Bodybuilding is more about managing your body well. It requires the right amount of balance between symmetry, body fat, body weight, and muscle mass.
Having extremely low body weights and expecting to lift heavy bulky stuff in the gym can really be unproductive and yield no results.
Bodyweight is directly related to the hunger hormone ‘ghrelin’, also referred to as Lenomorelin. The more you eat, likely it is for you to have higher body weight.
Lenomorelin is a naturally occurring peptide in the body that is used by bodybuilders to increase weight, enhance growth hormone production, and establish natural sleep and wake circadian rhythms.
Here, I’ll explain exactly how it works, how much to use, and where you can find it to purchase online.
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What Is Lenomorelin
Lenomorelin, more commonly known as ghrelin, is a pleiotropic hormone (1) synthesized and secreted by a certain group of endocrine cells located in the gastric mucosa throughout the gastrointestinal tract.
This peptide is made up of 28 Amino acids in a specific sequence. It is imperative to mention that at the third position of the peptide chain, serine residue is n-octanoylated, which gives the lenomorelin (ghrelin) its key characteristic property.
It is also sometimes called the ‘hunger hormone’ because of its principal role in increasing appetite in the body (2).
How Does Lenomorelin Work
Lenomorelin (ghrelin) establishes its connection with the central nervous system (CNS) of the body by binding with the growth hormone secretagogue receptor (GHS-R). The subsequent binding stimulates the anterior pituitary gland to secrete growth hormone (GH).
It also communicates with the hypothalamus, thereby stimulating the appetite (orexigenic) and preparing our body for increased food intake.
Studies suggest that lenomorelin also inhibits the secretion of insulin, which in turn regulates blood glucose levels by regulating the processes such as glycogenesis and glycogenolysis (3).
Besides glucose metabolism, lenomorelin also upregulates the maturation of osteoblasts (bone cells) (4).
Lenomorelin also stimulates the growth and proliferation of muscle cells, thus preventing the onset of certain chronic musculoskeletal disorders.
Perhaps lenomorelin also influences the natural circadian rhythm in an individual by setting up a sleep/wake timing (5).
Benefits Of Lenomorelin
If you track the normal blood levels of lenomorelin (ghrelin), you will observe a spike when your stomach is empty. The plasma levels of lenomorelin go down after food intake.
As lenomorelin (ghrelin) is known to increase appetite, it helps an individual consume more food. This results in an increased caloric intake, thereby helping in weight gain.
If you have any personal goals for weight gain as a bodybuilder or fitness pro, you can increase the ghrelin concentration in your body accordingly.
Lenomorelin also helps in adipogenesis, which helps in fat deposition.
Lenomorelin also regulates blood glucose levels by following a homeostatic pathway. These synergistically help improve the lean body mass.
As ghrelin also stimulates the release of growth hormone (GH), one would experience the overall benefits associated with higher growth hormone (GH) levels, such as effective wound healing, increased strength, stamina, and enhanced overall growth.
Lenomorelin also stimulates bone cell growth and minimizes the risk of developing bone-related chronic conditions such as osteoporosis. If you are an athlete, lenomorelin will help you sustain longer in your sport!
Lenomorelin also causes the differentiation of myocytes, which prevents muscle atrophy and helps build muscle, provided that you are also involved in effective workout regimes.
Optimal levels of ghrelin also seem to offer cardioprotective benefits, such as enhancing heart functioning, which plays a key role in the life of athletes and bodybuilders.
Is Lenomorelin Legal?
It is illegal to consume Lenomorelin (ghrelin) or any of the other peptides that mimic its action.
But lenomorelin (ghrelin) can be consumed for medical purposes if your sole purpose is weight gain. It is still important to seek advice from your doctor before deciding on consuming ghrelin.
Who Should Use Lenomorelin?
Anyone aiming for weight gain can consume lenomorelin (ghrelin). If you are deficient in growth hormone (GH), you can make lenomorelin a part of your routine.
If you are a bodybuilder or a fitness person and looking for a supplement to enhance your musculoskeletal growth, build endurance and stamina, and develop a strong physique, then lenomorelin (ghrelin) can be your go-to peptide.
How To Use Lenomorelin?
Lenomorelin is available in injectable forms only like most other hormonal therapies.
Once your dosage is decided, you can order lenomorelin (ghrelin) from a trusted store. You will receive a lyophilized form of lenomorelin into a vial (glass container).
By following specific instructions on the vial, you will be required to mix lenomorelin with the bacteriostatic water.
After your desirable volume is prepared, administer it via the subcutaneous method.
One of the studies administered subcutaneous ghrelin to 16 healthy individuals, and the results showed a 27% increase in food intake (6). This suggests both the efficacy of ghrelin as well as the effectiveness of the subcutaneous method.
Forms Of Lenomorelin
A couple of studies suggest that hormonal therapies are usually more effective when injected. Thus, you will only find lenomorelin as an injectable peptide.
Pharmacokinetics also suggests that injectable form is more effective and is also known to have better efficacy than other forms of intake (7).
As the purpose of consuming lenomorelin (ghrelin) differs, so do the dosage guidelines.
The clinical trials involving lenomorelin usually involved 7.5mcg/kg of subcutaneous administration to the subjects (8).
However, some research also suggests that ghrelin levels cant be regulated with drugs directly. Some of the scenarios in which there is upregulation of ghrelin levels are:
- Low protein intake
- Poor sleep
- Decreased muscle mass
Note that you should consult any health expert to decide your dosage criteria based on your personalized goals.
There is no such information available based on any of the clinical research trials that suggest a specific cycling duration for lenomorelin.
However, if we consider other similar ghrelin mimetics, such as ipamorelin, sermorelin, or hexarelin, lenomorelin can be cycled for 10-12 weeks before taking a break.
Lenomorelin (ghrelin) can be stacked with other growth hormone secretagogues (GHS), such as ipamorelin, sermorelin, or hexarelin.
As all growth hormone secretagogues (GHS) work in a similar way by binding to growth hormone secretagogue receptors (GHS-R), and most of them also mimic the lenomorelin (ghrelin), there will be an amplified release of growth hormone (GH) in the blood plasma.
You can learn more about other growth hormone secretagogues (GHS) on muscle+brawn by heading onto the ‘peptide’ sections.
Being a naturally occurring endogenous peptide, I couldn’t find any personal reviews by people because most people try to regulate the levels of lenomorelin (ghrelin) in natural ways and not inject it.
But based on my understanding, lenomorelin (ghrelin) injections would go well with people. Because essentially, what lenomorelin does is increase the appetite. So higher lenomorelin (ghrelin) levels will only cause more hunger pangs.
Lenomorelin Side Effects
Clinical trials suggest no adverse side effects. No-to-mild levels of side effects were reported by the subjects.
Transient flushing was one of the most common side effects experienced. Some of the individuals also reported gastric rumbles. Other downsides of excessive dosages include fatigue, vertigo, and change in mood as well as energy.
Where Can I Buy Lenomorelin?
Lenomorelin isn’t widely available in the market mainly because people generally don’t purchase this naturally occurring peptidic hormone.
Lenomorelin vs. Other Compounds
Lenomorelin vs. Hexarelin
Although both peptides are growth hormone secretagogues (GHS), there are structural differences between the two.
While lenomorelin (ghrelin) is a naturally occurring hormone, hexarelin is a synthetic peptide. Both the peptides primarily increase the growth hormone (GH) levels, hexarelin offers a ton of other supplementary benefits such as increased muscle building, burns down excessive body fat, and improving the mobility and flexibility of the skeletal system.
Perhaps what distinguishes hexarelin as a superior peptide is its cardiovascular advantages as it improves the normal parameters of the heart, such as cardiac output and stroke volume.
If you are an athlete or a fitness pro, hexarelin should be your go-to peptide.
Lenomorelin vs. Sermorelin
Lenomorelin and sermorelin comprise 28 and 29 Amino acids, respectively. Sermorelin also stimulates the release of growth hormone (GH), just like lenomorelin.
But sermorelin offers a lot for bodybuilders and athletes because it ensures effective healing, enhanced muscle building, and improved lean muscle mass.
What extra that sermorelin offers is improved neurological functioning.
Lenomorelin vs. Ipamorelin
Although structurally different, ipamorelin is somewhat functionally similar to lenomorelin.
Ipamorelin binds with a lot of receptors located peripherally. It increases the lean body mass significantly, ensures a smooth recovery phase from injuries, improves your bone, joints, and tendon growth as well as acts as an anti-aging peptide.
Is Lenomorelin Legit?
If you were to ask my opinion, I would say Yes!
Lenomorelin (ghrelin) occurs naturally in the body, and there is plenty of pharmacodynamical studies available.
It all depends on your purpose of intake. If your purpose is to increase body weight, then lenomorelin seems to be a relatively better candidate to use.
But if you are a bodybuilder or an athlete, I would suggest you use other growth hormone secretagogue (GHS) peptides because they are more multi-dimensional and seem to have more efficacy and efficiency.
You would see better and quicker results using other peptides, which are essentially the mimetics of lenomorelin (ghrelin).
What triggers the release of ghrelin
Ghrelin levels are primarily regulated by food intake.
How does ghrelin affect sleep?
Ghrelin increases non-rapid eye movement (NREM) sleep probably by binding with the growth hormone-releasing hormone (GHRH) receptor. This assists in formulating a normal physiological sleep/wake cycle.
What affects ghrelin?
Fasting and feeding, in short.
How do I turn off the ghrelin hormone?
Consuming healthy fats can decrease ghrelin levels significantly.
What regulates ghrelin release internally?
Insulin, glucagon, oxytocin, somatostatin, dopamine, glucose, and long-chain fatty acids regulate ghrelin secretion through their direct interaction with ghrelin cells.
Do ghrelin blockers work?
Animal studies, even when ghrelin antagonists were found to be safe and block the hormone’s activity, they failed to treat obesity.