Have you ever tried to understand the process of growth and development in human life?
Or, have you ever been hit with the question of why the process of growth is so active in the early years of life but slows down after a certain age?
Or maybe, you are one of those people to whom the idea of aging sounds a bit depressing.
Well, the answer to all your questions is the action of growth hormone (GH) in the human body.
As soon as you turn 30, growth hormone (GH) levels begin to deteriorate which means the growth process starts to stall and you gradually begin to notice the physical signs associated with aging.
To prevent a decline in growth hormone (GH) levels, compounds like Sermorelin are synthesized to prolong the process of growth.
In this article, I’ll help you decide whether or not Sermorelin should be your ultimate aging hack.
Key Takeaways
- Growth hormone (GH) plays a crucial role in the process of growth and development in human life, and its decline after the age of 30 can lead to physical signs of aging.
- Sermorelin is a synthetic peptide that mimics the action of natural growth hormone-releasing hormone (GHRH) and can be used to increase GH levels in the body.
- Sermorelin can enhance muscle growth, promote efficient wound healing, reduce body fat, improve sleep quality, enhance brain functioning, and support cardiovascular health.
- Sermorelin is commonly used in bodybuilding to naturally increase growth hormone levels, and its recommended dosage varies depending on experience levels.
- Sermorelin is not illegal but requires a prescription from a medical practitioner, and it can be used by individuals experiencing signs of rapid aging, in addition to children with growth hormone deficiency.
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What is Sermorelin
The hypothalamus, located just above the pituitary gland (1), releases a growth hormone-releasing hormone (GHRH) which, in turn, stimulates the production and secretion of growth hormone (GH) from the pituitary gland (2).
Sermorelin (3), an acetate salt, is a synthetic peptide containing 29 Amino acids.
This artificial peptide (GRF 1-29 NH2) mimics the action of naturally occurring growth hormone-releasing hormone (GHRH) composed of 44 Amino acid residues.
How Does Sermorelin Work
All hormones act on specific target sites in the human body. Since sermorelin mimics the action of growth hormone-releasing hormone (GHRH), it also follows a particular course of action.
The growth hormone-releasing hormone receptors (GHRHr) are located in the anterior pituitary gland.
Sermorelin binds with these receptors to trigger the increased production and secretion of growth hormone (GH) by somatotroph cells (4).
As feedback mechanisms maintain the hormonal levels, the increased serum concentration of growth hormone (GH) stimulates another endogenous hormone called somatostatin, also known as growth hormone inhibiting hormone (GHIH) (5).
Growth hormone inhibiting hormone (GHIH) initiates a negative feedback mechanism to stop the secretion of any more growth hormone (GH) by the somatotroph cells so that hormonal levels don’t overshoot.
Thus, sermorelin makes sure to keep the entire homeostatic coordination of the hypothalamus-pituitary-somatostatin intact.
Apart from this, sermorelin also improves the sleep-related circadian rhythm by reducing the production of stress hormones. This further amplifies the release of growth hormone (GH).
Where To Buy Sermorelin
Sermorelin
Sermorelin, an acetate salt, is a synthetic peptide containing 29 Amino acids. This artificial peptide (GRF 1-29 NH2) mimics the action of naturally occurring growth hormone-releasing hormone (GHRH) composed of 44 Amino acid residues.
The growth hormone-releasing hormone receptors (GHRHr) are located in the anterior pituitary gland. Sermorelin binds with these receptors to trigger the increased production and secretion of growth hormone (GH) by somatotroph cells.
As feedback mechanisms maintain the hormonal levels, the increased serum concentration of growth hormone (GH) stimulates another endogenous hormone called somatostatin, also known as growth hormone inhibiting hormone (GHIH).
Growth hormone inhibiting hormone (GHIH) initiates a negative feedback mechanism to stop the secretion of any more growth hormone (GH) by the somatotroph cells so that hormonal levels don’t overshoot.
Thus, sermorelin makes sure to keep the entire homeostatic coordination of the hypothalamus-pituitary-somatostatin intact.
Apart from this, sermorelin also improves the sleep-related circadian rhythm by reducing the production of stress hormones. This further amplifies the release of growth hormone (GH).
Sermorelin Overview
⭐️ Top Benefits: Increases natural HGH production
🧪 Form: Injectable liquid
⌛️ Max Time Used: Up to 3 months
💰 Average Cost: $42.99
❤️🩹 Side Effects: Insulin resistance
☢️ Dangers: Not really
📚 Best Peptide Stack: HGH / IGF-1 / GHRP / CJC-1295
⚤ Men/Women: Men and women
➡️ Go to the Full review
- Enhanced muscle growth
- Efficient healing of wounds
- Reduces body fat
- Better sleep quality
- Improves brain functioning
- Cardiovascular growth
- Injection site pain
- Insulin resistance
- might experience headaches, nausea, dizziness, flushing, allergic reactions, loss of taste, hyperactivity, and paleness of skin
Benefits of Sermorelin
The primary function of sermorelin is to restore growth hormone (GH) levels and delay the process of aging.
In doing that, there are many secondary benefits experienced by the human body due to the Sermorelin administration.
The major ones are as follows:
Enhanced muscle growth:
Sermorelin triggers the bulking of muscles by stimulating the muscle cells to increase more rapidly in number.
Muscle gain is tremendous after vigorous workout sessions. Besides, sermorelin ensures faster recovery after a hardcore exercise.
Efficient healing of wounds:
Sermorelin ensures rapid yet efficient healing of wounds. This happens due to the proliferative action of growth cells surrounding the injured areas.
Particularly, it helps in the faster recovery of patients who have arthritis or other manageable chronic conditions.
Reduces body fat:
Sermorelin cuts down extra body fats, especially abdominal fat tissue. The burning of fats in the form of adipose tissue supplements the energy requirements of the body.
Better sleep quality:
As talked about earlier, sermorelin maintains sleep-related circadian rhythms. Hence, it helps you get a deep sleep without disruption.
Quality sleep organically improves your performance throughout the day.
Improves brain functioning:
Sermorelin therapy triggers the regeneration of brain cells which minimizes the delay in cognitive capacities of an individual.
Cardiovascular growth:
Sermorelin therapy is known to treat patients suffering from cardiovascular problems such as congestive heart failure.
It indirectly minimizes the risk of developing heart diseases by triggering the growth and regeneration of heart cells.
Sermorelin Usage in Bodybuilding
Sermorelin being a Human Growth Hormone (HGH) secretagogue, increases growth hormone levels naturally.
Research indicates that excess growth hormone can lead to the formation of collagen (a significant muscle protein) in tendons and skeletal muscles.
This helps increase your muscle growth and bulking.
For beginners, the studied dosage is 50-100 mcg of Sermorelin before bedtime.
For intermediate and advanced users, 100-200 mcg of the peptide is advised.
However, for bodybuilding, the Sermorelin dosage is usually started above 500 mcg.
Is Sermorelin Legal
Although sermorelin isn’t illegal or declared a banned substance by the Drug Enforcement Agency (DEA), you will be required to obtain an authentic prescription from a medical practitioner before making a legal purchase of sermorelin.
Who Should Use Sermorelin
Sermorelin is prescribed primarily to children showing growth hormone (GH) deficiency symptoms and to evaluate pituitary function.
However, doctors may recommend Sermorelin therapy later in life if you experience signs of rapid aging, such as rough or fragile skin, slow recovery from injuries, and prolonged feelings of fatigue.
How To Use Sermorelin
Sermorelin can only be administered through injections. Subcutaneous injection into your body fat is a common way for sermorelin therapy.
I would personally recommend adopting this way because of its ease of use.
Alternatively, if you have professional help available, you may inject intravenously.
Both ways are equally effective, so it all narrows down to personal choice at this point.
Forms Of Sermorelin
Authentic sermorelin is only available in injectable forms.
I believe this is because of the high effectiveness of the sermorelin experienced when you inject it directly.
Note that you may come across some stores selling Sermorelin in capsules/tablet form.
There is a very high chance that these oral modes of sermorelin are not genuine and completely fake (6).
Sermorelin Dosage
The first thing we need to understand is that the dosages used in the medical world vs the bodybuilding world are vastly different.
Bodybuilders will often push way past what is deemed normal to get the best results possible.
Studies looking at the dosage for normal human beings found that 0.5 – 1.0mg twice daily have found good results when looking at HGH and IGF-1 levels.
But again, this particular study was done on elderly people, hardly the biggest of us (7).
Another study looking at elderly men found that 2mg at night did increase HGH and IGF-1 levels, but less than the study before.
This would indicate that timing certainly matters when it comes to Sermorelin dosing (8). Another study showed that long-term treatment is needed before you see a result (9).
So, what about bodybuilders? Well, as you know, no study will tell us how much bodybuilders should take.
Thus, I’m going to create a quick table for you to reference some ideas from:
| Option | Dosage | Timing/Duration | Reasoning |
| Opt. 1 | 0.5 – 1.0mg x 2 per day | 2 – 4 months | Increase in basal HGH and IGF |
| Opt. 2 | 0.3mcg per kg x 1 per day | 2 – 4 months | Increase in basal HGH and IGF |
| Opt. 3 | 2.0 – 3.0mg x 1 per day (Before cardio) | 2 – 4 months | Fat loss |
| Opt. 4 | 2.0 – 3.0mg x 1 per day (After weights) | 2 – 4 months | Muscle gain |
Sermorelin Cycle
Generally, this peptide triggers the release of growth hormone (GH) within 2 hours.
You can split your daily requirement into 2-3 smaller doses across the day. This will regularly induce the release of growth hormone (GH) for best results.
Alternatively, you can choose to inject it at once before going to bed to set up a natural trigger in the body.
You should expect the benefits of sermorelin intake after continuing the use for as long as 3-6 months.
Sermorelin Stacks
The synergistic effects of using sermorelin and various other peptides trigger a greater release of growth hormone (GH) levels in the body.
Many users have experienced maximum benefits organically after stacking sermorelin with other relevant peptides such as Ipamorelin, GHRP-2, and GHRP-6.f.
Thus, many of the recognizable brands like Pure Rawz offer a sermorelin blend with other peptides.
Sermorelin Experiences
As it still lies in a grey area, we could only find a handful of reviews left by people on multiple platforms.
- Fouke said,
“I’m 55. I started taking it 7 months ago. My Dr told me that it would take a couple of months to begin kicking in for weight loss, but my sleep would improve in the 1st week.
He was correct. My sleep apnea has ceased. I’ve lost 75 lbs. (270 to 195). I am also dieting and exercising. The doctor told me that about half of the weight loss was due to the Sermorelin injections. To be honest, though, I did not have any energy to exercise before the injections.”
- An anonymous female aged between 45-54 says,
“Improved energy & stamina, LIBIDO, lean muscle, weight loss, thicker hair, improved mental function.”
- Another male aged between 55-64 said,
“Improved muscle firmness and loss of body fat.”
On the other hand, there were a few opinions that showed the other side of Sermorelin’s use.
- Rambo, aged between 55-64 expressed,
“I have only taken it for a week, but I am experiencing extreme somnolence (sleepiness) after I take it, the next day. I was wondering if this side effect passes over time. It is difficult to concentrate the next day.”
- Haley had quite a rough time using Sermorelin, due to which she went on to leave a review that,
“I always got a red welt after use and the last two times I injected it I got severe itching of palms of hands and soles of feet.
I was using an autopen for injections. I discontinued use due to fear of serious allergic reaction.”
Side Effects Of Sermorelin
As it mimics the action of one of the naturally occurring hormones in the body, it doesn’t show many severe side effects.
The side effects reported are generally mild and diminish after a more regular administration.
Immediately after injecting, you might experience headaches, nausea, dizziness, flushing, allergic reactions, loss of taste, hyperactivity, and paleness of skin.
Severe symptoms experienced, which are rather uncommon, include insomnia, depression, and hypothyroidism.
Additionally, few cases have been reported of developing antibodies against sermorelin, but the exact pathophysiology is not yet known.
Sermorelin vs Other Peptides
| Sermorelin | Ipamorelin | Modified GRF 1-29 | CJC-1295 | |
| Mechanism of Action | Mimics GHRH to stimulate GH | Stimulates pituitary gland | Mimics GHRH to stimulate GH | Stimulates GH secretion |
| Mechanism Difference | Similar end function | Different mechanisms of action | Similar end function | Different half-life |
| Structural Differences | Minimal | – | Altered amino acids for GH | – |
| Synergistic Effects | Achieves results | Synergistic benefits | – | Prolonged effects |
Sermorelin vs Ipamorelin
Although both peptides are pretty similar in terms of their end functioning, there still lies a significant difference in the mechanism of action (8).
Ipamorelin stimulates the pituitary gland in other ways for a greater release of growth hormone (GH).
Despite different mechanisms, the synergistic functioning of both peptides has achieved some phenomenal results.
The benefits include higher natural growth to increased libido and much more!
Sermorelin vs Modified GRF 1-29
These two peptides don’t have much of a difference in terms of their functioning. However, there are some recognizable structural differences.
Four specific amino acids have been altered in modified GRF 1-29 mainly for logistics reasons and to enhance growth hormone release (GH).
Sermorelin vs CJC-1295
As CJC-1295 is also one of the Growth hormones secretagogues (GHSs) (10), it also has quite a similar functioning. But, sermorelin and CJC-1295 differ in their half-lives.
Having a greater half-life means CJC-1295 can stay in serum for a longer time and show prolonged effects compared to sermorelin.
Is Sermorelin Legit
After reading out personal stories of people about their sermorelin experience, the clinical studies performed on sermorelin, and the prospective benefits, I think sermorelin offers some real magic in the body!
In the end, it pretty much all comes down to what you decide for yourself because everyone’s body requirements, personal goals of growth, and mindset about growth therapies differ.
Does Sermorelin increase testosterone levels?
According to clinical trials performed on rats, there has been a significant increase in levels of testosterone (11).
Is Sermorelin better than HGH?
Yes, it is. Sermorelin triggers the release of growth hormone (GH) naturally, while HGH therapy suppresses the natural mechanism.
Can I take too much of Sermorelin?
No, use it according to your doctor’s prescribed dosage. Higher sermorelin will increase the risk of side effects.
Can Sermorelin make you hungry?
Sermorelin can increase hunger. This is because growth hormone naturally stimulates hunger hormone in the body. Additionally, it also carries out rapid glucose oxidation and lipogenesis.
Does Sermorelin help you retain the water?
Yes, it helps your skin become more elastic by retaining water. Retaining water is rather a homeostatic benefit. This is because people deficient in growth hormone (GH) often get dehydrated and lose fluids.
Is Sermorelin a steroid?
No, it’s a peptide that mimics the action of natural hormones.
Hi, Insulin resistance is listed above as a side effect. Can you elaborate on the mechanism for this and how common it is? I am using it for weight loss and regaining muscle but definitely don’t want to move towards insulin resistance. Thank you.
I’ve been taking Sermorelin for 6 months to help build muscle and increase strength.
Should I cycle off if it and if so, for how long?