HGH-FRAG 176-191 Peptide Guide: Benefits, Uses, Dosage

HGH-FRAG 176-191 is a spliced version or derivative of HGH and is known to tigger lipolytic activity, cause hypoglycemia as well as musculoskeletal strengthening with much less adverse effects compared to its parent compound. Read through the end to find out whether you should use this peptide or not.
Medically reviewed by Dr. Mohammed Fouda
Dr. Fouda uses his extensive knowledge and expertise as an academic scholar to medically review articles for scientific accuracy and credibility, ensuring that the medical information presented is up-to-date and trustworthy. He is responsible for ensuring the quality of the medical information presented on our website.

In this modern era where everyone is looking for ways to look fit and muscular, more supplements in the form of peptides are coming up in the market to meet customer demands. 

Scientists are finding more ways to utilize the already present biomolecules and form derivatives with enhanced effectiveness and potency. 

One such peptide is HGH-FRAG 176-191.

It is a derivative version of a naturally found Human Growth Hormone that has been modified in several ways for better and faster results. 

This article explains everything you need to know about HGH-FRAG 176-191, all the way from its molecular composition to its benefits, possible side effects, dosages, legality, and the best vendor to buy from. 

Warning: The content on Muscleandbrawn.com and the information included in this article is intended for entertainment and informational purposes only. It is not intended nor implied to be a substitute for professional medical advice. Prior to buying anything, check that it is compliant where you live with your current government laws. We frequently mention research chemicals that are not made for human consumption. Therefore, before purchasing any product for personal use, consult with your doctor or healthcare provider first.


HGH-FRAG is a sliced version of Human Growth Hormone. Distinctly it comprises the last 16 amino acids sequence of HGH from the 191-long sequence of the latter. Chemically the peptide goes by C39H60N8O13 (1). 

However, unlike HGH, the HGH-FRAG has quite a different working mechanism. One would think that being a spliced part of Growth Hormone, HGH fragments would also be conventionally working the same way. Nevertheless, the answer is no. 

Unlike its parent GH, HGH-FRAG does not bind to Growth Hormone Receptors (GHR) because it does not consist of all 191 amino acids. Thus, it can neither transcribe the formation of IGF-1 nor carry out any anabolic functions the way GH would. 

So, what does HGH-FRAG 176-191 do after all? 

Well, it has retained the lipolytic properties of GH. Henceforth, the HGH-FRAG peptide is most frequently used to carry out desired lipid metabolism functions. 

How Does HGH-FRAG Work?

The working mechanism behind HGH-FRAG is still not fully understood and is subjected to numerous criticism in the scientific community. However, there are three main areas where HGH-FRAG showed superlative effects. Let’s look into these research-backed mechanisms and gain more insight into how HGH-FRAG 176-191 got so welcomed worldwide. 

HGH-FRAG, unlike Growth hormone, does not retain all the properties of its parent biomolecule. Rather, it took one great attribute, i.e., lipolysis. HGH-FRAG 176-191 practical use in obese mice has resulted in an increased formation of beta-3 adrenergic receptors in fatty tissues. (2

These receptors are involved in fat mobilization and utilization in adipose tissue and are also found to mediate the thermogenesis process in muscles, especially the skeletal muscles. (3

Research also suggests that a three-week course with HGH-FRAG therapy in obese mice resulted in an approximate cut down of 50% in weight gain. (4

Interestingly, HGH-FRAG 176-191 therapy only ensued in obese/weight mice. It didn’t cause any significant weight loss in an average-weighted mouse. (2)  

Another possible mechanism of action followed by HGH-FRAG is its property to cause hypoglycemia due to its C-terminal. Scientists began researching whether the same hypoglycemic attributes were found in the fragments of HGH or not. 

One such fragment was 176-191. The peptide fragment could potentially decrease blood glucose levels and thus can technically be used in the treatment regimen of pre-diabetes and diabetes mellitus type 2 (DMT2). (5)

However, more meta-analysis and clinical trials on a much larger scale are needed for any of the above mechanisms to be stated with hard-core evidence. 

More authentic research is being done on knowing and investigating the possible effects of HGH-FRAG 176-191 on cartilage regeneration and growth. In experiments, the use of HGH-FRAG alongside Hyaluronic acid injections in rabbits increased the cartilage growth to substantial levels. (6

Scientists believe that increased and legitimate investigations in this matter can further unfold the idea of using HGH-FRAG 176-191 in treating osteoarthritis and minimizing surgery. 

Benefits of HGH-FRAG

HGH-FRAG has been in the market for a long time and has been subjected to repeated clinical trials before it ever got into the hands of the general populace. 

Some of the research-backed benefits of HGH-FRAG 176-191 include the reduction of fat reserves without any severe side effects, inhibiting lipolysis, increased energy levels, strengthening and build-up of muscle mass, and substantial decrease in obesity. 

Because HGH-FRAG regulates blood glucose levels, it can be said that it mitigates the risk of developing any cardiometabolic disorders, such as Type 2 Diabetes Mellitus (T2DM). 

It is also believed that it does not alter the IGF-1 serum levels or interact with other body mechanisms. 

It can also be used to increase bone density and upregulate muscle recovery, thus affecting your overall musculoskeletal system. 

HGH FRAG Usage in Bodybuilding

Although HGH FRAG is the spliced-out version of the human growth hormone, it only contains the lipolytic attributes of the hormone. Therefore, during the cutting phase of the bodybuilding workout routine, HGH FRAG can be used to burn out excess calories and inhibit more fat gain. 

For this purpose, studies suggest 200 mcg/day of HGH FRAG before breakfast. As you move ahead with the regime, you can dose up to 250 mcg or 300 mcg per day as well.

The legality of HGH isn’t a straightforward answer. HGH is currently prohibited by the World Anti-Doping Agency, which monitors the fight against drugs in sports. 

In the United States, HGH is completely illegal to be distributed or prescribed by physicians for reasons other than the ones already approved by FDA. 

In children, HGH Fragment therapy is legal to be used in cases of poor and stunted growth in cases of Turner’s syndrome, Prader-Willi syndrome, chronic renal insufficiency, and hGH insufficiency. In adults, however, the use is limited to be used for treating the wasting syndrome of AIDS and hGH deficiency. 

However, according to sources, HGH-FRAG 176-191 isn’t a regulated peptide. Thus, one can find the peptide in authentic online stores or peptides, unlike Human Growth Hormone (HGH), which is FDA regulated and legal in only certain medical conditions

Who Should Use HGH-FRAG?

HGH-FRAG is most commonly used by people looking for effective yet rapid ways to reduce weight. Thus, fitness enthusiasts are the most usual and frequent users of HGH-FRAG peptides. 

However, if you’re allergic to certain components that the peptide might contain, get in contact with your primary physician before starting your journey with HGH-FRAG. 

What’s worth mentioning here is that the HGH-FRAG peptide is different from the Human Growth peptide, with the latter having side effects and legal restrictions.


The optimal dosage differs from person to person and is also heavily dependent on why HGH-FRAG therapy was started. However, according to sources, HGH-FRAG can be divided into three categories based on needs and tolerance. 

For beginners, 200 mcg of HGH-FRAG is recommended in the morning before breakfast and 200 mcg pre-training. This should be continued 5 to 7 weekly via subcutaneous injections for favorable outcomes. 

The dosage can be increased to 250 mcg and 300 mcg for intermediate or advanced levels, respectively. 

One needs to ensure that for multiple dosages, the administration with HGH-FRAG should be given with a minimum of the 3-hour gap in between to prevent any distressing side effects.

HGH-FRAG Cycling

With the right dosages and proper administration of HGH-FRAG, the cycling of the peptide should be done for approximately four to eight weeks. 

However, it is primarily dependent on the desirable results. 

Nonetheless, the cycle of HGH-FRAG 176-191 should not last more than 12 weeks at the max. 

Forms Of HGH-FRAG?

HGH-FRAG is most commonly found only in injection forms. It is very unlikely for any brands to offer peptides in the form of powder, pills, or capsules. 

How To Use HGH-FRAG?

HGH-FRAG is usually given via intravenous, subcutaneous route instead of pills or capsules. 

A typical protocol can include injecting HGH-FRAG 250 to 500 mcg per injection 1 to 2 times daily. 

However, make sure that HGH-FRAG injections are given on an empty stomach. Thus before breakfast and pre-lunch timings are the most appropriate. 

HGH-FRAG Side Effects

Supplementation with Human Growth Hormone comes off with side effects and health concerns. Misuse, overdosing, or wrong timing of any medications has its fair share of repercussions. 

With Human Growth Hormone, the side effects might be severe. These include joint inflammation, increased risk of predisposition to diabetes because of decreased insulin sensitivity, and carpal tunnel syndrome due to inflamed joints. Besides this, increased doses of growth hormone can lead to decreased or difficulty in having proper schedules. 

Nevertheless, the HGH-FRAG 176-191 is specifically designed to avoid any side effects and is instead full of benefits. Minor side effects such as rashes or swelling on the injection site can be common. 

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HGH-FRAG Experiences

One of the best ways to know and gather unbiased information without malice or intrusion is to look for customer experience. These user experiences can help one decide better whether they want their money to be utilized in products that look all shiny and glowy but have question marks regarding their quality and authenticity. 

For that matter, I skimmed different subreddits to get an accurate insight. I have included a few Reddit reviews for you to decide better on HGH-FRAG 176-191. 

One such user said,

β€œTried and had good results, lower back fat decreased (was already lean but the lower back is very stubborn). Real is hard to find, though.”

Others faced some issues with their HGH-FRAG supplementation and said, 

β€œMy same experience as well. Didn’t notice any fat loss benefit. No PCT or sides.”

β€œI’ve tried this compound a few times.. I honestly… don’t rate it. My Diet was on point and my results were due to my training and dieting. I feel like it didn’t work too well for me.”


HGH-FRAG can work effectively on its own as well. However, stacking it with other compounds is proved to be efficacious and productive. Let’s look at some stacks you wouldn’t want to miss. 

Liquid Growth Hormone + HGH-FRAG 176-191

This is one of the most popular used stacks around the globe. HGH-FRAG and the human growth hormone help increase muscle mass side by side, assisting in lipid metabolism and reducing fat reserves. 

It is particularly important for people who haven’t had the chance to increase their muscle mass. For the right dosage and optimal results, five units of Liquid Growth hormone and 1000 mcg of HGH-FRAG (divided into 3-4 injections) would be a good start. 

GHRP-6 + HGH-FRAG 176-191 + Melanotan 2

This stack is usually used by those looking for a way to increase their overall energy and reduce fat from their body. GHRP-6 Peptide is believed to regulate your appetite. This helps you gain more strength and energy. 

The cycle should last eight weeks for this stack, with all the components being taken together. 100 mcg of GHRP-6, 250 mcg of HGH-FRAG 176-191, and approximately a single dose of Melanotan 2 at 1 mcg per 1 kg of body weight are recommended specific results. 

Nonetheless, get yourself in touch with your physician to get proper and reassured dosages. 

Where to buy HGH-FRAG?

Owing to some legal issues, you may not be able to find HGH-FRAG very commonly at stores. Therefore, I have tried to pick the 2 best vendors selling the peptide online so that you can make your purchase without any worries. 

Best Fat Loss Peptides

HGH Fragment 176-191 (AOD 9604)

Fat loss or Beta Oxidation is the process in which the body will use Free Fatty Acids and break them down to produce energy. The development of therapeutic compounds to increase this process is ever going, as obesity rates are higher than ever.

One of the newer treatment ideas has been tested in vitro research, HGH Fragment. This is a fragment of the whole HGH Peptide, and this part is ideal for the act of lipolysis.

It will lead to increased lipase levels in the body, which will lead to increased fat being released into the blood from your fat cells [1]. More fat in the blood means you can use that fat more effectively as fuel when living/training.

Clinical studies have found Frag to be quite effective at helping individuals lose fat. Pair this with a good resistance training program and diet, and you’re bound to shed a few pounds

HGH Frag Overview

⭐️ Top Benefits:
Increases natural HGH production
Promotes weight loss
Enhances fat metabolism
May aid in muscle mass preservation during weight loss
πŸ§ͺ Form: Injectable liquid
βŒ›οΈ Max Time Used: 14 weeks
πŸ’° Average Cost: $50
β€οΈβ€πŸ©Ή Side Effects:
Potential insulin resistance
Possible injection site reactions
May experience headaches
Potential for joint pain
☒️ Dangers:
Limited long-term safety data available
Potential for abuse or misuse
Not approved by the FDA for weight loss
Possible unknown long-term risks
πŸ“š Best Peptide Stack: GHRP/HGH/IGF-1
⚀ Men/Women: Suitable for both men and women
➑️ Go to the Full review

  • Does not cause Insulin resistance as pure HGH does
  • Has the potential to cause spot-reducing fat loss
  • Does cause some Insulin resistance

HGH-FRAG vs Other Compounds 


Human Growth Hormone (HGH) is a native hormone in human serum comprising 191 amino acids. It is an essential hormone that regulates many different mechanisms in humans. 

Compared to HGH, HGH-FRAG 176-191 is a peptide fragment composed of the last 16 amino acids of HGH. The peptide does not contain all the properties of its parent. Rather the derivative is laded with lipolytic properties as backed by most research. 

HGH-FRAG vs Ipamorelin

Ipamorelin peptide therapy is often used to increase your body’s ability to produce human growth hormone naturally. This way it aids in the reduction of body weight alongside increasing the lean muscle mass. 

Ipamorelin is much more tolerable due to letting your own body produce growth hormone instead of replacing it. Thus it is much safer than synthetic growth hormone peptides such as HGH-FRAG. 

Is HGH-FRAG Legit? 

All in all, it can be deduced from all the above information that HGH-FRAG is legitimate and henceforth, it can be used to reduce overall body fat by increasing lipid metabolism, increasing lean muscle mass, and also assisting in maintaining energy homeostasis. 

With HGH-FRAG 176-191, there are very low chances of developing any severe side effects, unlike synthetic HGH. Thus, you’re in safe hands with this peptide. 

How long does it take to see results on HGH fragments?

It usually takes three months for one to be able to see results. However, it can get long, depending on your initial body mass. 

Can HGH Fragment 176-191 contribute to weight loss?

HGH-FRAG 176-191 is majorly renowned for its action on stored fat in our body and for mobilizing it to decrease the overall reserves. HGH-FRAG uses the accumulated fat for energy rather than the calories you just took, unlike your body. 

This way, you can cut down fat from certain areas of your body, such as the hips, breasts, abdomen, and thighs. 

Does the HGH fragment build muscle?

HGH helps to maintain, build, and repair healthy tissue in the brain and other organs. This hormone can help to speed up healing after an injury and repair muscle tissue after exercise. This helps to build muscle mass, boost metabolism, and burn fat.

What is better HGH or peptides?

Well, peptides that boost your own body’s natural production of growth hormone can be a safer way to increase levels.

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1) https://pubchem.ncbi.nlm.nih.gov/compound/Somatotropin-_176-191
2) https://pubmed.ncbi.nlm.nih.gov/11713213/
3) https://pubmed.ncbi.nlm.nih.gov/15935402/
4) https://pubmed.ncbi.nlm.nih.gov/11146367/
5) https://pubmed.ncbi.nlm.nih.gov/645904/
6) https://pubmed.ncbi.nlm.nih.gov/26275694/


Kumar Rathi

Kumar Rathi | Writer

Kartik is a medical student with a passion for anatomy and physiology. He writes research papers, articles and blogs to raise awareness and also has a strong interest in teaching and public speaking. Aspiring to be a successful cardiologist, Kartik believes in connecting with people on a personal level and is an expert in peptides.

Read all articles
Dr. Mohammed Fouda

Dr. Mohammed Fouda | Reviewer

Dr. Fouda uses his extensive knowledge and expertise as an academic scholar to medically review articles for scientific accuracy and credibility, ensuring that the medical information presented is up-to-date and trustworthy. He is responsible for ensuring the quality of the medical information presented on our website.

Read all articles
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Queen Bee Quezada Rahn
Queen Bee Quezada Rahn
1 year ago

What is the difference between the High Frag and AID9604

John Mc Carron
John Mc Carron
7 months ago

I have received a 12ml of Fragment 176-191 & Mod GRF 1-29 & Ipamorelin, how much water do I add to reconstitute the powder?

Daniel Louwrens BSc PT
5 months ago
Reply to  John Mc Carron

If you received 12ml of something, you did not receive a powder. Powders are not measured in ml, liquids are.


Chemical Structure

Mechanism of Action

Human growth hormone fragment, aka HGH-FRAG, has lipolytic and hypoglycemic properties. It Increases the formation of beta-3 adrenergic receptors in fatty tissues. The receptors then increase the utilization and mobilization of fats. Hypoglycemic attributes are found in HGH-FRAG due to the presence of the C-terminal. It also has possible effects on cartilage Regeneration and growth alongside hyaluronic acid.

Class of Compound


Street Names

Somatotropin, Human growth hormone, Hgh


Decreases obesity, increases muscle build-up, increases energy levels

Side Effects and Dangers

Joint inflammation, diabetes, carpal tunnel syndrome


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