Best Peptides for Weight Loss

People use peptides to meet their different goals. Some aim to build and bulk muscles, while others often want to speed up their recovery process. Many people often start using various peptides to optimize their athletic performance and level up their game.

But one of the characteristics of peptides is weight loss. If you are someone who is aspiring to lose some weight and cut down body fat, then this article is for you.

I will review some of the major peptides that significantly reduce body weight. You will see the optimal dosage guidelines of each peptide and other potential benefits that peptides offer.

Key Takeaways

• Semaglutide is the best available option for weight loss. It acts as an agonist for glucagon-like peptide 1 and maintains blood hormone levels of glucagon. The clinical trials show a 15% weight loss in the subjects, thus proving its effectiveness.
• Tesamorelin is well-known for managing HIV-associated lipodystrophy. The clinical trials of this potential peptide show that it cuts down visceral adipose tissue (VAT), particularly in the abdominal region.
• AOD 9604, a fragment derivative of Growth hormone (GH), promotes lipolysis and inhibits lipogenesis. It utilizes the body fat reserves to prevent any accumulation and eventually leads to weight loss.
• Amino-1MQ, also known as an anti-obesity drug, inhibits an enzyme in the cells, thus speeding up the fat metabolism. It reduces blood cholesterol levels, ensuring that the lipid profile is below the obesity range.
• CJC-1295 stimulates the release of growth hormone (GH) as well as Insulin-like growth factor 1. It acts on target cells such as adipocytes (fat cells) and promotes fat breakdown. Stacking it with Ipamorelin can offer optimal synergistic benefits in weight loss.

How Do Peptides Work?

Although all peptides work by following a different mechanism of action, what’s typical of all the peptides is that they stimulate the release of growth hormone (GH) from the anterior pituitary gland (1).

Here we will talk about different ways in which peptides trigger weight loss.

The growth hormone (GH) released due to peptide stimulation travels to different areas of the body and acts on various target sites such as adipocytes (fat cells), hepatocytes (liver cells), and myocytes (muscle cells).

The subsequent binding on target cells accelerates the rate of fat metabolism and causes fat loss from the central regions of the body.

Some peptides work by stimulating lipolysis, which is the breakdown of body fat (2).

Some groups of peptides work by inhibiting lipogenesis, which is the synthesis of body fat (3).

A few peptides responsible for causing weight loss also work by regulating the blood levels of hormones, such as insulin and glucagon. They boost the release of insulin, which is responsible for keeping blood glucose levels low. Thus, it minimizes the chance of weight gain.

How To Take Peptides

Once you have decided on the specific peptide you will use, you need to look for its available forms. Some peptides can be taken orally or be used as patches, whereas others can only be used in injectable form. Read our full peptide guide here.

Many studies have shown that peptide hormonal therapies are most effective when injected (4). Thus, most vendors only produce peptides in this form.

How To Reconstitute Peptides

You will get the lyophilized (powdered) form of peptide in the vial (glass container).

Before using the peptide, you will have to mix it with the bacteriostatic water, depending on your dosage guidelines. Add the water drop by drop to the vial for maximum interaction between water and peptide.

This way, your reconstituted peptide is ready to be administered. Make sure to use it immediately or at least keep it in favorable conditions before using it.

How To Inject Peptides

Your reconstituted peptide can be either injected intramuscularly, intravenously or subcutaneously.

• The intravenous injection mode requires supervision from an expert because it involves locating a vein and then injecting it.
• The intramuscular mode of injection involves direct administration into muscles.
• Perhaps the most common yet feasible way to administer peptides is via the subcutaneous method. This means administering the dosage directly to the area under the skin. The abdominal area near the stomach region is a common site for this mode of injection.

Are Peptides Safe For Weight Loss?

For sure!

Most of the peptides mimic the action of naturally occurring endogenous peptides. If you are a healthy person with no pre-existing set of conditions, then different peptide therapies can be really effective for weight loss.

It will help you slack down unnecessary body fat, help maintain weight, and keep your physique slim.

Best Peptides For Weight Loss

The 5 peptides which essentially reduces body weight are given below:

1) Best Appetite Suppressant: Semaglutide

Semaglutide is a peptide, which is analogous to glucagon-like peptide 1 synthesized by the intestinal epithelial cells. It is primarily given to patients diagnosed with any chronic weight-related condition such as Diabetes Mellitus Type 2, hypercholesterolemia, hypertension, etc.

It acts as a receptor agonist for glucagon-like peptide 1 (5) and manages blood sugar levels in an individual.

Semaglutide works by regulating hormones such as insulin, which is ultimately responsible for keeping blood sugars level low. It also downregulates the secretion of glucagon, thus preventing any conversion of glycogen to glucose.

The clinical trials involving Semaglutide reported a 15% loss in body weight. It is hypothesized that Semaglutide achieves this by reducing appetite acutely as well as lowering fasting triglycerides and VLDL cholesterol chronically.

The half-life of Semaglutide is very high, which aids in weight loss. The effectiveness of Semaglutide in managing obesity led to the FDA approving this drug.

As the half-life of Semaglutide is very high, a low dosage once a week is recommended. Start with 0.25mg of Semaglutide a week, and if it is well-tolerated, then you can go as high as 2.4mg.

I would highly recommend Semaglutide to people aiming for weight loss in organic ways. Not only does this peptide trigger weight loss, but it also offers a couple of supplemental benefits.

Semaglutide Summary

Semaglutide (GLP-1)

Semaglutide gets grouped with other Peptides but is more commonly known as a GLP-1 receptor agonist. It mimics the action of human incretin glucagon-like peptide-1 (GLP-1).

This is something that you would want when trying to lose weight, and this is why Semaglutide is being used as an anti-obesity medication (combined with a good diet and training plan). It is simply a method of glycemic control.

When trying to lose weight or even trying to increase weight dramatically (bulking), glycemic control could help a tremendous amount.

Semaglutide will help your pancreas release the right amount of insulin when your blood sugar is high. So, it helps your body produce the correct amount of insulin needed.

This can help you avoid chronically high levels of blood sugar, which can have some severe impacts on your health. Fitness fanatics will also know that elevated blood sugar levels are one of the major causes of inflammation, fat gain, and heart disease.

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Semaglutide Overview

⭐️ Top Benefits: Increases glycaemic control and decreases hunger
🧪 Form: Injectable liquid
⌛️ Max Time Used: 6 – 8 Weeks
💰 Average Cost: $119.99
❤️‍🩹 Side Effects: Allergic reaction
☢️ Dangers: Allergic reaction
📚 Best Peptide Stack: HGH / IGF-1 / HGH-Frag
⚤ Men/Women: Men and women
➡️ Go to the Full review

• Increases insulin control
• Decreases hunger

• Pain at the injection site
• Allergic reaction

2) Best Peptide for Fat Loss: Tesamorelin

The first peptide that has proved effective in weight loss is Tesamorelin.

Tesamorelin Acetate is a synthetic peptide comprising 44 Amino acids. Tesamorelin mimics the action of growth hormone-releasing hormone (GHRH) and triggers the release of growth hormone (GH) from the anterior pituitary gland. It then travels to the various target sites such as adipocytes (fat cells) and hepatocytes (liver cells).

Lipodystrophy (6), a condition characterized by abnormal accumulation of body fat in certain areas of the body, such as the abdominal region, is one of the common symptoms in HIV patients as well as people taking antiretroviral medication.

The clinical trials involving the use of Tesamorelin have shown a considerable reduction in visceral adipose tissue (VAT) in patients diagnosed with HIV-associated lipodystrophy.

Other outcomes from the clinical trials include reducing trunk fat, waist circumference, and waist-to-hip ratio (7).

This means that Tesamorelin somehow regulates the unnecessary accumulation of body fat and eliminates it, leading to weight loss. Cutting down the extra layer of fat from the prominent areas of the body, such as the abdominal region, makes you look less chubby too.

This results in an improved body physique, a slim figure and helps you maintain your weight within strict limits.

2mg of Tesamorelin once a day has proven to be effective in cutting down abdominal fat and eventually weight loss.

Tesamorelin Summary

Tesamorelin

As Tesamorelin mimics the action of a naturally occurring endogenous hormone, it also acts on specific target sites. Hence, the mechanism of action followed by tesamorelin is very specific.

Tesamorelin binds to the growth hormone-releasing hormone receptors (GHRHr) located in the anterior pituitary gland. This binding stimulates the somatotrophic cells in the pituitary gland to synthesize and secrete growth hormone (GH).

Growth hormone (GH) acts primarily on adipocytes (fat cells), hepatocytes (liver cells), myocytes (muscle cells), and osteoblasts (bone cells).

To ensure the tesamorelin-induced release of growth hormone (GH) is within set limits, a negative feedback mechanism is initiated, so that serum growth hormone (GH) levels don’t overshoot.

As tesamorelin triggers the release of growth hormone (GH) naturally, it maintains homeostatic coordination between Hypothalamus and pituitary gland.

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Tesamorelin Overview

⭐️ Top Benefits: Increases natural HGH production
🧪 Form: Injectable liquid
⌛️ Max Time Used: 14 weeks
💰 Average Cost: $91.99
❤️‍🩹 Side Effects: Insulin resistance
☢️ Dangers: Not really
📚 Best Peptide Stack: GHRP / HGH / IGF-1
⚤ Men/Women: Men and women
➡️ Go to the Full review

• Muscle gain
• Fat Loss
• Increased bone density

• Injection site pain
• Insulin resistance

3) Best Growth Hormone Peptide

Growth hormone (GH) is a peptide that is made up of 191 Amino acids. AOD 9604 is a modified derivative of growth hormone (GH), which comprises the last 15 Amino acids of the growth hormone’s (GH) sequence, i.e., 176 to 191.

This modified peptide possesses strong fat-burning capabilities and is used as an anti-obesity drug. AOD 9604 works by accelerating the metabolism to burn down any excess body fat.

It does this in two main ways, stimulating lipolysis while inhibiting lipogenesis. AOD 9604 doesn’t affect blood sugar levels either.

Lipolysis is the breakdown of fats into its constituents, which are fatty acids and glycerol. The fatty acids and glycerol then travel to target sites mainly for generating ATP.

AOD 9604 also inhibits lipogenesis, which means that it doesn’t allow the synthesis of fats or triglycerides.

In this way, not only is there no new buildup of fats, but also abdominal fat reserves are utilized, leading to weight loss and a slimmer physique.

Administering 0.25mg to 1mg of AOD 9604 for 24 weeks has shown effective results in causing weight loss with minimal side effects.

ADO 9604 Summary

AOD 9604

Losing excessive body weight and getting rid of obesity has just become much easier with the introduction of AOD9604 in the market.

AOD9604 is a synthetic fragment of the human growth hormone (HGH) C-terminus (176-191). This hexadecapeptide has shown great effects on fat metabolism by upregulating lipolysis and inhibiting lipogenesis.

AOD9604 targets fat-rich areas and promotes fat breakdown without disturbing the overall metabolic profile.

AOD9604 was well advocated as an anti-obesity medication in the past as it cuts down fat deposition. Perhaps this was confirmed in one of the clinical trials taking place in Australia, where nearly 300 obese individuals experienced weight loss.

Besides, AOD9604 doesn’t affect IGF-1 and insulin levels, thus ensuring minimal risk of developing glucose intolerance and diabetes mellitus. With AOD9604, you don’t have to worry about hypercholesterolemia as well!

The good news is that AOD9604 is an FDA-approved drug as an anti-obesity drug, so you don’t have to worry about adverse effects at all. All you can expect is mild headaches, indigestion, nausea, swelling, etc.

AOD9604 can really be your go-to therapy for weight loss but make sure to use it at the right dosages, or else a disturbed metabolic profile awaits you!

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Features

💉 Forms : Powders, Spray
🕑 Cycle Length: 20 Days
💊 Dosage: 300 mcg/day
Benefits: Weightless, Prevents Hypercholesterolemia
💸 Cost : $79.99
⚠️ Side Effects: Headache, Indigestion
Stacks: AOD 9604/Semaglutide

• Marked fat loss
• Can help prevent cardiovascular and metabolic disorders away

• Pain, redness, and flushing of the face can be experienced after the injection

4) Growth Hormone Peptide for Fat Loss

CJC-1295 is a peptide comprising 30 Amino acids. It mimics the action of growth hormone-releasing hormone (GHRH) and stimulates the release of growth hormone (GH) from the anterior pituitary gland.

CJC-1295 also elevates the serum levels of Insulin-like growth factor 1.

Together these act on specific target sites such as adipocytes (fat cells) to accelerate fat metabolism. It also lowers blood glucose levels, which plays an important role in weight loss in an individual.

Most people stack CJC-1295 with Ipamorelin to achieve the optimum and synergistic benefits of both peptides.

The accurate dosage of both peptides can help individuals lose weight as well as experience other benefits, such as muscle growth, strengthening the immune system, and accelerating the process of healing.

Take a 250/100mcg of CJC-1295 and Ipamorelin stack for 12 to 16 weeks to see effective results in losing weight and acquiring a slim body.

CJC 1295 Overview

CJC 1295

CJC 1295 is considered one of the potent growth hormone secretagogues (GHS). 

The peptide was first developed to stimulate the natural production of growth hormone and IGF-1 from the anterior pituitary gland. CJC 1295 also provides an inhibitory effect on the release of somatostatin, an inhibitor of growth hormone. 

These hormones aid in increasing lean body mass, endurance, and strength. Researchers also believe that CJC 1295 is capable enough to regulate sleep cycles. Evidence suggests that growth hormone secretagogues such as CJC 1295 play an important role in maintaining and improving cardiovascular function, wound healing and repair, increased protein synthesis, and much more. 

For bodybuilders, it is recommended to stack CJC 1295 with Ipamorelin to gain maximized benefits. Nonetheless, if you’re a beginner, you might experience unpleasant side effects such as vertigo, increased body temperature, and mood swings. 

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CJC 1295 Overview

⭐️ Top Benefits: Increase lean muscle mass, Enhanced endurance 
🧪 Form: Injectable 
💉 Typical Dosage: 250 mcg to 300 mcg 
⌛️ Typical cycle duration: 60 to 90 days 
💰 Average Cost: $49
✅ Availability: Easily available 
❤️‍🩹 Side Effects and Dangers: Vertigo, Increased body temperature 
📚 Best Peptide Stack: CJC-1295 / Ipamorelin, CJC-1295 / GHRP-2
🔄 See before and after
➡️ Go to the Full review

• Increased muscle mass 
• Increased muscle strength 
• Cardioprotective effects

• Vertigo
• Mood swings 
• Increased body temperature

Anti-Obesity Medication

AMINO-1MQ

The last peptide for discussion is 5-AMINO-1MQ. 5-AMINO-1MQ is a small molecular drug and a derivative of methylquinolinium.

It is potentially a strong candidate to be used for weight loss and as an anti-obesity treatment.

As it enters the cell, it blocks the activity of an enzyme called nicotinamide N-methyltransferase (NNMT). This subsequent blocking of NNMT leads to an increased concentration of nicotinamide dinucleotide NAD+.

As the levels of NAD+, which is also a cofactor, rise, so does the cellular metabolism.

Your body essentially now utilizes body fat significantly for the generation of energy and also inhibits adipogenesis.

It also reduces blood cholesterol levels, making it less likely to depose and cause obesity.

Perhaps the research involving the use of 5-AMINO-1MQ shows that it is safe and effective both for the reversal of obesity caused primarily by diet as well as minimizes the chances of developing it in the future.

A calorie deficit chart will give you a better idea of your performance if you start taking 5-AMINO-1MQ for weight loss.

As it is only available in capsule forms, taking 1 capsule per day for 2-3 months is recommended to see effective results.

• Can lower cholesterol and blood pressure as well

• Not as strong as other Peptides on this list
• More research is needed

Additional Benefits Offered By Peptides

While weight loss is one of the benefits of peptide therapy, there are other potential effects on the body, such as rapid wound healing and quick yet efficient recovery by promoting angiogenesis. Some peptides have anti-inflammatory properties.

Peptides help in building and bulking up muscles and increase muscle mass significantly.

Bodybuilders, athletes, and fitness pros often use peptides with the aim to build stamina and endurance while also improving flexibility in the body.

Perhaps some peptides also improve cardiovascular health and minimize the risk of any pathologies related to the heart in the future.

Peptides also help in regulating the circadian rhythms and ensure an efficient sleep/wake cycle (8).

Alternatives For Weight Loss

While peptides are one of the safest options for weight loss, other alternatives, such as different SARMs, natural herbal supplements, and some drugs, reduce body fat.

SARMs For Weight Loss

Cardarine, one of the highly used SARMs, is a PPAR agonist. It upregulates the expression of genes that promote fat catabolism and thus prevents the accumulation of body fat.

Ostarine, another SARM, is also a potential compound for weight loss. It is hypothesized that it has a nutrient partitioning effect, due to which it is effective in weight loss.

Many SARMs users have also given RAD 140 (Testolone) 10 on 10 in promoting weight loss. It cuts down body fat and prevents any accumulation.

Weight Loss Supplements

Hydroxycut is one of the most popular weight loss formulas. It is a mixture of caffeine and other plant extracts and has been highly effective.

Conjugated Linoleic Acid (CLA) (9) is one of the compounds found naturally in fats. Being a healthier ‘trans’ fat promotes fat metabolism, reduces appetite, and aids in weight loss.

Take-Home Message

Peptides are perhaps one of the safest options for weight loss. Not only will they help in cutting down body fat but also regulate cholesterol and triglyceride levels. Using different peptides, you can easily limit your body weight and impress everyone with your body shape.

I would recommend peptides for sure, considering they impact your body with minimal side effects and offer added benefits.