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Ligandrol LGD 4033 SARM Review

Compound Summary

Class of Compound

SARM

Mechanism of Action

Ligandrol binds to specific receptors in the skeletal muscles called the Androgen receptors. The binding of Ligandrol to these receptors initiates a cascade of events that lead to changes in the genetic expression of muscle cells leading to increased muscle growth and repair.

Top Studies

Street Names

Anabolicum, LGD-403, VK5211

Used For

  • Increases protein synthesis in muscles
  • Develops muscle mass and endurance
  • Stimulates muscle repair

Side Effects and Dangers

  • Short-term aggression and violence
  • Acne and sleeping difficulties
  • Liver and kidney damage
  • May cause depression and hypertension

Chemical Structure

Scientific Name: 4-((R)-2-((R)-2,2,2-trifluoro-1-hydroxyethyl) pyrrolidin-1-yl)-2-trifluoroMethyl) benzonitrile

Most guys are looking to take SARMs in order to put on muscle mass in the quickest and safest way possible. One of the best selective androgen receptor modulators for this is Ligandrol LGD-4033.
In this article, I’ll reveal exactly what you need to know about Ligandrol prior to taking your first cycle so that you can maximize its benefits and get the results you want.

What is Ligandrol?

Ligandrol LGD-4033 is a selective androgenic receptor modulator (SARM) that was developed by Ligand Pharmaceuticals. It is primarily a mass building SARM that was originally developed to treat muscle-wasting conditions.
According to results obtained from clinical trials, humans can take up to 222 mg per day of Ligandrol for 14 consecutive days. This compound has demonstrated effectiveness in increasing muscle size, reducing body fat, and promoting strength.

Disclaimer: The information included in this article is intended for entertainment and informational purposes only. It is not intended nor implied to be a substitute for professional medical advice. Prior to buying anything, check that it is compliant where you live with your current government laws.

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How Does Ligandrol Work?

LGD 4033 is a selective androgen receptor molecule that binds to androgen receptors within bones and muscles. Unlike anabolic steroids, it is not be converted into estrogen and it does not affect your liver or kidneys. [1]

Benefits of Ligandrol

Ligandrol is one of the best SARMs for increasing lean mass and it activates the muscle regeneration process after a workout. This SARM also increases both energy and strength.
Ligandrol can be stacked with a cutting SARM for weight loss in order to preserve muscle size while you are stripping off body fat.
In terms of weight loss, Ligandrol is able to attach to fat receptors and stimulate fat loss. It will boost the metabolism for faster calorie burning. [2]

Is Ligandrol Legal?

Yes, Ligandrol is legal, however, it can only be sold for research purposes. It has not been authorized by the Federal Drug Administration (FDA) for sale as a dietary supplement so websites can only market them as research tools.

Who Should Use Ligandrol?

You should not consider taking Ligandrol or any other type of SARM until you have completed puberty. Additionally, you should only use Lignadrol if you are training intensely in the gym and following a diet that promotes muscle building.

Ligandrol Cycle

The recommended cycle length for Ligandrol is 8-10 weeks. We recommend starting with an 8-week cycle your first time, taking 10mg/day throughout its duration.
If you have little to no side effects and are tolerating the chemical well, you may ramp it up to 10 weeks on your second cycle. You should follow your cycle with a 3 week PCT using 10 mg of Clomid per day.

Ligandrol Dosage

The recommended dosage for Ligandrol LGD 4033 for men is 10 mg per day for 8-10 weeks. Women should cut that dosage in half to 5 mg per day for an 8-10 week cycle.

Ligandrol For Bodybuilding

Ligandrol is an excellent SARM for bodybuilding. It is generally considered to be the second-best selective androgen receptor modulator after Testolone for increasing muscular bodyweight.
We recommend using 10 mg of Ligandrol during your muscle-building cycles. More experienced bodybuilders can take it up to a max of 15 mg per day.

Ligandrol For Cutting

Ligandrol can also be used for cutting and it is best to stack it with Stenabolic. One of the best cycles for this stack includes using 2.5 mg Ligandrol and 30 mg Stenabolic per day for the course of 8 weeks.
You should follow your cycle with a 3 week PCT using 10 mg of Clomid per day.

Ligandrol For Women

Women can take Ligandrol but in smaller doses than men. It’s best to use 5 mg per day for bulking or 1.25 mg per day for cutting.

Ligandrol Stack

Ligandrol can be stacked for both bulking and cutting. If you are really serious about packing on muscle mass, I recommend stacking 5 mg of Ligandrol LGD 4033 per day with 15 mg of Testolone per day for the course of 8 weeks.

Ligandrol Side Effects

According to the latest clinical trials, Ligandrol LGD 4033 is not toxic to the liver, nor does it affect blood pressure levels, prostate tissue, LDL levels, or interfere with the functioning of the kidneys.
To date, there have been no negative side effects noted with regard to the use of Ligandrol at the recommended dosage.

Ligandrol PCT

Ligandrol will have a suppressive effect on the body’s natural production of testosterone which normally occurs for a period of 28-56 days. Thus, you will need to follow every cycle with a Post Cycle Therapy of three weeks.
I suggest that you use Clomid at a dosage of 10 mg per day for 21 days as this will be sufficient to negate the suppressive effects of Ligandrol.

Does Ligandrol Work?

There is no doubt that when it comes to building lean body mass, Ligandrol LGD 4033 definitely works! Individual results vary but some people may gain between 8-12 pounds of lean mass over the course of an 8-week period.
Ligandrol is also effective when it comes to fat loss and it will help you to preserve muscle mass when it comes to cutting, especially when it is stacked with a SARM like Stenabolic.

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Is Ligandrol Safe?

Yes, Ligandrol LGD 4033 is a safe nonsteroidal oral selective androgen receptor that selectively targets the receptors in the bone and muscle cells. On the basis of the information that we currently have, we can say that is safe in the short to medium-term timeframe.

Where to Buy Ligandrol

Ligandrol can be purchased from a wide range of websites. However, buying SARMs online is definitely a case of ‘caveat emptor (‘let the buyer beware’).
This is an unregulated industry that has given rise to a lot of shady operators. As a result, you need to be very careful about where you buy your SARMs from.
The best SARMs retailer is called bioScience. It is run by BioScience Pharmaceuticals, which has been around since 2013.

Ligandrol vs RAD140

Ligandrol LGD 4033 and Testolone RAD 140 are the two best bulking SARMs available. For the best results, I recommend stacking these two powerful compounds for an 8 week cycle. Use 5 mg of Ligandrol and 15 mg of Tesolone daily.

Ligandrol vs S4

Both Ligandrol and Andarine S4 are mass building SARMs. Of the two, Ligandrol is the most potent and should be used in preference.
However, if you find that LGD 4033 is not tolerated well by your body, try the milder S4.

Ligandrol vs YK-11

YK-11 is a very powerful mass builder that is classified by some as a steroid. One of its mechanisms of action is that it inhibits myostatin, which is a protein that prevents muscle building.
This is a hardcore chemical that is not recommended for use by beginners. We recommend that beginners start with Ostarine of Ligandrol.
If, after 3 or 4 cycles, you feel you need something stronger, then you can consider a cycle of YK-11.

Ligandrol vs Ostarine

Ostarine is the mildest SARM that exists and it is often recommended as a beginner SARM. It is not as potent a muscle builder as Ligandrol but it will also not suppress your body’s natural testosterone production as much as Ligandrol, either.
Ligandrol is a logical next step after taking your first cycle of Ostarine.

Should You Take Ligandrol?

SARMs are a much smarter and safer choice than steroids. When it comes to putting on mass, Ligandrol, stacked with Testolone, will give you the results you’re after so long as you are putting in the hard work in the gym and giving your body the right calories it needs to build the mass.
Start with Ligandrol on its own your first 8-week cycle. On your second and subsequent cycles, try stacking LGD 4033 with Testolone for even greater results.

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References
See all references
[1] Selective Androgen Receptor Modulators (SARMs): USADA. (2020, July 27). Retrieved from https://www.usada.org/spirit-of-sport/education/selective-androgen-receptor-modulators-sarms-prohibited-class-anabolic-agents/
[2] Basaria, S., Collins, L., Dillon, E. L., Orwoll, K., Storer, T. W., Miciek, R., Ulloor, J., Zhang, A., Eder, R., Zientek, H., Gordon, G., Kazmi, S., Sheffield-Moore, M., & Bhasin, S. (2013). The safety, pharmacokinetics, and effects of LGD-4033, a novel nonsteroidal oral, selective androgen receptor modulator, in healthy young men. The journals of gerontology. Series A, Biological sciences and medical sciences, 68(1), 87–95. https://doi.org/10.1093/gerona/gls078

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Steve Theunissen

Steve Theunissen

For the past five years, I have been a full-time fitness writer.  I also love to write about history and have written more than thirty books on the great battles throughout history. I live in sunny Tauranga, New Zealand with my wife of 33 years, Shelley.

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