7 Best Nootropic Peptides: Selank to Semax + Others

Nootropics can help with work, training, or even just mental health. Nootropic peptides offer a better route of administration with greater results.

Nootropic peptides are a class of compounds known for their cognitive-enhancing effects. They work by stimulating the brain’s neurotransmitters, increasing blood flow to the brain, and improving brain cell communication. In this article, we will discuss the 7 best nootropic peptides, including their primary attributes, pros, and cons.

πŸš€ Get ready for a mind-blowing journey as we dive into the world of nootropic peptides! These cognitive-enhancing superheroes work their magic by stimulating the brain’s neurotransmitters, increasing blood flow to the brain, and improving brain cell communication. 🧠πŸ’₯

Did you know that a whopping 74% of people have tried or are open to trying nootropics to boost their brainpower? πŸ“ˆ

In this article, we’ll reveal the 7 best nootropic peptides, including their primary attributes, pros, and cons. But wait, there’s a spoiler! One of these peptides might just be the secret weapon you’ve been searching for to unlock your full cognitive potential. 🀯 So buckle up, and let’s explore the fascinating world of nootropic peptides! 🌟

NameEffectsAdministrationDurationSide EffectsCost
Semax🧠 Memory, Focus, Mood🚬 Nasal Spray30-60 minutesβœ”οΈ Headache, NauseaπŸ’²πŸ’²
NoopeptπŸ“š Memory, Learning, MoodπŸ’Š Oral30-60 minutesβœ”οΈ Headache, NauseaπŸ’²
Selank😰 Anxiety, Depression, Focus🚬 Nasal Spray30-60 minutesβœ”οΈ Headache, NauseaπŸ’²
CerebrolysinπŸ€” Memory, Learning, FocusπŸ’‰ Injectable6-8 hoursβœ”οΈ Injection site pain, NauseaπŸ’²
Epitalon⏳ Anti-aging, Sleep, MoodπŸ’‰ Injectable4-6 hoursβœ”οΈ Injection site pain, NauseaπŸ’²
P21🧠 Memory, Learning, FocusπŸ’‰ Injectable30-60 minutesβœ”οΈ Injection site pain, NauseaπŸ’²πŸ’²πŸ’²πŸ’²
GHK-Cu Peptide🧠 Memory, SkinπŸ₯ Cream30-60 minutesβœ”οΈ NoneπŸ’²

Warning: The content on Muscleandbrawn.com and the information included in this article is intended for entertainment and informational purposes only. It is not intended nor implied to be a substitute for professional medical advice. Prior to buying anything, check that it is compliant where you live with your current government laws. We frequently mention research chemicals that are not made for human consumption. Therefore, before purchasing any product for personal use, consult with your doctor or healthcare provider first.

What are Nootropic Peptides?

Nootropic peptides are short chains of amino acids that can boost cognitive function. These peptides are designed to mimic the effects of neurotransmitters in the brain, leading to improved memory, focus, and learning. They are often used as supplements to improve cognitive performance in individuals who are studying, working long hours, or experiencing age-related cognitive decline.

Best Nootropic Peptides:

#1: Best for Students and Professionals: Semax

Semax is a synthetic peptide that boosts memory and focus while reducing anxiety. It is administered via nasal spray and has been shown to be effective in improving cognitive function in individuals with brain injuries. Semax has also been studied for its potential to treat depression and ADHD. It works by increasing levels of brain-derived neurotrophic factor (BDNF), a protein that promotes the growth and survival of neurons. Additionally, Semax has been found to have neuroprotective properties, meaning it may help prevent damage to the brain from injury or disease. Some users have reported improved mood and motivation after using Semax. However, more research is needed to fully understand its effects and potential uses.

Order Semax Here

Pros:

  • Enhances memory and focus
  • Reduces anxiety
  • Improves cognitive function

Cons:

  • Mild headaches
  • Nasal irritation

Semax Dosage:

0.25-1mg/day via nasal spray. Start with lowest effective dose and gradually increase. Do not exceed recommended dose. Consult healthcare professional before use. Not for pregnant or breastfeeding women or individuals with certain medical conditions.

#2: Best for Elderly Individuals: Noopept

Noopept is an oral capsule that enhances memory and learning while promoting neuroprotection. It is particularly useful for individuals experiencing age-related cognitive decline. Noopept is a synthetic nootropic compound that is similar in structure to Piracetam, but is estimated to be up to 1000 times more potent. It works by stimulating the production of nerve growth factor (NGF) and brain-derived neurotrophic factor (BDNF), which are essential for the growth and survival of neurons. Noopept has also been shown to improve mood, reduce anxiety, and increase overall cognitive function. Additionally, it has been found to have antioxidant properties, which may help protect the brain from damage caused by free radicals.

Buy Noopept Here

Pros:

  • Enhances memory and learning
  • Promotes neuroprotection

Cons:

  • Headaches
  • Irritability

Noopept Dosage

10-30mg/day in 2-3 divided doses. Start low, and increase gradually. Consult healthcare professional before use. Not for pregnant or breastfeeding women or individuals with certain medical conditions.

#3: Best For Individuals with Anxiety or Depression: Selank

Selank is a nasal spray that reduces anxiety, improves mood, and enhances cognitive function. It has been shown to be effective in reducing symptoms of anxiety and depression in clinical trials. Selank is a synthetic peptide that was developed in Russia in the 1980s. It is a derivative of the naturally occurring peptide tuftsin. Selank has been found to have neuroprotective and neurorestorative effects, and it may have potential as a treatment for Alzheimer’s disease and other neurodegenerative disorders. Selank has also been shown to have anti-inflammatory effects and to modulate the immune system. It is generally well-tolerated and has a low risk of side effects.

Buy Selank Here

Pros:

  • Reduces anxiety
  • Improves mood
  • Enhances cognitive function

Cons:

  • Mild headaches
  • Nasal irritation

Selank Dosage

250-500mcg/day via nasal spray. Start low, increase gradually. Consult healthcare professional before use. Not for pregnant or breastfeeding women or individuals with certain medical conditions.

P21 is a synthetic peptide that improves memory and learning while enhancing neuroplasticity. It has been shown to be effective in improving cognitive function in individuals with age-related cognitive decline. It works by increasing the production of brain-derived neurotrophic factor (BDNF), a protein that promotes the growth and survival of neurons. In addition to its cognitive benefits, P21 has also been shown to have neuroprotective effects and may be useful in the treatment of neurodegenerative diseases. However, more research is needed to fully understand the potential benefits and risks of P21 supplementation in humans.

Buy P21 Here

Pros:

  • Improves memory and learning
  • Enhances neuroplasticity

Cons:

  • None reported

P21 Dosage

5-10mg/day via subcutaneous injection. Start low, increase gradually. Consult healthcare professional before use. Not for pregnant or breastfeeding women or individuals with certain medical conditions.

#5: Best for Individuals with Neurodegenerative disorders: Cerebrolysin

Cerebrolysin is administered via intramuscular injection and enhances cognitive function while improving memory and learning. It has been shown to be effective in improving cognitive function in individuals with neurodegenerative disorders. Cerebrolysin is a neuropeptide drug that is derived from pig brain proteins. It has been found to have neuroprotective effects and can improve brain function by promoting the growth of neurons and synapses. Cerebrolysin has also been shown to have potential therapeutic benefits for stroke, traumatic brain injury, and Alzheimer’s disease. Clinical studies have demonstrated that Cerebrolysin can improve cognitive function, memory, and attention in healthy individuals as well as those with cognitive impairment.

Buy here

Pros:

  • Enhances cognitive function
  • Improves memory and learning

Cons:

  • Nausea
  • Headaches

Cerebrolysin Dosage

5-10ml/day via intramuscular injection. Start with lowest effective dose and gradually increase. Consult healthcare professional before use. Not for pregnant or breastfeeding women or individuals with certain medical conditions.

#6: Best for Individuals interested in Anti-Aging: Epitalon

Epitalon is a synthetic peptide that promotes longevity and improves sleep. It has been shown to be effective in improving sleep quality and reducing oxidative stress. Epitalon is a synthetic tetrapeptide that has been found to have anti-aging properties. It works by stimulating the production of telomerase, an enzyme that helps to maintain the length of telomeres, which are the protective caps on the ends of chromosomes. Epitalon has also been shown to have immune-boosting effects and to help regulate the body’s circadian rhythms. Additionally, it has been found to have potential as a treatment for certain types of cancer.

Epitalon Dosage

5-10mg subcutaneous injection per day via subcutaneous injection. Start with lowest effective dose and gradually increase. Consult healthcare professional before use. Not for pregnant or breastfeeding women or individuals with certain medical conditions.

Pros:

  • Promotes longevity
  • Improves sleep

Cons:

  • None reported

#7: Best for Individuals interested in Skin Health: GHK-Cu Peptide

GHK-Cu is a topical cream that improves wound healing, enhances collagen synthesis, and reduces inflammation. It has been shown to be effective in improving skin health and reducing signs of aging. GHK-Cu has also been found to have antioxidant properties and can protect against UV damage. It has been studied for its potential in treating hair loss and promoting hair growth. Additionally, GHK-Cu has been shown to have anti-cancer effects and may have potential as a therapeutic agent for certain types of cancer.

GHK-Cu Dosage

A topical cream that can be applied once or twice daily to the affected area. Do not exceed the recommended dose. Consult with a healthcare professional before starting a new nootropic peptide regimen. Not for use by pregnant or breastfeeding women or individuals with certain medical conditions.

Pros:

  • Improves wound healing
  • Enhances collagen synthesis
  • Reduces inflammation

Cons:

  • None reported

But wait, How Did Nootropic Peptides Get Invented? (A History)

The journey of nootropic peptides began in the early 1970s when Dr. Corneliu E. Giurgea, a Romanian psychologist and chemist, coined the term “nootropics” to describe compounds that enhance cognitive functions without causing harm. The first synthetic nootropic, Piracetam, was developed by Giurgea himself, paving the way for further research in this field.

In the late 20th century, Russian scientists made significant advancements in peptide-based nootropics. Semax and Selank were two pioneering peptides developed during this time. Both substances were designed to mimic naturally occurring neuropeptides found in the human brain, with Semax being an analogue of adrenocorticotropic hormone (ACTH) and Selank sharing structural similarities with tuftsin – a natural immunomodulatory peptide.

As research continued into the 21st century, scientists discovered more promising candidates like Noopept, which is structurally similar to Piracetam but considered more potent. Other notable developments include Cerebrolysinβ€”a porcine-derived peptide mixtureβ€”and synthetic peptides such as P21 and Epitalon.

Today’s ongoing studies focus on understanding the precise mechanisms behind these peptides’ cognitive-enhancing effects and exploring their potential applications in treating neurodegenerative diseases like Alzheimer’s and Parkinson’s. As our understanding of these powerful compounds deepens, we can expect even more exciting breakthroughs in the world of nootropic peptides.

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How Do Nootropic Peptides work in the Brain?

Nootropic peptides function by interacting with various neurotransmitter systems and receptors present in the brain. They modulate synaptic plasticity, which is crucial for learning and memory formation. Additionally, nootropic peptides can stimulate neurogenesis, the process of creating new neurons, and promote neuronal survival.

These compounds can also increase cerebral blood flow, ensuring that brain cells receive adequate oxygen and nutrients. Furthermore, they enhance the efficiency of cellular energy metabolism by improving mitochondrial function. This results in a boost in overall cognitive performance, including memory retention, focus, learning abilities, mood stabilization, and reduction of anxiety or depression symptoms.

Overall, nootropic peptides work synergistically to optimize brain function through various mechanisms that support both short-term cognitive enhancement and long-term neuronal health.

Nootropics vs Nootropic Peptides

While nootropics and nootropic peptides share the goal of enhancing cognitive function, they work in different ways. Nootropics are typically synthetic compounds that improve cognitive function by increasing blood flow to the brain or modulating neurotransmitters. Nootropic peptides, on the other hand, work by mimicking the effects of neurotransmitters in the brain. They are often more targeted in their effects and have fewer side effects than traditional nootropics.

FAQs

What are nootropic peptides?

Nootropic peptides are a class of compounds that are known for their cognitive-enhancing effects. They work by stimulating the brain’s neurotransmitters, increasing blood flow to the brain, and improving brain cell communication.

Are nootropic peptides safe?

In general, nootropic peptides are considered safe when used as directed. However, like any supplement or medication, they can have side effects. It’s important to talk to your doctor before taking any nootropic peptides.

How do I take nootropic peptides?

Nootropic peptides can be taken via nasal spray, oral pills, or injection. The best method of administration will depend on the specific peptide and its intended effects.

Do nootropic peptides have any side effects?

Some common side effects of nootropic peptides include headaches, nausea, and injection site pain. However, these side effects are typically rare and mild. It’s important to talk to your doctor before taking any nootropic peptides to ensure that they are safe for you.

Can I mix different types of nootropic peptides?

It’s generally not recommended to mix different types of nootropic peptides without first consulting a doctor. Mixing different types of peptides can increase the risk of side effects and may not result in any additional benefits.

What is the best peptide for cognition?

One peptide that has shown promise in improving cognitive function is Semax. It has been studied for its potential to enhance memory, attention, and overall cognitive performance. However, it’s important to note that Semax’s availability and approved usage may vary by country, and its use should be guided by a healthcare professional.

What is the most powerful nootropic in the world?

Lion’s Mane Mushroom is a natural nootropic that has been used for centuries in traditional Chinese medicine. It is known for its potential cognitive benefits, including enhancing memory, focus, and overall brain health. Lion’s Mane contains bioactive compounds, such as hericenones and erinacines, which are believed to stimulate nerve growth factor (NGF) production in the brain, promoting the growth and development of neurons.

What peptides are nootropics?

Semax: Semax is a synthetic peptide that has shown promise in improving cognitive function, memory, and attention. It is believed to modulate neurotransmitters and promote neuroprotection and neurogenesis.
Noopept: Noopept is a synthetic peptide that is commonly classified as a nootropic. It is reported to have neuroprotective effects and may enhance memory, learning, and cognitive function.
Selank: Selank is a synthetic peptide with anxiolytic and potential nootropic properties. It is believed to modulate the levels of neurotransmitters and reduce anxiety, potentially improving cognitive performance.
Cerebrolysin: Cerebrolysin is a mixture of peptides derived from pig brains. It has been investigated for its potential neuroprotective and cognitive-enhancing effects, including improvements in memory, attention, and overall cognitive function.

What peptides are good for brain fog?

Semax: Semax is a synthetic peptide that has been investigated for its potential cognitive-enhancing properties. It is believed to modulate neurotransmitters and may help improve focus, attention, and overall cognitive function.
Selank: Selank is a synthetic peptide that has been studied for its potential anxiolytic (anti-anxiety) effects. As brain fog can sometimes be associated with anxiety or stress, Selank may indirectly alleviate brain fog by reducing anxiety levels.
Cerebrolysin: Cerebrolysin is a mixture of peptides derived from pig brains. It has been researched for its neuroprotective and neurotrophic effects, which may have positive impacts on cognitive function and potentially alleviate brain fog.

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Gudasheva TA, et al. (2018). Noopept in the treatment of mild cognitive impairment in patients with stroke. doi: 10.17116/jnevro201811807122

Ostrovskaya RU, et al. (2008). Memory restoring and neuroprotective effects of the proline-containing dipeptide, GVS-111, in a photochemical stroke model. doi: 10.1007/s11055-008-9045-9

Sacktor N. (2018). Mechanisms of HIV-Associated Neurocognitive Disorder. doi: 10.1007/s11904-018-0387-8.

Contributors

Daniel Louwrens BSc PT

Daniel Louwrens BSc PT | Writer

Daniel Louwrens is a well-rounded fitness professional with over 10 years of experience in bodybuilding and fitness. He holds a BSc in Chemistry from the University of Western Cape and is a certified International Personal Trainer and Nutritionist. He is also a skilled bodybuilder and head coach for Muscle and Brawn. With his knowledge and expertise, he provides personalized training, nutrition, and recovery guidance to help clients reach their fitness goals.

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