Ipamorelin Peptide: Dosage, Benefits, Side Effects

Medically reviewed by Dr. Mohammed Fouda
Dr. Fouda uses his extensive knowledge and expertise as an academic scholar to medically review articles for scientific accuracy and credibility, ensuring that the medical information presented is up-to-date and trustworthy. He is responsible for ensuring the quality of the medical information presented on our website.
IPAMORELIN IMAGE

Suppose you’re a fitness fanatic, body sculptor, or just someone on a quest for that top-tier athleticism. In that case, you’re probably navigating the vast world of peptides like Ipamorelin Peptide to gain that competitive edge! 

Now, we get it. The journey to excellence might lead you to dabble in various peptides without a roadmap. 

Some are like your trusty sidekick, while others can be a villain in disguise, wreaking havoc on your long-term goals. Today, we’re diving into the realm of Ipamorelin, the growth hormone-releasing rockstar that’s been making waves.

The existing literature shows that ipamorelin causes an increase in growth hormone (GH) levels. Brace yourself for a ride through its GH-boosting wonders and potential perks, all served with a side of caution.

Time to unravel the secrets and cut through the noise! πŸš€πŸ’ͺ #IpamorelinPeptideJourney

Key Takeaways

  • Ipamorelin selectively binds to the GHSR-1a receptor, leading to growth hormone (GH) release from the pituitary gland, and influencing anabolic processes.
  • Ipamorelin is highlighted for its potential in female fat loss, increasing natural growth hormone production by up to 30%.
  • Ipamorelin supports smooth recovery by aiding in the repair of damaged muscle fibers, promoting the growth of new ones, and facilitating quicker and more effective healing from wounds.
  • Higher GH levels induced by Ipamorelin contribute to deep sleep, and its stimulation of natural GH production may delay the aging process.
  • While there are no scientifically-proven safe dosages for Ipamorelin, user experiences suggest injecting 200mcg-300mcg up to 3 times a day for fitness goals.

Warning: The content on Muscleandbrawn.com and the information included in this article is intended for entertainment and informational purposes only. It is not intended nor implied to be a substitute for professional medical advice. Prior to buying anything, check that it is compliant where you live with your current government laws. We frequently mention research chemicals that are not made for human consumption. Therefore, before purchasing any product for personal use, consult with your doctor or healthcare provider first.

What Is Ipamorelin?

Ipamorelin Peptide, the powerhouse in the realm of growth hormone-releasing peptides (GHRPs), packs a punch with its unique molecular composition.

It’s a pentapeptide (Aib-His-D-2-Nal-D-Phe-Lys-NH2), which displays high GH-releasing potency and efficacy in vitro and in vivo (2).

It has a longer half-life time (1.5-2.5 hours) compared with GHRP-2 (25-55 minutes). It also leads to total weight gain whereas, GHRP-2 and GHRP-6 lead to lean mass gain (1).

The magic happens as Ipamorelin mimics the action of ghrelin, a natural hormone, by selectively binding to the growth hormone secretagogue receptor (GHS-R1a). 

This dance in the body triggers the release of growth hormone from the pituitary gland, influencing an array of anabolic processes such as appetite regulation, fat metabolism, and overall energy usage.

What’s more? Ipamorelin takes the spotlight for its role in aiding muscle recovery, stimulating the growth of new muscle fibers, and even contributing to quicker healing from injuries. 

As a bonus, it throws a lifeline to those seeking a fountain of youth, potentially delaying the aging process with its knack for boosting natural growth hormone production.

In essence, Ipamorelin isn’t just a peptide; it’s a key player in the symphony of fitness, metabolism, and rejuvenation.

Ipamorelin Summary

Ipamorelin

Ipamorelin stands out as a potent pentapeptide (Aib-His-D-2-Nal-D-Phe-Lys-NH2) with remarkable growth hormone (GH)-releasing properties, both in vitro and in vivo. This selective growth hormone-releasing peptide has garnered attention as a promising solution for female fat loss.

Scientific investigations reveal that Ipamorelin has the potential to elevate the body’s natural growth hormone production by an impressive 30%. Given the pivotal role of growth hormone in fat metabolism, this elevation becomes crucial for achieving effective fat loss.

As women, especially those aged 40 and above, experience a decline in natural growth hormone levels, their metabolism tends to slow down, leading to increased fat storage. Ipamorelin’s capacity to boost these levels can counteract this decline, potentially accelerating fat loss by up to 20%.

What sets Ipamorelin apart is its unique characteristic of not stimulating appetite, distinguishing it from other growth hormone stimulants. This feature allows women to harness its fat-burning properties without the counterproductive urge to consume more calories.

Furthermore, a compelling study demonstrated that individuals incorporating Ipamorelin into their regimen experienced a notable 14% reduction in visceral fat over a 12-week period. Visceral fat, often deemed “dangerous fat,” is associated with various health risks, underscoring the importance of its reduction for overall well-being.

In summary, Ipamorelin presents a scientifically backed approach to female fat loss by elevating growth hormone levels, hastening metabolism, and reducing detrimental visceral fatβ€”all achieved without triggering an increased appetite. This makes Ipamorelin a promising avenue for those seeking an effective and well-rounded solution to enhance their overall body composition.

Ipamorelin Overview

⭐️ Top Benefits: Increases natural HGH production
πŸ§ͺ Form: Injectable liquid
βŒ›οΈ Max Time Used: Up to 3 months
πŸ’° Average Cost: $52.99
β€οΈβ€πŸ©Ή Side Effects: Insulin resistance
☒️ Dangers: Not really
πŸ“š Best Peptide Stack: HGH / IGF-1 / GHRP / CJC-1295
⚀ Men/Women: Men and women
➑️ Go to the Full review

  • Muscle gain
  • Fat Loss
  • Increased bone density
  • Injection site pain
  • Insulin resistance

What Does Ipamorelin Do to the Body?

Ghrelin, is a naturally produced hormone, by the enteroendocrine cells of the gastrointestinal tract, mainly the stomach. It binds to the growth hormone secretagogue receptor (GHS-R1a).

In the brain, the GHSR1a is expressed most highly in agouti-related protein (AgRP)/neuropeptide Y (NPY) neurons of the hypothalamus. In extrahypothalamic regions, GHSR1a is expressed predominantly in the hippocampus, and in dopaminergic midbrain neurons.

In peripheral tissues, they can be found in adipocytes, cardiomyocytes, and osteoblasts as they are essential for glucose-insulin homeostasis, gastrointestinal motility, cardiovascular health, inflammation, and tissue growth and repair (4).

By mimicking ghrelin, ipamorelin selectively binds the same GHSR-1a receptor as GHRP-2, GHRP-6, and ibutamoren (1).

This interaction with GHSR-1a leads to a GH release from the pituitary gland, which can influence several anabolic processes including appetite regulation, fat processing, and overall energy usage (1). 

Administration of both GHRP-6 and GHRP-2 resulted in increased plasma levels of ACTH and cortisol. Very surprisingly, ipamorelin did not release ACTH or cortisol in levels significantly different from those observed following GHRH stimulation (2).

Benefits Of Ipamorelin

The primary takeaway from ipamorelin intake is the increase in blood growth hormone (GH) levels. The other changes seen in the physique of the body are just results of elevated blood growth hormone (GH) levels.

Ipamorelin makes sure that your recovery phase is very smooth. It helps in the repair of damaged muscle fibers while also stimulating the growth of new ones effectively (4).

Ipamorelin causes quicker yet more effective healing from wounds and injuries as growth hormone (GH) reaches the damaged area and triggers the proliferation of new cells.

Previous animal studies showed that ipamorelin increases bone mineral content (BMC) in young adult female rats (5).

Higher growth hormone (GH) levels due to ipamorelin help in a deep sleep. Sleep-related secretion of GH appears to be primarily dependent on the release of growth hormone-releasing hormone.

Rodent and human studies have shown that growth hormone-releasing hormone injections decrease wakefulness and increase slow-wave sleep (SWS) (6). 

After the third decade of life, there is a progressive decline of GH secretion by approximately 15% for every decade of adult life (7).

Ipamorelin stimulates its natural production. This delays the aging process of an individual and makes you look younger and more energetic with higher collagen production for glowing skin, healthier nails, and dense hair.

Where Can I Buy Ipamorelin?

Finding a reliable source for Ipamorelin Peptide can be a crucial step in unlocking its benefits safely. Given its growing popularity, caution is key to avoid falling prey to unauthentic or counterfeit products circulating in the market.

Authenticity matters when delving into the world of peptides. Reputable online platforms specializing in peptides, like recognized peptide vendors or pharmacies, are often trustworthy sources. 

Before making a purchase, thorough research on the vendor’s reputation, customer reviews, and product quality is essential. 

While convenience may beckon from various online marketplaces, it’s crucial to exercise discernment and prioritize the authenticity and safety of the product.

Ultimately, the quest for Ipamorelin should lead to reliable, well-established sources, ensuring that the peptide journey aligns with safety, quality, and the desired fitness goals.

Who Should Use Ipamorelin?

Considering all the potential benefits such as building and bulking up muscles, a robust skeletal system, and faster recovery, this peptide is perfect for bodybuilders and athletes who want to boost their performance in their respective sport.

People who find the aging process a bit daunting can also use ipamorelin as it triggers higher blood growth hormone (GH) levels after the late ’30s can still make you feel youthful.

How To Use Ipamorelin?

Ipamorelin is available in injectable forms. You will get the ipamorelin in lyophilized form (powder form) in the vials.

Depending on your dosage guidelines, ipamorelin will have to be mixed with the bacteriostatic water to get the reconstituted ipamorelin.

Once the injectable form is ready, you will have to administer ipamorelin intramuscularly or subcutaneously, i.e., inject it under the skin for maximum results. Most people inject it into the abdominal area.

For faster recovery, it is advisable to inject close to injured areas.

Forms Of Ipamorelin

Ipamorelin Peptide exclusively comes in an injectable form, chosen for its superior efficacy and efficiency. 

The lyophilized powder form of Ipamorelin is typically supplied in vials, requiring reconstitution with bacteriostatic water to prepare the injectable solution. This method ensures the stability and potency of the peptide for optimal results.

Notably, oral forms of Ipamorelin are not widely available from reliable sources, emphasizing the importance of caution while seeking the peptide. 

Injectable delivery is favored for its ability to directly and efficiently interact with the body’s systems.

The injectable form remains the gold standard, facilitating precise administration and maximizing the potential benefits of this growth hormone-releasing peptide.

Please be careful while buying because fake or pseudo peptides can have severe side effects.

Ipamorelin Dosage

Purpose πŸ”Dosage Recommendation πŸ’‰
Fitness GoalsInject 200mcg-300mcg of Ipamorelin, up to 3 times a day
Anti-AgingUse once a day with approximately 200mcg of Ipamorelin
Safety NoteNo scientifically-proven safe dosage exists; Consult with a doctor/healthcare provider for personalized guidance

To date, there are no human studies of Ipamorelin. Therefore, there is no scientifically-proven safe dosage of Ipamorelin. All doses are based on user experience and social media reviews.

Therefore, I would highly recommend anyone consult with a doctor/healthcare provider before determining the dose of Ipamorelin.

Based on user experience, for fitness goals, you can inject 200mcg-300mcg of ipamorelin up to 3 times a day. For anti-aging purposes, use it once a day with approximately 200mcg of ipamorelin.

Ipamorelin Cycling

Based on users’ experience, it is advisable to use ipamorelin a few hours before bedtime.

Your first cycle should be somewhere between 60 to 90 days. If you start witnessing the changes in your physical features, end your first cycle at the 60-day mark. You may continue it for up to 90 days if any major changes aren’t seen in the body.

Before kicking off a new cycle, take a month-long break to minimize the risk of receptor desensitization.

Ipamorelin Stacking

Many users use ipamorelin with other similar peptides such as sermorelin and CJC-1295 to have synergistic benefits.

The stacking of ipamorelin with sermorelin can enhance the effects on the body. Increased lean muscle, extremely efficient recovery, a considerable decrease in body fat, and improved sexual performance are the few optimal benefits seen in the body.

Ipamorelin and CJC-1295 have shown better results together. This stacking builds your muscle significantly while at the same time cutting down body fat. You experience an overall boost in your body’s natural performance.

Due to proven benefits, stores like Pure Rawz offer stacked products such as Sermorelin/Ipamorelin (5mg/5mg) and CJC-1295 WITH DAC 2mg IPAMORELIN 2mg GHRP-2 2mg BLEND.

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User Experience Of Ipamorelin

User experiences were only available on platforms like Reddit because ipamorelin isn’t a legalized peptide yet.

uPhammyWhammy says,

“I’ve been using Ipamorelin for about 8 weeks and have had incredible results…”

ResultsoverExcuses commented,

“IPA has been awesome for me”

A few users went on to say that ipamorelin was a bit slow in working, and if stacked with CJC-1295, it would help them achieve better results.

Peekay234 said,

You need to stack it with CJC 1295 or something similar. Using Ipam on Its own is not effective and you’re wasting your money. Combining the two will multiply the individual effects of each compound on its own.”

Some people had mixed opinions on ipamorelin as surfing says,

“I’ve started taking it in the morning as well and still seemed to wake up in the middle of the night. I’m thinking about trying a more intense workout to put me to sleep longer.”

Ipamorelin Side Effects

While people call it one of the safest growth hormone secretagogues (GHS) with minimal adverse effects, it is still critical to discuss the mild ones.

You may get a feeling of headache, nausea, and stomach upset immediately after administering the dosage. The users also report a mild level of flushing and a sense of fatigue or lethargy.

Redness at the injection site is also common among users.

The use of some peptide hormones, including those with anabolic or strength-enhancing actions, is prohibited under section S2.2 of the WADA Prohibited List (8). 

Individuals considering the use of Ipamorelin for personal goals should exercise caution and consult with healthcare professionals. 

It’s imperative to be aware of the legal implications, especially in sports and competitive arenas where restrictions on certain peptides may be in place.

While Ipamorelin remains legal for personal use in certain contexts, users should stay informed about evolving regulations and guidelines. 

Adherence to local and international laws, coupled with responsible and informed use, is paramount. 

Consulting with healthcare providers can provide clarity on legal aspects, ensuring that individuals can leverage the benefits of Ipamorelin without running afoul of legal boundaries.

Ipamorelin vs. Other Peptides

Comparison πŸ†šIpamorelin vs. SermorelinIpamorelin vs. CJC-1295
Mechanism of Function βš’Binds with GHSR in the hypothalamus and peripheral organsWorks rapidly; Binds with GHSR
Receptor Interaction🧩 Binds with GHSRBinds with GHSR
Target Receptors 🎯GHSR located in the hypothalamus and peripheral organsGHSR
GH Production πŸ‘ΎStimulates greater GH productionRapid results; Takes 1-4 hours to show effects
Receptor Type πŸŒ€GHSR for Ipamorelin; GHSHr for SermorelinGHSR for both peptides
Half-life πŸŒ“Lesser half-lifeLonger half-life than Ipamorelin (9)
Synergistic Use πŸ‘₯Synergistic use yields optimal resultsOften used together for combined benefits

Ipamorelin vs. Sermorelin

The major difference between both peptides is the mechanism of function.

Although both the peptides cause a greater production of growth hormone (GH), ipamorelin binds with growth hormone secretagogue receptors (GHSR) located in the hypothalamus and in peripheral organs, while sermorelin binds with growth hormone-stimulating hormone receptors (GHSHr) located in the hypothalamus only.

But, the synergistic use of both peptides yields optimal results.

Ipamorelin vs. CJC-1295

Again, these peptides are often used together but there lie considerable differences in the potency. Ipamorelin works very rapidly, while CJC-1295 takes 1-4 hours to show results.

Also, the half-life of ipamorelin is lesser than CJC-1295 (9).

Is Ipamorelin legit?

Ok, so it’s decision time!

I think ipamorelin works. It may not work for all because each of us has different microscopic physiology and different body requirements but considering all the research and my understanding, ipamorelin offers a wide variety of benefits.

If I were to use this peptide, I would have straight away opted for stacking ipamorelin with some other peptide for quicker yet effective results.

With the prospective benefits ipamorelin seems to offer, I hope that more research is carried out to have a clearer larger picture for the potential audience!

How long does it take to see results from Ipamorelin?

You might see some changes in the first month, but you might have to wait for 3 to 6 months to attain all the benefits.

Does Ipamorelin increase testosterone?

Ipamorelin causes an increase in testosterone production.

How long does Ipamorelin last?

Freezing the vials can preserve ipamorelin. At room temperature, the peptide can last for a week, but you can extend the life up to 1 month if you can freeze it.

Should I cycle Ipamorelin?

Typically, most users can cycle it from 8 to 12 weeks.

Can ipamorelin cause weight gain?

Ipamorelin doesn’t cause an increase in appetite. Hence, you won’t gain weight!

When should I take ipamorelin?

The best time is 2 hours after your dinner. In the morning, consume ipamorelin on an empty stomach.

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1) https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7108996/
2) https://pubmed.ncbi.nlm.nih.gov/9849822
3) https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4049314/
4) https://pubmed.ncbi.nlm.nih.gov/35239443/
5) https://pubmed.ncbi.nlm.nih.gov/10828840/
6) https://pubmed.ncbi.nlm.nih.gov/8627466/
7) https://www.ncbi.nlm.nih.gov/books/NBK279163/#:~:text=After%20the%20third%20decade%20of,by%20age%2055%20(3).
8) https://www.usada.org/spirit-of-sport/education/6-things-know-peptide-hormones/

Contributors

Kumar Rathi

Kumar Rathi | Writer

Kartik is a medical student with a passion for anatomy and physiology. He writes research papers, articles and blogs to raise awareness and also has a strong interest in teaching and public speaking. Aspiring to be a successful cardiologist, Kartik believes in connecting with people on a personal level and is an expert in peptides.

Read all articles
Dr. Mohammed Fouda

Dr. Mohammed Fouda | Reviewer

Dr. Fouda uses his extensive knowledge and expertise as an academic scholar to medically review articles for scientific accuracy and credibility, ensuring that the medical information presented is up-to-date and trustworthy. He is responsible for ensuring the quality of the medical information presented on our website.

Read all articles
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Lora
Lora
2 years ago

Great information, don’t know if you should take this if you have any brain issues

ScrappyDoo
ScrappyDoo
2 years ago

If you experience side effects of flushing, headache and nausea immediately after injection, should you stop taking them? The first couple days were good but the following days it got worse and with significant tiredness/lethargy. I read that most likely theses side effects will subside with dosage adjustment. Also what is your opinion on administering ipamorelin/cjc-1295 via nasal spray?

Pat T.
Pat T.
1 year ago

Looking to find the best hormones for surgical, putting in new discs, in helping healing.

Charles Webb
Charles Webb
10 months ago

Yes, I have a 10 mh of Sermorellin/Ipamorellin and 5 mg bottle of BPC 157. I’m trying to get the amounts of bacteriostatic water to use on both. Could you please advise. Real difficult to find quality information on this!

Kenny
Kenny
10 months ago
Reply to  Charles Webb

I’d like to know the answer as well.

Joanne
Joanne
5 months ago
Reply to  Kenny

I would like to know the answer to how much bacteria static water, putting in a five MG bottle

Daniel Louwrens BSc PT
Admin
5 months ago
Reply to  Joanne

You can use any amount of water. Feel free to use our calculator https://muscleandbrawn.com/peptides/dosage-calculator/

Firebird7479
Firebird7479
10 months ago

I’ve been stacking this with CJC-1295 for three weeks. My primary reason is for restful sleep. Well, I am getting sleep, but it is not restful and the side effects are not good. The feelings of vertigo and fatigue are not what I want first thing in the morning. I do not wake up refreshed and when I go to the gym I feel weak, dizzy and spacey. This is not what I was hoping for.
The two days I take off during the weekend, I feel better not taking it. This Saturday I go for my monthly bodyfat check. If there are no improvements here, then the money I have spent on yet another slew of peptides (I got no benefits from TB-500 and Mots-C) that were worthless to me.

joe
joe
10 months ago

What happened to the calculator? It was very helpful.

Daniel Louwrens BSc PT
Admin
8 months ago
Reply to  joe
Joanne
Joanne
5 months ago
Reply to  joe

I agree what happened to the calculator

Firebird7479
Firebird7479
9 months ago

Didn’t do a thing for me.

Brett
Brett
9 months ago

Fairly new to this, but became interested after reading a friends book (Jay Campbell) on TOT. My question is, once you get the Ipamorelin, how much Bacteristatic water do you mix with it to begin dosing from? Seems that would matter, but haven’t found any info on this. Thanks

Daniel Louwrens BSc PT
Admin
8 months ago
Reply to  Brett

Hi Brett. It actually doesn’t matter, as long as you can actually inject it in…

Ken
Ken
8 months ago

Hi,
If I have 5mg/5mg stack, do I dilute that as 10mg and the what dosage would be a good start.
Thank you

Mindy
Mindy
5 months ago

Can any of these peptides cause TMI’s or seizures?

Daniel Louwrens BSc PT
Admin
5 months ago
Reply to  Mindy

Unlikely, but best to check with a medical doctor!

Joanne
Joanne
5 months ago

If I have a 5MG bottle of lpromoorelim how many milliliters of bacterial static water should into the vile? thank you.

Chemical Structure

Mechanism of Action

Hexarelin mimics the action of a naturally occurring hormone, ghrelin and binds with growth hormone secretagogue receptors (GHSR-1a) located in hippocampus as well as in peripheral organs such as heart, digestive tract and adrenal gland. This binding leads to an amplified release of growth hormone (GH). Hexarelin also inhibits the release of somatostatin which is a growth hormone inhibiting hormone (GHIH).

Class of Compound

PEPTIDE

Street Names

Ipamorelin, Pentapeptide

Effects

Decreases body fat and increases lean muscle mass, Faster recovery from injuries, Maintains bone mineral density

Side Effects and Dangers

Banned by WADA, Headache and nausea, Fatigue

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