Best Peptides for Inflammation

Inflammation is not only a pain to deal with, but can make life unbearable and dangerous. Peptides seem like a good solution, let's look at how they work.

You know most of us go to the gym and try to keep ourselves in a good shape. We hear the word peptides and we all know about muscle tissue growth and muscle building.

But what is a healing peptide? What do we know about other benefits of peptides?

If you are curious to know, and you should be, let’s dicuss the Best Peptides for Inflammation.

Key Takeaways

  • Several proteins and peptides have demonestrated anti inflammatory properties.
  • There are several therapeutic peptides. So, you need to talk with your doctor first before taking any supplements.

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What Are Peptides?

Peptides consist of 2-50 amino acids, which are the “building blocks” of proteins. But a peptide doesn’t have as many amino acids as a protein does. [1, 2]

synthetic peptides can mimic some of those found naturally in the body. Some of these peptides are used for clinical conditions such as diabetes and multiple sclerosis. [1]

Peptides and peptidomimetics can function as immunomodulating agents by either blocking the immune system response or stimulating the immune system response to generate tolerance. [12]

Best Peptides for Inflammation

Anti Inflammatory Peptides

Inflammation is a natural defensive mechanism of our body as a response to toxic stimuli such as injuries and infections. [3]

The inflammatory response includes the production and secretion of pro-inflammatory mediators such as cytokines, chemokines, interleukins, and growth factors. [3]

Several proteins and peptides from egg, milk, soy, and plant, as well as from marine sources, demonstrated anti-inflammatory properties.

The treatment of inflammatory conditions based on the use of bioactive peptides as anti inflammatory agents, is being thoroughly investigated. [3]

BPC 157

Best Peptides for Inflammation

What Is BPC 157

Pentadecapeptide BPC 157, composed of 15 amino acids. It is a partial sequence of body protection compound (BPC) that is discovered in and isolated from human gastric juice. [9]

What Are the benefits of BPC 157?

Since superior protection against different gastrointestinal and liver lesions and antiinflammatory and analgesic activities were noted for pentadecapeptide BPC, the beneficial mechanism of BPC 157 and its likely interactions with other systems were studied. [11]

Angiogenesis

Angiogenesis is a natural and complex process controlled by angiogenic and angiostatic molecules, with a central role in healing process. [10]

Pentadecapeptide BPC 157 promotes healing demonstrating particular angiogenic/angiomodulatory potential. [10]

One of the most important modulating factors in angiogenesis is the vascular endothelial growth factor (VEGF). [10]

The angiogenic potential of BPC 157 seems to be closely related to the healing process in vivo with BPC 157 stimulating angiogenesis by up-regulating VEGF expression. [10]

Healing

It has been demonstrated to accelerate the healing of many different wounds. [9]

BPC 157 may resolve analogous nonhealing of wounds and persistent gastric ulcers better than standard agents. [11]

Bone, Tendon and Musculoskeletal Healing

One of the main benefits of BPC 157, is connective tissue repair and healing.

BPC 157 is one of the most commonly used peptides for treating joint pain, inflammation, strains, sprains and tendon injuries.

BPC 157 promotes the ex vivo outgrowth of tendon fibroblasts from tendon explants, cell survival under stress, and the in vitro migration of tendon fibroblasts, which is likely mediated by the activation of the FAK-paxillin pathway. [9]

It can also stimulate the tendon cells to produce more receptors which can bind to growth signaling molecules in order to speed up both growth and repair.

BPC 157-induced increase of growth hormone receptor in tendon fibroblasts may potentiate the proliferation-promoting effect of growth hormone and contribute to the healing of tendon.

BPC 157 also optimizes the spread of fibroblasts that play a key role in collagen synthesis, an essential and abundant structural protein found in the human body.

Damaged bone also undergoes a regeneration process after being treated with adequate doses of BPC 157. This occurs as a result of increased fibroblast growth.

Anti inflammatory Actions in the Gastrointestinal System

It is been demonestrated that BPC 157 has greater anti-ulcer potential and efficiency in to enhance wound healing compared with standard agents. [11]

It also showed encourging and efficient results in inflammatory bowel disease. [11]

BPC 157 promptly improves both skin and stomach mucosa healing, and closure of fistulas, with no leakage after up to 20 ml water intragastrically. [11]

TB 500

Best Peptides for Inflammation

What Is TB 500?

TB 500 is the one of the best healing peptides.

TB-500 is a synthetic version of the naturally occurring peptide LKKTETQ which is the active site within thymosin β4, responsible for actin binding, cell migration and wound healing. [7]

The key ingredient of TB-500 is the peptide LKKTETQ. [7]

Thymosin β4 is a highly conserved, naturally occurring, water-soluble regenerative peptide that is found in all tissues and in all cell types, except red blood cells. [5]

It is also found in, tears, saliva, cerebrospinal fluid, wound fluids and blood. Both platelets and leukocytes release Thymosin β4 into the wound fluid. [5]

Although Thymosin β4 contains only 43 amino acids, it appears to have a wide range of regenerative activities. [5]

How Does TB 500 Work?

Thymosin β4 is a small peptide with G actin-sequestering action. [6]

It is associated with induction of angiogenesis, accelerated wound healing, and increased metastatic potential of tumor cells. [6]

Thymosin β4 promotes angiogenesis, wound repair, and hair growth in normal and aged rodents. [6] It acts by increasing angiogenesis and cell migration and is currently in clinical trials for wound repair. [6]

Both chemically synthesized and recombinant forms have shown efficacy for dermal healing in preclinical models and in human patients. [5]

Thymosin β4 has shown repair and regenerative activity in dermal injury traumatic brain injury, spinal cord injury, stroke, multiple sclerosis, ischemic limbs, and cardiac damage due to ischemia. [5]

The first study to show that Thymosin β4-promoted tissue repair was a dermal study performed in rats. [5] It had been found to promote angiogenesis and was reported to be high in platelets [5]

TB-500 is thought to promote endothelial cell differentiation, angiogenesis in dermal tissues, keratinocyte migration, collagen deposition and decrease inflammation. [7]

Thymosin β4 has multiple biological activities such as down-regulation of inflammatory chemokines and cytokines, and promotion of cell migration, blood vessel formation, cell survival, and stem cell maturation. [8]

All of these activities contribute to the multiple wound healing properties that have been observed in animal studies. [8]

ARA 290

Best Peptides for Inflammation

ARA 290 is an 11-amino acid peptide modeled from the three dimensional structure of helix B of the erythropoietin (EPO) molecule that interacts with the innate repair receptor (IRR). [4]

ARA 290 has been evaluated extensively in a wide spectrum of preclinical models, including diet-induced insulin resistance, diabetic retinopathy, diabetic autonomic neuropathy, myocardial infarction, chronic heart failure, burns, traumatic brain injury and shock-induced multi-organ failure. [4]

some studies suggest this product gets into the central nervous systemextremely quickly, extremely fast, and lowers inflammation at the pain point rapidly.

The results of these studies show that ARA 290 prevents tissue injury, reduces inflammation and activates healing. [4]

To date ARA 290 has been shown to be safe when formally evaluated in preclinical animal toxicology, normal human volunteers and patients with sarcoidosis. [4]

Diabetic painful neuropathy has been shown to be mediated via an inflammatory chemokine pathway and strategies to reduce this inflammation have been shown to alleviate pain. [4]

In preclinical models of neuropathy, ARA 290 has been shown to prevent and improve peripheral neuropathic pain, an action that requires the innate repair receptor. [4]

In these events, ARA 290 is not acting as an analgesic, but rather reduces the underlying inflammation and stimulates nerve fiber regrowth from damaged axons. [4]

Recent studies of patients with sarcoidosis have shown that ARA 290 reduces neuropathic symptoms in conjunction with an increase of small nerve fibers. [4]

What Are Peptides? https://www.webmd.com/a-to-z-guides/what-are-peptides

What to know about peptides for health https://www.medicalnewstoday.com/articles/326701

La Manna, S., Di Natale, C., Florio, D., & Marasco, D. (2018). Peptides as Therapeutic Agents for Inflammatory-Related Diseases. International journal of molecular sciences, 19(9), 2714. https://doi.org/10.3390/ijms19092714

Brines, M., Dunne, A. N., van Velzen, M., Proto, P. L., Ostenson, C. G., Kirk, R. I., Petropoulos, I. N., Javed, S., Malik, R. A., Cerami, A., & Dahan, A. (2015). ARA 290, a nonerythropoietic peptide engineered from erythropoietin, improves metabolic control and neuropathic symptoms in patients with type 2 diabetes. Molecular medicine (Cambridge, Mass.), 20(1), 658–666. https://doi.org/10.2119/molmed.2014.00215

Chapter Eleven - Thymosin β4 Promotes Dermal Healing https://www.sciencedirect.com/science/article/pii/S008367291630005X

Thymic hormones https://www.sciencedirect.com/science/article/pii/B9780444537171001906

Ho, E. N., Kwok, W. H., Lau, M. Y., Wong, A. S., Wan, T. S., Lam, K. K., Schiff, P. J., & Stewart, B. D. (2012). Doping control analysis of TB-500, a synthetic version of an active region of thymosin β₄, in equine urine and plasma by liquid chromatography-mass spectrometry. Journal of chromatography. A, 1265, 57–69. https://doi.org/10.1016/j.chroma.2012.09.043

Philp, D., & Kleinman, H. K. (2010). Animal studies with thymosin beta, a multifunctional tissue repair and regeneration peptide. Annals of the New York Academy of Sciences, 1194, 81–86. https://doi.org/10.1111/j.1749-6632.2010.05479.x

Chang, C. H., Tsai, W. C., Lin, M. S., Hsu, Y. H., & Pang, J. H. (2011). The promoting effect of pentadecapeptide BPC 157 on tendon healing involves tendon outgrowth, cell survival, and cell migration. Journal of applied physiology (Bethesda, Md. : 1985), 110(3), 774–780. https://doi.org/10.1152/japplphysiol.00945.2010

Brcic, L., Brcic, I., Staresinic, M., Novinscak, T., Sikiric, P., & Seiwerth, S. (2009). Modulatory effect of gastric pentadecapeptide BPC 157 on angiogenesis in muscle and tendon healing. Journal of physiology and pharmacology : an official journal of the Polish Physiological Society, 60 Suppl 7, 191–196.

Skorjanec, S., Dolovski, Z., Kocman, I., Brcic, L., Blagaic Boban, A., Batelja, L., Coric, M., Sever, M., Klicek, R., Berkopic, L., Radic, B., Drmic, D., Kolenc, D., Ilic, S., Cesarec, V., Tonkic, A., Zoricic, I., Mise, S., Staresinic, M., Ivica, M., … Sikiric, P. (2009). Therapy for unhealed gastrocutaneous fistulas in rats as a model for analogous healing of persistent skin wounds and persistent gastric ulcers: stable gastric pentadecapeptide BPC 157, atropine, ranitidine, and omeprazole. Digestive diseases and sciences, 54(1), 46–56. https://doi.org/10.1007/s10620-008-0332-9

"Structure-Based Design of Inhibitors of Protein-Protein Interactions: Mimicking Peptide Binding Epitopes". Angewandte Chemie. 54 (31): 8896–927. doi:10.1002/anie.201412070. PMC 4557054. PMID 26119925.

Gokhale AS, Satyanarayanajois S. Peptides and peptidomimetics as immunomodulators. Immunotherapy. 2014;6(6):755-74. doi: 10.2217/imt.14.37. PMID: 25186605; PMCID: PMC4201125.

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