Is Peptide Therapy Safe?

Peptide Therapy is one of the most promising health treatments of the new age. For all its benefits, it surely has to have some health risks - right?

Peptide Therapy is growing in popularity, and for good reason. A new and daring method to try improve the health of anyone who is need of a little boost.

But there is always that knawing idea of safety… Peptides may seem scarty, but in reality they are just hard to understand.

Essentially, these are just Amino Acids bound together and used to solve a certain problem! Simple as that, or is it?

Grab your insulin needle and Google what “SUBQ” means while I break everything down for you.

Warning: The content on and the information included in this article is intended for entertainment and informational purposes only. It is not intended nor implied to be a substitute for professional medical advice. Prior to buying anything, check that it is compliant where you live with your current government laws. We frequently mention research chemicals that are not made for human consumption. Therefore, before purchasing any product for personal use, consult with your doctor or healthcare provider first.

Key Takeaways

What is Peptide Therapy?

Peptides are Amino Acids bound together with peptide bonds – hence the name. These occur naturally, however, specific Peptides are known to have physiological effects at certain doses [1].

These have been used for several years now, and the more scientists experiment with these compounds the more they learn just how many benefits these Peptides have.

Figure 1: Peptides are simply Amino Acids in a specific chain and sequence. When administered to the body these can have specific physiological effects

Peptide therapy refers to a treatment plan from an HRT (hormonal replacement therapy) clinic that solves a certain problem. The injured pituitary gland, improved athletic performance, severe fluid retention, anti aging, etc.

You work with a medical expert like a doctor to ensure you use the right dose of the right stuff to avoid side effects. The most popular of these treatment plans is Human Growth Hormone (HGH) replacement, as we see a reduction of HGH production as we age, which can have severe side effects like loss of bone mass, muscle mass, etc [2].

Benefits of Peptide Therapy

Because there are so many different Peptides, it is hard to list all the benefits, but here are some of the most important health concerns that can be solved:

  • Boost muscle growth which drops due to aging
  • Improved sexual function
  • Improved gut health
  • Possibly increased appetite
  • Healthier joints and skin
  • Improved wound healing
  • Fat loss, especially around the abdomen

Is Peptide Therapy Safe?

As with everything in life, there are some risks associated with Peptide Therapy. Again, it depends on which peptides you take, and the amount as well. This is why it is crucial you work with an HRT clinic to avoid side effects.

  • A study published in 2013 found that HGH Therapy seems to be safe. There are concerns with lifelong usage, however, more studies are needed [3]. The only acute issue is maintaining normal blood sugar levels, which is relatively easy
  • Several studies have looked at BPC-157, which is a Peptide used for wound healing. It seems to be extremely safe, with some people experiencing some stomach issues (granted, most actually feel benefits in their gut due to BPC-157)
  • A 2018 study [4[ is eager to point out that Growth Hormone secretagogue peptides are relatively safe, and the only concern is that those with certain medical conditions might be at risk of cancer

Overall, Peptide Therapy is safest when working with a legitimate HRT clinic.

Yes, but only through a clinic that is going to prescribe you these compounds. It is illegal to purchase HGH otherwise. You need a medical condition or reason to use these, hence a healthcare professional is needed.

Is Peptide Therapy Safe?
Figure 2: Peptide Therapy is legal when working with a medical professional

Growth Hormone Therapy

As mentioned, the most popular of these therapies are those that increase Growth Hormone production. CJC-1295, Ipamorelin, or MK-677 are common here. they could help increase muscle mass while also aiding in fat loss.

Growth Hormone Releasing Peptides are some of the safest on the market, and they help with a lot of health conditions. It has even been theorized as a regenerative medicine due to the massive increase in Insulin Like Growth Factor it causes.

Figure 3: HGH Therapy will (almost) improve all health markers in the body due to IGF-1 almost affecting every part of the body

Certain Peptides could replicate this, but there is no safer alternative than a Growth Hormone Releasing Peptide/Hormone (GHRP/GHRH).

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Other Peptides Used

There are various Peptides available at HRT clinics, and all can be used to solve certain problems the client is facing.

Peptides for Muscle Mass

If you suffer from muscle loss or weight loss due to aging, you’re most likely looking at HGH, or a GHRH/GHRP. These are the most commonly used Peptides to increase muscle mass. You would pair these with resistance training and a healthy diet to get the best results.

Peptides for Fat Loss

HGH, again, is going to be one of the best ones to improve body composition. That said, it does have side effects that something like AOD9604 or HGH-Fragment does not. These would help the human body shed fat without increasing insulin resistance or IGF-1 levels.

These are also commonly used by fitness enthusiasts to help with their fitness goals.

Peptides for Libido

There are some “rumors” that HGH could help with sexual function, however, the one most HRT clinics would prescribe is PT-141. Known to help with both male and female sexuality. You could also consider Melanotan II, however, that is quite rare.

Peptides for Health

“Health” is a general term. You would need to discuss it with the healthcare professional to find the specific peptide therapy needed.

Where to get Peptide Therapy?

The only way to get real Peptide Therapy is through a Peptide Clinic or HRT clinic. These are quite common around the states, however, you need to do more research to find the perfect one.

You have to consider costs, quality, and the offering they have. We have actually worked with a lot of clinics, and we definitely found one we prefer over others.

Conclusion: Is Peptide Therapy really Safe?

Yes, Peptide Therapy is safe. Granted you work with a medical expert. There are several athletes who use Peptides illegally, and they might suffer severe side effects due to the severity of the dose and the length of usage.

These Peptides may have virtually zero side effects if you do it hand in hand with a medical expert. Whether it be topical treatments or Peptide supplements, your safest option is working with a trusted HRT clinic.

Are Injecting Peptides safe?

For the most part, yes. Certain Peptides have side effects, such as HGH being able to cause insulin resistance. That said, subcutaneous injections are relatively safe, and it is not often you hear of a subcutaneous injection going wrong.

Are Peptide Injections worth it?

It depends on your desires. They will not magically change your world. You will still need to make lifestyle changes to get the results you want, but they do help – massively. Our bodies produce fewer hormones as we age, and these peptides can help combat this.

Is Peptide Therapy FDA-Approved?

Since the early 1980s, a total of 239 therapeutic proteins and peptides are approved for clinical use by US-FDA

Are Peptides Safe for Long-Term use?

It really depends. Using pure HGH for 30 years will certainly have side effects if you never pay attention to water retention or blood sugar levels. However, for the most part, these peptides are very safe. They are not known to cause heart disease or blood clots, and the individual Peptides that cause side effects that are more severe are usually not available to the public anyways.

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1) Zhu N, Dong F, Shi G, Lao X, Zheng H. HORDB a comprehensive database of peptide hormones. Sci Data. 2022 Apr 25;9(1):187. doi: 10.1038/s41597-022-01287-5. PMID: 35469024; PMCID: PMC9039076.

2) Gou P, Cheng X, Leng J, Su N. A Real-World Study of Recombinant Human Growth Hormone in the Treatment of Idiopathic Short Stature and Growth Hormone Deficiency. Ther Clin Risk Manag. 2022 Mar 16;18:113-124. doi: 10.2147/TCRM.S363564. PMID: 35342293; PMCID: PMC8943615.

3) Divall SA, Radovick S. Growth Hormone and Treatment Controversy; Long Term Safety of rGH. Curr Pediatr Rep. 2013 Jun 1;1(2):128-132. doi: 10.1007/s40124-013-0009-5. PMID: 23772352; PMCID: PMC3678547.

4) Sigalos JT, Pastuszak AW. The Safety and Efficacy of Growth Hormone Secretagogues. Sex Med Rev. 2018 Jan;6(1):45-53. doi: 10.1016/j.sxmr.2017.02.004. Epub 2017 Apr 8. PMID: 28400207; PMCID: PMC5632578.

5) Usmani SS, Bedi G, Samuel JS, Singh S, Kalra S, Kumar P, et al. (2017) THPdb: Database of FDA-approved peptide and protein therapeutics. PLoS ONE 12(7)


Daniel Louwrens BSc PT

Daniel Louwrens BSc PT | Writer

Daniel Louwrens is a well-rounded fitness professional with over 10 years of experience in bodybuilding and fitness. He holds a BSc in Chemistry from the University of Western Cape and is a certified International Personal Trainer and Nutritionist. He is also a skilled bodybuilder and head coach for Muscle and Brawn. With his knowledge and expertise, he provides personalized training, nutrition, and recovery guidance to help clients reach their fitness goals.

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