CJC-1295 Guide – Effects, Dosage, Side Effects

CJC-1295 is becoming one of the most popular used peptides among people. Its ability to increase GH and IGF-1 leads to various benefits to the human body. Join me in this article and figure out more regarding CJC-1295.

Compound Summary

Class of Compound

Peptide

Mechanism of Action

CJC-1295, an analog of GHRH, binds to the receptors on the anterior pituitary gland. From there, they stimulate the release of Growth Hormone (GH) and Insulin-like growth factor-1 (IGF-1)

Street Names

CJC-1295/DAC-GRF

Effects

Increase in lean muscle mass , Enhanced fat loss , Improved sleep cycle

Side Effects and Dangers

Mood swings , Vertigo , Increased body temperature

Chemical Structure

With more people taking a sharp turn towards health and fitness by aiming to develop lean muscle mass, enhance their strength and endurance, and lose fat, it is no surprise that the peptide industry is blooming at this particular point in time. 

Peptides, like CJC-1295, speed up the process for fitness enthusiasts and bodybuilders by triggering microcellular and macrocellular changes that lead to muscle building and bulking. 

Yes, you got me right! 

Today, we will discuss one of the most popular peptides to exist, CJC-1295, and see what it can offer to your body.

Gear up to read one of the most awaited peptide reviews and decide whether CJC-1295 should be your go-to peptide. 

Warning: The content on Muscleandbrawn.com and the information included in this article is intended for entertainment and informational purposes only. It is not intended nor implied to be a substitute for professional medical advice. Prior to buying anything, check that it is compliant where you live with your current government laws.

Key Takeaways: 

  • CJC-1295 is a synthetic analog of GHRH and a potential GHl secretagogue as well. 
  • It causes an increase in the levels of GH in the human body. This can assist in losing excess fat, gaining lean muscle mass, and many more. 
  • CJC-1295 can be best stacked with Ipamorelin to gain maximum benefits while keeping low doses of the peptides. 
  • BioTech peptides is one of the premium options to buy CJC-1295 from. 
  • CJC-1295 usually comes in powdered form; therefore, it must be reconstituted appropriately before its subcutaneous administration

What is CJC-1295?

CJC-1295 constitutes 30 amino acids in its structure and is one of the potent analogs of growth hormone-releasing hormone (GHRH) and an effective growth hormone (GH) secretagogue (1). The peptide was initially synthesized by ConjuChem Technologies after several modifications of its predecessor, Sermorelin Acetate. 

CJC-1295 occurs in two primary forms, with or without Drug Affinity Complex (DAC). CJC-1295 with DAC is considered to have a greater bioavailability and half-life than regular CJC-1295 due to its binding capability to a blood protein. With its potent binding to endogenous albumin, CJC-1295 takes more than 6-10 days to clear from the body; therefore gets more time to exert its effects (2)

Several studies have been conducted to evaluate the efficacy and potency of CJC-1295. 

Now I am sure you all must have had confusion about CJC-1295 and Ipamorelin because they are almost always used together. Let me make it clear for you guys. Both of them are DIFFERENT peptides. While the mechanism of action is slightly different, the effects produced are pretty similar, and only for that reason, the majority of people stack both peptides. 

How Does CJC-1295 Work?

I strongly believe that you should know the working mechanism of the peptide before really using it. With CJC-1295, it’s an easy one to grasp. 

CJC-1295, an analog of GHRH, binds to the receptors on the anterior pituitary gland. From there, they stimulate the release of Growth Hormone (GH) and Insulin-like growth factor-1 (IGF-1) (3). 

CJC-1295 Guide - Effects, Dosage, Side Effects
Fig 1. Effects of CJC-1295 in GH knockout mouse

Research suggests a very similar mechanism of action associated with Sermorelin. However, unlike Sermorelin, which causes a more pulsatile release of Growth Hormone, CJC-1295 triggers a more drastic release. 

Experiments have revealed that CJC-1295 can cause a 200-1000% increase in the body’s GH levels. Importantly, the levels remain up for more than 6 days, thus inducing pronounced effects overall.  

Benefits of CJC-1295 

CJC-1295 supplementation is associated with a wide array of benefits. Since the peptide works via the release of Growth Hormone and IGF-1, you can already expect a long list of effects! 

Increase in Lean Muscle Mass:

One of the BIGGEST advantages you can gain through CJC-1295 is an increase in lean muscle mass (4). The peptide does this via an increase in muscle protein synthesis and mass growth. The CJC-1295 and Ipamorelin stack offer a more significant increase in muscle growth and strength.

Triggers Fat Loss:

Other than that, CJC-1295 is widely known for its fat-loss attributes (5). Prolactin, another hormone secreted by the anterior pituitary, is associated with slowing the body’s metabolism. This is soon followed by a more significant visceral fat accumulation, one of the major risk factors for cardiovascular diseases.

However, with CJC-1295, you’re in safe hands! The peptide slows the release of prolactin and contributes to the rapid loss of unwanted fat. 

May Improve Sleep Cycle

Although limited studies are available, some scientists do claim CJC-1295 is involved in sleep improvement. Since GHRH is seen to promote deep and quality sleep, it makes sense that, being a GHRH analog, CJC-1295 does the same. With better sleep, your body gets a chance to repair tissue, make more neural connections, and cause an increase in muscle and bone density. 

Is CJC-1295 Legal?

This is always a tricky one to answer when it comes to peptides. 

As for now, the FDA is yet to approve the peptide for human consumption. However, one can purchase it via online vendors for research purposes. 

Nonetheless, as for other countries, the laws differ widely. 

Dosage & Cycling

It is suggested that 30 to 60 mcg per kg of body weight should be more than enough. Since CJC-1295 has a longer half-life, injecting it once a week is generally recommended.

Moreover, It would be best if you intake the peptide before going to bed. 

After cycling it for twelve weeks, one should follow a regimen of a month-long break from all kinds of peptides. 

You can view our comprehensive chart available to learn more about specific dosage and cycling guidelines. 

Side Effects of CJC-1295 

While there are generally fewer adverse effects associated with peptide intake, there are always some that you need to take care of! 

Generally, with CJC-1295, you shouldn’t be experiencing any nasty symptoms; however, in the worst-case scenario, CJC-1295 supplementation may be accompanied by vertigo, an increase in body temperature, and sudden mood swings. Other than these, you may experience anxiety, nausea, flu-like symptoms, and hives. 

To avoid vertigo from occurring, try consuming low doses of the said peptide. As far as raised body temperature goes, this is primarily seen in beginners consuming large amounts of the drug in the initial cycles. 

Who should use CJC-1295?  

After the age of 30, the body’s ability to synthesize and release Growth hormone declines naturally. This is accompanied by slow healing, weakness, and fatigue-like symptoms. 

Since CJC-1295 increases the body’s natural production of GH, it’s best to supplement after age 30 to raise and fasten metabolism. 

Forms of CJC-1295 

CJC-1295 comes in the form of powder. Therefore, it must be reconstituted with bacteriostatic water before ingesting. After doing so, it can be administered through subcutaneous injection.

To know the detailed procedure on how to reconstitute peptides, you may read the reconstitution guide on the website. 

User Reviews and Experiences 

Customer/User reviews are a real deal since they tell you so much about a peptide you would not otherwise know! 

Let’s dive into some of the Reddit reviews and see what we can make of them. 

“I’ve been using it for 2 weeks already. Besides a slight burn sensation in the administered area for a while. I’m not losing muscle mass, and my joints feel stronger.”

One of the users said this about CJC-1295

“ I’ve been on CJC-1295 since April. I’ve lost roughly 40lbs and maintained most of my muscle. I do jitsu 2-3 times a week, kettlebell circuits 2x a week and a heavy squat session 1x per week. I eat chicken, tuna, and steak with salad or small fruit. I sleep better now. I also have been on TRT for about 10 years. I did notice my free test and bound both values shot up to the higher thresholds even with reducing my weekly test protocol to 50mg x2 a week sub q.

Another one shares his experience by saying

“I found it amazing. I’m very lean to begin with but my strength went through the roof, pumps at the gym were amazing and overall got much more lean. Maybe gained 3-5lbs of muscle but the most noticeable difference was how much my veins just popped out of my arms and shoulders. Again, lean and vascular to begin with but In my opinion I had amazing results. Running it back for a second time in about two weeks. Took about 3 weeks to kick in”. 

Another one said

CJC-1295 Stacks 

One of the best ways to get enhanced benefits with lower doses is to stack peptides together. Generally, SARMs are seen to be stacked together for maximum benefits. However, research now suggests the same for peptides too. 

If you have been in the peptide industry for some time, you would have surely heard about CJC-1295 and Ipamorelin together, and perhaps this is one of the most popular stacks. 

Both peptides together trigger a significant release of growth hormone (GH)  in the human body. This allows the body to speed up the process of repair and healing. Research also indicates improved outcomes like increased lean muscle mass and fat loss. 

Although, both of these peptides differ significantly when it comes to their mechanism of action. CJC-1295 works by acting as an analog of GRHR and GH secretagogue. At the same time, Ipamorelin works by acting as an agonist for Ghrelin receptors. 

When cycling with these peptides, you must ensure the intake of 150 mcg of Ipamorelin and 150 mcg of CJC-1295. 

Where to Buy CJC-1295?

With so much of market and competition in the peptide industry, it is extremely important to pick the right vendor that specializes in selling authentic peptides at nominal costs. Perhaps BioTech peptides is one of the top options I would recommend! 

CJC 1295 Overview

CJC 1295

CJC 1295 is considered one of the potent growth hormone secretagogues (GHS). 

The peptide was first developed to stimulate the natural production of growth hormone and IGF-1 from the anterior pituitary gland. CJC 1295 also provides an inhibitory effect on the release of somatostatin, an inhibitor of growth hormone. 

These hormones aid in increasing lean body mass, endurance, and strength. Researchers also believe that CJC 1295 is capable enough to regulate sleep cycles. Evidence suggests that growth hormone secretagogues such as CJC 1295 play an important role in maintaining and improving cardiovascular function, wound healing and repair, increased protein synthesis, and much more. 

For bodybuilders, it is recommended to stack CJC 1295 with Ipamorelin to gain maximized benefits. Nonetheless, if you’re a beginner, you might experience unpleasant side effects such as vertigo, increased body temperature, and mood swings. 

CJC 1295 Overview

⭐️ Top Benefits: Increase lean muscle mass, Enhanced endurance 
🧪 Form: Injectable 
💉 Typical Dosage: 250 mcg to 300 mcg 
⌛️ Typical cycle duration: 60 to 90 days 
💰 Average Cost: $49
✅ Availability: Easily available 
❤️‍🩹 Side Effects and Dangers: Vertigo, Increased body temperature 
📚 Best Peptide Stack: CJC-1295 / Ipamorelin, CJC-1295 / GHRP-2
🔄 See before and after
➡️ Go to the Full review

  • Increased muscle mass 
  • Increased muscle strength 
  • Cardioprotective effects
  • Vertigo
  • Mood swings 
  • Increased body temperature

CJC-1295 vs. Other Compounds

CJC-1295 vs. Sermorelin

Both CJC-1295 and Sermorelin are more and less similar. Sermorelin was first synthesized by ConjuChem Technologies and is considered the predecessor of CJC-1295. 

Both of these peptides work by stimulating GHRH receptors on the anterior pituitary, thereby increasing the release of growth hormones in the human body. 

Nonetheless, there’s always a catch. Of the two peptides, Sermorelin provides a somewhat more natural ebb and flow of Growth hormone since it is cleared faster than CJC-1295. That means, during the given period, it is more likely for CJC-1295 to be present and stimulate the release of GH than Sermorelin. 

CJC-1295 vs. Mod Grf-129

These are essentially the same peptides, differing slightly in composition, thus making all the difference in efficacy. CJC-1295 differs from Modified Grf-129 due to the presence of a Drug Affinity Complex (DAC). 

Sermorelin and Mod Grf-129 have a very short half-life of approximately 30 minutes compared to CJC-1295, having a half-life of 8 days. Due to the fact of DAC, CJC-1295 can bind with endogenous albumin. 

Is CJC-1295 Legit? 

For sure! 

CJC-1295 is definitely user-friendly and has to offer a lot if used rightly! 

It has tremendous beneficial effects, such as increased muscle mass and fat loss, promotes deep sleep, and provides a better life. 

Perhaps what separates it from other peptides is that this peptide doesn’t have any adverse side effects and is comparatively much safer for human consumption than others. 

So what are you waiting for? Get your CJC-1295 right away! 

FAQs about CJC-1295

What forms does CJC-1295 come in?

CJC-1295 usually comes in the form of powder. Therefore, to make use of it, it first needs to be adequately reconstituted with bacteriostatic or sterile water. 

Is CJC-1295 Dangerous for human consumption?

Research suggests that CJC-1295 is safe and secure for it to be consumed by humans within the recommended dosage. No adverse side effects are reported.

Does CJC-1295 increase testosterone?

No, CJC-1295 causes an increase in the release of the Growth hormone IGF-1. It has no potential link with testosterone; therefore, after cycling with CJC-1295, you don’t have to undergo PCT.

 Is CJC-1295 legal?

CJC-1295 isn’t legal for human consumption, as guided by the FDA. However, it can easily be purchased from online vendors for experiments and research.

How to administer CJC-1295?

After thoroughly reconstituting CJC-1295 with bacteriostatic water, one can administer the peptide via subcutaneous injection.

Still Have Questions?

Drop us a comment down below and one of our expert coaches will respond to it.

1) Alba M, Fintini D, Sagazio A, et al. Once-daily administration of CJC-1295, a long-acting growth hormone-releasing hormone (GHRH) analog, normalizes growth in the GHRH knockout mouse. Am J Physiol Endocrinol Metab. 2006;291(6):E1290-E1294. doi:10.1152/ajpendo.00201.2006

2)Jetté L, Léger R, Thibaudeau K, et al. Human growth hormone-releasing factor (hGRF)1-29-albumin bioconjugates activate the GRF receptor on the anterior pituitary in rats: identification of CJC-1295 as a long-lasting GRF analog. Endocrinology. 2005;146(7):3052-3058. doi:10.1210/en.2004-1286

3)Teichman SL, Neale A, Lawrence B, Gagnon C, Castaigne JP, Frohman LA. Prolonged stimulation of growth hormone (GH) and insulin-like growth factor I secretion by CJC-1295, a long-acting analog of GH-releasing hormone, in healthy adults. J Clin Endocrinol Metab. 2006;91(3):799-805. doi:10.1210/jc.2005-1536

4)Gertner JM. Effects of growth hormone on body fat in adults. Horm Res. 1993;40(1-3):10-15. doi:10.1159/000183761

5) Sigalos JT, Pastuszak AW. The Safety and Efficacy of Growth Hormone Secretagogues. Sex Med Rev. 2018;6(1):45-53. doi:10.1016/j.sxmr.2017.02.004

Contributors

Kartik Kumar Rathi

Kartik Kumar Rathi | Writer

Kartik is a medical student with a passion for anatomy and physiology. He writes research papers, articles and blogs to raise awareness and also has a strong interest in teaching and public speaking. Aspiring to be a successful cardiologist, Kartik believes in connecting with people on a personal level and is an expert in peptide research.

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Bill Grinley
9 days ago

Hi, I’m a little confused: in the beginning of the article you say 30-60 mcg of CJC-1295 per Kg of bodyweight once a week. Later on you say Typical dosage: 250-300mcg- but for a 175lb man that’s 2,370 mcg (30mcg X 79kg= 2370mcg). Can you explain?
Also, with the CJC-1295 needing reconstitution, what is the proper dilution for 5mg of CJC-1295 and Bacteriostatic water?
Thank you,

Muscle and Brawn Team
9 days ago
Reply to  Bill Grinley

The standard testing dosage administered in the subjects is usually per kg of body weight whenever a peptide or any drug of intake is studied in the clinical trials to determine the actual efficacy and potency. Because peptides never make it to the last stage of clinical trials due to lack of FDA approval, no fixed dosage is decided. Therefore, most people use the trial and error method and decide on a standard dosage of peptides that works optimally for most users; in this case, that’s 250-300mcg.

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