All of us as kids have fantasized to have those big and bulky muscles when we grow up, no?
While gymming could possibly help you develop the body shape and optimal growth that you have always wished for, you definitely need a head-start, and this is where peptides help you climb up!
The growing use of peptide therapy in the recent past with phenomenal results has made it apparent that peptides are here to aid you in your optimal living.
Peptides almost cover all that men want, be it muscle growth, the right body composition, or enhanced overall health.
So all the men waiting for a headstart in their journey to the desired physical life, read my guide on the 5 best peptides you can practically use to achieve results.
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- 5 of the best peptides for men, especially for optimal muscle growth, include CJC 1295, Sermorelin, TB 500, Semaglutide, and Hexarelin.
- Most of these peptides work by stimulating human growth hormone levels released from the anterior pituitary gland.
- These help boost muscle growth, weight loss, and recovery and improve the immune system.
What are Peptides?
Peptides are short chains of amino acids that serve numerous fundamental functions of our body (1). With their rapid absorption and concise structure, they’re efficient in what they do.
Peptides are potent supplements for muscle bulking, fat loss, and improved endurance. Besides this, new synthetic peptides are being tested for their potential role in age-reversing and rapid wound healing. Peptides also contain antioxidants and anti-inflammatory attributes that can aid in boosting the immune system.
#1 Peptide for Growth Hormone Release: Sermorelin
Sermorelin is a 29 amino acid containing synthetic peptides. The peptide is one of the potent analogs of the human growth hormone-releasing hormone (GHRH). Therefore, Sermorelin mediates its effects by binding to the receptors of GHRH in the anterior pituitary gland. This, in turn, stimulates the release of human growth hormone from the somatotropic cells (2).
Sermorelin is indeed one of the best peptides for gaining muscle mass. The peptide stimulates the growth of the muscle cells via modulating the growth hormone levels; besides this, the peptide also improves sleep quality and efficient wound recovery.
#2 Peptide for Increasing Muscle Growth: CJC 1295
Like sermorelin, CJC 1295 is also a potential analog of growth hormone-releasing hormone. The peptide works by stimulating the anterior pituitary gland. This enhances the natural production of growth hormone and insulin-like growth factor 1 levels (3).
With higher levels, Human growth hormone and IGF-1 can benefit bones, muscles, and cartilage. The peptide increases protein synthesis in muscle cells, amplifying muscle mass (4). CJC 1295 also plays a minor role in reducing subcutaneous fat, thereby improving your lipid profile.
#3 Peptide For Rapid Healing: TB 500
TB 500, also known as Thymosin Beta 4, is a 43 amino acid peptide. TB 500 works in a unique way, unlike others. The peptide works by increasing the body’s reception towards actin filaments. This enhances cell growth, proliferation, and differentiation, specifically in keratinocytes and endothelial cells (5).
This, in turn, increases lean muscle mass and endurance. Besides this, the peptide is also reported to promote angiogenesis. This aids in efficient blood supply to wounds and thus promotes rapid recovery. Nonetheless, the peptide also improves cognitive brain function, cardiovascular health and enhances hair growth.
#4 Peptide For Optimal Energy Levels: Hexarelin
Hexarelin is a growth hormone secretagogue comprising six amino acids (6). The peptide works by stimulating the phospholipid-dependent protein kinase pathway leading to amplified growth hormone secretion. This is, in turn, accompanied by enhanced muscle growth and strength.
Interestingly, Hexarelin is also reported to mimic the action of a naturally occurring hormone, ghrelin. In this way, the peptide is known to regulate blood glucose homeostasis. Research also indicates a protective role in maintaining cardiovascular health and the musculoskeletal system.
#5 Best For Weight Loss: Semaglutide
Semaglutide is a GLP-1 agonist and is more of an anti-obesity peptide. The peptide helps regulate the average blood glucose levels by modulating the release of pancreatic insulin in a controlled manner. The peptide also slows the gastric emptying time, making you feel more full and therefore decreased appetite (7).
Nonetheless, when it comes to the cutting phase of your bodybuilding regimen, Semaglutide would be the one to go for. The starting dose for bodybuilding is around 0.25 mg per week. As weeks follow, you can dose up or down according to your requirement.
How Do Peptides Work?
It’s essential to know how different supplements work in the body. With this, you can better judge whether the product is best for your health. As far as peptides are concerned, they work in quite a simple way.
Most of these peptides act as growth hormone-releasing hormone analogs or growth hormone secretagogues. Either way, the peptides increase serum growth hormone levels and insulin-like growth factor-1. These hormones, in turn, increase protein synthesis, specifically in the skeletal muscle cells leading to rapid bulking.
Therefore, one can also consider these peptides as performance-enhancing drugs as these are often used among bodybuilders and athletes.
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How To Use Peptides?
Peptides are often available in liquid, nasal sprays, transdermal patches, topical creams, or injections.
While peptides are available in many forms, the injectable form is the most potent and effective way to administer peptides.
As far as injectable peptides are concerned, you must be very cautious. You must first reconstitute a lyophilized version of the peptide to use them. To do so, carefully add drops of bacteriostatic water into the vial according to the advised dosage.
Are Peptides Legal?
Regarding peptide legality, they’re yet to be approved by the Foods and Drugs Administration (FDA) in the United States.
Are Peptides Safe?
To be frank, with the limited data available from human-based clinical trials, one can’t say for sure whether these peptides impose any significant harm on the human body or not.
However, animal studies, as well as user experiences, show very promising results when it comes to peptide therapy and is definitely regarded as a far safer option than its counterparts available in the market, such as SARMs and anabolic steroids.
Are peptides Safe?
Peptides are considered very safe for human consumption when taken within the recommended doses.
What are the best peptides for men?
Some of the best peptides for men include CJC 1295, TB 500, Semaglutide, Hexarelin, and Sermorelin.
Can peptides cause serious side effects?
Besides mild headaches, nausea, and slight abdominal discomfort, there are no reported adverse effects.