Growth hormone-releasing peptides (GHRPs) have been in the market for quite a long now. People with growth hormone deficiency or young people aspiring to be bodybuilders use various growth hormone-releasing peptides (GHRPs) or their mimetics.
Growth hormone-releasing peptides (GHRPs) essentially trigger the release of growth hormone from the anterior pituitary gland. The widely used growth hormone-releasing peptides (GHRPs) are GHRP-2 and GHRP-6.
Research suggests that they are highly effective in their action of elevating the plasma levels of the growth hormone (GH) and have both been effective with better efficacy.
Although both the peptides are similar in some ways, pharmacodynamics and pharmacokinetics suggest considerable differences between the two.
In this review, I will dig into everything that you should know about GHRP-2 and GHRP-6 so that you can make the right bodybuilding choice for yourself!
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What is GHRP-2 and GHRP-6?
What is GHRP-2?
GHRP-2, a growth hormone-releasing peptide, more commonly known as Pralmorelin, is a synthetic growth hormone secretagogue (GHS). It is a hexapeptide containing 6 amino acids in the following specific sequence “H-D-Ala-D-2-Nal-Ala-Trp-D-Phe-Lys-NH2” (1).
What is GHRP-6?
GHRP-6, another growth hormone-releasing peptide, is also a synthetic growth hormone secretagogue (GHS). It contains 28 amino acids in a specific sequence, and structural studies also suggest that GHRP-6 contains unnatural D-amino acids (2). This gives the peptide its specific characteristic properties.
GHRP-6 has been in the market for more than a decade now, while GHRP-2 is a relatively new synthesis and is currently being studied (3).
Since both belong to the category of growth hormone secretagogues (GHS), they increase the serum levels of growth hormone (GH).
How Do GHRP-2 And GHRP-6 Work
How Does GHRP-2 Work
Being a growth hormone secretagogue (GHS), it binds to the growth hormone secretagogue receptor (GHS-R), which results in an increased natural secretion of growth hormone (GH) from the anterior pituitary gland (4).
GHRP-2 also works by suppressing the release of somatostatin, which is also called a growth hormone-inhibiting hormone (GHIH). As the somatostatin levels fall, the negative feedback system won’t remain intact, and growth hormone (GH) levels would spike substantially (5).
GHRP-2 is a potential agonist of the GHRP-2. As GHRP-2 works by activating the naturally occurring endogenous ligand ghrelin, it greatly stimulates appetite and hunger. Ghrelin activation also supplements further release of growth hormone (GH).
GHRP-2 also seems to slightly increase the serum levels of hormones such as prolactin, ACTH, and cortisol.
How Does GHRP-6 Work
Although GHRP-6 also stimulates the release of growth hormone (GH), it follows a slightly different pathway.
As discussed earlier, ghrelin, a naturally occurring peptide in the gut, can trigger the release of growth hormone (GH) upon activation.
GHRP-6 activates the ghrelin by binding to ghrelin receptors, which sends signals to the anterior pituitary gland for an increased release of growth hormone (GH) (6).
GHRP-6 also inhibits the expression of somatostatin. As somatostatin falls, there is no signaling pathway that can regulate growth hormone levels (GH). Hence, the blood levels of growth hormone (GH) increase substantially (2).
Increased growth hormone (GH) release by GHRP-6 also leads to a higher release of insulin growth factor-1 (IGF-1) by the liver (2). IGF-1 is an anabolic hormone, which is critical in growth and development.
Where Can I Buy GHRP-2 And GHRP-6?
I would personally recommend buying any of the peptides from brands like Pure Rawz. They offer economic, reliable, and authentic peptides and have been in this market for quite some time now.
Benefits of GHRP-2 and GHRP-6
Benefits Of GHRP-2
The increased release of growth hormone (GH) stimulates the growth and proliferation of muscle cells, which eventually leads to an increase in muscle mass (7).
Perhaps most bodybuilders prefer this peptide because of its tremendous ability to cause a reduction in body fat by carrying out lipolysis, which results in improved lean body composition.
Results from studies suggest that GHRP-2 helps in retaining calcium levels in the body. As we all know how calcium plays an integral role in our musculoskeletal strength because it causes adequate mineralization, so with increased calcium levels, one can have strong bones and joints.
Increased growth hormone (GH) levels lead to quick healing from injuries as it helps to stimulate the production of new cells at the site of injury.
It is also hypothesized that GHRP-2 decreases the inflammation of the liver.
The release of growth hormone (GH) also improves the sleep rhythm of an individual, leading to enhanced energy and productivity overall.
Benefits Of GHRP-6
Some of the benefits that GHRP-6 offers are the same as GHRP-2, such as increased muscle growth along with enhanced overall strength. It also helps in the quick healing of injuries like GHRP-2.
GHRP-6 decreases body fat significantly and makes it easier for individuals to lose weight.
As GHRP-6 triggers the secretion of Insulin growth factor-1 (IGF-1), it results in many anabolic effects on the body. GHRP-6 influences hair growth by making them stronger.
GHRP-6 also seems to enhance brain functioning by protecting the neurons and also stimulating the synthesis of new ones (8).
GHRP-6 enhances the normal skin appearance by protecting against all the wrinkles, thereby smoothing them.
This peptide is also seen to increase libido and improve sexual desires amongst individuals.
There is also strong evidence that suggests that GHRP-6 enhances immune function and minimizes cardiovascular problems.
Such a widespread action of GHRP-6 is because it can bind to ghrelin receptors, which are located on peripheral organs as well, such as the heart, testes, and skeletal muscles.
Are GHRP-2 And GHRP-6 Legal?
Is GHRP-2 Legal?
GHRP-2 is only legal for research or laboratory purposes so far. FDA hasn’t allowed GHRP-2 to be available for human consumption at the moment.
But as a lot of recent studies are being done so far on GHRP-2, you can expect it to be available sooner or later.
Is GHRP-6 Legal?
The answer for GHRP-6 legality is similar to the one for GHRP-2. It isn’t an FDA-approved drug yet but is available in the market for research purposes.
Who Should Use GHRP-2 And GHRP-6?
As both of the peptides eventually stimulate the release of growth hormone (GH), anyone with growth hormone (GH) deficiency should try out any of these peptides to cope up.
If you are a bodybuilder or an athlete, you are ofcourse more prone to injuries. GHRP-2 and GHRP-6 offer a solution to your injuries. It offers a side advantage of offering you quick healing from wounds.
Supplement your intense workout sessions with any of these peptides, and you will see your overall body changing with significant muscle growth, enhanced endurance, and stamina!
Perhaps if you are planning for weight loss, you should definitely consider these two peptides.
Also, make sure to check out GHRP-2 and GHRP-6 if you have undergone any injury and looking for a quick recovery.
How To Use GHRP-2 And GHRP-6?
The details about the usage of both the peptides are quite the same.
If you are a fan of oral intake, then there is good news. You can purchase capsules depending on your dosage and cycling guidelines.
Perhaps the most common mode of intake is the injectable form. Use the subcutaneous method of injection, and administer it in a flesh/muscular area. Most health experts recommend injecting it near the stomach or abdominal area.
If you are planning to use GHRP-2, avoid eating one hour prior to and after the administration of peptide therapy. This is to ensure effectiveness in the body.
If GHRP-6 is on your list, special instructions are to avoid eating or drinking for at least 30 minutes before and after the peptide therapy.
Also, avoid the intake of carbohydrates and fats before GHRP-6 therapy. This is because higher levels of sugar is seen to interfere with the efficiency of GHRP-6.
Forms Of GHRP-2 And GHRP-6
You can buy the injectable forms of GHRP-2 and GHRP-6 from any online store. Most people prefer injectable forms also because research suggests that hormonal therapies are more effective when administered via injections.
If you are a person who is afraid of needles, perhaps you can purchase the oral form of intake, which is capsules. Capsules are relatively easy to consume as well because you can put them close to your bed to minimize the chances of skipping any dose.
A good thing is GHRP-2 can also be administered via the intranasal pathway. So, you just have an extra option if you have decided on GHRP-2.
GHRP-2 And GHRP-6 Dosage
The recommended dosage guidelines are between 150mcg-300mcg. You can split the dosage into 1-3 equal turns, depending on your preference and also the reason for intake.
For example, if your goal is athletic advancement, go for 300mcg. If your goal is rather anti-aging, you can take 150mcg before going to bed.
The guidelines for GHRP-6 are around 100mcg-150mcg of intake. Your frequency of intake can vary from one to four times per day. Just make sure to follow any prerequisites for the GHRP-6 peptide therapy.
GHRP-2 And GHRP-6 Cycling
The typical cycle for GHRP-2 and GHRP-6 should last somewhere between 12-14 weeks. Going beyond 16 weeks might result in experiencing some side effects.
GHRP-2 And GHRP-6 Stack
Both peptides can be used with a couple of other growth hormone secretagogues (GHS) to experience maximum synergistic benefits.
People have stacked GHRP-2 with Sermorelin and have enjoyed a wide array of benefits. There are incidences of people using GHRP-2 with ipamorelin and TB-500 and enjoying tremendous benefits.
GHRP-6 with CJC-1295 is also known to trigger an increased release of growth hormone (GH), and CJC-1295 have known to improve the potency of GHRP-6.
GHRP-2 And GHRP-6 Experiences
As both the peptides are still not legalized to be used, I could only find reviews from discussions forums like Reddit.
So, let’s read out what people had to save about both of these peptides individually.
“…I’ve noticed an increase in strength and lean muscle, was curious how long it would stick around with continued heavy training, proper diet/sleep.”
Leo 1567 says,
“GHRP 2 is a bit better since it’s not as sloppy in prolactin and cortisol release, but I think IPA/CJC is better long term.”
A short review by some anonymous person said,
“GHRP-6 is reliable.”
Most people had concerns about extreme hunger instigated by GHRP-6.
“GHRP-6 will make you eat the entire fridge. You will be staring at, say, a package of dry pasta and wondering whether you ACTUALLY need to take the time to cook it.”
Side Effects Of GHRP-2 And GHRP-6
Side Effects Of GHRP-2
Talking about the side effects, you might only experience mild side effects if you stay within the dosage limit.
You might feel a bit more hungry after taking GHRP-2. The users of GHRP-2 also report moderate levels of headache and fatigue.
Perhaps if your dosage overshoots, a feeling of numbness might be experienced in the limbs (9).
Side Effects Of GHRP-6
The biggest side effect of GHRP-6 can be weight gain. GHRP-6 really spikes the hunger levels in an individual.
Also, as we discussed how GHRP-6 influences other hormonal levels, higher cortisol in blood circulation can trigger joint pain (2).
GHRP-2 VS GHRP-6
After knowing about all the minute details about GHRP-2 and GHRP-6 individually, let’s summarize the bullets that make them differ from each other.
The structural differences will be quite obvious to you now if you have been with me through the start.
Pharmacokinetics suggest that GHRP-2 has a shorter half-life as compared to GHRP-6. This means that GHRP-6 can circulate in the bloodstream before being degraded.
Pharmacodynamical studies suggest that GHRP-2 is more potent and effective when compared with GHRP-6. This is because GHRP-2 stimulates the increased release of growth hormone (GH) relative to GHRP-6 (10).
This is perhaps one of the most distinguishing differences.
Also, one of the differences that can also be considered a side effect of GHRP-6 is that it increases the appetite to a higher extent. GHRP-2, on the other hand, doesn’t stimulate hunger to that level.
I am hopeful that with this much information at your disposal, you can easily decide for yourself which peptide should be your go-to option based on your personal goals and judgment.
Are GHRP-2 And GHRP-6 Legit?
After considering the results from the clinical trials so far, the prospective benefits of both the peptides seem to be legit. With minimal side effects, GHRP-2 and GHRP-6 bring a lot to the table for bodybuilders.
The relative efficacies, potency, and effectiveness in the body make these peptides worth an investment.
More research on both the peptides and subsequent approval by FDA will help gain the trust of the potential audience as well.
I would recommend using these peptides but make sure to stay within the dosage guidelines.
Does Ghrp 2 and Ghrp 6 build muscle?
These growth hormone secretagogues (GHS) promote GH secretion that increases body mass on muscles, with a substantial reduction in body fat.
How long Ghrp 6 takes to work?
It takes roughly 20-30 minutes after administering the dosage.
How long does Ghrp 2 last once mixed?
If you have reconstituted it, use it within 20 days. Otherwise, it can last for 2 years.
How long does Ghrp 2 take to work?
The plasma levels of growth hormone (GH) spiked within 20 minutes.
Is Ghrp 6 and 2 steroid?
No, both of them are growth hormone-releasing peptides.
Is Ghrp 6 oldest or Ghrp 2?
Ghrp 6 is the oldest available in the market, while Ghrp 2 is relatively new.