Best SARMs for Cardio

Whether you're looking for the edge in your WOD at the local Box, or aiming to decrease your 5 mile time, if SARMs could help, should you use them?
Medically reviewed by Dr. Mohammed Fouda
Dr. Fouda uses his extensive knowledge and expertise as an academic scholar to medically review articles for scientific accuracy and credibility, ensuring that the medical information presented is up-to-date and trustworthy. He is responsible for ensuring the quality of the medical information presented on our website.

Flashbacks to PT class with the weird gym teacher chasing you around the field.

Heart palpitations that make you concerned.

Sweat in places you didn’t even know you had.

This is what the word cardio does to those who weigh more than 250.

But if you’re reading this article I’m gonna go ahead and guess you’re probably quite fit already.

The term SARMs however, conjures images of jacked dudes with buckets of chicken and rice.

One wouldn’t think that the two could ever cross paths!

That’d never happen, that’s like saying a guy eating a bat could shut down the global economy.

Huh? It what? That happened? Oh wow. Jeez.

Okay, well let’s see if there’s any real connection between SARMs and Cardio.

Warning: The content on and the information included in this article is intended for entertainment and informational purposes only. It is not intended nor implied to be a substitute for professional medical advice. Prior to buying anything, check that it is compliant where you live with your current government laws. We frequently mention research chemicals that are not made for human consumption. Therefore, before purchasing any product for personal use, consult with your doctor or healthcare provider first.

Two Best SARMs for Cardio

Ligandrol 4033 (LGD 4033) is an extremely common SARM, especially among beginners. Ligandrol is known to have benefits in regards the normal muscle gain and fat loss which both will aid in endurance and high-intensity cardiovascular activities. However, Ligandrol has a little secret up its sleeve.

Ligandrol has been shown to increase endurance. It can increase recovery. It can increase sex drive. It can increase your credit score. Ok maybe it can’t do that last one but it can do all the rest.

Originally formulated by Ligand Pharmaceuticals, it has now found popularity amongst men and women who rave about the muscle building, fat loss, and endurance effects.

LGD 4033 Summary

Ligandrol LGD-4033

Ligandrol LGD-4033 is a selective androgenic receptor modulator (SARM) that was developed by Ligand Pharmaceuticals. It is primarily a mass-building SARM that was originally developed to treat muscle-wasting conditions.

Ligandrol is one of the best SARMs for increasing lean mass and it activates the muscle regeneration process after a workout. This SARM also increases both energy and strength.

Ligandrol can be stacked with a cutting SARM for weight loss in order to preserve muscle size while you are stripping off body fat.

In terms of weight loss, Ligandrol is able to attach to fat receptors and stimulate fat loss. It will boost the metabolism for faster calorie burning.

Ligandrol LGD-4033 Overview

⭐️ Top Benefits: Muscle growth, strength gain, fat loss
πŸ§ͺ Form: Liquid, Powder
βŒ›οΈ Cycle Length: 6 – 10 weeks
πŸ’° Average Cost: $59.99
β€οΈβ€πŸ©Ή Side Effects: Aggression, acne, liver and kidney issues, and hypertension
☒️ Dangers: Hepatotoxicity, Renal toxicity
πŸ“š Best Stack: MK-677 / Cardarine / RAD 140
PCT Required: Yes
πŸ§β€β™‚οΈπŸ§β€β™€οΈMen/Women: Men
πŸ”„ See Results
➑️ Go to the Full review

  • Better recovery
  • Improved fat loss
  • Massive muscle gains
  • Aggression
  • Androgenic sides
  • Liver and kidney toxicity
  • Hypertension

Scary name, exhilarating results. Ostarine MK 2866 is your standard, run-of-the-mill SARM. With less affinity to the androgen receptors that can cause problems, this SARM can significantly increase muscle mass, decrease fat mass as well as boost performance.

Ostarine also has a reputation for being quite good for vascularity, which is going to be great for cardio purposes! More blood means more oxygen.

Ostarine Summary

Ostarine MK-2866

Ostarine is an orally-active, non-steroidal selective androgen receptor modulator (SARM ).

It’s considered to be the best SARM for beginners and it is most commonly used during bulking and recomp phases.

In a 12-week double-blind placebo-controlled phase II clinical trial involving 120 healthy elderly men and postmenopausal women, ostarine was shown to significantly increase muscle issues, and improve physical function and insulin sensitivity. [4]

Ostarine selectively binds itself to proteins within the body that are called androgen receptors. When attached to the androgen protein, it communicates the message for it to get bigger.

Unlike anabolic steroids, Ostarine does not convert to estrogen or DHT. [5]

Ostarine is legal, but only for research purposes. It has not been approved by the US Food & Drug Administration (FDA) and as a result, cannot be sold as a dietary supplement.

Ostarine MK-2866 Overview

⭐️ Top Benefits: Muscle growth, strength gain, fat loss
πŸ§ͺ Form: Liquid, Powder
βŒ›οΈ Cycle Length: 6 – 7 weeks
πŸ’° Average Cost: $54.99
β€οΈβ€πŸ©Ή Side Effects: Stomach pain, headaches, cholesterol increase, liver strain, and hypertension
☒️ Dangers: Hepatotoxicity
πŸ“š Best Stack: MK-677 / Cardarine / RAD 140
PCT Required: Yes
πŸ§β€β™‚οΈπŸ§β€β™€οΈMen/Women: Men and Women (Lower dose)
πŸ”„ See Results
➑️ Go to the Full review

  • Better recovery
  • Improved fat loss
  • Massive muscle gains
  • Stomach pain
  • Headaches
  • Liver toxicity
  • Hypertension
  • Cholesterol

What are SARMs?

SARMs (selective androgen receptor modulators) are products that were designed to replicate the male hormone testosterone but without any of the drawbacks. See, humans have androgen receptors in various places, ranging from muscles to the prostate. Both will force change when stimulated with the correct compound. Having big muscles? Sweet. Having a big prostate? Oof.

Testosterone has a high affinity to bind to all androgen receptors. When bound, they force a change in DNA, by the formation of new tissue i.e. muscle growth. Now of course, as I mentioned before, growth in certain parts of the body like the prostate is not desirable. This is where SARMs really come through. Due to their selective nature, they don’t bind to the receptors you wouldn’t want. You get all the growth and physiological benefits, with non of the drawbacks.

SARMs were originally designed to be used on patients who were suffering from muscle-wasting illnesses. SARMs could help these individuals gain muscle at an easier rate whilst having fewer side effects than other treatments like steroids.

How do SARMs work?

The body has androgen receptors (or NR3C4 – nuclear receptor subfamily 3, group C, member 4) all over the body in select tissue, ranging from muscle, prostate, reproductive and cardiovascular. They have the role of being activated by certain compounds such as androgenic hormones to serve the purpose of changing the DNA in that select tissue.


The most prominent of these androgenic hormones found in the human body would be Testosterone, which is essential for the health and development of human beings. Unfortunately, when doctors studied what happened when you give exogenous testosterone to people, they found that this Testosterone is also bound to the receptors in the prostate, which can cause cancer.

SARMs Rad140

Compared to Testosterone, a SARM like Rad140 is structurally very different from Testosterone as illustrated above. This is one of the reasons SARMs are selective in nature. They only bind to the androgen receptors in muscles and bones. Thus, they can have good effects without any of the drawbacks.

Cardio Benefits of SARMs

It will come as no surprise that SARMs are predominantly used for muscle gain and fat loss, and while those two can definitely aid in cardiovascular output, let’s dig a bit deeper to see if there are any other cardiovascular benefits to SARMs.

1) Muscle Gain

It will come as no surprise that SARMs cause muscle gain, that’s what they were designed for. Muscle gain is exceptionally good for cardiovascular output. Increased hypertrophy has been associated with a lowering of blood pressure, which of course means your muscles have easier access to oxygen and nutrients, meaning a better time for your lap.

While there is evidence that some SARMs like this GW-501516 can cause an increase in blood pressure, most of the SARMs will not. It should also be noted that having more muscle, means your power output is more, meaning in High-Intensity cardio environments you will have an exceptional advantage.

2) Decreased Fat Mass

Force = mass x acceleration. Fat people are slow. That’s not fat shaming, that’s just Newton being not-so-PC. If you carry around a few extra pounds of lard, you cannot really expect to be performing at your best.  The fat mass has been associated with high blood pressure, diabetes, and high cholesterol. While we all agree Tyson Fury might be the only guy to not live by this rule, for the most part, having less body fat is going to help you tremendously.

SARMs have been shown to accelerate fat loss when combined with a caloric deficit and training program. This will not only make you lighter but also decrease the load on your heart meaning that the Hemi power station can really focus on getting you moving.

3) Increased Performance

They don’t call it Performance Enhancing Drug for nothing! Some SARMs just straight-up improve performance. It has been well documented that certain SARMs can increase strength, which can can be advantageous in High-Intensity cardio environments. Other studies have found certain SARMs to increase growth hormone, which can lead to better recovery. Both of these variables can improve cardiovascular capabilities.

Yes and no. Hear me out. Currently, it’s only illegal to sell SARMs “for human consumption”. These products may only be sold as research compounds, and may not be advertised as a dietary supplement. Also, if you’re competing in a WADA (World Anti-Doping Association) controlled sport, steer clear of SARMs as they are listed as a banned substance.


The Best SARMs for Cardio

So now that we have established that SARMs can in fact have a positive effect on cardiovascular capabilities, let’s take a look at the best ones for the job.

Side Effects

Just like how the flu shot I got from the biggest guy in the gym made me cough for hours, even SARMs have side effects, unfortunately. SARMs were originally designed to have as few sides as possible, however, they do have some sides.

Testosterone Suppression

Some SARMs are so powerful that they do suppress Testosterone. I would do a lot of research about which SARM I’m going to put into my body. If you are going to use a more powerful SARM like S23, I would make sure I have something like Tamoxifen at hand for estrogenic side effects, and that I follow a planned PCT.

Organ Damage

Some SARMs are so powerful, they do in fact end up damaging your liver, prostate, and other organs as well. Thus, it is important to make sure you supplement with the correct products to protect your organs whilst on your SARM cycle.


SARMs having negative effects on your blood lipids is nothing new. Multiple studies have shown that SARMs lower HDL (good cholesterol).

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Who should use SARMs for Cardio?

Well, obviously someone who’s gone through puberty. Secondly, SARMs aren’t going to be that magic bullet that’s gonna get you fit without you actually doing something. SARMs still require a massive amount of work from yourself, diet, training, and resting like an absolute animal. We all know plenty of guys thinking that SARMs will be the key to them becoming the next big thing, and, well they still have the structural integrity of an Γ‰clair. You still need to put in the work.

Who should use SARMs

That being said, if you have your training and diet ducks in a row, SARMs could potentially be a game changer for you. With tonnes of anecdotal evidence and quite a few studies to show their effectiveness, the results speak for themselves.


How long are SARMs detectable?

It depends. Because every SARM is different chemically, it will be metabolized differently. Thus, certain SARMs might take longer to work out of the system.

Should I still take my SARM dose on off days?

Yes. For blood levels to remain as stable as possible, do not skip days while on the cycle.

Will I need a PCT?

If you run a low dose or run compounds that aren’t super strong, probably not. But, probably best to check your blood anyways.


SARMs are definitely a part of sports already. If there is a way to get an advantage people will find it. SARMs can without doubt improve your cardio output, but only if used correctly and optimally. They aren’t going to be a one-hit wonder in the way that they’ll fix a bad diet and training schedule, but they may be the extra 5% you need.

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Daniel Louwrens BSc PT

Daniel Louwrens BSc PT | Writer

Daniel Louwrens is a well-rounded fitness professional with over 10 years of experience in bodybuilding and fitness. He holds a BSc in Chemistry from the University of Western Cape and is a certified International Personal Trainer and Nutritionist. He is also a skilled bodybuilder and head coach for Muscle and Brawn. With his knowledge and expertise, he provides personalized training, nutrition, and recovery guidance to help clients reach their fitness goals.

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Dr. Mohammed Fouda

Dr. Mohammed Fouda | Reviewer

Dr. Fouda uses his extensive knowledge and expertise as an academic scholar to medically review articles for scientific accuracy and credibility, ensuring that the medical information presented is up-to-date and trustworthy. He is responsible for ensuring the quality of the medical information presented on our website.

Read all articles
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John Dunn
John Dunn
2 years ago

What would you suggest for a 57 year old man that wants to lean up but build more muscle have taken sarms before my favorite was rad 40

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