Best Injectable Anti-Aging Peptides

Anti aging peptides have existed in the market for quite some time now and are in frequent use by people. These peptides help you live longer and healthier by delaying the onset of your aging at cellular and molecular levels. Read more to find out my top 5 recommendations for anti aging peptides!
Medically reviewed by Dr. Mohammed Fouda
Dr. Fouda uses his extensive knowledge and expertise as an academic scholar to medically review articles for scientific accuracy and credibility, ensuring that the medical information presented is up-to-date and trustworthy. He is responsible for ensuring the quality of the medical information presented on our website.

I know how agonizing it is to look in the mirror and see yourself getting old with every passing day. Even the slightest idea of aging gives sheer anxiety to some people, and for others, it’s the outlook that accompanies the process of aging that distresses them. 

Ever wondered what aging looks like? Let me paint a picture for you.

Your temporary hair gets white; you no longer feel energetic; you start to lose the charm you once had; you are forced to take a back seat because your body no longer supports you. That’s what aging looks like in a nutshell! 

But guess what?

The interplay of market demand and scientific research has developed some tried and tested peptides that delay the process of senescence in a very natural way and not only help you live longer in various ways but also enjoy your youth. 

Gear up to know about my top peptide picks in the anti-aging category, which you can consider. These top 5 peptides are based on my comprehensive research and understanding and the personal experiences of people who have already used them. So, let’s dive into it!

Warning: The content on Muscleandbrawn.com and the information included in this article is intended for entertainment and informational purposes only. It is not intended nor implied to be a substitute for professional medical advice. Prior to buying anything, check that it is compliant where you live with your current government laws. We frequently mention research chemicals that are not made for human consumption. Therefore, before purchasing any product for personal use, consult with your doctor or healthcare provider first.

Key Takeaways: 

  • Epitalon works by increasing the activity of the telomerase enzyme. This leads to more new cells and reviving of older ones. 
  • CJC 1295 and Ipamorelin work by enhancing the growth hormone levels from the pituitary gland, leading to various benefits such as fat loss, increased muscle mass, increased collagen production, and reduce wrinkling of the skin
  • Sermorelin stimulates the production of HGH. It helps thicken hair and nails and alleviates wrinkling of the skin. 
  • BPC-157 works majorly by enhancing the angiogenesis and regeneration of new cells. This helps reduce and reverse aging. 
  • Thymosin Alpha-1 is a unique peptide that works by making your immune system more robust and potent. 

What are The Best Anti Aging Peptides?

#1 Epitalon

Epitalon is a synthetic peptide and putative anti-aging drug, which was identified as the putative active component of epithalamin (a bovine pineal gland extract) (1, 2, 3).

Epitalon is composed of 4 essential amino acids (Ala-Glu-Asp-Gly) (4). These amino acids make Epitalon the ‘fountain of youth.’ 

Epitalon is a telomerase activator. Telomerase is an enzyme within the cells that helps keep them alive by adding DNA to telomeres (the ends of chromosomes) (5).

Users recommend using 5-10 mg of Epitalon per day. However, Epitalon is not FDA-approved and therefore, before using it for personal purposes consult with your healthcare provider first.

Epitalon Summary

Epitalon

Epitalon, also commonly known as Epithalon peptide or Epithalone is a synthetic tetrapeptide with four amino acids in its structure.

This synthetic peptide was originally discovered by Russian scientist Vladimir Khavinson. Since then most of the clinical studies centered around Epitalon were carried out at the St. Petersburg Institute of Bioregulation and Gerontology.

Epitalon is a synthetic telomerase activator enzyme that upregulates the synthesis of telomerase enzyme by the pineal gland. Thus, telomeres at the end of chromosomes are renewed and more telomeres are available at the tips of DNA strands even after a cell divides repeatedly.

Besides, Epitalon treatment also stimulates melatonin production as well as regulates its secretion. This helps restore normal circadian rhythm as melatonin secretion is a critical chemical that balances the sleep/wake cycle.

Some human clinical studies also suggest that this synthetic pineal peptide Epitalon also modulates the blood levels of gonadotropins.

Epithalon Overview

⭐️ Top Benefits: Anti-aging and better sleep
🧪 Form: Injectable liquid
⌛️ Max Time Used: 2 – 3 Weeks
💰 Average Cost: $86.99
❤️‍🩹 Side Effects: Nausea and stomach discomfort
☢️ Dangers: Not really
📚 Best Peptide Stack: HGH / IGF-1
⚤ Men/Women: Men and women
➡️ Go to the Full review

  • Anti-aging
  • Better sleep
  • Nausea
  • Stomach discomfort

#2 Anti-Aging Peptide CJC-1295/Ipamorelin Combo

CJC 1295 is a synthetic analog of growth hormone-releasing hormone, comprising 30 amino acids. With this peptide, there’s increased stimulation of the anterior pituitary gland, leading to enhanced levels of growth hormones and insulin-like growth factor-1 (IGF-1). 

CJC 1295 is one of the peptides that leads to a wide range of systemic effects in the body. With this supplement, you have a better chance of reducing excess fat, gaining muscles, progressing rapidly in wound healing, and regulating mood and sleep. 

Moreover, with CJC 1295, you also experience anti-aging properties, such as producing more collagen and alleviating wrinkles.

CJC 1295 is often recommended to be stacked with Ipamorelin, a growth hormone secretagogue. Ipamorelin, like CJC 1295, causes an increase in the stimulation of growth hormones in the body. 

For effective results, an intake of 250/100mcg of CJC 1295 and Ipamorelin is suggested for 12 to 16 weeks.

10% off with BP10

Before and After

Read Full Biotech Peptides Review

  • Increases growth hormone
  • Enhanced muscle mass and protein synthesis
  • Pain, redness, and flushing of the face can be experienced after the injection

#3 Anti-Aging Peptide: Sermorelin

Sermorelin is one of the standard peptides that work by stimulating increased levels of human growth hormone (HGH). With enhanced levels, HGH can promote growth development. It is reported that after the age of 30, there’s a natural decline in the production of growth hormones. 


Although Sermorelin isn’t a substitute for HGH, it indeed does help reverse aging. With Sermorelin, you get the chance to reignite the youthful aura you once had. It helps to thicken your hair and nails, glowing skin, and many more. Other effects of Sermorelin therapy include increased muscle mass, rapid recovery, and perhaps improved libido. 


It is recommended to administer 0.2-0.3 mcg once daily at bedtime through subcutaneous injections. 

#4 Anti-Aging Peptide: Sermorelin

Sermorelin Summary

Sermorelin

Sermorelin, an acetate salt, is a synthetic peptide containing 29 Amino acids. This artificial peptide (GRF 1-29 NH2) mimics the action of naturally occurring growth hormone-releasing hormone (GHRH) composed of 44 Amino acid residues.

The growth hormone-releasing hormone receptors (GHRHr) are located in the anterior pituitary gland. Sermorelin binds with these receptors to trigger the increased production and secretion of growth hormone (GH) by somatotroph cells.

As feedback mechanisms maintain the hormonal levels, the increased serum concentration of growth hormone (GH) stimulates another endogenous hormone called somatostatin, also known as growth hormone inhibiting hormone (GHIH).

Growth hormone inhibiting hormone (GHIH) initiates a negative feedback mechanism to stop the secretion of any more growth hormone (GH) by the somatotroph cells so that hormonal levels don’t overshoot.

Thus, sermorelin makes sure to keep the entire homeostatic coordination of the hypothalamus-pituitary-somatostatin intact.

Apart from this, sermorelin also improves the sleep-related circadian rhythm by reducing the production of stress hormones. This further amplifies the release of growth hormone (GH).

Sermorelin Overview

⭐️ Top Benefits: Increases natural HGH production
🧪 Form: Injectable liquid
⌛️ Max Time Used: Up to 3 months
💰 Average Cost: $42.99
❤️‍🩹 Side Effects: Insulin resistance
☢️ Dangers: Not really
📚 Best Peptide Stack: HGH / IGF-1 / GHRP / CJC-1295
⚤ Men/Women: Men and women
➡️ Go to the Full review

  • Enhanced muscle growth
  • Efficient healing of wounds
  • Reduces body fat
  • Better sleep quality
  • Improves brain functioning
  • Cardiovascular growth
  • Injection site pain
  • Insulin resistance
  • might experience headaches, nausea, dizziness, flushing, allergic reactions, loss of taste, hyperactivity, and paleness of skin

#3 Anti-Aging Peptide: Thymosin Alpha-1

One of the best ways to reverse anti-aging is through a more robust and vigorous immune system. Thymosin Alpha-1 is just the right kick your immune system requires that can help fight illnesses beyond usual viral infections. 

This peptide works by augmenting the functions of T cells in our body and maintaining the levels of cytokines for immunity.  

The standard dose for Thymosin Alpha-1 ranges from 0.8-6.4 mg. 

10% off with BP10

Read Full Biotech Peptides Review

  • Improved adaptive immunity 
  • Has antiviral and antibacterial properties
  • Redness and swelling are expected at the site of injections

What are Peptides?

Peptides are short chains of amino acids, the latter being the building blocks of proteins. The unique sequencing of amino acids in each peptide helps distinguish them based on their varying physiological processes. 

With today’s escalating innovation and development, it is prevalent for people to undergo peptide therapy for varying reasons. It is believed that the use of peptides goes back to 1921, with the development of synthetic insulin. Since then, the use of more than 80 peptide drugs has been approved. Quite fascinating! 

How Are Peptides Useful for Anti-Aging?

As mentioned above, the unique arrangement and presence of different amino acids in a peptide are responsible for how it functions. Each one has a different physiological action on the body, leading to distinct pros and cons. 

Best Anti-Aging Peptides
Figure 1: As we age, we see a reduction in HGH and IGF-1 levels, both of which are detrimental to health

Tons of people are looking for ways to keep their skin from aging or even minimize the apparent signs of aging, such as wrinkling and sagging of skin at best. 

As you age, your body becomes less equipped when synthesizing collagen and elastin, the proteins that maintain the integrity of the skin. One of the efficient ways to reverse the signs of aging is through peptide therapy

Anti-aging peptides are short sequences of proteins that can imitate the actions of proteins such as collagen and elastin, stimulating their natural production in the body. 

It is also reported that peptides can enhance your body’s production of melanin, a skin pigment. With increased levels of melanin, you can protect your skin from sun damage and further alleviate the signs of aging. 

Specific peptides administered topically can mitigate wrinkle formation, make your skin more firm and robust, and possibly enhance blood flow and perfusion. These peptides are small enough to penetrate the skin and have more pronounced effects. 

Benefits of Anti-Aging Peptides 

Peptides play an extensive role when it comes to your body! They are the building blocks of proteins essential for the body’s normal functioning. Nonetheless, peptides can also lead to additional benefits. 

Peptides are often accompanied by anti-inflammatory properties, keeping your body from unnecessary damage. 

Best Injectable Anti-Aging Peptides
Figure 2: One of the best benefits of Peptides is the massive recovery boost you get from connective tissue

They help build lean muscle mass and healthy weight to make you look younger and stronger. 

Peptides can mimic the action of collagen and elastin, the two most important proteins that aid in maintaining skin integrity. 

Some peptides also provide quicker relief from wounds and maximize healing, thereby limiting the damage. 

Finally, anti-aging peptides also help increase blood flow and perfusion, especially in the skin, making it look younger and less dry. 

This one is quite a tricky question to answer. Peptides are used for various purposes; therefore, the legality of each type differs. 

Most peptides that have hormonal components can only be prescribed by doctors and are completely prohibited for over-the-counter self-medication by the FDA. However, a total of 239 peptides for therapeutic purposes were approved for clinical use by the FDA. 

Who Should Use Anti-Aging Peptides?

Anyone can indeed use anti-aging peptides or any peptides. I understand how intimidating it can be when adding new supplements to your regimen. The potential side effects and unpleasantness can keep anyone awake at night. 

Best Injectable Anti-Aging Peptides
Figure 3: Peptides are quite common in the elderly and aging population

However, with peptides, you’ve got nothing to worry about! Most of them are completely safe and do not pose any harm. However, topical peptides are contraindicated in cases of skin allergies. In my opinion, one shouldn’t wait for their skin to break out; instead, they should start using peptides in their early 20s and make the most of it. 

Forms of Anti-Aging Peptides 

Most anti-aging peptides usually come in serums or topical creams due to the rapid transdermal mode of action. You may find these peptides in injections, pills, or tablets. Significantly, the dose of each form can differ, so do look out for it. 

Are Anti-Aging Peptides Legit? 

With all of this discussion regarding peptides and, specifically, the anti-aging ones, it’s pretty clear they are as legit as they can be. Anti-aging peptides provide numerous benefits, such as anti-inflammatory properties, rapid wound healing, stimulation of collagen and elastin, more blood flow, and minimizing wrinkles. 

Peptides are the safest way you can supplement your body with. With next to no side effects and a more straightforward regimen, using peptides can be life-transforming for you.

However, it’s always the best idea to get in touch with your doctor and rule out any allergies or hindrances before you start using peptides. 

At what age should you start to use anti-aging peptides? 

Peptides can be included in your daily regimen as early as your 20s and 30s

How long do anti-aging peptides take to work on the skin?

It can take around 3 to 6 months of continuous peptide therapy for its effects/benefits to be visible.

How much do anti-aging peptide injections cost?

It is reported that peptide injections can cost anywhere between $100 to $300. However, you should expect the prices to differ for different stores and brands.

Can anti-aging peptides be taken orally?

Due to the fear of enzymatic degradation of peptides with oral intake, it is usually not opted for. However, scientists are trying to find ways for this to be avoided via oral administration.

Where do you put anti-aging peptides in a routine?

The best way to use a peptide serum is after an exfoliating toner and before a face moisturizer.

Still Have Questions?

Drop us a comment down below and one of our expert coaches will respond to it. We’ll also be answering questions on our Instagram!

1) https://pubmed.ncbi.nlm.nih.gov/14501183/
2) https://pubmed.ncbi.nlm.nih.gov/12937682/
3) https://pubmed.ncbi.nlm.nih.gov/16352683/
4) https://pubmed.ncbi.nlm.nih.gov/19386527/
5) https://pubmed.ncbi.nlm.nih.gov/18031173/

Contributors

Kumar Rathi

Kumar Rathi | Writer

Kartik is a medical student with a passion for anatomy and physiology. He writes research papers, articles and blogs to raise awareness and also has a strong interest in teaching and public speaking. Aspiring to be a successful cardiologist, Kartik believes in connecting with people on a personal level and is an expert in peptides.

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Dr. Mohammed Fouda

Dr. Mohammed Fouda | Reviewer

Dr. Fouda uses his extensive knowledge and expertise as an academic scholar to medically review articles for scientific accuracy and credibility, ensuring that the medical information presented is up-to-date and trustworthy. He is responsible for ensuring the quality of the medical information presented on our website.

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