If you are a bodybuilder, an athlete, or a fitness pro, your goal is always to stay ahead in the game. You aim to beat your competitors in all aspects. You aspire to climb the ladder to an expert badge as soon as possible.
To make your journey obstacle-free, you start using various peptides without knowing much about them. While most peptides do offer a wide array of benefits, some of them have severe side effects in the long run.
Let’s review one such peptide, Ipamorelin, a growth hormone-releasing peptide (GHRP) whose popularity has grown in recent times. The existing research shows considerable evidence that ipamorelin causes a spike in growth hormone (GH) levels.
I will make sure to cover all the details necessary for you, such as how it works, the potential benefits, the risk factors, and the best places to purchase so that you can decide whether to use it or not. So, let’s cut the slack!
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What Is Ipamorelin
Ipamorelin (1), a growth hormone secretagogue (GHS), comprises 5 Amino acids with the sequence (Aib-His-D-2-Nal-D-Phe-Lys-NH2).
Being a synthetic derivative of growth hormone-releasing peptide 1 (GHRP-1), it follows the same course of action and shows similar benefits in the body.
The research suggests that it is more effective in terms of functioning than other similar peptides like GHRP-2 and GHRP-6 (2).
How Does Ipamorelin Work
Ghrelin, a naturally produced hormone, is mainly produced in the stomach. It binds to one of the growth hormones secretagogue receptors (GHSR), known as type GHS-R1a.
Although these receptors are predominantly located in the hypothalamus, some of them also lie peripherally, such as on adipocytes, cardiomyocytes, osteoblasts, etc.
The end goal of ipamorelin is to cause the natural release of growth hormone from the anterior lobe of the pituitary gland (3).
Thus, Ipamorelin achieves this by mimicking the action of ghrelin as it binds to these highly selective growth hormone secretagogue receptor type 1a (GHS-R1a). This binding results in the secretion of somatocrinin also called growth hormone-releasing hormone (GHRH).
Growth hormone-releasing hormone (GHRH) travels to the pituitary gland and causes the pulsatile growth hormone (GH) release.
Ipamorelin also suppresses somatostatin expression, which is called growth hormone inhibiting hormone (GHIH). Hence, blood growth hormone (GH) levels continue to rise.
In this way, ipamorelin continues the homeostatic coordination between hypothalamus-pituitary-somatostatin.
Ipamorelin doesn’t stimulate other endocrine releases such as prolactin and cortisol levels (a stress hormone), making it an ideal peptide for bodybuilders (4).
Benefits Of Ipamorelin
The primary takeaway from ipamorelin intake is the spike in blood growth hormone (GH) levels. The other changes seen in the physique of the body are just the by-product of higher blood growth hormone (GH) levels.
Since ipamorelin binds to many of the receptors located peripherally, such as on adipocytes, it causes the reduction of excess body fat. This, in turn, increases the lean body mass significantly.
Ipamorelin makes sure that your recovery phase is very smooth. It helps in the repair of damaged muscle fibers while also stimulating the growth of new ones effectively. This hypertrophy is the prime reason why most bodybuilders use ipamorelin or consider consuming it shortly (5).
It is no surprise that ipamorelin causes quicker yet effective healing from wounds and injuries as growth hormone (GH) reaches the damaged area and triggers the proliferation of new cells.
There is sufficient evidence that suggests that ipamorelin causes an increase in bone deposition and maintains bone mineral density. This means that you will have healthier bones, strong tendons, and flexible joints.
It is also hypothesized that ipamorelin may cure some bone-associated chronic conditions such as osteoporosis.
Higher growth hormone (GH) levels due to ipamorelin help in a deep sleep. It helps in setting up a slow-wave sleep cycle which improves the quality of sleep. Better sleep can be correlated to optimized performance throughout the day (4).
As growth hormone (GH) levels start deteriorating at age 30, ipamorelin stimulates its natural production. This delays the aging process of an individual and makes you look younger and energetic with higher collagen production for glowing skin, healthier nails, and dense hair.
Where Can I Buy Ipamorelin?
There is a good chance that you might end up buying unauthentic or fake peptide because it is not so commonly available in the market.
I highly recommend Pure Rawz for their history of selling genuine fitness products.
Is Ipamorelin Legal
You can call it a banned substance but not an illegal peptide completely!
So, I mean that it is a banned substance by WADA, but you can make a legal purchase with a prescription from a medical practitioner.
Who Should Use Ipamorelin
Considering all the potential benefits such as building and bulking up muscles, a robust skeletal system, and faster recovery, this peptide is perfect for bodybuilders and athletes who want to boost their performance in their respective sport.
People who find the aging process a bit daunting can also use ipamorelin as it triggers higher blood growth hormone (GH) levels after the late ’30s can still make you feel youthful.
Also, people who want to lose weight should take ipamorelin as it causes fat loss.
How To Use Ipamorelin
Ipamorelin is available in injectable forms. You will get the ipamorelin in lyophilized form (powder form) in the vials.
Depending on your dosage guidelines, ipamorelin will have to be mixed with the bacteriostatic water to get the reconstituted ipamorelin.
Once the injectable form is ready, you will have to administer ipamorelin intramuscularly or subcutaneously, i.e., inject it under the skin for maximum results. Most people inject it into the abdominal area (6).
For faster recovery, it is advisable to inject in close proximity to injured areas.
Forms Of Ipamorelin
There is profound evidence that hormonal therapies are usually effective when they are injected (7). Therefore, you will only find ipamorelin in the injectable form because of better efficacy and efficiency.
Note that oral forms of ipamorelin are not yet available in the market, or at least at reliable stores. Please be careful while buying because fake or pseudo peptides can have severe side effects.
The dosage guidelines differ a bit depending on the purpose of intake. But it is important to start with a low dosage and then increase gradually.
If you plan to use ipamorelin to meet your fitness goals, you can inject ipamorelin up to 3 times a day with each administration comprising 200mcg-300mcg of ipamorelin.
If your goal is to use ipamorelin as an anti-aging peptide, use it once a day with approximately 200mcg of ipamorelin.
Although higher ipamorelin levels will substantially increase growth hormone levels (GH), you still wouldn’t want to overdose.
Although you can take ipamorelin any time of the day, it is advisable to use ipamorelin before a few hours of going to bed. This sets up a natural timer of growth hormone (GH) release and helps in deep sleep.
Your first cycle should be somewhere between 60 to 90 days. If you start witnessing the changes in your physical features, end your first cycle at the 60-day mark (8).
You may continue it for up to 90 days if any major changes aren’t seen in the body.
Before kicking off a new cycle, take a month’s break. This is important because it will minimize the chances of receptor desensitization.
Many users use ipamorelin with other similar peptides such as sermorelin and CJC-1295 (9) to have synergistic benefits.
The stacking of ipamorelin with sermorelin can enhance the effects on the body. Increased lean muscle, extremely efficient recovery, a considerable decrease in body fat, and improved sexual performance are the few optimal benefits seen in the body.
Ipamorelin and CJC-1295 have shown better results together. This stacking builds your muscle significantly while at the same time cutting down body fat. You experience an overall boost in your body’s natural performance.
Due to proven benefits, stores like Pure Rawz offer stacked products such as Sermorelin/Ipamorelin (5mg/5mg) and CJC-1295 WITH DAC 2mg IPAMORELIN 2mg GHRP-2 2mg BLEND.
User Experience Of Ipamorelin
User experiences were only available on platforms like Reddit because ipamorelin isn’t a legalized peptide yet.
“I’ve been using Ipamorelin for about 8 weeks and have had incredible results…”
“IPA has been awesome for me personally”
A few users went on to say that ipamorelin was a bit slow in working, and if stacked with CJC-1295, it would help them achieve better results.
“You definitely need to stack it with CJC 1295 or something similar. Using Ipam on Its own is not really effective and you’re basically wasting your money. Combining the two will multiply the individual effects of each compound on its own.”
Some of the people had mixed opinions on ipamorelin as surfinwig says,
“I’ve started taking it in the morning as well and still seemed to wake up in the middle of the night. I’m thinking about trying a more intense workout to put me to sleep longer.”
Ipamorelin Side Effects
While people call it one of the safest growth hormones secretagogues (GHS) with minimal adverse effects, it is still critical to discuss the mild ones.
You may get a feeling of headache, nausea, stomach upset immediately after administering the dosage. The users also report a mild level of flushing and a sense of fatigue or lethargy.
Redness at the injection site is also common amongst users.
Ipamorelin vs. Other Peptides
Ipamorelin vs. Sermorelin
The major difference between both peptides is the mechanism of function.
Although both the peptides cause a greater production of growth hormone (GH), ipamorelin binds with growth hormone secretagogue receptors (GHSR) located in the hypothalamus and in peripheral organs, while sermorelin binds with growth hormone-stimulating hormone receptors (GHSHr) located in the hypothalamus only.
But the synergistic use of both the peptides yields optimal results.
Ipamorelin vs. CJC-1295
Again, these peptides are often used together but there lie considerable differences in the potency. Ipamorelin works very rapidly, while CJC-1295 takes 1-4 hours to show results. Also, the half-life of ipamorelin is lesser than CJC-1295 (9).
Is Ipamorelin legit?
Ok, so it’s decision time!
I think ipamorelin definitely works. It may not work for all because each of us has different microscopic physiology and different body requirements but considering all the research and my understanding, ipamorelin offers a wide variety of benefits.
If I were to use this peptide, I would have straight away opted for stacking ipamorelin with some other peptide for quicker yet effective results.
With the prospective benefits ipamorelin seems to offer, I hope that more research is carried out to have a clear larger picture for the potential audience!
How long does it take to see results from Ipamorelin?
You might see some changes in the first month, but you might have to wait for 3 to 6 months to attain all the benefits (10).
Does Ipamorelin increase testosterone?
Ipamorelin causes an increase in testosterone production.
How long does Ipamorelin last?
Freezing the vials can preserve ipamorelin. At room temperature, the peptide can last for a week, but you can extend the life up to 1 month if you can freeze it.
Should I cycle Ipamorelin?
Typically, most users can cycle it from 8 to 12 weeks.
Can ipamorelin cause weight gain?
Ipamorelin doesn’t cause an increase in appetite. Hence, you won’t gain weight!
When should I take ipamorelin?
The best time is 2 hours after your dinner. In the morning, consume ipamorelin with an empty stomach.