Best Peptides For Muscle Growth

Here, I discuss 5 of the best peptides for muscle growth in detail and include both their benefits and side effects. I'll also reveal the best peptide stack.

Despite regularly hitting the gym hard and maintaining strict control of their diet, many people continue to struggle in the pursuit of obtaining their desired physique. Whether it’s due to poor genetics, suboptimal training, or a combination of these two factors along with other issues, it may seem nearly impossible for some individuals to achieve their bodybuilding goals, even after spending several years dedicated to the sport.

As such, a handful of these athletes may choose to accelerate muscle growth through the use of certain compounds. Peptides, which are chains of amino acids, have become one of the most popular compounds used for athletic enhancement over the last decade and have much fewer side effects than steroids or SARMs.

Here, I’ll reveal what the 5 best peptides are for muscle growth and guide you on how to safely use them. I’ll also present their potential side effects so that you can make an informed decision on whether or not to use them as a part of your bodybuilding journey.

FeaturesTB 500SermorelinHexarelinFollistatinCJC-1295
💪 Muscle Strength✅✅✅✅✅✅✅✅✅
🩸 Wound Healing✅✅✅✅🚫✅✅
🏃‍♂️ Endurance⬆️⬆️⬆️⬆️⬆️⬆️⬆️⬆️
💉 Dosage1-8 mg/Week200-300 mcg/Day200-300 mcg/Day50-100 mcg/Day300 mcg/Day
Cycle4 Weeks4 Weeks12-16 Weeks10 to 30 Days12-16 Weeks
Fat Loss🚫✅✅✅🚫✅
Cognitive Function✅✅🚫🚫✅
Cardiovascular health✅✅✅✅Probably✅
⚠️ Side EffectsMildMild to SevereSlightly SevereSevereVery Mild
Increased Protein Synthesis✅✅✅✅✅✅✅✅✅
Calcium Retention🚫🚫🚫🚫✅

Peptides For Muscle Growth

Before learning more about different peptides that can be used, it is important to have a thorough understanding of how peptides work at the cellular level to bring about prominent muscle growth. There are multiple categories of peptides that bodybuilders specifically use to trigger muscle growth, such as growth hormone-releasing hormone (GHRH), growth hormone-releasing peptides (GHRPs), and growth hormone secretagogues (GHS).

Although the end goal is the same to bring muscle growth, different peptides follow different pathways.

Our muscle fibers are made up of contractile filaments called actin and myosin, which are responsible for contracting and relaxing muscles for mobility.

Peptides like TB-500 make our body more responsive to actin by increasing its reception. This increases the growth and proliferation of muscle cells.

Other peptides, such as ipamorelin, sermorelin, hexarelin, and CJC-1295, stimulate the natural release of growth hormone (GH) from the anterior pituitary gland. Growth hormone (GH) can act on myocytes and trigger the growth of new muscle fibers.

There are also peptides that inhibit the release of somatostatin, also known as growth hormone-inhibiting hormone (GHIH). Thus, growth hormone (GH) levels are always kept at the optimal limit to achieve considerable growth of muscles.

Peptides also stimulate the release of insulin-like growth factor-1 (IGF-1) from the liver. IGF-1 causes the production of muscle proteins which leads to increased muscle growth.

Peptides like follistatin 344 inhibit a naturally occurring regulator of muscle growth called myostatin. Myostatin acts to limit muscle growth beyond a certain point. Follistatin 344 inhibits myostatin which leads to excessive growth of muscle fibers, leading to amplified muscle growth.

Alternatively, these peptides also promote angiogenesis, which is the formation of new blood vessels around the muscle region. This ensures an adequate supply of oxygen, nutrients, hormones, and growth factors to the myocytes for optimal muscle growth.

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Best Peptides For Muscle Growth

Currently, the market is flooded with dozens of different types of peptides, but here I’ll clarify which peptides are the best for achieving significant muscle growth.

#1 Peptide for Muscle Growth

TB-500 For Muscle Growth

TB-500 is a synthetic derivative of a naturally occurring peptide, Thymosin Beta-4, in the body (2).

It contains a specific peptide segment (17) LKKTETQ(23), which works to upregulate the reception of actin by the various parts of the body (3).

As discussed earlier, actin is the main contractile protein in the muscle fibers. The increased reception leads to enhanced cell growth and proliferation of myocytes (muscle cells).
This also leads to increased muscle strength and solid stamina in the user.

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  • Rapid wound healing
  • Heals ligament and joint injuries
  • Regenerates brain function
  • Improves cardiac health
  • Helps build endurance
  • Stimulates hair growth


  • Lacks human-based clinical trials are available
  • Nausea
  • Mild Headaches
  • Lightheadedness
#2 Peptide for Muscle Growth

Sermorelin For Muscle Growth

Sermorelin Acetate (4), also known as GRF 1-29 NH2, is a synthetic peptide containing 29 amino acids.

It mimics the action of the naturally occurring growth hormone-releasing hormone (GHRH). The subsequent binding of sermorelin to the growth hormone-releasing hormone receptors (GHRHr) stimulates somatotrophic cells to secrete growth hormone (GH) (5).

Higher growth hormone (GH) levels stimulate the production of new muscle fibers at a faster rate. This leads to bulking of muscles.

Sermorelin users have also reported experiencing greater muscle gain after intense workout sessions.

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  • Enhanced muscle growth
  • Efficient healing of wounds
  • Reduces body fat
  • Better sleep quality
  • Improves brain functioning
  • Cardiovascular growth


  • might experience headaches, nausea, dizziness, flushing, allergic reactions, loss of taste, hyperactivity, and paleness of skin
  • insomnia, depression, and hypothyroidism
#3 Peptide for Muscle Growth

Hexarelin For Muscle Growth

Hexarelin acetate, a growth hormone-releasing peptide (GHRP), is a 6 amino acid peptide. It belongs to the growth hormone secretagogue class (GHS) (6).

Hexarelin works in a similar way to ghrelin, which is a naturally occurring hormone. Hexarelin binds with growth hormone secretagogue receptors (GHSr) located in the hippocampus and peripheral organs to trigger growth hormone release (GH).

Hexarelin induced growth hormone (GH) release causes the growth of muscle fibers. This leads to bulking up of muscles and greater lean muscle mass. One may experience greater body strength after the use of hexarelin.

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  • ensures an organic growth hormone release
  • enhancing body strength
  • greatly improves cardiovascular functioning
  • burns down body fat


  • higher cortisol levels, increased prolactin levels, and insulin desensitization
  • Low libido is also a common complaint
  • A feeling of fatigue and lethargy
#4 Peptide for Muscle Growth

Follistatin 344 For Muscle Growth

Follistatin 344, a glycoprotein that is a recombinant derivative of the naturally occurring follistatin, comprises 323 amino acids (7).
Our bodies contain myostatin, which negatively regulates the growth of muscles. Follistatin 344 inhibits myostatin activity. This blocking of myostatin means muscle growth is no longer limited.

Thus, new muscle fibers are seen to grow at a faster rate in the body. Overall muscle mass increases significantly, giving the individual extra strength.

One of the famous studies involving mice (with no myostatin) recorded a 117% increase in muscle fibers. This gives us an insight that follistatin 344 might be working in several ways in the body to cause greater muscle growth.

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  • increased growth of muscle fibers
  • Higher growth of muscle cells
  • build endurance and enhance the athletic capabilities


  • weakening of joints and ligaments
  • increased body temperature
  • may also experience irritation and rashness at the injection site
#5 Peptide for Muscle Growth

CJC-1295 For Muscle Growth

CJC-1295, a peptide analog of growth hormone-releasing hormone (GHRH), comprises 29 amino acids (8).

It also causes the pulsatile release of growth hormone (GH) from the pituitary gland. CJC-1295 induced growth hormone (GH) release offers a wide array of effects on muscle growth.

It causes the retention of calcium which is important for muscle contraction. It triggers increased protein synthesis required for muscle growth. CJC-1295 also sets up a balance between muscle mass and fat loss leading to enhanced strength for bodybuilders.

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  • increased retention of calcium
  • increased protein systhesis and muscle growth
  • increased breakdown of fat


  • reactions at the injection site, such as pain, redness or swelling along with flushing of the face.

How To Take Peptides

Once you have decided on the specific peptide you will use, you need to look for its available forms. Some peptides can be injected, taken orally, or be used as patches, whereas others can only be used in injectable form.

Many studies have shown that peptide hormonal therapies are most effective when injected and as such most vendors only produce peptides in this form (1).

How To Reconstitute Peptides

You will get the lyophilized (powdered) form of peptide in the vial (glass container).

Before using the peptide, you will have to mix it with the bacteriostatic water, depending on your dosage guidelines. Add the water drop by drop to the vial for maximum interaction between water and peptide.

This way, your reconstituted peptide is ready to be administered. Make sure to use it immediately or at least keep it in favorable conditions before using it.

How To Inject Peptides

Your reconstituted peptide can be either injected intramuscularly, intravenously or subcutaneously.

  • The intravenous injection mode requires supervision from an expert because it involves locating a vein and then injecting it.
  • The intramuscular mode of injection involves direct administration into muscles.
  • Perhaps the most common yet feasible way to administer peptides is via the subcutaneous method. This means administering the dosage directly to the area under the skin. The abdominal area near the stomach region is a common site for this mode of injection.

Are Peptides Safe For Bodybuilding?

As all peptides work in a specific way, each of them needs to undergo human-based clinic trials to prove their safety.

Since not many peptides have completed human-based clinical trials, the WADA and FDA haven’t legalized the usage of many peptides available.

But results from several animal-based clinical trials suggest that peptides are generally safe. They have been tested positive to bring muscle growth in the subjects involved in research.

With a few side effects here and there, such as headache, redness at the injection site, and appetite changes, no severe side effects have been reported, which is why many bodybuilders are often inclined to use peptides over steroids or SARMs to catalyze their journey.

Best Peptide Stack For Muscle Growth

A lot of bodybuilders stack peptides to experience optimum synergistic benefits. Amongst the stacked peptides, the most common is the use of CJC-1295 and ipamorelin.

Ipamorelin (9), also a growth hormone secretagogue (GHS), comprises 5 amino acids. It binds with receptors located peripherally, such as on myocytes and adipocytes.

As both the peptides work towards increasing the serum levels of growth hormone (GH), they can be used well together to build muscle significantly, lose body fat and cause a boost in overall energy levels.

Since both the peptides have different half-lives, these can work together to supplement each other’s effects.

Take-Home Message

After studying the working of peptides thoroughly, I believe that peptides can definitely catalyze the process of muscle building and bulking. Some of the peptides like follistatin 344 work in an organic and direct way to bring muscle growth. In contrast, others such as sermorelin and hexarelin follow an indirect route to build muscles. Nonetheless, if you follow dedicated workout sessions and a strict diet, you should definitely use peptides to achieve results faster.

What peptides do bodybuilders use?

Bodybuilders use a wide variety of peptides that best fit their interests.
Most bodybuilders aim for greater muscle growth and faster recovery from injuries.
Peptides like TB-500, Ipamorelin, Sermorelin, GHRP-2, and GHRP-6 help bodybuilders achieve maximum synergistic benefits.

What’s better, SARMs or peptides?

SARMs boost your growth at a faster rate, while peptides bring about relatively slow effects. SARMs stacking cause dramatic benefits in the body while the changes brought about by peptides bring an unpredictable change.

What is the best supplement for muscle growth?

While dozens of supplements bring muscle growth, naturally occurring compounds such as creatine trigger natural muscle growth. Creatine enhances muscle strength and allows you to gain muscle.

Still Have Questions?

Drop us a comment down below and one of our expert coaches will respond to it, you can also email is at

Kartik Kumar Rathi

Kartik is a Doctor in training currently in his third year of medical school with the ultimate goal of becoming a successful cardiologist, he currently contributes to health blogs, research papers and also founded a social health startup to help educate others.
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8 months ago

Hello i have few doubts on peptides usage friends are saying if we use peptides we are unfit for sexual life and testosterone count will decrease. could you please suggest me which one best and what are the side effects it will accures.

anthony Artioli
7 months ago

What is better PEPTIDES for long term health,when not using them,,
Found lost alot weight about year after stopping PEPTIDES,
Some athletes have mentioned use a natural pulse hormone release,more easier I to maintain weight not lose all your hard work gaining muscle strength.
So what is the healthiest hormone release peptide thay won’t play around with me as much,,, was using CJC1295 with DAC,is what I used that n sarms 22,
Gopi you can give some ideas what is the healthier option for when you stopp don’t want to crash again must get back my weight,any ideas would be appreciated
Thanks for your time

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