Thymosin Beta 4 (TB4) Peptide: Benefits, Dosage, Side Effects

Thymosin Beta-4 is an endogenously occurring peptide that is magical when it comes to wound healing and quick recovery. Research claims that it has a lot of benefits to offer, such as greater stamina, intact corneal health, and enhanced cardiovascular health. Read through the end to know more about it!
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Bodybuilding enthusiasts and athletes often find themselves in a situation where a bruise or a wound hinders their progress and slows them down.

Here is where peptides like Thymosin Beta-4 come to the rescue. Known for its wound-healing properties, this peptide can also further enhance muscle growth, tone, and stamina.

In this article, I will ensure to include all relevant scientific and anecdotal evidence available on Thymosin beta-4 so that by the end of this review, you will be able to decide for yourself if this peptide is the ideal solution for your problems or not.

Warning: The content on Muscleandbrawn.com and the information included in this article is intended for entertainment and informational purposes only. It is not intended nor implied to be a substitute for professional medical advice. Prior to buying anything, check that it is compliant where you live with your current government laws. We frequently mention research chemicals that are not made for human consumption. Therefore, before purchasing any product for personal use, consult with your doctor or healthcare provider first.

Key Takeaways

  • Thymosin Beta-4 is an endogenously occurring peptide that plays a key role in wound healing and improves recovery time after injuries, thus making it an ideal peptide for bodybuilders and athletes. 
  • It also enhances your stamina, strength, and endurance. 
  • Thymosin Beta-4 holds a lot of benefits for your corneal health. 
  • Thymosin Beta-4 offers quick recovery after a heart attack or MI. 

What is Thymosin Beta-4?

Thymosin Beta-4 is a small, endogenous peptide that is originally isolated from the Thymus gland and comprises 43 amino acids. 

It belongs to the ‘Thymosin’ family of lymphocyte growth factors initially extracted from calf thymuses, with Thymosin Beta-4 being the most abundant of Beta-Thymosins (1).

This peptide is mainly found in the thymus gland but is also present in the spleen and peritoneal macrophages (2).

How Does Thymosin Beta-4 Work?

Thymosin Beta-4 is a multifunctional peptide that mediates different wound healing stages at a cellular level. It also has several other biological functions that are executed by encoding gene fragments.

These biological functions mainly seem complex for someone new to the scene, so I have broken down everything for you.

Damaged tissues often suffer from ischemia and necrosis eventually. In such situations, Thymosin Beta-4 plays an essential role in promoting angiogenesis. It does this by upregulating the expression of vascular endothelial growth factor (VEGF), which regulates the formation of new blood vessels, and helps reclaim damaged tissue (3).

A study done on mice claims that Thymosin Beta-4 prevents cell death by inhibiting transforming growth factor pathways in different tissues. This specifically allows cells of the eye, heart, and nerves to have a longer life even after undergoing any kind of damage.

It is worthwhile to note that Thymosin Beta-4 also has anti-microbial properties. It not only increases the rate of cell survival but also ensures that the site of the wound is kept safe from different infections (4).

Inflammation and swelling in an early wound site exacerbate tissue damage; thus, it becomes essential to control this. Thymosin Beta-4 is able to do so by inhibiting the release of cytokines such as tumor necrosis factor-a (TNF-a) and preventing further damage.

Once the wound is protected, Thymosin Beta-4 focuses on tissue regeneration by promoting stem cell mobilization, migration, and differentiation (5). It does this by sequestering actin monomers to maintain high concentrations of unpolymerized actin, which plays a pivotal role in cell movements.  

Researchers claim that Thymosin Beta-4 inhibits the migration and proliferation of Hepatic stellate cells or HSCs, thus protecting the liver from fibrotic damage (6).

Thymosin Beta 4 (TB4) Peptide: Benefits, Dosage, Side Effects
Fig 1. Effects of Thymosin Beta-4 on regeneration of Hepatic Stellate cells

Benefits of Thymosin Beta-4

The benefits of Thymosin Beta-4 have been explored through clinical trials on both human and animal models.

One of the prime benefits of Thymosin Beta-4 is its ability to modulate the wound-healing process through its anti-apoptotic and anti-inflammatory properties. This greatly benefits athletes and bodybuilders who frequently experience muscle tears and skin damage. 

Perhaps the peptide protects bodybuilders and athletes from any adverse complication that may accompany an injury and then helps them recover faster.

Not only this, but Thymosin Beta-4 is also known to enhance strength and stamina, thus proving a must-use for people in sports!

Myocardial infarction leads to a sudden cessation of blood flow and oxygen to a part of the heart, which may lead to death. In this situation, Thymosin beta-4 protects the affected part of the heart via its anti-apoptotic and anti-inflammatory activity (7).

Thymosin Beta-4 has exhibited firm therapeutic effects in corneal injury that may result from undue chemical contact. This peptide reduces inflammation, inhibits apoptosis, and regulates the balance of cellular matrices in order to preserve the cornea (8).

Some research suggests glycine Thymosin Beta-4 eye drops have proven to be effective against eye dryness and reduce inflammatory cytokine levels (9).

Our liver can be injured due to blunt trauma, diseases, or medications that disturb the body’s biochemical functions. In such instances, Thymosin Beta-4 employs anti-oxidative functions in liver tissues and prevents fibrotic scar formation. This keeps liver function intact.  

In a correlation to a study done on mice, Thymosin Beta-4 was also seen to promote fibronectin expression in human dermal papilla cells leading to hair growth and potentially serving as a solution to baldness (10).

By alleviating inflammation in diseased and damaged tissues, Thymosin Beta-4 exerts therapeutic effects on a multitude of disorders, including colon cancer and ulcerative colitis (11).

Is Thymosin Beta-4 Legal?

Clinical trials performed to test the efficacy of Thymosin Beta-4 have yielded promising results. Also, WHO has recognized Thymosin Beta-4 as well, which means it is surely legal and effective!

Who Should Use Thymosin-Beta 4?

Thymosin Beta 4 (TB4) Peptide: Benefits, Dosage, Side Effects

Due to its speedy wound-healing properties, Thymosin Beta-4 can be safely used by people who are looking for a way to manage their injuries and recover quickly. This specifically includes gym and fitness enthusiasts.

It can also be administered to patients who may have suffered from a myocardial infarction, liver damage, and kidney damage. Its anti-inflammatory properties are also specifically beneficial for patients with arthritis.

Taking into account its wonderful effects on the corneal tissue, it can be taken by people suffering from dry eye syndrome as well.

Forms of Thymosin Beta-4

Thymosin Beta-4 is mainly available in the form of powder which needs to be reconstituted before injection. This is because of its better potency, greater bioavailability, and hassle-free administration.

Eye drops containing 0.1% of Thymosin Beta-4 are also used for symptoms of dry eye (12).

How to Use Thymosin Beta-4?

Thymosin Beta 4 (TB4) Peptide: Benefits, Dosage, Side Effects

Since injections are the most popular form of Thymosin Beta-4, they can be injected intramuscularly or subcutaneously. People also inject it closer to the site of a wound or an injured area to yield better results.

Eye drops, on the other hand, can be easily administered using a dropper.

To know more about ways to administer peptides, read my detailed guide on the website!

Thymosin Beta-4 Dosage

General recommended dosage for Thymosin Beta-1 is 2-12 mg. In the form of an injection, 0.25 ml can be injected subcutaneously.

For Thymosin Beta-4 eye drops, solutions are made with a concentration of 0.1% Thymosin Beta-4 and glycine.

Thymosin Beta-4 Cycle

Thymosin Beta 4 (TB4) Peptide: Benefits, Dosage, Side Effects

Injections containing 0.25 ml of Thymosin Beta-4 can be injected daily for 20 days for quick wound repair. It can be taken for 3 – 6 months for prolonged action and protective functions, alternating the intake every other week.

Based on clinical studies, eye drops can be safely administered for 7-14 days for effective results (13).

Thymosin Beta-4 Stack

Thymosin Beta-4 has proven to considerably affect patients experiencing baldness by aiding hair growth. It is, therefore, often stacked with BPC-157, which is also similarly used for hair regeneration.

BPC-157 also has anti-inflammatory and wound repair properties that, when combined with Thymosin Beta-4, provide an exponential result.

Thymosin Beta-4 User Reviews

Honestly speaking, I tried looking at many platforms and couldn’t find any authentic and trustworthy user reviews on Thymosin Beta-4. 

And, whatever little the internet has on Thymosin Beta-4 is about some of the adverse effects that it may trigger. 

While this makes me doubt its safety profile, scientific evidence advocates otherwise. 

Thymosin Beta-4 Side Effects

One main side effect of Thymosin Beta-4 correlates to its anti-apoptotic activity. This peptide may encourage the metastatic potential of tumor cells, allowing them to spread rapidly.

Other than this, studies have proven Thymosin Beta-4 to be a safely consumable peptide. 

A few mild common side effects related to the injection of this peptide are redness, discomfort at joints, and sometimes even tiredness, lethargy, and headaches.

Where Can I Buy Thymosin Beta-4?

It is very important to make the right purchase, especially when it concerns a health product. Here at Muscle and Brawn, we always find the right brands to provide authentic products to our readers. 

Thymosin Beta-4 by BioTech Peptide

BioTech peptides offer 2 variants of Thymosin Beta-4, which are 5mg and 10mg, at a price of $70 and $119, respectively. 

BioTech peptides are at the top, with their products being >99% pure. They also offer discounts of 5% or 10% depending on the fact that how much quantity you can purchase.

They have a same-day shipping facility with a 30-day money-back guarantee and extremely strict quality control checks.

Perhaps what really amazes me is their customer reviews. They have a 5.0 rating with extremely satisfied clients, thus giving them an edge in selling peptides

  • 99% purity guaranteed
  • Positive customer reviews
  • Little pricey

Thymosin Beta-4 vs. Other Peptides

Thymosin Beta-4 vs. TB-500

Many people seem confused between Thymosin Beta-4 and TB-500. Before digging into what TB-500 has to offer, let me clarify that both peptides differ. 

TB-500 is a derivative of thymosin beta-4 and is artificially synthesized in the laboratory. The main fragment of the peptide which gives TB-500 its critical functional property is (17)LKKTETQ.

However, many stores sell the same product, no matter whether they name it TB-500 or Thymosin Beta-4. 

This implies that you can expect all the benefits of Thymosin Beta-4 to be present in TB-500. Perhaps research claims that TB-500 offers enhanced benefits compared to its parent compound. 

The main function of both these peptides is to promote healing, and they apply similar mechanisms to achieve this goal, but the origin of these compounds differs.

Thymosin Beta-4 vs. BPC-157

Both these peptides are proven to accelerate wound healing and act as anti-inflammatory agents.

However, one main difference between the two is the localized area where they are most effective. BPC-157 exerts most of its healing properties on the gut epithelium – and Thymosin Beta-4 is the most potent healer for muscle and dermal injuries.

Thymosin Beta-4 vs. Thymosin Alpha-1

Thymosin Beta-4 and Thymosin Alpha-1 are both peptides that are derived from the same origin – Thymosin fraction 5, and they work to administer the process of recovering from a disease or injury.

Thymosin Beta-4 mainly focuses on external wound protection and regeneration, while Thymosin Alpha-1 backs up the immune system in a diseased state and helps the body to fight infections.

Is Thymosin Beta-4 Legit?

Based on the clinical findings pertaining to Thymosin Beta-4, it can be deduced that this peptide plays a key role in modulating the different mechanisms essential for repairing and recovering injured tissues. 

It has further proven to be of the essence for patients suffering from corneal, cardiac, renal, and hepatic disease.

It also helps with muscle growth and tone, thus largely benefiting people who are seeking to bulk up their muscles.

While its uses are multiple and all-encompassing, more extensive research on human subjects is required to explore this peptide’s efficacy and other benefits.

FAQs About Thymosin Beta-4

How does thymosin beta 4 enhance performance?

Thymosin Beta 4 is released in the body to help people heal from traumas. In the process of healing from injury, Thymosin Beta 4 also reduces the amount of scar tissue and improves flexibility. It also has potent anti-inflammatory properties.

What is thymosin beta 4 used for?

Thymosin beta-4 promotes angiogenesis, wound repair, and hair growth in normal and aged rodents. It acts by increasing angiogenesis and cell migration and is currently in clinical trials for wound repair.

Where does thymosin beta 4 come from?

After the injury, thymosin β(4) is released by platelets, macrophages, and many other cell types to protect cells and tissues from further damage and reduce apoptosis, inflammation, and microbial growth.

How long can you take thymosin beta 4?

The suggested dosage for Thymosin Beta 4 is to inject 0.25mL subcutaneously daily for 20 days.

Still Have Questions?

Drop us a comment down below and one of our expert coaches will respond to it. We’ll also be answering questions on our Instagram!

1)https://pubmed.ncbi.nlm.nih.gov/12852257/
2)https://pubmed.ncbi.nlm.nih.gov/15980226/
3)https://pubmed.ncbi.nlm.nih.gov/29956769/
4)https://pubmed.ncbi.nlm.nih.gov/17852183/
5)https://pubmed.ncbi.nlm.nih.gov/20536457/
6)https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4463665/#:~:text=Exogenous%20T%CE%B24%20reduces%20liver%20fibrosis,an%20activator%20or%20an%20inhibitor
7)https://pubmed.ncbi.nlm.nih.gov/24348421/
8)https://pubmed.ncbi.nlm.nih.gov/15980226/
9)https://pubmed.ncbi.nlm.nih.gov/32382416/
10)https://pubmed.ncbi.nlm.nih.gov/17947589/
11)https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8724243/
12)https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4445951/
13)https://www.mdpi.com/1422-0067/23/10/5458

Contributors

Kumar Rathi

Kumar Rathi | Writer

Kartik is a medical student with a passion for anatomy and physiology. He writes research papers, articles and blogs to raise awareness and also has a strong interest in teaching and public speaking. Aspiring to be a successful cardiologist, Kartik believes in connecting with people on a personal level and is an expert in peptides.

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Thymosin Beta 4

Chemical Structure

Mechanism of Action

Thymosin Beta-4 plays an essential role in different stages of wound healing. It does so by firstly fighting off pathogens that may be present at the site of injury. It then inhibits cytokines to prevent inflammation which may cause further damage and then promotes stem cell migration and differentiation which helps in the closure of wounds. One of its main functions also pertains to angiogenesis.

Class of Compound

Peptide

Street Names

Thymosin Beta-4, TB4, Timbetasin

Effects

Anti-inflammatory agent , Promotes rapid wound healing , Promotes angiogenesis

Side Effects and Dangers

Discomfort at joints, Headaches ,Lethargy

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