Semaglutide (GLP-1) for Bodybuilding

Semaglutide is a new Peptide that can be used to help you lose weight and slow gastric emptying. Let's look at its application in bodybuilding.
Medically reviewed by Dr. Mohammed Fouda
Dr. Fouda uses his extensive knowledge and expertise as an academic scholar to medically review articles for scientific accuracy and credibility, ensuring that the medical information presented is up-to-date and trustworthy. He is responsible for ensuring the quality of the medical information presented on our website.

Losing weight might be the goal of most of the human population, but for those of us that chase mass above all else, it probably isn’t.

That said, looking at how much weight loss is needed to step on stage, it is not uncommon for bodybuilders to use various compounds to lose a bit of extra body weight.

Semaglutide is one of those “new” compounds that you may or may not have heard of. It has the makings of something quite good, however, more investigation is needed.

Without further ado, let us dive in and see if this new peptide is worth your hard-earned money.

Warning: The content on Muscleandbrawn.com and the information included in this article is intended for entertainment and informational purposes only. It is not intended nor implied to be a substitute for professional medical advice. Prior to buying anything, check that it is compliant where you live with your current government laws. We frequently mention research chemicals that are not made for human consumption. Therefore, before purchasing any product for personal use, consult with your doctor or healthcare provider first.

Key Takeaways

  • Semaglutide is known as a GLP-1 receptor agonist
  • Semaglutide can help the pancreas produce the right amount of insulin
  • Semaglutide has also been shown to slow gastric emptying, helping with weight loss
  • Semaglutide is an approved FDA drug for obesity, available online but you technically need a prescription

What is Semaglutide?

As mentioned, Semaglutide gets grouped with other Peptides but is more commonly known as a GLP-1 receptor agonist. It mimics the action of human incretin glucagon-like peptide-1 (GLP-1) [1].

This is something that you would want when trying to lose weight, and this is why Semaglutide is being used as an anti-obesity medication (combined with a good diet and training plan). It is simply a method of glycemic control.

When trying to lose weight or even trying to increase weight dramatically (bulking), glycemic control could help a tremendous amount.

How does Semaglutide work?

Without making things seem a lot more complicated than they are, Semaglutide will help your pancreas release the right amount of insulin when your blood sugar is high. So, it helps your body produce the correct amount of insulin needed.

This can help you avoid chronically high levels of blood sugar, which can have some severe impacts on your health. Fitness fanatics will also know that elevated blood sugar levels are one of the major causes of inflammation, fat gain, and heart disease.

Semaglutide for Bodybuilding
Figure 1: GLP-1 Agonists can help with various parts of human physiology

Another great benefit of Semaglutide is the fact that not only will it reduce your risk of diabetes, but it will also slow gastric emptying [2].

What this means is that it will simply “keep the food in you for longer”, helping you remain fuller for longer. This can be very beneficial for someone in a calorie deficit and looking at those who have used it, patients experienced improvements in hunger and weight loss.

Findings suggest that since it has been approved by the FDA, several hundreds of people, especially those that are pre-diabetic saw the most improvement.

How to use Semaglutide for Bodybuilding?

Now that we know the basics of how the endocrine society would describe this new drug, let’s look at how you could use this treatment to improve the quality of your bodybuilding.

We know that Semaglutide could help you remain fuller for longer, so, it will help you eat less while trying to lose weight – specifically. Trying to use it as a GDA when packing on pounds in bulk is a bit trickier. Sure, it might help your pancreas produce more insulin when needed, but this creates a problem.

Semaglutide (GLP-1) for Bodybuilding
Figure 2: Semaglutide is really helpful for weight loss

The beta cells in the pancreas that do produce insulin will become tired and burned out quite quickly – this is exactly why bodybuilders use insulin! Semaglutide does not take the load off from the pancreas it just makes sure the pancreas produces enough.

Therefore, there is no real reason why to use Semaglutide in bulk. This medicine was never created for someone eating thousands upon thousands of calories. If you are looking for the “ultimate” GDA, you might want to consider Metformin.

Semaglutide Dose – Bodybuilding

As a bodybuilder, you are probably heavier and more active (with more muscle tissue) than the average human being. Thus, with most drugs, you need a bit more. That said, you still need to be careful with subcutaneous Semaglutide seeing as it can lower blood sugar levels which can lead to hypoglycemia.

The starting dose is 0.25mg per week and can be adjusted from there. Many patients need more, while other obese individuals need slightly less. Get a blood glucose monitor and make informed decisions yourself.

Semaglutide Cycle – Bodybuilding

A cycle that has Semaglutide within it is usually set up to help with losing a few pounds. It can also be used in a body composition model, or just for those looking to avoid muscle loss.

Semaglutide can be stacked with other Peptides, SARMs, Anabolics, Supplements, or natural remedies. As always, use caution when using subcutaneous Semaglutide with anything else – especially things that will lower your blood sugar levels even further.

Semaglutide for Weight Loss?

Semgalutide is a valuable tool to be used for fat loss. Semaglutide has been tested readily and most participants had amazing reactions compared to the placebo:

  • A two-year-long study found “change in body weight from baseline to week 104 was –15.2% (0.9) with Semaglutide and –2.6% (1.1) with placebo” [3]
  • Another 40-week-long study found similar results, that the group using Semaglutide had lost weight while the placebo group ended up gaining weight [4]

It is safe to say that Semaglutide works well for fat loss and weight loss. Plus, you reduce the risk of Diabetes! Another great option to use with Semaglutide is going to be Metformin, a drug that allows you to be way more insulin sensitive – potentially lowering your need for Semaglutide.

Where to buy Semaglutide

Semaglutide is not the easiest thing to find online, and even though there are significant weight loss benefits, many reputable sources just do not stock it. Unless you get a prescription for it, you can go to a trusted vendor Biotech Peptides for a fully COA-tested product, or Amino Asylum for cheaper but of more questionable quality (under Biotech Peptides).

Semaglutide Summary

Semaglutide (GLP-1)

Semaglutide gets grouped with other Peptides but is more commonly known as a GLP-1 receptor agonist. It mimics the action of human incretin glucagon-like peptide-1 (GLP-1).

This is something that you would want when trying to lose weight, and this is why Semaglutide is being used as an anti-obesity medication (combined with a good diet and training plan). It is simply a method of glycemic control. [1,2]

When trying to lose weight or even trying to increase weight dramatically (bulking), glycemic control could help a tremendous amount.

Semaglutide will help your pancreas release the right amount of insulin when your blood sugar is high. So, it helps your body produce the correct amount of insulin needed.

This can help you avoid chronically high levels of blood sugar, which can have some severe impacts on your health. Fitness fanatics will also know that elevated blood sugar levels are one of the major causes of inflammation, fat gain, and heart disease.

Semaglutide Overview

⭐️ Top Benefits: Increases glycaemic control and decreases hunger
🧪 Form: Injectable liquid
⌛️ Max Time Used: 6 – 8 Weeks
💰 Average Cost: $119.99
❤️‍🩹 Side Effects: Allergic reaction
☢️ Dangers: Allergic reaction
📚 Best Peptide Stack: HGH / IGF-1 / HGH-Frag
⚤ Men/Women: Men and women
➡️ Go to the Full review

  • Increases insulin control
  • Decreases hunger
  • Pain at the injection site
  • Allergic reaction

Benefits of Semaglutide

  • Reduction in body weight
  • Helps you feel fuller for way longer
  • Reduced risk of fatty liver disease
  • Treatment has been linked to a reduced risk of Diabetes
  • When combined with a good diet, can lead to muscle gain in some individuals
  • Better bowel movements
  • Reduce risk factors for cardiovascular diseases, including stroke

Side Effects of Semaglutide

  • Stomach aches
  • Nausea
  • Constipation

Conclusion: Semaglutide for Bodybuilding

Semaglutide is one of those drugs that only a few will even end up using. You’re typically looking at the huskier guy or gal that always struggles to remain lean or has trouble in a cut.

On prep, we tend to use a kitchen sink approach and use just about anything we can get our hands on. Semaglutide is luckily a safer option than most, seeing as most of the participants in the studies did not report any significant side effects.

That said, caution is still advised – especially for those who are using more than one “treatment” or something else that also lowers blood sugar levels. Going hypo could put your life at risk.

Other than that one caveat, it’s a solid addition to anyone who struggles to lose weight! Personally, hunger is always a bitch on prep, and I recently used Sibutramine which also curbs appetite and it helped.

Is Semaglutide worth it for weight loss?

Granted you are going to make a lifestyle intervention. Various studies are showing how effective it is. It probably is not the holy grail of fat loss, however, for good enough fat loss it certainly is a drug to consider.

Who should not take Semaglutide?

Those suffering from Type 1 Diabetes or those who are already taking something that lowers blood glucose levels.

What happens after you stop Semaglutide?

Not much, to be honest. The therapy does not suppress any natural hormones, and while findings do not follow up with patients after the studies are completed, we can assume that if they keep dieting and training, they had sufficient results.

What diet is best with Semaglutide?

A sustainable diet. We can give you the perfect diet but if you are not even sticking to the damn diet what use is it? That said, eating fewer carbs could help, but that remains to be seen from personal use.

Reconstitution and Dosage Calculator

Still Have Questions?

Drop us a comment down below and one of our expert coaches will respond to it. We’ll also be answering questions on our Instagram!

Contributors

Daniel Louwrens BSc PT

Daniel Louwrens BSc PT | Writer

Daniel Louwrens is a well-rounded fitness professional with over 10 years of experience in bodybuilding and fitness. He holds a BSc in Chemistry from the University of Western Cape and is a certified International Personal Trainer and Nutritionist. He is also a skilled bodybuilder and head coach for Muscle and Brawn. With his knowledge and expertise, he provides personalized training, nutrition, and recovery guidance to help clients reach their fitness goals.

Read all articles
Dr. Mohammed Fouda

Dr. Mohammed Fouda | Reviewer

Dr. Fouda uses his extensive knowledge and expertise as an academic scholar to medically review articles for scientific accuracy and credibility, ensuring that the medical information presented is up-to-date and trustworthy. He is responsible for ensuring the quality of the medical information presented on our website.

Read all articles
Subscribe
Notify of

2 Comments
Oldest
Newest Most Voted
Inline Feedbacks
View all comments
Roger Velazquez
1 month ago

What has been a suggested dosage for Semaglutide for the treatment of T2D?

Chemical Structure

Mechanism of Action

Semaglutide is a potent agonist of glucagon-like peptide 1 (GLP-1) receptors. It also upregulates the insulin levels in the plasma and downregulates the level of glucagon. All of this ensures adequate blood sugar levels.

Class of Compound

Peptide

Street Names

N/A

Effects

Weight loss, fat loss, lower blood sugar levels, reduces appetite

Side Effects and Dangers

Allergic reaction, subcutaneous injection sites

2
0
Ask our coaches a question below!x
()
x

FREE EBOOK

Get the SARMs and Peptides Secrets Ebook 📔 + Learn….

How to Safely Use SARMs to Sculpt “Three-Dimensional Muscles” and Torch Fat

The ONE Thing You MUST do Before starting SARMs if You Want to Keep Yourself Out of the Hospital

The MILDEST SARM that gives you gains without all the bloating

How to Properly Use SARMs to build 3D Muscles Without Experiencing “Sloppy Noodle Syndrome”

 

Get the SARMs and Peptides Secrets Ebook 📔

How to Safely Use SARMs, peptides, and blood work to customize your athletic bio-optimization, to Sculpt “Three-Dimensional Muscles” and Torch Fat.