Safest Peptides for Muscle Gain + Weight Loss

One of the concerns prior to starting a peptide therapy is whether there will be any adverse effects on health. Read through the end to learn about the top 5 safest peptides to exist in the market!
Medically reviewed by Dr. Mohammed Fouda
Dr. Fouda uses his extensive knowledge and expertise as an academic scholar to medically review articles for scientific accuracy and credibility, ensuring that the medical information presented is up-to-date and trustworthy. He is responsible for ensuring the quality of the medical information presented on our website.

Now, to be honest, we should unanimously agree that one of the first things we are usually concerned about is safety and efficacy before starting on any specific peptide therapy.

In these times, the market is brimmed with all kinds of peptides. Some peptides can promote weight loss, enhance muscle growth, build lean muscle mass, strengthen the immune system, initiate wound healing, produce anti-aging effects, and whatnot.

While all of it may sound impulsive, there are a lot of things that one needs to look for before deciding on specific peptide therapy. And one of the biggest boxes to be ticked is whether the peptide is SAFE for usage or not!

But nothing to worry about, as I have filtered the top 5 peptides that are safest to be used. Read through the end to know more about each of the peptides and start on your peptide therapy with no concerns for any adverse effects at all!

Warning: The content on and the information included in this article is intended for entertainment and informational purposes only. It is not intended nor implied to be a substitute for professional medical advice. Prior to buying anything, check that it is compliant where you live with your current government laws. We frequently mention research chemicals that are not made for human consumption. Therefore, before purchasing any product for personal use, consult with your doctor or healthcare provider first.

Key Takeaways

  • Glutathione is on top as it is the safest with potent antioxidant properties and significantly enhances your overall health
  • HGH FRAG is a peptide fragment of human growth hormone (HGH) that possesses lipolytic properties and ensures lower blood glucose levels
  • TB-500 ranks in 3rd position as it works to shorten your recovery time from any injuries and enhances your musculoskeletal health with no risks
  • BPC-157 is another well-known peptide when it comes to rebuilding, regeneration, and regrowth after an injury. Besides, BPC-157 also offers some other minor benefits, such as neurological effects
  • Last in line is Ipamorelin which is a growth hormone secretagogue (GHS). It increases human growth hormone (HGH) levels, resulting in all associated effects

What Are Peptides?

Peptides are short chains of amino acids that make up proteins. These peptides are based on the unique arrangement and sequencing of different amino acids which is responsible for many unique functional properties.

After the first synthetic peptide was introduced in the market, many other artificially synthesized peptides hit the market and brought a revolution!

These peptides are thought to interact with the proteins found in the human body. This leads to the regulation of various physiological and biochemical processes in the human body. 

5 Safest Peptides you can Buy

Glutathione Summary


Glutathione, an endogenous tripeptide with an amino acid sequence of cysteine, glutamic acid, and glycine, is often available at stores with the name GSH. This potent anti-oxidant molecule is produced by the liver and neuroglia in our body.

Glutathione plays a key role in detoxification and getting rid of all the oxidants and scavenger particles produced in the human body due to various biochemical processes. It is important to mention that one of the major roles of glutathione is to protect red blood cells, as they are more susceptible to oxidative stress.

Because glutathione levels decline as we age, this makes us more prone to developing cancers and other related disorders, so one can also correlate the role of glutathione in delaying the onset and progression of cancer.

Glutathione Overview

⭐️ Top Benefits: Recovery from injuries; both muscular and organ
πŸ§ͺ Form: Injectable liquid, Nasal Spray
βŒ›οΈ Max Time Used: 8 weeks
πŸ’° Average Cost: $76.99
β€οΈβ€πŸ©Ή Side Effects: Allergy risk (small)
☒️ Dangers: Not really
πŸ“š Best Peptide Stack: TB 500 / BCP 157 / HGH / IGF-1

  • Improved recovery from injuries (organ and muscle)
  • Improved all bodily functions
  • Injection site pain
  • Allergy risk

HGH-Fragment 176-191

HGH-FRAG is a sliced version of Human Growth Hormone. Distinctly it comprises the last 16 amino acids sequence of HGH from the 191-long sequence of the latter. Chemically the peptide goes by C39H60N8O13. 

However, unlike HGH, the HGH-FRAG has quite a different working mechanism. One would think that being a spliced part of Growth Hormone, HGH fragments would also be conventionally working the same way. Nevertheless, the answer is no. 

Unlike its parent GH, HGH-FRAG does not bind to Growth Hormone Receptors (GHR) because it does not consist of all 191 amino acids. Thus, it can neither transcribe the formation of IGF-1 nor carry out any anabolic functions the way GH would. 

Research suggests that a three-week course with HGH-FRAG therapy in obese mice resulted in an approximate cut down of 50% in weight gain.

HGH-Fragment 176-191 Overview

⭐️ Top Benefits: Muscle buildup, Anti-obesity effects
πŸ§ͺ Form: Injectable forms
πŸ’‰ Typical Dosage: 200 mcg to 300 mcg
βŒ›οΈ Typical cycle duration: 4 to 8 weeks
πŸ’° Average Cost: $63
βœ… Availability: Easily available
β€οΈβ€πŸ©Ή Side Effects and Dangers: Joint problems, Insulin sensitivity
πŸ“š Best Peptide Stack: HGH Frag / Mod GRF 1-29, HGH Frag / Ipamorelin or CJC-1295
➑️ Go to the Full review

  • Muscle buildup
  • Fat loss
  • Increased overall energy
  • Stomach discomfort
  • Joint problems
TB500 Summary


Thymosin beta-4 is a small peptide with G actin-sequestering action. It is associated with the induction of angiogenesis and accelerated wound healing (10).

TB-500 is a synthetic version of the naturally occurring peptide LKKTETQ. The peptide segment (17)LKKTETQ(23) is the active site within the protein thymosin Ξ²(4) responsible for actin binding, cell migration and wound healing

Muscle fibers are made up of actin and myosin, which are contractile filaments. These filaments allow our muscles to contract and relax for mobility and carry out efficient metabolism and cell signaling.

TB-500 increases our body’s response to actin by increased reception of the protein by the peptide segment (17)LKKTETQ(23). This upregulation promotes increased cell growth, healthy cell proliferation, healing effects, and cell migration, particularly keratinocytes and endothelial cells.

TB-500 promotes angiogenesis which is the formation of new blood vessels. It builds up new blood vessel pathways for efficient blood supply to the wounds for increased healing. It also augments beneficial inflammation at the site of injuries.

TB-500 Overview

⭐️ Top Benefit: Rapid recovery from injuries
πŸ§ͺ Form: Injectable liquid, Capsules, Transdermal patches
πŸ’‰ Typical Dosage: 7.66 mg/week
βŒ›οΈ Typical cycle duration: 14 weeks
πŸ’° Average Cost: $69.99
βœ… Availability: Easily available
β€οΈβ€πŸ©Ή Side Effects and Dangers: Headaches and stomach discomfort
πŸ“š Best Peptide Stack: BPC-157 / TB-500
➑️ Go to the Full review

  • Rapid wound healing
  • Heals ligament and joint injuries
  • Helps build endurance
  • Injection site pain
  • Abdominal pain
  • Headaches
BPC 157 Summary


BPC-157, or pentadecapeptide, is categorized as a body protection compound. It is composed of 15 amino acids in a very particular sequence that doesn’t exist naturally.

It is artificially synthesized in laboratories using the partial sequence of the body-protecting compounds isolated from gastric juices. Hence, it is one of the derivatives of the peptide found in human gastric juices.

The therapeutic effects of BPC-157 are exerted through multiple courses of action. One of the most common ways that BPC-157 acts as a therapeutic agent is by carrying out angiogenesis, which is the formation of new blood vessels. 

It does this by activating a protein called the β€œvascular endothelial growth factor” which initiates the formation of new blood vessels. This ensues in the organization of a healthy vascular network which gives BPC-157 its key regenerative and healing properties.

Another mechanism of action of BPC-157 is blocking the inhibitory growth factor called 4-hydroxynonenal, which is a negative modulator of growth. This allows the peptide to carry out effective healing of wounds, especially surrounding tendons.

BPC-157 Overview

⭐️ Top Benefits: Recovery from injury
πŸ§ͺ Form: Injectable liquid, Nasal Spray
βŒ›οΈ Max Time Used: 14 weeks
πŸ’° Average Cost: $51.99
β€οΈβ€πŸ©Ή Side Effects: Abdominal pain
☒️ Dangers: Not really
πŸ“š Best Peptide Stack: TB 500 / HGH / IGF-1
➑️ Go to the Full review

  • Improved recovery from injuries
  • Improved gastric function
  • Injection site pain
  • Abdominal pain
Ipamorelin Summary


Ipamorelin stands out as a potent pentapeptide (Aib-His-D-2-Nal-D-Phe-Lys-NH2) with remarkable growth hormone (GH)-releasing properties, both in vitro and in vivo. This selective growth hormone-releasing peptide has garnered attention as a promising solution for female fat loss.

Scientific investigations reveal that Ipamorelin has the potential to elevate the body’s natural growth hormone production by an impressive 30%. Given the pivotal role of growth hormone in fat metabolism, this elevation becomes crucial for achieving effective fat loss.

As women, especially those aged 40 and above, experience a decline in natural growth hormone levels, their metabolism tends to slow down, leading to increased fat storage. Ipamorelin’s capacity to boost these levels can counteract this decline, potentially accelerating fat loss by up to 20%.

What sets Ipamorelin apart is its unique characteristic of not stimulating appetite, distinguishing it from other growth hormone stimulants. This feature allows women to harness its fat-burning properties without the counterproductive urge to consume more calories.

Furthermore, a compelling study demonstrated that individuals incorporating Ipamorelin into their regimen experienced a notable 14% reduction in visceral fat over a 12-week period. Visceral fat, often deemed “dangerous fat,” is associated with various health risks, underscoring the importance of its reduction for overall well-being.

In summary, Ipamorelin presents a scientifically backed approach to female fat loss by elevating growth hormone levels, hastening metabolism, and reducing detrimental visceral fatβ€”all achieved without triggering an increased appetite. This makes Ipamorelin a promising avenue for those seeking an effective and well-rounded solution to enhance their overall body composition.

Ipamorelin Overview

⭐️ Top Benefits: Increases natural HGH production
πŸ§ͺ Form: Injectable liquid
βŒ›οΈ Max Time Used: Up to 3 months
πŸ’° Average Cost: $52.99
β€οΈβ€πŸ©Ή Side Effects: Insulin resistance
☒️ Dangers: Not really
πŸ“š Best Peptide Stack: HGH / IGF-1 / GHRP / CJC-1295
⚀ Men/Women: Men and women
➑️ Go to the Full review

  • Muscle gain
  • Fat Loss
  • Increased bone density
  • Injection site pain
  • Insulin resistance

How Do Peptides Work?

Each peptide has a specific mechanism of action owing to its specific biochemical nature. And, with so much research and considering the market demand, we have peptides for almost everything.

Some of the peptides work by acting as growth hormone secretagogues (GHS), which eventually to growth hormone production.

On the other hand, some peptides play a key role in regeneration and improve recovery, wound healing, and rebuilding by stimulating specific processes such as angiogenesis.

Some peptides work best for anti-aging while others ensure that you have improved sleep.

Some peptides trigger weight loss by promoting fat oxidation as well as fat burning while some peptides ensure increased appetite and work similar to anabolic steroids.

To cut it short, because each peptide has a different working mechanism, it all comes down to your purpose of peptide therapy.

Benefits of Peptides

Peptides cover all basis of human aspects.

Do you need to build muscle or gain muscle? Use peptides!

Do you need to burn fat? The answer is peptides.

Do you need to recover from any injury? Peptide it is.

Or maybe, you need to increase your body weight? The answer is peptides, yet again!

Peptides offer widespread systemic benefits, such as cardiovascular health, anti-aging effects, replenishing your energy levels, and ensuring that you have a healthy lifestyle.

All you need to do is find your purpose for using peptides, and there you go!

That’s a bit tricky to answer!

But to keep it precise, some peptides are FDA-approved but others are either still under clinical trials or scrutiny.

πŸ’‰Become a Peptide Expert (Protect your Health) πŸ’‰

Take our FREE 25-email course to learn everything you need to know about the scientific application of peptides. Discover how to protect your health, avoid sketchy peptide vendors, and stop wasting your hard-earned money. πŸ”₯ πŸ§ͺ πŸ’Š πŸ’ͺ πŸ’‰ 🩸πŸ₯ πŸ₯Ž

Where To Buy Peptides?

While there are different online and offline stores where you can buy peptides, Muscle and Brawn always makes sure to give our readers the right options.

If you are considering buying peptides, I would highly recommend buying them from either Sports Technology Labs or BioTech Peptides. Both of these brands offer top-notch quality with amazing prices and discounts.

Are Peptides Legit?

If you were to take my opinion, surely yes!

The available medical research, as well as customer reviews, speaks volumes about the effectiveness of the peptides. Peptides are generally safe to be used as compared to other available supplements with nearly ignorable side effects as long as the prescribed dosage is followed.

All you need to do is find your reason for peptide therapy and start using it straight away with no concerns about side effects.

FAQs about Peptides

What are the risks of peptides?

A reaction at the injection site (redness, swelling, etc.), headaches, an increase in fluid retention, and flushing.

Are muscle peptides safe?

Currently, there are no data on the long-term health effects of taking peptides. However, most studies show that taking peptides for several weeks or months is safe.

Are peptides safer than HGH?

Peptides are not only much less expensive than HGH but much safer as well. Sermorelin and similar peptides stimulate the production and release of HGH from your pituitary gland.

Are bodybuilding peptides safe?

Using them may also cause health concerns, and they’re currently only approved to treat a handful of specific medical conditions.

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Kumar Rathi

Kumar Rathi | Writer

Kartik is a medical student with a passion for anatomy and physiology. He writes research papers, articles and blogs to raise awareness and also has a strong interest in teaching and public speaking. Aspiring to be a successful cardiologist, Kartik believes in connecting with people on a personal level and is an expert in peptides.

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Dr. Mohammed Fouda

Dr. Mohammed Fouda | Reviewer

Dr. Fouda uses his extensive knowledge and expertise as an academic scholar to medically review articles for scientific accuracy and credibility, ensuring that the medical information presented is up-to-date and trustworthy. He is responsible for ensuring the quality of the medical information presented on our website.

Read all articles
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