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Andarine S4 SARM Review

Compound Summary

Class of Compound

SARM

Mechanism of Action

Andarine has a strong affinity for androgen receptors (AR). Once it binds to the AR of the muscle tissue, it stimulates the protein synthesis leading to gain in muscle mass and improved healing of damaged muscles.

Top Studies

Street Names

GTX-007, S-4, S-40503

Used For

  • Helps gain muscle mass
  • Can improve bone strength
  • Creates cut and dry look

Side Effects and Dangers

  • Hormone suppression
  • Vision-related problems, night blindness
  • Liver toxicity

Chemical Structure

Scientific Name: (2S)-3-(4-acetamidophenoxy)-2-hydroxy-2-methyl-N-[4-nitro-3-(trifluoromethyl) phenyl] propenamide

If you’re looking for a SARM that’s slightly more powerful than Ostarine but not as potent as RAD 140, then it’s time you got familiar with Andarine S4! While still relatively mild, Andarine is a logical progression on your second or subsequent cycles of taking SARMs.

In this article, I’ll get you up to speed on everything you need to know before making the decision on whether or not to take S4. With more than 30 years of experience in bodybuilding and sports nutrition, I’ve studied this SARM since it first came onto the market.

Let me share the benefit of that research with you!

What is Andarine?

Andarine is a selective androgen receptor modulator that is also known as S-4 and Gtx-007. It was developed by Gtx Inc. and was originally designed to treat muscle-wasting diseases.

Its anabolic activity has been viewed to be comparable to testosterone, but unlike anabolic steroids, andarine does not suppress luteinizing hormone (LH) or follicle-stimulating hormone (FSH). Neither does it increase estradiol levels.

As a result, Andarine is able to increase muscle and bone mass without affecting the prostate and does not result in many of the negative side effects that come with the use of anabolics. [1]

Andarine has become popular as a cutting agent since it accomplishes fat loss by decreasing lipoprotein lipase (LPL) levels and decreasing water retention. Andarine will also prevent you from losing your hard-earned muscle mass and  it may even help you to put on lean muscle mass. [2]

Disclaimer: The information included in this article is intended for entertainment and informational purposes only. It is not intended nor implied to be a substitute for professional medical advice. Prior to buying anything, check that it is compliant where you live with your current government laws.

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Ostarine MK 2866
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Ostarine MK 2866

Ostarine has been shown to be extremely effective in increasing lean muscle mass and reducing body fat.

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Testolone RAD 140
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Testolone RAD 140

Testolone is considered to be the strongest SARM available and it was originally designed to offset the effects of muscle wasting diseases.

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Best for Women
Ligandrol LGD-4033
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Ligandrol LGD-4033

Ligandrol has been shown to increases muscle mass and strength as well as decrease body fat and bone turnover.

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Best for Strength
Myostine YK-11
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Myostine YK-11

Myostine has been shown to be as effective as testosterone in enhancing lean muscle mass and strength.

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Best for Fat Loss
Andarine S4
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Best for Fat Loss
Andarine S4

Andarine is considered to be the best SARM for fat loss and reducing water retention.

Ideal for Cutting
Not for Women
25mg 2X Daily
4-8 Week Cycle
$59.99/Vial

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How Does Andarine Work?

As a SARM, Andarine selectively attaches itself to androgen receptors in muscle and bone cells. This is very different from anabolic steroids which attach to all androgen receptors.

As a result, Andarine will not result in the negative side effects that are produced by anabolics. Instead, it will reduce the levels of lipoprotein lipase which enhances fat burning and it will also promote the loss of water from under the skin, making your muscles appear ripped!

Benefits of Andarine

Andarine is considered to be the best SARM for fat loss without side effects. However, it will also help to prevent muscle loss while in the cutting phase.

Additionally, Andarine has been shown to increase energy levels and will also enhance post-workout recovery. In fact, anecdotal evidence suggests that a person who is on an Andarine cycle can cut their workout recovery time in half from 72 hours to 36 hours, thus allowing them to get more workouts in over the course of a week.

Is Andarine Legal?

Andarine, along with all other SARMS, can be legally sold almost everywhere around the world. However, it must only be marketed as a research product.

SARMs have not been classified as dietary supplements by the FDA so the market is unregulated. That means that you need to be very cautious when buying SARMs, whether online or in person.

Only buy tour SARMs from established, reputable companies that have a track record of superior service. The one that we recommend is bio Science.

Andarine is on the banned substances list put out by WADA (World Anti Doping Agency) and USADA (United States Anti Doping Agency). As a result, Andarine and other SARMs should not be taken by professional athletes.

Who Should Use Andarine?

You should not take Andarine or any other SARM unless you have completed puberty. People who are beyond puberty and have extensive experience with intense training and diligent dieting may consider using Andarine for fat-loss and muscle-building enhancement.

Andarine Cycle

A typical Andarine cycle is between 8 and 12 weeks. I suggest starting with an 8 week cycle the first time you use Andarine.

If it is well-tolerated, step it up to 10 weeks on your second cycle. On your third and subsequent cycles, you can max your cycle length up to 12 weeks.

Andarine Dosage

The recommended dosage for Anadrine is 50 mg per day. However, a major side effect of yellow-tinted vision has been noted at this dosage.

For that reason, I recommend reducing your dosage to a more conservative amount of 30 mg per day.

Since Andarine has a half-life of 4 hours, you should divide your dosage into three 10 mg portions over the course of the day.

Andarine For Bodybuilding

Andarine has become an increasingly popular supplement for bodybuilders. Although most bodybuilders use it as part of a cutting stack, it is also a good progressive bulking agent.

I would recommend an 8-week cycle of Andarine as your second cycle after completing your first cycle with Ostarine, which is generally regarded as the mildest SARM on the market.

Andarine is more potent than Ostarine but not as powerful as compounds like Testolone. However, if you are an experienced SARM user, you will probably be using such SARMs are Testolone or YK-11.

We recommend taking 20 mg per day split into four equally spaced doses over the course of 8 weeks for a bulking cycle.

Because it is a mild SARM with a very low suppressive effect on your body’s natural production of testosterone, you do not need to follow your cycle with Post Cycle Therapy.

Andarine For Cutting and Weight Loss

Andarine can be used by itself or as part of a stack. We recommend taking 30 mg per day split into four equally spaced doses over the course of 8 weeks for cutting.

Andarine For Women

Anadarine is considered to be one of the best SARMs for women since it is among the mildest selective androgen receptor modulators. It does an excellent job of stripping body fat off women to produce the sleek, athletic look that many women in the industry are after.

Andarine Stack

Anadarine can be even more effective when used as part of a stack. My favorite cutting stacks combines the following compounds taken over the course of 8 weeks:

  • 30 mg of Andarine per day, split into four equally spaced doses
  • 20 mg of Cardarine per day, 30 minutes before working out
  • 25 mg of Ostarine 25 mg per day

Andarine Side Effects

There has been one major side effect noted with Andarine at a dosage of 50 mg per day or more – yellowing of vision. There have also been numerous reports that people’s eyesight becomes more sensitive when they use Andarine and that they have greater difficulty adjusting to the dark.

This vision impairment usually manifests itself about halfway through a cycle and continues until you go off the SARM. All users who have experienced this vision impairment found that it went away after use with no long term effects.

No other side effects have been noted at this time.

Andarine PCT

Due to the mildness of its testosterone suppression effect, there is no need to use post cycle therapy after completing an Andarine cycle.

Does Andarine Work?

Yes, Anadraine definitely works – especially when it comes to getting ripped! On an 8-week cycle, it is not uncommon for people to have dropped up to 5% bodyfat from its use and it will also help you to avoid muscle-loss when cutting.

Is Andarine Safe?

Yes, Andarine is safe to use in the short to medium term as long as you keep the dosage below 50 mg per day. The only reported side effect has been some vision impairment at higher dosages, but this is a temporary effect.

This SARM has not been around long enough for me to state categorically whether it will have long term negative effects for users.

Where to Buy Andarine

Andarine can be purchased from a large number of online retailers. However, I seriously advise being cautious as to which website you choose to deal with.

I highly recommend dealing with a company that is based in the USA and that has developed a track record of reliability and positive customer feedback. For my money, the number one company that needs those criteria is Science.Bio.

They’ve been around for around 8 years and have established an excellent reputation.

Andarine vs RAD140

Andarine is far milder than RAD 140 (Testolone). Whereas RAD 140 is one of the most popular bulking agents, Andarine is primarily used as a cutting agent.

Andarine vs YK-11

YK-11 is another extremely potent mass building SARM. It is on the opposite end of the spectrum to Andarine and is not stacked with it.

Andarine vs Ligandrol

Ligandrol is more potent than Andarine but not as strong as RAD 140 or YK-11. It has greater mass building potential but is also more suppressive than Andarine.

Andarine vs Ostarine

Ostarine is considered the mildest SARM on the market. It is recommended as an introductory SARM for people to use alone on their first cycle.

If they want to focus on cutting for their second and subsequent cycles, they should use Andarine which can be stacked with Ostarine.

Should You Take Andarine S4?

If you are at the stage where you feel that you have reached your natural peak, then taking Andarine to help get ripped may be a good option for you. Make sure that you are beyond puberty, training consistently and intensely. and following a clean diet before its use to achieve maximum results.

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This is Crazy Bulk's ultimate stack for boosting testosterone levels, accelerating gains, and building strength. Contains Testolone, Ostarine, Ligandrol and Anadrine.

Most Products Once Daily
Liquid Form
6-8 Week Cycle
$197.96/Month

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Best SARMs Deal for More Advanced Users
Complete SARMs Stack

Science Bio offers 25% off your order if you purchase this complete liquid metabolics bundle with over 9 liquid metabolic SARMs.

Most Products Once Daily
Liquid Form
6-8 Week Cycle
$326.17/Month

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Best Overall
Ostarine MK 2866
3
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Best Overall
Ostarine MK 2866

Ostarine has been shown to be extremely effective in increasing lean muscle mass and reducing body fat.

Best for Beginners
For Men & Women
10-25mg Daily
6-8 Week Cycle
$59.99/Vial

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Best for Bulking
Testolone RAD 140
4
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Best for Bulking
Testolone RAD 140

Testolone is considered to be the strongest SARM available and it was originally designed to offset the effects of muscle wasting diseases.

Most Potent SARM
Not for Women
10-20mg Daily
6-12 Week Cycle
$59.99/Vial

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Best for Women
Ligandrol LGD-4033
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Best for Women
Ligandrol LGD-4033

Ligandrol has been shown to increases muscle mass and strength as well as decrease body fat and bone turnover.

All-in-1 SARM
For Men & Women
5-10mg Daily
~8 Week Cycle
$59.99/Vial

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Best for Strength
Myostine YK-11
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Best for Strength
Myostine YK-11

Myostine has been shown to be as effective as testosterone in enhancing lean muscle mass and strength.

Testosterone Derivtative
Not for Women
10-20mg Daily
8-12 Week Cycle
$59.99/Vial

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Best for Fat Loss
Andarine S4
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Best for Fat Loss
Andarine S4

Andarine is considered to be the best SARM for fat loss and reducing water retention.

Ideal for Cutting
Not for Women
25mg 2X Daily
4-8 Week Cycle
$59.99/Vial

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References

See all references

[1] Selective Androgen Receptor Modulators (SARMs): USADA. (2020, July 27). Retrieved from https://www.usada.org/spirit-of-sport/education/selective-androgen-receptor-modulators-sarms-prohibited-class-anabolic-agents/

[2] Mohler, M. L., Bohl, C. E., Jones, A., Coss, C. C., Narayanan, R., He, Y., … & Miller, D. D. (2009). Nonsteroidal selective androgen receptor modulators (SARMs): dissociating the anabolic and androgenic activities of the androgen receptor for therapeutic benefit. Journal of medicinal chemistry, 52(12), 3597-3617.

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Steve Theunissen

Steve Theunissen

For the past five years, I have been a full-time fitness writer.  I also love to write about history and have written more than thirty books on the great battles throughout history. I live in sunny Tauranga, New Zealand with my wife of 33 years, Shelley.

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