Best SARMs for Weight Loss

Feeling like you could get more Tinder matches if you occupied less real estate? Yeah. SARMs have been shown to aid in muscle gain and fat loss - but which are best?
Medically reviewed by Dr. Mohammed Fouda
Dr. Fouda uses his extensive knowledge and expertise as an academic scholar to medically review articles for scientific accuracy and credibility, ensuring that the medical information presented is up-to-date and trustworthy. He is responsible for ensuring the quality of the medical information presented on our website.

Let’s face it. You’re overworked. You’re stressed. Your pants don’t fit so great and you feel the need to switch off the lights before having sex.

I’ve been there. But fear not, there may be a solution. Not for the depression, just the fat though.

SARMs (Selective Androgen Receptor Modulators) have been all the rave these days, with people proclaiming that they could change your life, make you ripped, and so much more.

Is this just some weird scam like that lady with the deep voice and the blood pills, or are these SARMs legit? Let’s discuss the best SARMS for weight loss and find out.

Key Takeaways

  • SARMs (Selective Androgen Receptor Modulators) can be effective for weight loss by binding to specific receptors and causing changes in the body, but not all SARMs are the same.
  • Some SARMs are better at burning fat, while others focus on muscle gain and fat loss. Weight loss is primarily achieved through a caloric deficit and exercise.
  • Cardarine (GW501516) is a popular SARM for weight loss, as it accelerates weight loss and preserves muscle during a diet. It is known to increase vascularity and improve cardiovascular capabilities.
  • Andarine S4 is another effective SARM for weight loss, as it lowers lipoprotein lipase, accelerates fat loss, and promotes muscle retention and recovery.
  • MK-677, while not a SARM, can help with weight loss by increasing human growth hormone (HGH) release, which leads to fat loss and muscle gain.

Warning: The content on and the information included in this article is intended for entertainment and informational purposes only. It is not intended nor implied to be a substitute for professional medical advice. Prior to buying anything, check that it is compliant where you live with your current government laws. We frequently mention research chemicals that are not made for human consumption. Therefore, before purchasing any product for personal use, consult with your doctor or healthcare provider first.

So which are the Best SARMS for Weight Loss?

Weight loss will be predominantly determined by a caloric deficit, and hopefully, you’re doing some training as well. If not, go do some weights.

Regardless, if you’re looking for that fat-burning supercharger in the shape of the best SARMS for weight loss, here are the best options:

SARM NameCardarine GW501516Andarine S4MK-677
Top BenefitsEndurance and fat lossMuscle growth, strength gain, fat lossMuscle growth, strength gain, fat loss
FormLiquid, PowderLiquid, PowderLiquid, Powder
Cycle Length6 – 8 weeks6 – 8 weeks8 – 12 weeks
Average Cost$59.99$59.99$64.99
Side EffectsLiver toxicity and stomach painVision issues, headaches, liver toxicityWater retention, gyno
Best StackMK-677 / Testolone / LGD 4033MK-677 / Cardarine / RAD 140Cardarine / LGD 4033 / RAD 140
PCT RequiredNoYesNo
Men/WomenMen and WomenMenMen and Women

#1 SARM for Weight Loss: Cardarine GW501516

One hell of a name, and one hell of a tool! Cardarine is an exceptional tool and one of the best SARMS for weight loss. It’ll preserve muscle loss while you’re on your diet, but also massively accelerate weight loss.

As mentioned earlier, Cardarine is technically not a SARM but a PPAR Delta Agonist. It’ll bind to PPAR Delta receptors, and cause the body to just burn more energy.

Usually dosed as a liquid shown here by Sports Technology Labs, you do sometimes find pills or capsules.

Cardarine is also known to increase vascularity – combined with weight loss this could also massively help with cardiovascular capabilities

Cardarine Summary

Cardarine (GW-501516)

Cardarine is also known to be a PPAR (Peroxisome proliferator-activated receptor) agonist. These receptors are located at various sites in the body, one of which is on muscles. Cardarine binds with PPAR and carries out multiple effects such as reduction in glucose metabolism, promoting fat loss, and enhancing endurance.

Cardarine enhances Lipid metabolization, meaning that it speeds up the rate at which your body takes stored body fat and converts it into energy. Bodybuilders often use this supplement when they are prepping for a contest, as it fits very well into a cutting stack.

Cardarine has been found to lower harmful LDL cholesterol and boost healthy HDL cholesterol.

That means that the drug can potentially help people to avoid suffering from heart attacks, cardiovascular disease, strokes, blocked arteries, and much more besides. It’s rare that performance-enhancing drugs actually promote cardiovascular health and well-being, but that is precisely what Cardarine appears to do, making it very popular.

Cardarine (GW-501516) Overview

⭐️ Top Benefits: Endurance and fat loss
🧪 Form: Liquid, Powder
⌛️ Cycle Length: 6 – 8 weeks
💰 Average Cost: $59.99
❤️‍🩹 Side Effects: Liver toxicity and stomach pain
☢️ Dangers: Hepatotoxicity
📚 Best Stack: MK-677 / Testolone / LGD 4033
PCT Required: No
🧍‍♂️🧍‍♀️Men/Women: Men and Women
🔄 See Results
➡️ Go to the Full review

  • Better recovery
  • Improved fat loss
  • Stomach cramps
  • Liver toxicity

#2 Best SARM for Weight Loss: Andarine S4

Next on our list for best SARMS for weight loss is Andarine S4. No, I’m not referring to the souped-up Audi, I’m talking about how souped-up you’re gonna be after taking S4!

Fun fact, souped-up comes from old horse racing when horses used to be fed the special sauce in their soup.

Anyways, S4 is quite a strong SARM. In fact, it’s widely advised not to be the first SARM you sign the dotted line with.

S4 will amplify your weight loss endeavors by lowering lipoprotein lipase, which will accelerate fat loss. It will also make you more anabolic, and the chances of you losing muscle will be very slim.

Bonus, it massively accelerates recovery periods as well! Hop on over to Sports Technology Labs to get yourself a flavored Andarine S4 – something you don’t find every day.

S4 Summary

S4 Andarine

Andarine (developmental code names GTx-007S-4) is an investigational selective androgen receptor modulator (SARM) developed by GTX, Inc for the treatment of conditions such as muscle wasting, osteoporosis, and benign prostatic hypertrophy (BPH). [7]

Its anabolic activity has been viewed to be comparable to testosterone, but unlike anabolic steroids, Andarine does not suppress luteinizing hormone (LH) or follicle-stimulating hormone (FSH).

As a result, Andarine is able to increase muscle and bone mass without affecting the prostate and does not result in many of the negative side effects that come with the use of anabolics. 

Andarine has become popular as a cutting agent since it accomplishes fat loss by decreasing lipoprotein lipase (LPL) levels and decreasing water retention. Andarine will also prevent you from losing your hard-earned muscle mass and it may even help you to put on lean muscle mass. 

S4 Andarine Overview

⭐️ Top Benefits: Muscle growth, strength gain, fat loss
🧪 Form: Liquid, Powder
⌛️ Cycle Length: 6 – 8 weeks
💰 Average Cost: $59.99
❤️‍🩹 Side Effects: Vision issues, headaches, and liver toxicity
☢️ Dangers: Hepatotoxicity
📚 Best Stack: MK-677 / Cardarine / RAD 140
PCT Required: Yes
🧍‍♂️🧍‍♀️Men/Women: Men
🔄 See Results
➡️ Go to the Full review

  • Better recovery
  • Improved fat loss
  • Massive muscle gains
  • Headaches
  • Liver toxicity
  • Vision issues

#3 Best SARM for Increased Growth Hormone + Weight Loss: MK677

No, I’m not talking about secret experiments or futuristic tech – I’m here to introduce you to the potential growth hormone powerhouse that is MK-677!

MK-677, also known as Ibutamoren, is not your typical SARM. It’s technically a growth hormone secretagogue that can significantly boost your body’s production of growth hormone. 

And why is that so appealing? Well, growth hormone plays a crucial role in various physiological processes, including muscle growth, fat loss, and overall well-being.

One of the most remarkable benefits of MK-677 is its ability to increase your growth hormone levels without the need for injections or synthetic hormones. 

Instead, it stimulates your body to release more growth hormone naturally. This can lead to improved muscle mass, fat metabolism, and even better sleep quality.

So, if you’re looking for a way to enhance your body’s anabolic state and potentially improve your body composition, MK-677 might be the way to go. 

It’s an option worth considering, especially if you’re already familiar with SARMs and want to explore a different avenue to achieve your fitness goals.

MK 677 Summary


MK 677 is commonly grouped with SARMs when in reality it is not a SARM at all. It is also not a Peptide. Regular SARMs will bind to the Androgen Receptors in the muscle tissue (and bone tissue as well) to cause an increase in muscle protein synthesis.

MK 677, however, is a Growth Hormone secretagogue, meaning it will not interact with the Androgen Receptors at all, but only cause an increased release of Human Growth Hormone (HGH) from your own Pituitary gland.

Increased HGH can lead to increased fat loss, and muscle gain, and even improve overall life quality.

MK 677 Overview

⭐️ Top Benefits: Muscle growth, strength gain, fat loss
🧪 Form: Liquid, Powder
⌛️ Cycle Length: 8 – 12 weeks
💰 Average Cost: $64.99
❤️‍🩹 Side Effects: Water retention and gyno
☢️ Dangers: Hypertension
📚 Best Stack: Cardarine / LGD 4033 / RAD 140
PCT Required: No
🧍‍♂️🧍‍♀️Men/Women: Men and Women
➡️ Go to the Full review

  • Better recovery
  • Improved fat loss
  • Massive muscle gains
  • Water retention
  • Gyno

What are SARMs?

The human body has Androgen receptors throughout, spread from muscles, and bones, to even the prostate.

They play a crucial role, as the natural Androgenic hormones humans produce need to bind at specific places for our bodies to function normally.

Thus, a good and safe amount of Androgenic hormones is all fine and good.

Steroids are exogenous Androgenic hormones. These bind to all of the androgenic receptors in the human body and cause a biological change in them.

This is great for muscle hypertrophy, but not so great for other parts – such as your prostate or your liver.

See, those will also undergo the change due to the exogenous hormones, and that’s how you end up with prostate cancer.

Best SARMs for Weight Loss

Steroids are often prescribed to individuals suffering from certain muscular atrophy illnesses, such as AIDS patients. In fact, AIDS patients are often prescribed Anadrol.

Anadrol is an extremely powerful oral steroid, and incredibly liver toxic. SARMs, like the RAD140 shown above, were designed to perform similarly to steroids in muscular hypertrophy but to not have the adverse effects associated with steroids.

SARMs, as the name suggests, are selective in nature, and will only (mostly) bind to the Androgen receptors within the muscles and bones, therefore having fewer side effects than steroids.

How do SARMs for Weight Loss Work?

Think of SARMs as instructors to Androgenic receptors. They bind to these receptors and instruct them to force a change in that particular area.

Fat-burning SARMs are the ones that don’t specifically mimic Testosterone at the receptor. Something like Cardarine acts as a PPAR Delta Agonist.

Other SARMs will act differently, and cause an increase in fat-burning capabilities in their way. Something almost all SARMs will do is cause muscle hypertrophy.

Other Benefits of SARMs

SARMs are so much more than just a fat-burning booster, there’s a reason plenty of athletes started using these things.

1) Increase in Lean Muscle Mass

SARMs are very well known for causing an increase in lean muscle mass. They were originally designed for that purpose, to help hospital patients who are suffering from muscle wastage.

Plenty of bodybuilders, cross-fitters, and other athletes use SARMs like S23 for their potent muscle-building qualities.

2) Endurance

It won’t come as a surprise that some Crossfit athletes have been found to use SARMs, as they could really help their performance.

One of those benefits is the fact that SARMs can boost your endurance. Yup, SARMs like Ligandrol have been shown to significantly improve cardiovascular capabilities.

3) Increased Bone Density

Ever looked at your local powerlifter and thought “Wow 5 minutes rest between squats, jeez”. Me too. But have you also thought as to how their bones can cope with those massive squats??

Well, it won’t come as a surprise that weight training has been shown to increase bone density. Thus, having strong bones is certainly going to help you.

Guess what? SARMs bind to the androgenic receptors in your bones and increase their density.

Kinda? Well, the only way to purchase them is if they’re labeled as “Research Chemicals”. If they aren’t labeled as such, well that’s illegal.

If you are someone who is competing in a sport that is regulated by WADA (World Anti-Doping Agency) then you’re out of luck, they’re banned.

Fun fact, even drinking too much coffee before a test will get you banned!


Side Effects of SARMs

Unfortunately, everything comes at a price. Chips come with guilt, online dating comes with Chlamydia, and owning a Tesla comes with smugness.

SARMs will have side effects, and will almost always be dose-dependent. What that means is the more you use, the worse you end up experiencing the sides.

Side effects can be individual, and can also just be down to the type of SARM you’re using. Let’s look at some of the most common ones.

Testosterone Suppression

Yup, even SARMs can do this. See, normally exogenous Testosterone will suppress your endogenous production of Testosterone.

SARMs, most of them at least, do not cause this at all. Some SARMs such as the aforementioned S4 can do this.

In this scenario, it might be best to make use of a PCT (post-cycle treatment) to keep your testes functioning.

Organ Damage

While SARMs were designed to not be as toxic as steroids, they unfortunately are still toxic, just like your ex. Specifically the liver and kidneys.

See, all oral steroids and SARMs need to be broken down by the liver, and that process does put a fair bit of strain on the liver. Solution? Lower doses, or just use the correct supplements.


Another common side effect we hear steroid users complain about is, “Oh, my lipids are out of range.”. Basically, they have cholesterol issues.

This is something that SARMs definitely do cause, as quite a few studies (and anecdotal evidence) do show that SARMs lower HDL (the good cholesterol).

Who should use SARMs for Weight Loss?

Adults. If you haven’t completed puberty or you’re not fully developed, walk away. If you are an adult, and you are looking to get a slight edge in your weight loss journey, it could very well be for you.

Just make sure you study the specific side effects associated with the SARM you intend on using – for instance, don’t use SARMs unless your lipids are in range.

Best SARMs for Weight Loss

That being said, you’re still gonna have to work. SARMs won’t magically you look like Chris Hemsworth.

Dieting, training, rest, and supplementation, all still play the biggest roles when it comes to weight loss.

Common Questions on SARMs

How much weight can I lose on SARMs?

It depends. Someone with 30% body fat is going to lose a lot faster than someone at 3%. Optimally, you’d aim to lose between 0.5 – 1.0 % of body weight per week.

Do you lose your gains after SARMs?

If you fail to train and diet correctly, yes. Keep on training and dieting, you could end up keeping 80% of your gains.

Do I gain the fat back after SARMs?

Again, if you keep eating correctly and training, you’ll gain minimal fat.

Do SARMs increase Aggression?

Some do yes. The stronger SARMs like S23 could potentially increase aggression whilst on the cycle.

What is the safest SARM for cutting?

RAD 140, MK 677 and LGD 4033 are considered 3 of the safest SARMs for cutting.


We’re all looking for that edge to get rid of some weight and get that perfect Gram pic.

SARMs can very well be that edge for the right person, with hundreds of people claiming that they have great results from SARMs.

Unfortunately, it’s not the magic pill we all wish existed, and will still require dieting and training. Otherwise, solid stuff!

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Daniel Louwrens BSc PT

Daniel Louwrens BSc PT | Writer

Daniel Louwrens is a well-rounded fitness professional with over 10 years of experience in bodybuilding and fitness. He holds a BSc in Chemistry from the University of Western Cape and is a certified International Personal Trainer and Nutritionist. He is also a skilled bodybuilder and head coach for Muscle and Brawn. With his knowledge and expertise, he provides personalized training, nutrition, and recovery guidance to help clients reach their fitness goals.

Read all articles
Dr. Mohammed Fouda

Dr. Mohammed Fouda | Reviewer

Dr. Fouda uses his extensive knowledge and expertise as an academic scholar to medically review articles for scientific accuracy and credibility, ensuring that the medical information presented is up-to-date and trustworthy. He is responsible for ensuring the quality of the medical information presented on our website.

Read all articles
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