Getting rid of unnecessary body fat is a dream of many. Most of us want to get into perfect shape by losing excessive weight and staying slim and fit.
Losing excess weight and cutting down accumulated body fat is not only relevant for aesthetic body shape, but being overweight and obese accounts for several cardiovascular and cardiometabolic disorders such as hypertension, coronary artery disease, diabetes mellitus, etc.
The weight loss journey is absolutely daunting but is a very critical journey to embark on.
While one may believe that all of this is possible by hitting intense gym sessions and making lifestyle changes, this is not always true.
Considering the market demand, the evolving medical researchers have dedicated their time to developing effective anti-obesity medications and making your weight loss journey slightly achievable.
One such anti-obesity medication cum peptide that we are talking about today is AOD9604. This well-researched peptide has been a weight loss companion for many, and people have had phenomenal before and after results.
What is AOD9604?
AOD9604 is actually a peptide derivative of human growth hormone (hGH) as it constitutes the short C-terminal 176-191 amino acid fragment (1).
Structurally it is a hexadecapeptide and is also sometimes referred to as (Tyr-hGH177-191).
This peptide was originally developed as a potent anti-obesity medication because of its lipolytic properties (fat-burning). However, with more research, AOD9604 showed many other benefits, such as mitigating the risks of developing several complications.
How Does AOD9604 Work?
The 176-191 amino acid fragment of the hGH is responsible for regulating fat metabolism, thus, one can really now understand the composition of the AOD9604 peptide.
AOD9604 regulates fat metabolism by especially targetting areas having a high amount of fat deposition. This is achieved by modulating 2 main processes, which are stimulating lipolysis and inhibiting lipogenesis.
To make it clear, lipolysis refers to the breaking down of the deposited body fat, while lipogenesis implies the synthesis of fat.
Despite being a peptide derivative of hGH, it stimulates fat breakdown by binding to receptors that hGH doesn’t bind to. Besides, unlike hGH, it also doesn’t seem to affect insulin levels, thus alleviating the risk of diabetes mellitus, etc.
Pharmacodynamical studies of AOD9604 also suggest that this peptide modulates the release of hormones playing a role in fat metabolism from the pituitary gland.
Benefits of AOD9604
One of the obvious benefits of AOD9604 is helping you lose excess weight by burning down body fat by boosting fat metabolism. Thus, using the AOD9604 peptide will ensure that you overcome your obesity and cut down excess fat deposition (2).
The anti-obesity effects were confirmed in several clinical trials performed (3). One of the clinical trials was performed in Australia, where 300 obese individuals were administered the peptide, and all the subjects experienced weight loss significantly.
Because AOD9604 promotes weight loss without really affecting IGF-1 levels and insulin levels, it reduces the risk of developing glucose intolerance and other metabolic disorders.
Not only this, but stimulating lipolysis and inhibiting lipogenesis means AOD9604 can theoretically play a major role in decreasing the chances of hypercholesterolemia.
What’s surprising is that the benefits of AOD9604 expand beyond the horizon of weight loss.
There is substantial evidence suggesting the plausible role of AOD9604 in improving musculoskeletal health. Stacking AOD9604 with some other peptides alleviates any joint and cartilage pain (4).
Adding to this, some research suggests that this peptide helps in managing and treating cartilage complications such as osteoarthritis and osteoporosis.
Is AOD9604 Legal?
Surprisingly, owing to the clinical research augmented by strong anecdotal evidence, AOD9604 is an FDA-approved drug and is preached as a potent anti-obesity medication.
Because it falls into the FDA’s Generally Recognized As Safe Program (GRAS) category, you can surely use the peptide without worrying about legal issues.
Who Should Use AOD9604?
Because other prospective benefits of AOD9604 are still under-research, I would only recommend AOD0604 to people looking for anti-obesity medication and who want to get rid of their excess body weight.
Forms of AOD9604
You will find most of the peptides available in powder form that need to be reconstituted before you can inject them.
You can also find the spray version of AOD9604 on some of the local vendors.
How To Use AOD9604
Using AOD9604 is no different than injecting other usual peptides. However, if you are new to this, I would suggest you to open the link and read the detailed guide on ‘how to inject peptides.’
AOD9604 Dosage and Cycle
The exact dosage of AOD9604 will largely depend on how much weight you really want to lose. It is better if you consult your primary physician regarding the specific dosage guidelines.
Nonetheless, clinical trials and user experiences have suggested that administering 300mcg of the peptide has been really effective for people.
However, make sure to not exceed the dosage range of 500mcg to 600mcg per day because you might risk experiencing adverse effects.
Also, make sure to only use it continuously for 20 days and then take a break.
Best Time to Take AOD9604
Although this is a subjective question, you are advised to use this peptide in the morning prior to your breakfast. This is because it will help to metabolize the food well throughout the day and help you burn calories rather than stacking them.
Side Effects of AOD9604
Because AOD9604 is approved by FDA, you don’t have to worry about experiencing many adverse effects.
Headache, GIT issues such as indigestion, nausea, redness and swelling are some of the side effects you may experience after using this peptide (5).
It is recommended to not overdose on this peptide because that can seriously disturb your overall metabolism.
Also, if you have any preexisting conditions or you already use other medications, it is advisable to consult with your doctor before really using AOD9604 as it may have some serious interactions inside your body.
User Reviews and Experiences
I must say that user reviews on AOD9604 are quite mixed. Although this peptide is backed up by scientific evidence, anecdotal evidence is not really great, but one can really get an idea of the efficacy and effectiveness of the peptide after reading user experiences.
However, i did see some of the reviews reporting some side effects after using the peptide.
One of the users said,
“I tried it, it was honestly a good feeling drug. I would compare the fat loss effects similar to that of HGH frag 176-191. No noticeable side effects other than some PIP (which is weird because I’ve injected plenty of times before). In terms of labs, there was a negligible change compared to my pre cycle bloods.
Based off my experience, and my experience alone, I can say it works (as long as you also work of course).
I’d rate it a 6.5 on the fat burning scale.”
One of the other users said,
Been taking AOD9604 nasal spray for a few weeks. Fat loss has been pretty incredible however been getting lots of headaches, feels a bit like a very weak migraine constantly.
Is this a normal side effect? Or is the product potentially impure? Not sure whether to continue or not as feels a little worrying.”
Stacking AOD9604 with other intense fat-burning peptides can really yield phenomenal results in terms of improving weight loss.
AOD9604 and Semaglutide
Semaglutide is an FDA-approved glucagon-like peptide-1 receptor agonist (GLP-1 RA) that is sold in the market under 3 different brand names.
This peptide regulates the levels of hormones involved in the metabolic pathways such as insulin and glucagon. This results in lower blood sugar levels and ultimately leads to weight loss as confirmed by one of the clinical trials where subjects reported a 15% loss in body weight.
Being FDA-approved implies that this peptide is often prescribed to patients diagnosed with diabetes mellitus, hypertension, or hypercholesterolemia.
People often use AOD9604 and Semaglutide to achieve better results within no time.
Where to Buy AOD9604?
There were a couple of good online vendors offering this peptide, but most of them have been discontinued due to various reasons.
Nonetheless, I have still tried to find a good vendor that you can purchase AOD9604 from.
AOD9604 vs Other Compounds
AOD9604 vs HGH
One thing that needs to be clear is that AOD9604 is a derivative of human growth hormone. Structurally, AOD9604 comprises of the amino acids ranging from 176-191 of the HGH segment.
The specific peptide fragment 176-191 regulates fat metabolism and targets fat cells, thus resulting in fat burning and weight loss.
AOD9604 vs CJC 1295/Ipamorelin
Now, if you know about peptides a bit, I am sure that you must have heard about stacking CJC 1295 with Ipamorelin to achieve optimal weight loss.
Both CJC 1295 and ipamorelin mimic the action of growth hormone-releasing hormone (GHRH), and in turn, stimulate the release of growth hormone (GH) from the anterior pituitary gland.
The subsequent release of growth hormone (GH) results in binding to adipocytes, thus promoting fat metabolism and leading to weight loss.
In order to achieve optimal weight loss, it is recommended to take 250/100mcg of CJC-1295 and Ipamorelin stack for 12 to 16 weeks to see effective results in losing weight and acquiring a slim body.
Is AOD9604 Legit?
While scientific evidence greatly backs up AOD9604, it is a bit difficult to make the right interpretation from user experiences.
AOD9604 definitely falls into FDA’s GRAS category and definitely triggers a fat loss in individuals by regulating fat metabolism, but user reviews have been mixed as some people didn’t really experience any significant effects.
If you were to take my opinion, there are better alternatives available in the market that can aid you in your weight loss journey, such as Semaglutide and 5-Amino-1MQ.
Does AOD 9604 work for weight loss?
One of the most notable benefits that AOD 9604 brings is the ability to help regulate blood sugar and manage insulin levels. This, in turn, will aid inflammation and weight loss.
How long does it take AOD 9604 to work?
Usually, the effects of AOD 9604 take action after 12 weeks.
What is the half-life of AOD 9604?
AOD9604 had a very short half-life of only approximately 3 min after IV injection. At 12 min past IV injection, almost all of the AOD9604 had cleared from the blood plasma, resulting in a relatively small AUC.
Does AOD 9604 need to be refrigerated?
Once reconstituted, it must be stored in the refrigerator.
What are the side effects of AOD 9604?
In short-term studies, some obese people injected with AOD-9604 experienced headaches, chest tightness, palpitations, and euphoric feelings, which were considered to be drug-related.
Is AOD 9604 a steroid?
One of the most researched types is AOD 9604, a synthetic analog of the human growth hormone, or HGH.