Despite consistent workouts and strict diets, many struggle to achieve their dream physique. Factors like genetics or ineffective training can hinder progress.
As a result, some athletes turn to peptides—amino acid chains—to boost muscle growth. These have fewer side effects compared to steroids or SARMs.
Let’s dive into the top 5 peptides for muscle growth, how to use them safely, and their potential risks. Equip yourself with knowledge for your bodybuilding journey, what the pros, cons, and dangers are – And where to buy them.
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- Peptides vs. Steroids/SARMs: Athletes are turning to peptides, amino acid chains, for muscle growth due to their reduced side effects compared to steroids or SARMs.
- Peptide Mechanisms:
- TB-500: Boosts muscle cell growth by enhancing the body’s response to actin.
- Sermorelin: Imitates the natural growth hormone-releasing hormone, stimulating faster muscle growth.
- Hexarelin: Triggers growth hormone release, leading to muscle fiber growth and increased lean muscle.
- Safety and Usage: The article emphasizes that while peptides offer benefits, they should be used safely, understanding their potential risks. Before purchasing or using peptides, it’s crucial to consult with healthcare providers and ensure compliance with local regulations.
Muscle Growth Peptide Comparison
|💪 Muscle Strength||✅||✅✅||✅||✅✅✅||✅✅|
|🩸 Wound Healing||✅✅||✅✅||🚫||✅||✅|
|💉 Bodybuilding Dosage||1-8 mg/Week||200-300 mcg/Day||200-300 mcg/Day||50-100 mcg/Day||300 mcg/Day|
|🔄 Cycle length||4 Weeks||4 Weeks||12-16 Weeks||10 to 30 Days||12-16 Weeks|
|💦 Fat Loss||🚫||✅||✅✅||🚫||✅|
|🧠 Cognitive Function||✅||✅||🚫||🚫||✅|
|🫀 Cardiovascular health||✅||✅||✅✅||Probably||✅|
|🩺 Side Effects||Mild||Mild to Severe||Slightly Severe||Severe||Very Mild|
|🧬 Increased Protein Synthesis||✅||✅✅||✅||✅✅✅||✅✅|
|🥛 Calcium Retention||🚫||🚫||🚫||🚫||✅|
How Do Peptides Help Muscle Growth?
Before learning more about different peptides that can be used, it is important to have a thorough understanding of how peptides work at the cellular level to induce muscle growth. There are multiple categories of peptides that bodybuilders specifically use to trigger muscle growth, such as growth hormone-releasing hormone (GHRH), growth hormone-releasing peptides (GHRPs), and growth hormone secretagogues (GHS).
Although the end goal is the same to induce muscle growth, different peptides follow different pathways.
Our muscle fibers are made up of contractile filaments called actin and myosin, which are responsible for contracting and relaxing muscles for mobility (1).
Peptides like TB-500 make our body more responsive to actin by increasing its reception. This increases the growth and proliferation of muscle cells (2).
Other peptides, such as Ipamorelin, Sermorelin, Hexarelin, and CJC-1295, stimulate the natural release of growth hormone (GH) from the anterior pituitary gland (3,4). Growth hormone (GH) can act on myocytes and trigger the growth of new muscle fibers.
Some peptides inhibit the release of somatostatin, also known as growth hormone-inhibiting hormone (GHIH) (5). Thus, growth hormone (GH) levels are always kept at the optimal limit to achieve considerable growth of muscles.
Peptides like follistatin 344 inhibit a naturally occurring regulator of muscle growth called myostatin (7). Myostatin acts to limit muscle growth beyond a certain point. Follistatin 344 inhibits myostatin which leads to excessive growth of muscle fibers, leading to amplified muscle growth (7).
Additionally, these peptides also promote angiogenesis, which is the formation of new blood vessels around the muscle region (8). This ensures an adequate supply of oxygen, nutrients, hormones, and growth factors to the myocytes for optimal muscle growth.
1) Best Peptide for Muscle Growth + And Recovery (Athleticism)
TB-500 is a synthetic version of the naturally occurring peptide LKKTETQ. The peptide segment (17)LKKTETQ(23) is the active site within the protein thymosin β(4) responsible for actin binding, cell migration, and wound healing (9).
As discussed earlier, actin is the main contractile protein in the muscle fibers. The increased reception leads to enhanced cell growth and proliferation of myocytes (muscle cells). This also leads to increased muscle strength and solid stamina.
2) Best Growth Hormone Peptide Antagonist
Sermorelin acetate is the acetate salt of an amidated synthetic 29-amino acid peptide (GRF 1-29 NH 2 ) that corresponds to the amino-terminal segment of the naturally occurring human growth hormone-releasing hormone (GHRH or GRF) consisting of 44 amino acid residues (11).
It mimics the action of the naturally occurring growth hormone-releasing hormone (GHRH). The subsequent binding of sermorelin to the growth hormone-releasing hormone receptors (GHRHr) stimulates somatotrophic cells to secrete growth hormone (GH).
Higher growth hormone (GH) levels stimulate the production of new muscle fibers at a faster rate. This leads to bulking of muscles.
Sermorelin users have also reported experiencing greater muscle gain after intense workout sessions.
Hexarelin acetate, a growth hormone-releasing peptide (GHRP), is a 6 amino acid peptide. It belongs to the growth hormone secretagogue class (GHS).
Hexarelin works similarly to ghrelin, which is a naturally occurring hormone. Hexarelin binds with growth hormone secretagogue receptors (GHSr) located in the hippocampus and peripheral organs to trigger growth hormone release (GH).
Hexarelin-induced growth hormone (GH) release causes the growth of muscle fibers. This leads to bulking up of muscles and greater lean muscle mass. One may experience greater body strength after the use of hexarelin.
5) Best Peptide for Muscle Growth + Fat Loss Combination
CJC-1295, a peptide analog of growth hormone-releasing hormone (GHRH), comprises 29 amino acids.
It also causes the pulsatile release of growth hormone (GH) from the pituitary gland. CJC-1295-induced growth hormone (GH) release offers a wide array of effects on muscle growth.
It causes the retention of calcium which is important for muscle contraction. It triggers increased protein synthesis required for muscle growth. CJC-1295 also sets up a balance between muscle mass and fat loss leading to enhanced strength for bodybuilders.
How To Take Peptides
Once you have decided on the specific peptide you will use, you need to look for its available forms. Some peptides can be injected, taken orally, or used as patches, whereas others can only be used in injectable form.
Many studies have shown that peptide hormonal therapies are most effective when injected and as such most vendors only produce peptides in this form.
Where to Buy These Peptides?
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Best Peptide Stacks for Muscle Growth
The efficacy and safety of peptides largely depend on individual physiology, goals, and how they’re administered. When it comes to muscle growth, several peptides have garnered attention for their potential effects on increasing muscle mass and strength. It’s always crucial to consult with a medical professional before starting any peptide regimen. That said, here’s a popular peptide stack for muscle growth:
- CJC-1295 DAC with GHRP-6 or GHRP-2: This is a popular combination that maximizes growth hormone release. CJC-1295 DAC is a long-acting growth hormone-releasing hormone (GHRH) analog, and when combined with a growth hormone-releasing peptide (GHRP), like GHRP-6 or GHRP-2, it can lead to significant GH release.
- Ipamorelin: Another GHRP, it’s considered one of the safest and most effective for GH release, with fewer side effects (less hunger spikes than GHRP-6 and no cortisol or prolactin spikes). It can be combined with CJC-1295 (without DAC) for synergistic effects.
- IGF-1 LR3 or IGF-1 DES: IGF-1 (Insulin-like Growth Factor-1) plays a direct role in muscle growth. LR3 has a longer half-life, and DES is a shorter, more potent version. They can be used post-workout to help with muscle growth and repair.
- BPC-157 and TB-500: While they aren’t directly related to muscle growth, these peptides are often included in muscle-building stacks due to their injury recovery and healing properties.
Remember, the combination and dosage will depend on individual goals and needs. Additionally, it’s vital to be aware of potential side effects, both of individual peptides and when they’re combined. The legal status of peptides can also vary by country or region. It’s essential to ensure you are complying with local regulations and using peptides responsibly. Always consult with a medical professional before starting any peptide regimen.
Are Peptides Safe For Bodybuilding/Muscle Growth?
As all peptides work in a specific way, each of them needs to undergo human-based clinical trials to prove their safety.
Since not many peptides have completed human-based clinical trials, the WADA and FDA haven’t legalized the usage of many peptides available.
But results from several animal-based clinical trials suggest that peptides are generally safe. They have tested positive to bring muscle growth in the subjects involved in the research.
With a few side effects here and there, such as headache, redness at the injection site, and appetite changes, no severe side effects have been reported, which is why many bodybuilders are often inclined to use peptides over steroids or SARMs to catalyze their journey.
Best Peptide Stack For Muscle Growth
A lot of bodybuilders stack peptides to experience optimum synergistic benefits. Amongst the stacked peptides, the most common is the use of CJC-1295 and ipamorelin.
Ipamorelin, also a growth hormone secretagogue (GHS), comprises 5 amino acids. It binds with receptors located peripherally, such as on myocytes and adipocytes.
As both the peptides work towards increasing the serum levels of growth hormone (GH), they can be used well together to build muscle significantly, lose body fat, and cause a boost in overall energy levels.
Since both the peptides have different half-lives, these can work together to supplement each other’s effects.
After studying the working of peptides thoroughly, I believe that peptides can catalyze the process of muscle building and bulking. Some of the peptides like follistatin 344 work organically and directly to bring muscle growth. In contrast, others such as sermorelin and hexarelin follow an indirect route to build muscles. Nonetheless, if you follow dedicated workout sessions and a strict diet, you should use peptides to achieve results faster.