Andarine S4 Complete Guide: Benefits, Uses, Dosage

If you’re looking for a SARM that’s slightly more powerful than Ostarine but not as potent as RAD 140, then it’s time you got familiar with this detailed Andarine S4 review!

While still relatively mild, Andarine is a logical progression on your second or subsequent cycles of taking SARMs.

In this article, I’ll get you up to speed on everything you need to know before deciding on whether or not to take S4.

With more than 30 years of experience in bodybuilding and sports nutrition, I’ve studied this SARM since it first came onto the market.

Let me share the benefit of that research with you through this Andarine S4 Review!

Key Takeaways

  • Andarine, also known as S-4 and Gtx-007, is a selective androgen receptor modulator (SARM) designed to treat muscle-wasting diseases.
  • Andarine is popular for its fat loss benefits, reducing water retention, and preventing muscle loss during cutting phases.
  • Andarine is legally available for research purposes but is on the banned substances list for professional athletes, according to WADA and USADA.
  • Users should be beyond puberty and have experience with intense training and dieting before considering Andarine. A typical cycle is 8 to 12 weeks.
  • Andarine dosages should be carefully managed, with 30 mg per day as a recommended dosage to avoid side effects like yellow-tinted vision.

Warning: The content on and the information included in this article is intended for entertainment and informational purposes only. It is not intended nor implied to be a substitute for professional medical advice. Prior to buying anything, check that it is compliant where you live with your current government laws. We frequently mention research chemicals that are not made for human consumption. Therefore, before purchasing any product for personal use, consult with your doctor or healthcare provider first.

What is Andarine?

Andarine is a selective androgen receptor modulator that is also known as S-4 and Gtx-007. It was developed by Gtx Inc. and was originally designed to treat muscle-wasting diseases.

Its anabolic activity has been viewed to be comparable to testosterone, but unlike anabolic steroids, andarine does not suppress luteinizing hormone (LH) or follicle-stimulating hormone (FSH).

Neither does it increase estradiol levels.

As a result, Andarine can increase muscle and bone mass without affecting the prostate and does not result in many of the negative side effects that come with the use of anabolics. [1]

Andarine has become popular as a cutting agent since it accomplishes fat loss by decreasing lipoprotein lipase (LPL) levels and decreasing water retention.

Andarine will also prevent you from losing your hard-earned muscle mass and it may even help you to put on lean muscle mass. [2]

How Does Andarine Work?

S4 Summary

Safest SARM for Strength: S4 Andarine

Andarine, known by its developmental code names GTx-007 and S-4, emerges as a noteworthy investigational selective androgen receptor modulator (SARM) meticulously crafted by GTX, Inc. 

Positioned for potential applications in treating muscle wasting, osteoporosis, and benign prostatic hypertrophy (BPH), Andarine stands out in the realm of Safest SARMs.

Unlike traditional anabolic steroids, Andarine boasts an anabolic activity on par with testosterone while avoiding the suppression of luteinizing hormone (LH) or follicle-stimulating hormone (FSH). 

This distinctive feature sets Andarine apart, allowing it to foster increased muscle and bone mass without the typical drawbacks associated with anabolics, making it a standout in the category of Safest SARMS.

In its role as a cutting agent, Andarine showcases its effectiveness in fat loss by actively reducing lipoprotein lipase (LPL) levels and curbing water retention.

Beyond its contribution to fat loss, Andarine serves as a reliable guardian of hard-earned muscle mass during cutting phases, offering the potential for the acquisition of lean muscle mass. 

S4 Andarine Overview

⭐️ Top Benefits: Muscle growth, strength gain, fat loss
🧪 Form: Liquid, Powder
⌛️ Cycle Length: 6 – 8 weeks
💰 Average Cost: $59.99
❤️‍🩹 Side Effects: Vision issues, headaches, and liver toxicity
☢️ Dangers: Hepatotoxicity
📚 Best Stack: MK-677 / Cardarine / RAD 140
PCT Required: Yes
🧍‍♂️🧍‍♀️Men/Women: Men
🔄 See Results
➡️ Go to the Full review

  • Better recovery
  • Improved fat loss
  • Massive muscle gains
  • Headaches
  • Liver toxicity
  • Vision issues

As a SARM, Andarine selectively attaches itself to androgen receptors in muscle and bone cells.

This is very different from anabolic steroids which attach to all androgen receptors.

As a result, Andarine will not result in the negative side effects that are produced by anabolics.

Instead, it will reduce the levels of lipoprotein lipase which enhances fat burning and it will also promote the loss of water from under the skin, making your muscles appear ripped!

Andarine S4 Review: Benefits of Andarine S4

Andarine is considered to be the best SARM for fat loss without side effects. However, it will also help to prevent muscle loss while in the cutting phase.

Additionally, Andarine has been shown to increase energy levels and will also enhance post-workout recovery.

Anecdotal evidence suggests that a person who is on an Andarine cycle can cut their workout recovery time in half from 72 hours to 36 hours, thus allowing them to get more workouts in for a week.

This Andarine S4 Review would not be complete without discussing its legality!

Andarine, along with all other SARMS, can be legally sold almost everywhere around the world. However, it must only be marketed as a research product.

SARMs have not been classified as dietary supplements by the FDA so the market is unregulated. That means that you need to be very cautious when buying SARMs, whether online or in person.

Only buy tour SARMs from established, reputable companies that have a track record of superior service. The one that we recommend is bio Science.

Andarine is on the banned substances list put out by WADA (World Anti-Doping Agency) and USADA (United States Anti-Doping Agency).

As a result, Andarine and other SARMs should not be taken by professional athletes.

Who Should Use Andarine?

Another vital thing to discuss in this Andarine S4 review is who should buy it.

You should not take Andarine or any other SARM unless you have completed puberty.

People who are beyond puberty and have extensive experience with intense training and diligent dieting may consider using Andarine for fat loss and muscle-building enhancement.

Andarine Cycle

A typical Andarine cycle is between 8 and 12 weeks. I suggest starting with an 8-week cycle the first time you use Andarine.

If it is well-tolerated, step it up to 10 weeks on your second cycle.

On your third and subsequent cycles, you can max your cycle length up to 12 weeks.

Andarine Dosage

The recommended dosage for Anadrine is 50 mg per day. However, a major side effect of yellow-tinted vision has been noted at this dosage.

For that reason, I recommend reducing your dosage to a more conservative amount of 30 mg per day.

Since Andarine has a half-life of 4 hours, you should divide your dosage into three 10 mg portions over the day.

Andarine For Bodybuilding

Andarine has become an increasingly popular supplement for bodybuilders. Although most bodybuilders use it as part of a cutting stack, it is also a good progressive bulking agent.

I would recommend an 8-week cycle of Andarine as your second cycle after completing your first cycle with Ostarine, which is generally regarded as the mildest SARM on the market.

Andarine is more potent than Ostarine but not as powerful as compounds like Testolone. However, if you are an experienced SARM user, you will probably be using such SARMs are Testolone or YK-11.

We recommend taking 20 mg per day split into four equally spaced doses over 8 weeks for a bulking cycle.

Because it is a mild SARM with a very low suppressive effect on your body’s natural production of testosterone, you do not need to follow your cycle with Post Cycle Therapy.

Andarine S4 Review For Cutting and Weight Loss

Andarine can be used by itself or as part of a stack. We recommend taking 30 mg per day split into four equally spaced doses over 8 weeks for cutting.

Andarine S4 Review For Women

Anadarine is considered to be one of the best SARMs for women since it is among the mildest selective androgen receptor modulators.

It does an excellent job of stripping body fat off women to produce the sleek, athletic look that many women in the industry are after.

Andarine Stack

Anadarine can be even more effective when used as part of a stack. My favorite cutting stacks combine the following compounds taken over 8 weeks:

  • 30 mg of Andarine per day, split into four equally spaced doses
  • 20 mg of Cardarine per day, 30 minutes before working out
  • 25 mg of Ostarine 25 mg per day

Andarine S4 Review Side Effects

There has been one major side effect noted with Andarine at a dosage of 50 mg per day or more – yellowing of vision.

There have also been numerous reports that people’s eyesight becomes more sensitive when they use Andarine and that they have greater difficulty adjusting to the dark.

This vision impairment usually manifests itself about halfway through a cycle and continues until you go off the SARM.

All users who have experienced this vision impairment found that it went away after use with no long-term effects.

No other side effects have been noted at this time.

Andarine PCT

Due to the mildness of its testosterone suppression effect, there is no need to use post-cycle therapy after completing an Andarine cycle.

Does Andarine Work?

Andarine, also known as S4, is indeed an effective compound in the world of selective androgen receptor modulators (SARMs). 

Its mechanism of action primarily involves targeting androgen receptors in muscle and bone tissues, promoting muscle growth, and potentially aiding in fat loss. 

When used responsibly and as part of a well-structured fitness and dietary regimen, Andarine can yield notable results, particularly in terms of achieving a lean and ripped physique.

One of the remarkable benefits of Andarine is its ability to aid in fat loss and muscle preservation during cutting cycles. 

Throughout an 8-week cycle, many users report significant reductions in body fat percentage, often around 5%

This makes it a popular choice among individuals who are seeking a leaner, more defined appearance. 

While the extent of fat loss can vary among users due to factors such as diet and exercise, the effects of Andarine on body composition are generally favorable.

Additionally, Andarine is known for its muscle-sparing properties during calorie deficits. When people aim to shed body fat, there’s a risk of losing lean muscle mass. 

Andarine helps mitigate this concern, allowing individuals to maintain their hard-earned muscles while reducing fat, which is crucial for a balanced and aesthetic physique.

It’s important to note that the effectiveness of Andarine is most pronounced when used in conjunction with proper diet and exercise

Combining it with a well-structured workout routine and a balanced diet can maximize its benefits. 

Furthermore, individual responses to Andarine may vary, so it’s advisable to start with a conservative dosage and monitor any side effects.

Is Andarine Safe?

Yes, Andarine is safe to use in the short to medium term as long as you keep the dosage below 50 mg per day.

The only reported side effect has been some vision impairment at higher dosages, but this is a temporary effect.

This SARM has not been around long enough for me to state categorically whether it will have long-term negative effects on users.

Where to Buy Andarine

Andarine can be purchased from a large number of online retailers.

However, I seriously advise being cautious as to which website you choose to deal with.

I highly recommend dealing with a company that is based in the USA and that has developed a track record of reliability and positive customer feedback.

For my money, the number one company that needs those criteria is Chemyo.

They’ve been around for around 8 years and have established an excellent reputation.

Andarine vs RAD140

Andarine (S4)RAD140 (Testolone)YK-11Ligandrol (LGD-4033)Ostarine (MK-2866)
PurposeCutting agentBulking agentMass-buildingModerate mass-builderIntroductory SARM
PotencyMilderRobustPotentGreater mass-buildingMildest
Main BenefitFat loss and muscle preservationMuscle gain and preservationMuscle gainsMuscle gainEnhanced recovery
Suitable ForLean and defined physiqueSignificant muscle massMuscle gainsMuscle gain without extreme potencyNew users and introductory use
StackabilityStacks well with OstarineNot commonly stacked with AndarineNot typically stacked with AndarineMay require caution PCTEffective in cutting cycles

Andarine (S4) and RAD140 (Testolone) are both popular selective androgen receptor modulators (SARMs), but they serve different purposes. 

Andarine is milder than RAD140, making it a preferable option for individuals who seek a less aggressive approach to SARMs. 

While RAD140 is renowned for its potent bulking properties, Andarine is primarily used as a cutting agent. 

It is valued for its ability to aid in fat loss and muscle preservation during calorie deficits, making it an excellent choice for those looking to achieve a lean and defined physique. 

In contrast, RAD140 is a more robust choice for individuals aiming to pack on significant muscle mass.

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Andarine vs YK-11

YK-11 is another formidable SARM, known for its exceptional mass-building capabilities. 

In comparison to Andarine, YK-11 is at the opposite end of the spectrum in terms of its primary purpose. 

While Andarine is often used during cutting cycles to reduce body fat and preserve lean muscle, YK-11 is employed by those looking to achieve substantial muscle gains

These two SARMs are typically not stacked together because they have different goals and may have conflicting effects.

Andarine vs Ligandrol

Ligandrol, often referred to as LGD-4033, is another SARM that falls between Andarine and more potent options like RAD140 and YK-11. 

It offers greater mass-building potential than Andarine, making it a suitable choice for those looking to gain muscle mass without the extreme potency of RAD140 or YK-11. 

However, it’s important to note that Ligandrol can be more suppressive to natural testosterone production compared to Andarine. 

Users should be cautious and consider post-cycle therapy when using Ligandrol, especially for extended periods.

Andarine vs Ostarine

Ostarine (MK-2866) is considered the mildest SARM available and is often recommended as an introductory option for those new to SARMs. 

It’s a versatile compound that can be used alone on a first cycle to experience the benefits of enhanced muscle growth and recovery

However, for individuals looking to focus on cutting during their second and subsequent cycles, Andarine can be an excellent choice. 

Andarine can be stacked with Ostarine to further enhance the fat-cutting and muscle-preserving effects, offering a more comprehensive approach to body composition goals. 

This combination can provide a balanced approach to achieving a lean and well-defined physique.

Andarine S4 Review: Should You Take Andarine S4?

If you are at the stage where you feel that you have reached your natural peak, then taking Andarine to help get ripped may be a good option for you.

Make sure that you are beyond puberty, training consistently and intensely. and following a clean diet before its use to achieve maximum results.


Does Andarine Really Work?

Yes, Andarine (S4) has been shown to work effectively in enhancing lean muscle growth, improving strength, and aiding fat loss. However, individual results may vary, and it’s essential to use it responsibly.

What is Andarine S4 Used For?

Andarine S4 is primarily used for enhancing lean muscle mass and improving strength. It is also known for its fat-cutting properties, making it popular among bodybuilders and athletes.

Is S4 for Bulking or Cutting?

Andarine S4 is versatile and can be used for both bulking and cutting cycles. It helps in increasing lean muscle mass while simultaneously reducing body fat, making it suitable for various fitness goals.

Does Andarine Affect Testosterone?

Andarine S4 is known to have a mild impact on testosterone levels, which may result in decreased libido in some users. It’s advisable to use it with caution and consider post-cycle therapy (PCT) if necessary to restore testosterone levels.

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Steve Theunissen

Steve Theunissen | Writer

Steve Theunissen is a seasoned fitness professional with 25+ years of experience. He has multiple certifications from the International Sports Sciences Association, including Certified Personal Trainer, Fitness Nutrition Certification, and Strength and Conditioning Certification. He's a knowledgeable and experienced bodybuilding coach, combining his passion for fitness with his writing skills to educate and inspire. Whether starting out or looking to take training to the next level, Steve Theunissen is the ideal coach to help reach fitness goals.

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9 months ago

I’ve tried a few cycles of various SARMs and never had any side effects until this week with S4. I noticed my vision going yellow, colored halos in my peripheral vision at night, and poor vision in the dark. Taking S4 was the only change, and after looking up S4 side effects, understood why. I discontinued use after only 5 days at 2 x 25mg/day. I read elsewhere that starting a lower dosage and then backing off is recommended as soon as any vision change is noticed. I personally won’t be doing S4 again and hope to see in the dark like I did before.

Chemical Structure

Mechanism of Action

Andarine has a strong affinity for androgen receptors (AR). Once it binds to the AR of the muscle tissue, it stimulates the protein synthesis leading to gain in muscle mass and improved healing of damaged muscles.

Class of Compound


Street Names

GTX-007, S-4, S-40503


  • Helps gain muscle mass
  • Can improve bone strength
  • Creates cut and dry look

Side Effects and Dangers

  • Hormone suppression
  • Vision-related problems, night blindness
  • Liver toxicity

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