Tirzepatide Guide – Dosages & Sides for Weight Loss

Tirzepatide is a peptide known as a GLP=1 receptor agonist, and studies show it can help with insulin control and weight loss. Is it better than Semaglutide?

Are you tired of constantly monitoring your blood sugar levels and injecting insulin multiple times a day? What if there was a solution that could help you manage your diabetes without the hassle? Introducing Tirzepatide, a new drug that has the potential to revolutionize diabetes treatment.

But here’s the shocking part: recent studies have shown that Tirzepatide not only helps lower blood sugar levels but can also aid in significant weight loss. That’s right, this drug may have the power to not only control your diabetes but also help you shed unwanted pounds.

Read on to learn more about Tirzepatide and how it could be the game-changer you’ve been waiting for.

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Key Takeaways

  • Tirzepatide is a promising new drug that can help improve glycemic control and aid in body weight reduction for people with type 2 diabetes mellitus.
  • Tirzepatide works by mimicking the effects of the hormone glucagon-like peptide 1 (GLP-1) in the body, which helps regulate blood sugar levels and suppresses appetite.
  • Studies have also shown that Tirzepatide may be particularly effective for people with a family history of diabetes mellitus or obesity, as it can help improve both glycemic control and body weight simultaneously.

What is Tirzepatide?

Tirzepatide is a GLP-1 receptor agonist developed for the treatment of type 2 diabetes mellitus. This medication mimics the hormone GLP-1 to improve glycemic control and promote weight loss [1].

Tirzepatide has undergone extensive testing, including animal reproduction studies and clinical trials, and has shown to be safe and effective. The medication has already surpassed clinical trials and has been approved by the FDA for use in the United States [1].

In human studies, Tirzepatide has shown promising results in improving glycemic control and promoting significant weight loss, exceeding the efficacy of other GLP-1 receptor agonists currently available. Tirzepatide could revolutionize diabetes treatment and become a new therapeutic option for individuals with type 2 diabetes mellitus who struggle to manage their blood sugar levels and weight [2].

How Does Tirzepatide Work?

Tirzepatide acts via two mechanisms of action:

  • As a GLP 1 receptor agonist, it works by mimicking the effects of the hormone GLP-1 in the body. Tirzepatide binds to GLP-1 receptors in the body and activates them, leading to similar effects as GLP-1. GLP-1 is a naturally occurring hormone that stimulates the release of insulin from the pancreas, reduces the amount of glucose produced by the liver, and slows down the absorption of glucose from the gut. This results in lower blood sugar levels and improved insulin sensitivity.
  • In addition to its GLP-1 receptor activity, Tirzepatide also has activity on another hormone called glucose dependent insulinotropic polypeptide (GIP). GIP stimulates insulin secretion from the pancreas and promotes fat storage, but Tirzepatide reduces the effects of GIP to promote weight loss.

By activating GLP-1 receptors and reducing the effects of GIP, Tirzepatide can improve glycemic control, promote weight loss, and improve insulin sensitivity. A subcutaneous Tirzepatide injection has been shown to be safe and effective in clinical studies.

Overall, Tirzepatide is a promising new treatment option for people with type 2 diabetes who struggle to manage their blood sugar levels and weight.

Tirzepatide Guide

Figure 2: Tirzepatide as a dual GLP-1 / GIP receptor agonist that mimics the actions of GLP-1 and GIP

Benefits of Tirzepatide

Below listed Tirzepatide benefits are supported by clinical studies and guidelines from organizations such as the American Diabetes Association.

  • Improved glycemic control: Tirzepatide has been shown to significantly reduce blood glucose levels in people with type 2 diabetes, improving glycemic control and reducing the risk of complications associated with poorly controlled diabetes.
  • Weight loss: Tirzepatide has been shown to promote significant weight loss in people with type 2 diabetes, which can help improve overall health and reduce the risk of complications associated with obesity.
  • Nonalcoholic fatty liver disease (NAFLD): Tirzepatide has been shown to improve liver function and reduce liver fat in people with NAFLD, a common complication of type 2 diabetes mellitus [3].
  • Low risk of thyroid C cell tumors: Tirzepatide has been found to have a low risk of causing thyroid C cell tumors, a concern with some other GLP-1 receptor agonists [4].
  • Potential benefits for diabetic retinopathy: Tirzepatide may have potential benefits for diabetic retinopathy, a complication of diabetes that can lead to blindness [1].

Side Effects of Tirzepatide

Based on clinical studies, Tirzepatide may cause few adverse effects, although these are generally mild to moderate and resolve over time. Here are some potential side effects of Tirzepatide [5]:

  • Hypersensitivity reactions at the injection site such as pain, redness, and swelling
  • Nausea
  • Diarrhea
  • Vomiting
  • Decreased appetite
  • Constipation
  • Abdominal pain
  • Fatigue
  • Headache
  • Dizziness

In pregnant women, there is a potential risk for adverse fetal outcomes, and the use of Tirzepatide is not recommended during pregnancy. Additionally, Tirzepatide may lead to a modest increase in blood pressure and has been associated with rare cases of thyroid C-cell tumors in animal studies, but no such adverse effects have been observed in clinical trials in humans.

Tirzepatide is a legal drug that has been approved by the United States Food and Drug Administration (FDA) for the treatment of type 2 diabetes.

Tirzepatide received its FDA approval in early 2022, following the successful completion of the SURPASS clinical trials program, which demonstrated its efficacy and safety in reducing blood glucose levels and promoting weight loss in patients with type 2 diabetes [6].

Who Should Use Tirzepatide? 

Tirzepatide is indicated for use in patients with type 2 diabetes who require additional glycemic control, particularly those who have not achieved optimal blood glucose levels with other antidiabetic medications.

It may also be appropriate for patients who need to lose weight or have a high body mass index (BMI).

Who Should Not Use Tirzepatide? 

Patients with a personal or family history of thyroid tumors such as thyroid C-cell tumors, medullary thyroid carcinoma or multiple endocrine neoplasia syndrome type 2 (MEN 2) should not use this medication.

Pregnant and breastfeeding individuals are also advised against the use of this medication. Women who are taking birth control pills should discuss with their healthcare provider prior to taking the medication.

Additionally, the safety and efficacy of Tirzepatide have not been established in patients with severe hepatic impairment, so caution should be exercised in this population.

Tirzepatide Dosage

Subcutaneous injection of Tirzepatide is recommended for patients with type 2 diabetes mellitus.

The recommended starting dose of tirzepatide is 5 mg once a week, which can be increased to 10 mg once a week after 4 weeks. Another dose escalation of 15mg once a week for 4 additional weeks is also acceptable [7].

Routine monitoring of blood glucose and body weight is recommended, and missed doses should be taken as soon as possible within 5 days of the missed dose.

Results of Tirzepatide

First Two Weeks-this stuff is magic – It took more bacteriostatic water to dissolve than any other (non-Tirzepatide) peptides I’ve tried. Even with gentle rocking and 2mL of water (I was shooting to dissolve in 1 mL, no dice). Finished clear. Minor, transient irritation at injection site (more than other peptides I’ve tried). Started during an extremely stressful time when I was almost completely inactive. I’m usually a 3-6 day a week rec lifter but have been super limited by a now chronic injury. I only went on one 3 mile jog and was much more sedentary than usual. I’m a woman, early 30s, starting weight was 167lbs, est. 32% BF (from a renpho scale, IDK how accurate). I’ve never tried Mounjaro so I cannot compare. I do not have insulin resistance. Week 1, 2.5mg: Somewhat reduced appetite (but not enough to stop stress eating…still emotionally satisfying to eat-and I did A LOT of it), thirsty, no nausea. End of week Weight: 164.6lbs (-2.4 lbs), (est 30.9 %BF)”

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Where Can I Buy Tirzepatide

Tirzepatide Summary

Tirzepatide (GLP-1)

Tirzepatide gets grouped with other Peptides but is more commonly known as a GLP-1 receptor agonist. It mimics the action of human incretin glucagon-like peptide-1 (GLP-1).

This is something that you would want when trying to lose weight, and this is why Tirzepatide is being used as an anti-obesity medication (combined with a good diet and training plan). It is simply a method of glycemic control.

When trying to lose weight or even trying to increase weight dramatically (bulking), glycemic control could help a tremendous amount.

Tirzepatide will help your pancreas release the right amount of insulin when your blood sugar is high. So, it helps your body produce the correct amount of insulin needed.

In addition to its GLP-1 receptor activity, Tirzepatide also has activity on another hormone called glucose-dependent insulinotropic polypeptide (GIP). GIP stimulates insulin secretion from the pancreas and promotes fat storage, but Tirzepatide reduces the effects of GIP to promote weight loss.

Tirzepatide Overview

⭐️ Top Benefits: Increases glycaemic control
🧪 Form: Injectable liquid
⌛️ Max Time Used: 6 – 8 Weeks
💰 Average Cost: $159.99
❤️‍🩹 Side Effects: Allergic reaction
☢️ Dangers: Allergic reaction
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Men/Women: Men and women
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  • Increases insulin control
  • Decreases hunger
  • Pain at the injection site
  • Allergic reaction

Tirzepatide vs. Other Compounds

Tirzepatide vs Semaglutide

Tirzepatide and Semaglutide are both GLP-1 receptor agonists that have shown significant improvements in glycemic control and body weight reduction in patients with type 2 diabetes mellitus in clinical trials.

However, tirzepatide has shown greater weight loss effects than Semaglutide in early clinical studies, and may have a potential role in early detection and prevention of diabetes [8].

Tirzepatide vs Liraglutide

Tirzepatide and liraglutide are both GLP-1 receptor agonists that have been shown to improve glycemic control and reduce body weight in patients with type 2 diabetes mellitus.

However, tirzepatide has demonstrated greater reductions in HbA1c and body weight in clinical trials [9]. Additionally, tirzepatide may have a more favorable safety profile in patients with renal impairment or cardiovascular disease compared to liraglutide.

For example, in a Phase 3 trial, tirzepatide was associated with a lower risk of hypoglycemia compared to liraglutide. However, further studies are needed to fully compare the efficacy and safety of these two medications in patients with these conditions.

Tirzepatide vs Metformin

Metformin and tirzepatide are both used to treat type 2 diabetes, but they work in different ways. Metformin reduces glucose production in the liver, while tirzepatide is a GLP-1 receptor agonist that increases insulin sensitivity and stimulates insulin secretion.

Metformin is often the first-line treatment for type 2 diabetes, but it can be contraindicated in patients with renal impairment and cardiovascular disease. In contrast, tirzepatide has shown promising results in clinical trials involving such patients. However, a phase 3 trial demonstrated that while tirzepatide showed significant results, the patients treated had more non-severe adverse effects compared to metformin [9]

However, tirzepatide is a newer medication and may be more expensive than metformin. The choice between these medications depends on the individual patient’s needs and health status.

Conclusion: Is Tirzepatide Legit?

In conclusion, Tirzepatide is the real deal for those looking to control their blood sugar and shed some pounds. It’s not a magic potion, but it’s as close as we can get – without turning into a pumpkin at midnight. 

People Also Ask

Is tirzepatide approved for weight loss?

Tirzepatide is not specifically approved for weight loss, but rather for the treatment of type 2 diabetes. However, in clinical trials, it has shown significant weight loss benefits in addition to improving glycemic control.

Can non-diabetics take tirzepatide for weight loss?

Certainly. Besides managing Type 2 diabetes, tirzepatide has demonstrated efficacy in obesity management for individuals without diabetes.

Is Tirzepatide hard on kidneys?

It may have some impact, however, studies demonstrate that indicate that individuals treated with tirzepatide had a lower incidence of renal complications compared to those who were administered insulin.

What foods should be avoided with Tirzepatide?

Fried and oily foods and foods high in sugar must be avoided as these may cause nausea when taken with the medication.

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Farzam K, Patel P. Tirzepatide. [Updated 2022 Dec 27]. In: StatPearls [Internet]. Treasure Island (FL): StatPearls Publishing; 2023 Jan-. Available from: https://www.ncbi.nlm.nih.gov/books/NBK585056/

Juan P. Frias et al., Tirzepatide versus Semaglutide Once Weekly in Patients with Type 2 Diabetes, The New England Journal of Medicine, August 5, 2021. N Engl J Med 2021; 385:503-515. https://www.nejm.org/doi/full/10.1056/NEJMoa2107519

Hartman ML, Sanyal AJ, Loomba R, Wilson JM, Nikooienejad A, Bray R, Karanikas CA, Duffin KL, Robins DA, Haupt A. Effects of Novel Dual GIP and GLP-1 Receptor Agonist Tirzepatide on Biomarkers of Nonalcoholic Steatohepatitis in Patients With Type 2 Diabetes. Diabetes Care. 2020 Jun;43(6):1352-1355. doi: 10.2337/dc19-1892. Epub 2020 Apr 14. PMID: 32291277; PMCID: PMC7245348. https://pubmed.ncbi.nlm.nih.gov/32291277/

Nauck MA, Friedrich N. Do GLP-1-based therapies increase cancer risk? Diabetes Care. 2013 Aug;36 Suppl 2(Suppl 2):S245-52. doi: 10.2337/dcS13-2004. PMID: 23882053; PMCID: PMC3920789. https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3920789/

Mishra R, Raj R, Elshimy G, Zapata I, Kannan L, Majety P, Edem D, Correa R. Adverse Events Related to Tirzepatide. J Endocr Soc. 2023 Jan 26;7(4):bvad016. doi: 10.1210/jendso/bvad016. PMID: 36789109; PMCID: PMC9915969.https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9915969/

FDA Approves Novel, Dual-Targeted Treatment for Type 2 Diabetes. May 13, 2022. https://www.fda.gov/news-events/press-announcements/fda-approves-novel-dual-targeted-treatment-type-2-diabetes

Yu Y, Hu G, Yin S, Yang X, Zhou M, Jian W. Optimal dose of tirzepatide for type 2 diabetes mellitus: A meta-analysis and trial sequential analysis. Front Cardiovasc Med. 2022 Aug 31;9:990182. doi: 10.3389/fcvm.2022.990182. PMID: 36119737; PMCID: PMC9472131. https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9472131/

Frías JP, Davies MJ, Rosenstock J, Pérez Manghi FC, Fernández Landó L, Bergman BK, Liu B, Cui X, Brown K; SURPASS-2 Investigators. Tirzepatide versus Semaglutide Once Weekly in Patients with Type 2 Diabetes. N Engl J Med. 2021 Aug 5;385(6):503-515. doi: 10.1056/NEJMoa2107519. Epub 2021 Jun 25. PMID: 34170647. https://pubmed.ncbi.nlm.nih.gov/34170647/

Alkhezi OS, Alahmed AA, Alfayez OM, Alzuman OA, Almutairi AR, Almohammed OA. Comparative effectiveness of glucagon-like peptide-1 receptor agonists for the management of obesity in adults without diabetes: A network meta-analysis of randomized clinical trials. Obes Rev. 2023 Mar;24(3):e13543. doi: 10.1111/obr.13543. Epub 2022 Dec 29. PMID: 36579723. https://pubmed.ncbi.nlm.nih.gov/36579723/

Ludvik B, Giorgino F, Jódar E, Frias JP, Fernández Landó L, Brown K, Bray R, Rodríguez Á. Once-weekly tirzepatide versus once-daily insulin degludec as add-on to metformin with or without SGLT2 inhibitors in patients with type 2 diabetes (SURPASS-3): a randomised, open-label, parallel-group, phase 3 trial. Lancet. 2021 Aug 14;398(10300):583-598. doi: 10.1016/S0140-6736(21)01443-4. Epub 2021 Aug 6. PMID: 34370970. https://pubmed.ncbi.nlm.nih.gov/34370970/


Priyal Gandhi B.Sc

Priyal Gandhi B.Sc | Writer

Priyal is a seasoned Pharmaceutical Consultant and Technical Writer with a B.Sc degree and CAPM certification. With over 7 years of experience, Priyal has helped numerous clients with drug importation and launch of 15+ new drugs and nutraceuticals. She reviews scientific records including formulation, research and development, product testing, stability, and worldwide shipments to ensure regulatory compliance and successful market entry.

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addie burton
addie burton
8 months ago

can you stack Tirzepatide and AOD9604??

2 months ago
Reply to  addie burton

Yes, a lot of people. I personally do on my research subjetcs. 5 mg Tirz once per week and 300 mcg AOD daily for 6 weeks then stop

Peggy Ross
Peggy Ross
7 months ago

With a 5ml vial of Tirzepitide how much Bacteriostatic water do you reconstitute it with?

2 months ago
Reply to  Peggy Ross

I need to know how much bacteriostatic water to use.

Germaine Cordano
Germaine Cordano
1 month ago

Is there a benefit to getting this IM versus subq?

Daniel Louwrens BSc PT

For this compound, probably not

8 days ago

I am in the midst of a 2nd cycle of Semaglutide and am currently using the maximum dosage 2.4mg/week, with no noticeable results. Frustrated, with my dismal weightloss, I now plan to finish off this cycle with Tirzepatide. Since I am at the highest dosage of Semaglutide (2.4mg), is it safe to transition directly to the highest dosage (15mg) of Tirzepitide?


Chemical Structure

Mechanism of Action

By activating GLP-1 receptors and reducing the effects of GIP, Tirzepatide can improve glycemic control, promote weight loss, and improve insulin sensitivity. A subcutaneous Tirzepatide injection has been shown to be safe and effective in clinical studies.

Class of Compound


Street Names



Improved glycemic control and weight loss

Side Effects and Dangers

Nausea, Diarrhea, Vomiting, and Decreased appetite


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