PTD DBM Peptide Guide – The Best Peptide for Hair Loss?

Worried about hair loss? Explore the relatively new peptide for hair regrowth called PTD-DBM that works at cellular level to ensure that you look as young as possible!
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What’s the secret to looking younger? Drumroll, please… It’s your fabulous hair! That’s right.

By giving your hair some extra love and attention, you can instantly feel as young as possible.

As we age, our bodies go through biochemical changes that can result in a multitude of transformations. One such change is the dreaded loss and thinning of hair, especially in men, which has a fancy name: Androgenetic alopecia. It’s like your hair decides to take an unplanned vacation!

But fear not, my friends, for science has come to the rescue! Enter PTD-DBM, the superhero peptide that fights against those pesky hair degenerative processes. This peptide ensures hair growth. And guess what? This marvelous peptide doesn’t stop there. It also possesses wound-healing properties.

So, in this detailed review, we’ll dive deep into the mechanism of PTD-DBM and explore its benefits so that you can make a decision for yourself!                                                                     

Warning: The content on Muscleandbrawn.com and the information included in this article is intended for entertainment and informational purposes only. It is not intended nor implied to be a substitute for professional medical advice. Prior to buying anything, check that it is compliant where you live with your current government laws. We frequently mention research chemicals that are not made for human consumption. Therefore, before purchasing any product for personal use, consult with your doctor or healthcare provider first.

Key Takeaways

  1. PTD-DBM peptide combats hair loss and promotes the regeneration of hair follicles.  
  2. It can also accelerate wound healing through the Wnt/β-catenin signaling pathway.  
  3. Since this is a relatively newer peptide, the potential side effects of PTD-DBM are still unexplored. 

What is PTD-DBM?

PTD-DBM is a synthetic peptide that is short for Protein Transduction Domain-fused Dishevelled Binding Motif. 

It was first originally formulated in South Korea as a topical agent for treating baldness. 

How does PTD-DBM work?

PTD-DBM exerts all its effects by modulating just one mechanism in the body.

The wnt/β-catenin signaling pathway is an evolutionarily conserved mechanism that plays a part in maintaining cellular homeostasis. 

PTD DBM Peptide Guide - The Best Peptide for Hair Loss?
Fig 1. Wnt/β-catenin signaling pathway mediated by PTD-DBM 

Β-catenin is expressed in the dermal papilla, where it promotes anagen induction, duration, as well as keratinocyte regulation and differentiation. Therefore β-catenin is the protein responsible for healthy hair growth. (1

This pathway, however, is usually hampered due to a cell pathway-linked protein called CXXC-type zinc finger protein 5 (CXXC5) which acts as a negative regulator. It binds another protein, called the Dishevelled protein, and prevents the development of hair follicles. 

PTD-DBM works by acting as a competitive inhibitor of CXXC5 and halts its binding process. It then allows the Wnt/β-catenin signaling pathway to progress smoothly. (2

As a result, the follicular development process is stimulated, which eventually leads to the formation of new hair. 

A study done on mice indicated that the application of PTD-DBM can also help in accelerating wound healing by acting as a regulator of the Wnt/β-catenin signaling pathway, which is responsible for dermal cell proliferation and differentiation. (3

Benefits of PTD-DBM

Since PTD-DBM has a very specific mechanism of action, its benefits are also relatively precise and easy to understand. 

  • By facilitating the Wnt/β-catenin signaling pathway, PTD-DBM proactively prevents hair loss.
  • It also has the ability to generate new hair follicles and thus promotes hair regrowth.  
  • PTD-DBM is extremely beneficial in the treatment of androgenetic alopecia, which is characterized by baldness caused by androgens in men. (4
  • This peptide is also effective on damaged scalps and promotes the growth of fuller, natural hair.
  • PTD-DBM has also proven to have a positive effect on the regeneration of epithelial cells and thus can be used in cases of wounds and injuries. 

PTD-DBM is still a relatively unexplored peptide requiring further research on human subjects.

As a result of this, it has not been approved by the FDA for human use. 

Who should use PTD-DBM?

PTD-DBM has displayed irrefutable effects on hair growth, and it also simultaneously promotes hair regeneration. Therefore, it can be used by anyone who is suffering from hair loss and wants to get their normal healthy hair back. 

It specifically forms a part of an effective treatment plan in conditions such as dihydrotestosterone (DHT) induced alopecia in men that primarily affects the top and front of the scalp.

For women, it has hair restoration properties that allow the aging and thinner hair to appear more voluminous. 

PTD-DBM can also be used in cases of injuries due to its rapid wound-healing properties. 

Forms of PTD-DBM

PTD-DBM is a topical peptide and is therefore available in three different forms. These include topical spray bottles, drops, and foam. 

How To Use PTD-DBM

PTD-DBM is applied to the scalp directly. Just like any other topical medication, it is generally recommended to have a clean and dry scalp before application.

A tested method of applying PTD-DBM is alongside rolling or micro needling, which is known as wound-induced hair neogenesis. 

This method involves the use of a derma roller with fine needles on it that are used to pierce the skin, causing slight trauma, which induces the generation of healthy follicles. The treatment of androgenetic alopecia, therefore, involves rolling. 

PTD-DBM Dosage

PTD-DBM sprays are usually available as a 0.001% solution in 25 ml of spray bottles. Liquid forms of this peptide are also available in vials of 5 mg.

PTD-DBM Cycling

It is generally recommended to apply PTD-DBM spray to the scalp daily for at least a month. 

Significant results have been reported after 5 weeks of treatment. It is also, however, safe to use for longer periods of time if needed. 

PTD-DBM Stacks

For synergistic benefits, PTD-DBM is often stacked with other peptides as well as valproic acid.  

These peptides include Thymosin Beta, Zn-Thymulin, and GHK-Cu, which especially works in conjunction with PTD-DBM to stimulate hair growth.

Valproic acid stimulates the Wnt/β-catenin signaling pathway, thus, PTD-DBM is almost always administered along with it, and this, by far, is the ideal treatment for hair loss. (5

PTD-DBM User Reviews

Because the research is limited, let’s dig into some of the user reviews and see if we can get real insights on the peptide!

One of the users said,

“9 days in. Nothing so far. I get a little sleepier the days after I dermaroll but I’ve been working a shit ton, and my sleep schedule is pretty poor.

There have been no other side effects. I am seeing small vellus hairs, but I can’t really comment on regrowth just yet. It’s pretty minimal.”

Unfortunately, that’s what Reddit has to offer. There is near to nothing solid on this peptide that could convince you to use it.

PTD-DBM Side Effects

Since PTD-DBM is a relatively newer peptide, there is little scientific literature available. Therefore its side effects have not yet been explored. 

Some common side effects may include irritation or itchiness in the treatment area, but there is no scientific evidence present. 

Where Can I Buy PTD-DBM?

As far as PTD-DBM is concerned, I would recommend you buy it from any of your trusted vendors because this peptide ain’t offered by many vendors at the moment.

But make sure you check the quality of peptide before really buying it!

PTD-DBM vs. Other Peptides

PTD-DBM vs. Thymosin Beta-4 (TB4)

PTD-DBM and Thymosin Beta-4 are both peptides that have proven to be effective in speeding up the process of wound healing. However, their mechanisms differ. 

PTD-DBM is a synthetic peptide that exerts its effect indirectly by regulating the Wnt/β-catenin signaling pathway, whereas Thymosin Beta-4 is a naturally occurring peptide that directly stimulates stem cell proliferation. 

PTD-DBM vs. GHK-Cu

PTD-DBM and GHK-Cu are both peptides that are used in the regeneration of hair follicles and thus can be used in the treatment of hair loss. 

On the one hand, PTD-DBM is a synthetic peptide, whereas GHK-Cu can be naturally found in saliva and urine.  

PTD-DBM vs. Zn-Thymulin

Both these peptides are targeted toward androgenic alopecia, which is hair loss prevalent in males due to dihydrotestosterone levels, but they have different sites of origin.

PTD-DBM is a synthetic peptide, whereas Zn-Thymulin is a nonapeptide hormone that is produced by thymic epithelial cells.

Is PTD-DBM Legit?

PTD-DBM has so far provided remarkable benefits in terms of countering hair loss and alopecia. 

By regenerating hair fibers, PTD-DBM provides people with an immense confidence boost and thereby raises their mental well-being.

PTD-DBM is also said to have wound healing properties which, however, needs further exploration through clinical trials.

It is also important to note that the lack of sufficient data makes this peptide a little risky for human consumption and can have potential adverse side effects that we are not aware of as yet. Thus I think it would be better to opt for more conventional hair loss therapies until we have some definite evidence regarding PTD-DBM. 

FAQs

What are the other best peptides for hair growth?

#1. GHRP-2.
#2. Ipamorelin.
#3. TB-500.
#4. BPC-157 Peptide.
#5. CJC-1295.

Is peptide good for hair?

Peptides have been proven to improve the size of our hair follicles.

How does PTD-DBM work?

PTD-DBM is a topical hair product that helps activate pathways that help rescue DHT-induced hair follicle miniaturization. Activating these pathways has been associated with hair restoration and wound healing.

What peptides block DHT?

Copper peptides block a hormone called DHT that inhibits hair growth. DHT or dihydrotestosterone is a byproduct of testosterone and it is known to inhibit hair growth.

Reconstitution and Dosage Calculator

Still Have Questions?

Drop us a comment down below and one of our expert coaches will respond to it. We’ll also be answering questions on our Instagram!

1)Bejaoui, M., Villareal, M. O., & Isoda, H. (2019). β-catenin-mediated hair growth induction effect of 3,4,5-tri-O-caffeoylquinic acid. Aging, 11(12), 4216–4237. https://doi.org/10.18632/aging.102048

2)Lee, S. H., Seo, S. H., Lee, D. H., Pi, L. Q., Lee, W. S., & Choi, K. Y. (2017). Targeting of CXXC5 by a Competing Peptide Stimulates Hair Regrowth and Wound-Induced Hair Neogenesis. The Journal of investigative dermatology, 137(11), 2260–2269. https://doi.org/10.1016/j.jid.2017.04.038

3)Lee, S. H., Kim, M. Y., Kim, H. Y., Lee, Y. M., Kim, H., Nam, K. A., Roh, M. R., Min, doS., Chung, K. Y., & Choi, K. Y. (2015). The Dishevelled-binding protein CXXC5 negatively regulates cutaneous wound healing. The Journal of experimental medicine, 212(7), 1061–1080. https://doi.org/10.1084/jem.2014160

4)Ryu, Y. C., Park, J., Kim, Y. R., Choi, S., Kim, G. U., Kim, E., Hwang, Y., Kim, H., Han, G., Lee, S. H., & Choi, K. Y. (2023). CXXC5 Mediates DHT-Induced Androgenetic Alopecia via PGD2. Cells, 12(4), 555. https://doi.org/10.3390/cells12040555

5)Lee, S. H., Yoon, J., Shin, S. H., Zahoor, M., Kim, H. J., Park, P. J., Park, W. S., Min, doS., Kim, H. Y., & Choi, K. Y. (2012). Valproic acid induces hair regeneration in murine model and activates alkaline phosphatase activity in human dermal papilla cells. PloS one, 7(4), e34152. https://doi.org/10.1371/journal.pone.52

Contributors

Kumar Rathi

Kumar Rathi | Writer

Kartik is a medical student with a passion for anatomy and physiology. He writes research papers, articles and blogs to raise awareness and also has a strong interest in teaching and public speaking. Aspiring to be a successful cardiologist, Kartik believes in connecting with people on a personal level and is an expert in peptides.

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Chemical Structure

Mechanism of Action

PTD-DBM is a synthetic peptide that is majorly used for the treatment of hair loss. It works by competitively inhibiting a protein called CXXC-type zinc finger protein 5 (CXXC5) which binds with Dishevelled protein and prevents the development of hair follicles. By inhibiting this action, PTD-DBM allows the Wnt/β-catenin signaling pathway to progress usually which would have otherwise been inhibited. This allows the growth of hair follicles which is largely dependent on the Wnt/β-catenin signaling pathway. PTD-DBM also helps in wound healing.

Class of Compound

Peptide

Street Names

PTD-DBM, Protein Transduction Domain-fused Dishevelled Binding Motif

Effects

Prevents hair loss , Regenerate hair follicles , Accelerates cutaneous wound healing

Side Effects and Dangers

Itching

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