bitter Orange Extract)

Synephrine is an alkaloid occurring naturally in some plants such as bitter oranges (Citrus Aurantium). It has adrenaline-like effects, which is why it is speculated to boost metabolic rate and fat oxidation.

Most of the research on synephrine is focused on its safety rather than its effectiveness. That is because reports raised concerns that synephrine might be related to hypertension, arrhythmia, or even myocardial infarction.[10]

However, the alkaloid is often in combination with caffeine and other ingredients, which might be accountable for some side effects.[11]

A review from 2011 found no adverse effects due to supplementation with the natural form – p-synephrine.[12] The researchers suggest that studies showing adverse effects are performed with m-synephrine (the artificial form) or intravenous applications of high doses.

Another 60-day double-blind, placebo-controlled study from 2013 also found no adverse effects after supplementation.[13]

Unfortunately, studies on its effectiveness are not as optimistic. The majority of clinical trials with people have very poor design and quality.

One study estimated that synephrine might barely boost resting energy expenditure with an extra 65 kcals.[14] The study was funded by Nutratech.

The majority of non-sponsored studies tend to find no statistically significant benefit for weight loss.[15] [16]

The latest double-blind randomized trial also included only 20 subjects and reported that the energy expenditure after taking synephrine is similar to a placebo.[17]


As studies suggest, the active component capsaicin found in chili peppers can increase metabolism by activating brown adipose tissues.[18]

Evidence shows that it can promote fat-oxidation and support your metabolism while in energy restriction.[19]

As an extra benefit, studies reveal that capsaicin improves the feeling of fullness and thus can reduce your desire to eat after dinner.[20]

These findings are also confirmed by systematic reviews and meta-analyses.[21] [22]

One trial suggests that capsaicin can lead to a 20% increase in energy expenditure but the effect lasts for 10-30 minutes.[23]

However, the 24-hr effect might be insignificant as another study suggests it is only 50 extra kcals burned.[24]

Besides, plenty of studies find no effect at all from capsaicin consumption.[25] [26] [27]

It seems like even if there is a short-term boost in thermogenesis, it is not likely to result in an overall increase in your caloric deficit or rate of weight loss.

In addition, regular consumption might have long- term risks. Studies performed in Mexico suggest that capsaicin might increase the risk of gastric cancer but more studies are needed to test this hypothesis.[28] [29] [30]


Acetyl-L-carnitine is an amino acid with a role in energy production and fat oxidation. Our body can produce it on its own from other essential amino acids.

The function of carnitine is to transport fatty acids into the mitochondria for oxidation. It seems logical that supporting the transport and mitochondrial function itself would lead to higher fat oxidation.

However, the majority of studies find no benefit in terms of weight loss. There is no additional fat oxidation even when supplementation is coupled with exercise and caloric deficit.[31] [32] [33]

On the bright side, studies suggest that supplementation with it can benefit healthy aging, brain function, liver function, insulin sensitivity, blood pressure, and even sperm quality.[34] [35] [36] [37] [38]

If you are vegan and not consuming enough essential amino acids, then your body can have trouble producing enough L-carnitine on its own.[39]

Then supplementation might have additional benefits for weight loss. Otherwise, you are getting enough L-carnitine through your diet and you won’t burn any extra fat by supplementation.

Common side effects due to supplementation include nausea and stomach discomfort.

Natural Fat Burners That Work

The best natural fat burner without a doubt is coffee.

It boosts your metabolism, reduces your appetite and (green coffee) reduces the amount of calories you absorb from carbs. Those effects are thanks to not one but two ingredients – caffeine and chlorogenic acid.

According to studies, caffeine can influence thermogenesis and increase the total energy burned by roughly 10%.[40] [41]

Other studies suggest that high caffeine intake is associated with weight loss in women, via increased thermogenesis and suppressed leptin.[42]

Caffeine can improve physical performance as well, which can lead to even higher energy expenditure.

However, you can develop tolerance towards all the effects of caffeine, which makes them ineffective at that point.  Tolerance occurs even quicker in higher doses.

Chlorogenic acid is found in green coffee. The process of roasting significantly reduces its levels. Despite the name of the acid, there is no chlorine in it.

Chlorogenic acid inhibits one of the enzymes responsible for breaking down carbohydrates. Thus, it reduces the amount of calories absorbed from carbs in the digestive system.

A 2011 systematic review and meta-analysis of randomized clinical trials, suggests that the effectiveness of Chlorogenic acid as a weight-loss supplement is promising, although the quality of the studies is poor.[43]

Thanks to the effect on carbohydrate metabolism, chlorogenic acid supplementation could help control your blood pressure and blood sugar levels.[44]

In addition to all the benefits, coffee is also the biggest source of antioxidants in typical western diets.[45]

Side Effects of Fat Burners

Most fat burners have side effects that range from mild stomach discomfort to serious conditions.

Caffeine is the most commonly used and effective fat burning supplement but it can have serious side effects if overdosed. Some people are more sensitive to those effects than others.

The recommended dose for adults is up to 400 mg per day. For adolescents, it is up to 100mg daily. Pregnant women should also limit their caffeine intake because the effects on the baby are not completely known.

The symptoms of overdose include dizziness, headache, irritability, vomiting, irregular or fast heartbeat, and convulsions. Allergic reactions to green coffee extract are also possible.

In extreme cases, fatal heart arrhythmia has been reported.[46]

Depending on the dose and time of consumption, caffeine can have negative effects on sleep, which potentially negates the weight loss benefits.[47]

Are Fat Burners Dangerous

While most natural ingredients in fat burners are safe in recommended doses, there are some exceptions.

Such an example is usnic acid. It naturally occurs in certain lichen species and used to be an ingredient in some fat burners.

That was one of the ingredients in the infamous LipoKinetix – a weight loss supplement that caused liver failure in numerous patients according to several reports.[48]

Usnic acid is not only considered hepatotoxic but it could interfere with various medications.

Another blend of herbal extracts – OxyELITE Pro has also been linked to cases of acute liver failure.[49]

FDA warns that it might contain Fluoxetine which is associated with serious side effects including suicidal thoughts, abnormal bleeding and seizures.[50]

A product called “Exolise” has also been linked to cases of acute liver failure and eventually withdrawn from the market.[51]

This product contained another natural ingredient – Chinese green tea extracts (Camellia sinensis).

Epigallocatechin-3-gallate (EGCG) is the main polyphenol (antioxidant) in green tea extract and it is quite common in many fat burners.

It has been investigated for possible effects against cancer cells in vitro.[52] However, it is not likely to have the same effects in vivo.[53]

In terms of weight loss, the evidence is inconsistent and most studies find effectiveness only when EGCG is taken in combination with caffeine.[54] [55] [56]

It is important to note that EGCG might not be completely safe.[57] Green tea extracts might be hepatotoxic in high doses, according to studies performed in mice.[58] [59]

There are reports of such cases in people supplementing with green tea and EGCG.[60] [61]

However, it is yet unclear if the previously reported hepatotoxicity is due to a possible presence of a pesticide called endosulfan which is now banned.[62]

5 Best Fat Burners

Best Fat Burner for Women: Lean Bean

Best Fat Burner for Women

Lean Bean is an extremely popular product amongst women and for a good reason – it contains pure extract of green coffee which supports fat burning and reduced caloric intake with some caffeine and chlorogenic acid. The addition of glucomannan might improve the satiation levels for some but it won’t do much else.

  • Contains Green Coffee

  • Turmeric reduces inflammation and joint pain

  • Optimal dosage

  • Glucomannan, Chromium, Choline and Garcinia Cambodia are likely ineffective for fat loss according to studies

  • Zinc is in an oxide form which has poor absorption

Best Thermogenic Fat Burner for Men: Burn Lab Pro

Performance Lab Supplements Review

This fat burner is stimulant-free and 100% natural! Burn Lab Pro unites today’s 5 top ingredients for fat loss, training intensity, and muscle gain.

The following major fat burners are included in this product:

  • ForsLean – The only Coleus forskohlii shown in human research to help shed fat and build muscle.
  • Capsimax – The most effective cayenne pepper fat burner on the market.
  • HMB – HMB supplies a balanced combination of muscle-sparing, muscle-building, and muscle recovery benefits that support lean muscle mass.
  • NutriGenesis GTF Chromium – A key mineral for fat loss and body composition, primarily due to its ability to enhance insulin activity.
  • BioPerine – It stimulates a rise in body heat (thermogenesis) that accelerates calorie burning and it’s been suggested to block the formation of new fat cells.

Burn Lab Pro® contains no other ingredients in its formulation and is contained within vegan-friendly, prebiotic-infused capsules made from pullulan (fermented tapioca).

  • 5 major fat burners
  • All-natural and suitable for all diets

  • Some people may be sensitive to black pepper
  • 3 capsules per serving

Best Appetite Suppressant: PhenQ

Best Fat Burners

PhenQ contains a powerful blend of natural ingredients along with its trademarked formula, a-Lacys Reset, that work together to increase metabolism, reduce appetite, and promote fat burning.

Some of this product’s key ingredients include:

  • Capsimax Powder – Extremely strong thermogenic formula
  • Calcium Carbonate – Discourages cells from storing excess fat
  • Chromium Picolinate – Regulates blood sugar levels which leads to a reduction in cravings and overall appetite
  • Caffeine – Acts as a stimulant to decrease appetite, increase fat loss, and improve focus
  • Nopal – Helps suppress appetite
  • L-Carnitine Furmarate – Assists the conversion of fat into energy
  • Contains α-Lacys Reset which was developed using cutting edge science and research
  • Contains potent thermogenic ingredients
  • Helps reduce cravings and suppresses appetite
  • Doesn’t disclose ingredients contained in α-Lacys Reset

Best Custom Fat Burner: Persona Nutrition

Best Prenatal Vitamins

Persona Nutrition provides each of its customers with their own personalized, monthly subscription vitamin pack to best meet their specific health needs.

In order to best customize individual vitamin packs, customers should initially complete a quick assessment on Persona’s website to receive personalized, science-backed supplement recommendations.

We’ve included Persona on our fat burner list since it provides its customers with add-in options for ingredients that aid the fat loss process through promoting better digestion, supporting blood sugar levels, enhancing nutrient absorption, improving thyroid function, and aiding hormone regulation.

Persona offers the following ingredient add-ins for customers to include as a part of their custom fat-burning vitamin pack:

  • Blood Sugar Balance – Supports glucose metabolism through the use of benfotiamine (an underappreciated form of vitamin B1 shown to lessen damage from high glucose levels) and alpha-lipoic acid (an antioxidant that may promote normal glucose regulation).
  • Selenium – Selenium is an important nutrient that helps the body produce selenoproteins which act as antioxidants that support thyroid function and boost the immune system.
  • 5 HTP – An amino acid that helps support a healthy appetite through creating serotonin. Serotonin is associated with mood, appetite, digestion, sleep, and memory.
  • Metabolism Support – This blend is essential for a fully functioning digestive system and it contains select vitamins, enzymes, and an herbal blend to help the body better metabolize protein, fat, and carbohydrates.
  • Daily Probiotic – Contains Lactobacillus rhamnosus, a live and active strain of bacteria, that supports healthy digestion and maintains the integrity of the intestinal lining
  • Aloe Plus, Peppermint Plus, & Ginger Extract – Used to support healthy digestion, relieve occasional upset stomach, and may assist the body in eliminating excess gas from the intestinal tract.
  • Green Tea Extract – Promotes energy, normalizes blood sugar levels, and supports a healthy weight through the use of its major antioxidant, epigallocatechin gallate (EGCG).
  • Apple Pectin – Pectin is a soluble fiber that is utilized for various benefits, most commonly known to improve digestive and colon health. Apple Pectin is a soluble fiber that can help create a feeling of fullness as well as balance the digestive system and glucose levels.
  • Appetite Support – Contains the scientifically researched ingredients Chromium, GymnaHerb®, NeOpuntia®, and Phase 2® Carb Controller™ that work synergistically to aid weight loss through encouraging a healthy appetite, supporting healthy blood sugar, and supporting healthy cholesterol.
  • Digestive Enzymes – Enzymes that support the digestive system and nutrient absorption as well as reduce digestive discomfort.
  • Highly detailed online assessment
  • Live nutritionist support
  • 80 + ingredients available
  • Not all ingredients are trademarked
  • Uses proprietary blends within some add-ins
  • Does not rely on blood or DNA tests

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The Take-Home Message

The harsh truth is you cannot lose weight without being in a caloric deficit and the most reliable way to achieve it is with a diet.

Indeed, some natural products can help you maintain a deficit easier by boosting the amount of energy you burn and suppressing your appetite but the effect is not always significant.

Besides, you should pick fat burners carefully, because many can be more harmful than helpful.

Vibration Plates for Weight Loss

When lifting, the general rule is low reps/high weight for strength and high reps/low weight for toning. And when it comes to using a vibration plate, high reps/low weight is always going to be the way to go.

One of the most touted uses of a vibration plate is for weight loss. After all, if you could simply stand on a platform for 15-20 minutes at a time and lose more weight as a result, then why wouldn’t you do it?

The vibrations of the platform cause your muscles to contract at up to 50x their natural speed.

This is because the body naturally reacts to certain stimuli – and vibrations are one such stimuli. Numerous studies have shown that adding a vibration plate to an already active workout routine led to greater weight loss as a result. For standing on a plate for 15 minutes a day, that’s very convenient.


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Dr. Dimitar Marinov

Dr. D. Marinov is our medical expert. He has written, fact-checked and medically reviewed tons of articles on topics about medicine, health, infections, and nutrition.

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