PEG-MGF Peptide Guide – Is it Really Worth It?

Looking for ways to particularly enhance muscle growth? PEG MGF is all you need to achieve your muscle building goals. Read more to find out everything about PEG MGF!

If you have been going to the gym for quite some time now, I am pretty sure that you will all agree that the most difficult part of the fitness journey is to precisely build and bulk muscles.

Gaining muscle without gaining fat is something that most bodybuilders struggle with, and it’s not definitely easy.

This is where peptides like PEG MGF come to the rescue, as it is able to promote skeletal muscle tissue growth and strength gains.

PEG MGF also possesses regenerative properties, which allows it to be used in case of injuries or wounds that may result while intense workout regimens.

This is why PEG MGF is a top pick amongst many fitness enthusiasts.

But, hey, newbies, you don’t have to worry if you don’t know about PEG MGF because this review is all you need to master the nitty gritty of this peptide before you can decide if you really want to use it!

Warning: The content on Muscleandbrawn.com and the information included in this article is intended for entertainment and informational purposes only. It is not intended nor implied to be a substitute for professional medical advice. Prior to buying anything, check that it is compliant where you live with your current government laws. We frequently mention research chemicals that are not made for human consumption. Therefore, before purchasing any product for personal use, consult with your doctor or healthcare provider first.

Key Takeaways:

  1. PEG MGF is a pegylated version of MGF that increases the half-life of this naturally occurring peptide.
  2. PEG MGF works to enhance skeletal muscle growth by stimulating the satellite cells as well as promoting cell proliferation.
  3. Other predominant effects of PEG MGF include wound healing, anti-inflammatory, and other neurodegenerative disorders.

What is PEG-MGF?

Mechano growth factor (MGF) is a naturally occurring peptide that is found in the muscle, bone, cardiac and neural tissue. (1

MGF has a short half-life of 5-7 minutes as compared to pegylated MGF (PEG-MGF), which has a half-life of 48- 72 hours. For this reason, MGF is often pegylated, which is the process of attaching polyethylene glycol, before it is considered for use.

PEG MGF is derived from insulin-like growth factor 1 (IGF-1) and thus functions similarly to it. 

How Does PEG MGF Work?

The effects of PEG MGF on the body are pleiotropic in nature, and thus it has the ability to affect more than one system in the body. The mechanism of action of PEG-MGF is minimally understood by animal testing and then correlated to its actions on humans. 

The most apparent effect of this peptide is seen on the skeletal muscle tissue of the body, where it stimulates myoblast division, fusion, and maturation and thus induces muscle growth. It does this by increasing muscle stem cell count and then forming new muscle cells. 

In case of an injury to the skeletal muscle cells, MGF peptide can amplify the recruitment of macrophages and neutrophils to the site of injury, thereby accelerating healing. (2

Healing of wounded tissue, however, is often accompanied by inflammation which can lead to negative effects in the body if prolonged. In such situations. PEG MGF decreases the expression of inflammatory hormones. 

As we have discussed previously that PEG MF is an isoform of IGF-1, and their effects are also similar in nature. Just like IGF-1, PEG MF has the ability to enhance fat metabolism and improve energy homeostasis in humans. (3

PEG-MGF Peptide Guide - Is it Really Worth It?
Fig 1. Effects of MGF on IGF-1R activation

Other than skeletal muscle, PEG MGF can employ protective functions on cardiac muscle as well by inhibiting apoptosis and increasing the proliferation of cardiac stem cells. This was seen in a study with mouse models that received PEG MGF and exhibited less cell death during eight hours of hypoxia as compared to the control group. (4

The pathologic injury that follows a heart attack significantly decreases cardiac function due to cardiac remodeling. By the administration of PEG MGF, cardiomyocyte injury in mice was observed to be minimal. (5

PEG MGF increases the proliferation of osteoblasts which are bone mineralizing cells. Similarly, it can also enhance the function of chondrocytes which are cartilage forming cells. 

MMP-1 and MMP-2 are ligament repairing factors that specifically act to keep the tooth in place within the bone. Research suggests that PEG MGF can enhance the expression of these factors. (6

Within the central nervous system, this peptide can prevent neuron degeneration and, therefore a multitude of disorders, even though the exact mechanism for this is not known yet. (7

Benefits of PEG MGF

The benefits of PEG MGF are evident from its mechanism of action, with one pathway bearing different benefits. 

By alerting the immune system in case of injury, PEG MGF helps in quicker wound healing of damaged muscle tissue. It then protects the body from any kind of damage by acting as an anti-inflammatory substance and can improve recovery. 

Being an isoform of IGF-1, PEG MF peptide has the ability to stimulate the receptor of IGF-1, which then enhances fat metabolism and promotes a lean body mass thus, it is great for people who want to reduce weight.

IGF-1 receptors decrease the aging process and also improve muscle repair. Both these qualities make this peptide effective for anti-aging and wound healing purposes. 

Research in mice has reported that the administration of PEG MGF was shown to increase 25% the mean muscle fiber size. (8) This makes PEG MGF a unique peptide for bodybuilders who are looking for a way to bulk up their muscles.

Its cardioprotective effects make it extremely beneficial for people who may have suffered from a heart attack by protecting them from further damage and retaining the function of their myocytes. 

In cases of fractures and other bone and cartilage injuries, PEG MGF can help reduce the healing time. Research in mice has proved that this peptide can enhance the migration and, therefore, maturation of chondrocytes from the bone. (9

A very unique and lesser known benefit of PEG MGF is its application in dental trauma and procedures. By increasing the firmness of the tooth within its cavity, PEG MGF can prevent tooth loss in instances of injury, thus avoiding tooth extraction.

PEG MGF has the ability to regenerate neurons and is thus extremely beneficial in disorders such as Amyotrophic lateral sclerosis (ALS), in which the integrity of motor neurons is affected. It can restore neuron function and cognitive abilities of aging individuals as well. (10

PEG MGF has not been approved by the FDA. 

This is due to the lack of studies done on human subjects despite the current scientific data that establish its efficacy.

Who Should Use PEG MGF?

PEG MGF is a peptide for bodybuilders who are carrying out intense physical training. It can immensely help with building up muscle while simultaneously losing unnecessary body fat.

It can be used as a repairing agent as well. In cases of muscle, bone, cartilage, and tooth injury, administration of PEG MGF can speed up healing for anyone who wants to quickly get back to their normal routine!

PEG MGF is effective for people who may have suffered from a heart attack or are diagnosed with cognitive disorders with neurodegeneration. 

How To Use PEG MGF?

The vial of PEG MGF should be injected subcutaneously or intramuscularly in the area that needs to be targeted to ensure localized delivery. 

The site of injection should be properly cleaned before administration.  

PEG MGF Dosage

The general recommended dosage for PEG MGF is 150 mcg per day. 

PEG MGF Cycling

150 mcg vials of PEG MGF can be injected once a day for 2 – 3 times in a week. This cycle can be continued for as long as 8 – 10 weeks in order to observe distinguishable results.

2 – 3 capsules of PEG MGF can be safely consumed in a day. 

PEG MGF Stacks

PEG MGF is often stacked with its parent molecule IGF-1 because they both have the same functions and the ability to stimulate IGF-1 receptors. 

Another peptide that can be added to the mix is MOTS-C, which is a peptide that boosts glucose metabolism, reduces fat, and improves insulin sensitivity. 

These three peptides together form a highly potent stack that meets the demands of bodybuilding enthusiasts.  

PEG MGF User Reviews

Time to dig into some of the user insights about PEG MGF because that’s the real deal after scientific research evidence.

One of the users left a very comprehensive guide about the peptide as he said,

“There was local and neighboring systemicgrowth. As an example I worked chest tris & shoulders. I dosed shoulders & chest. Those grew. I did not dose triceps but they grew as well…

Recovery was enhanced. In fact during one week I experimented with hitting the upper pecs every day for 4 straight days. The theory was to work the muscle to make it receptive to MGF and then give it MGF. 

I have backed off now and examined in enough detail to say that the growth is genuine and not the result of any swelling.”

Another one said,

“I tried it and It improve recovery like crazy. Use it on rest day though”

Other PEG MGF peptide user said,

“It felt like a permanent pump in the muscle bellies. Like dbol without the water retention. Went away as soon as I stopped, no permanent gains noted, just looked really good while I was on.”

Seems like people are pretty satisfied with the PEG MGF. Safe to use it, I guess?

PEG MGF Side Effects

One most common side effects of PEG MGF is the resultant low blood sugar level.

Some people have also reported that their legs and feet get inflamed after the intake of this peptide, and their heartbeat slows down. 

Where Can I Buy PEG MGF?

Because the use of PEG MGF has increased considerably, you will find a couple of online peptide vendors selling it, but you can trust everyone, right?

If you are waiting for my recommendation, BioTech Peptides is a good-to-go option surely.

MGF (Mechano Growth Factor)

MGF or Mechano Growth Factor falls within the family of IGF-1 (insulin like growth factor) Peptide hormones within the body.

To put it very scientifically, MGF is an alternatively spliced variant of insulin-like growth factor-I. Sometimes MGF will also be referred to as an Isoform of IGF-1.

MGF (and IGF-1) will both be released in a response to stress being placed on muscle cells. When a muscle undergoes weight training or something like that, there will be an endogenous expression of these two compounds.

After training, IGF-1 is spliced, creating the MGF with a unique C-terminal peptide. This in turn jumpstarts hypertrophy and tissue growth via recovery.

Interestingly enough, data suggest that we lose the MGF expression ability as we age. This is one of the reasons for muscle loss as we age.

MGF (Mechano Growth Factor) Overview

⭐️ Top Benefits: Increases muscle hypertrophy and recovery
🧪 Form: Injectable liquid
⌛️ Max Time Used: 6 – 8 Weeks
💰 Average Cost: $54.99
❤️‍🩹 Side Effects: Hypoglycemia
☢️ Dangers: Hypoglycemia can be dangerous if unexpected
📚 Best Peptide Stack: HGH / IGF-1
⚤ Men/Women: Men and women
➡️ Go to the Full review

  • Increases muscle hypertrophy
  • Increases recovery
  • Pain at the injection site
  • Hypoglycemia

PEG MGF vs. Other Peptides

PEG MGF vs. IGF-1

PEG MGF and IGF-1 both have the ability to stimulate the IGF-1 receptors and therefore bring about similar changes in the body.

IGF-1, however, is the parent peptide through which a small molecule of PEG MGF is obtained, and thus their source of origins differ. 

PEG MGF vs. MOTS-C

Both these peptides are specifically used for bodybuilding purposes as they can reduce fat from the body.

Despite some common functions, MOTS-C has the ability to regulate the glucose metabolism of the body, and this is something that PEG MGF can not do.

PEG MGF vs. Tesamorelin

PEG MGF and Tesamorelin are mainly fat loss peptides, but the type of fat these help in reducing from the body differ. 

PEG MGF can stimulate IGF-1 receptors through which it stimulates the metabolism of fat from the overall body. On the other hand, Tesamorelin is only directed towards the fat that develops in the abdomen and stomach as a result of the HIV virus. 

Is PEG MGF Legit?

Studies that are mainly done on mice provide us with compelling evidence of the efficacy of PEG MGF. Its effect on humans, however, is still lesser known and therefore requires further research. 

Even though the side effects that have been reported are few, they can be threatening in certain cases, which makes the safety of this peptide a bit debatable.

Despite the lack of scientific literature, pre-existing studies do conclude that PEG MGF works as an effective peptide in building up body mass and is thus suited for the needs of bodybuilders.

Its anti-inflammatory and bone-repairing actions take it a step ahead of the other peptides in the market, giving it an edge over them! 

FAQS

Is PEG MGF safe?

Pegylation is the addition of polyethylene glycol (PEG) to the peptide. The addition of the PEG group is a safe and effective way to increase the MGF half-life to 48-72 hours. Conveniently, the PEG group does not bind itself to other substances in the body and is excreted rapidly via urination.

How fast does PEG-MGF work?

Rabbits treated with high doses of MGF showed the same level of healing at four weeks that was seen in controls at six weeks.

What is the difference between MGF and PEG-MGF?

The distinction between IGF-1 and MGF is that MGF stimulates myoblasts division by stimulating different receptors. PEG-MGF helps increase the muscle stem cell count so that more may fuse and become part of adult muscle cells.

Still Have Questions?

Drop us a comment down below and one of our expert coaches will respond to it. We’ll also be answering questions on our Instagram!

1)Expression of IGF-1 isoforms after exercise-induced muscle damage in humans: characterization of the MGF E peptide actions in vitro. (2009, August 1). PubMed. https://pubmed.ncbi.nlm.nih.gov/19567392/

2)Sun, K., Cheung, K., Au, S. W., Yeung, S. S., & Yeung, E. W. (2018). Overexpression of Mechano-Growth Factor Modulates Inflammatory Cytokine Expression and Macrophage Resolution in Skeletal Muscle Injury. Frontiers in Physiology, 9. https://doi.org/10.3389/fphys.2018.00999

3)Janssen, J. a. M. J. L., Hofland, L. J., Strasburger, C. J., Van Den Dungen, E. S. R., & Thevis, M. (2016). Potency of Full- Length MGF to Induce Maximal Activation of the IGF-I R Is Similar to Recombinant Human IGF-I at High Equimolar Concentrations. PLOS ONE, 11(3), e0150453. https://doi.org/10.1371/journal.pone.0150453

4)Doroudian, G., Pinney, J. R., Ayala, P., Los, T., Desai, T. A., & Russell, B. (2014). Sustained delivery of MGF peptide from microrods attracts stem cells and reduces apoptosis of myocytes. Biomedical Microdevices, 16(5), 705–715. https://doi.org/10.1007/s10544-014-9875-z

5)Peña, J. R., Pinney, J. R., Ayala, P., Desai, T. A., & Goldspink, P. H. (2015). Localized delivery of mechano-growth factor E-domain peptide via polymeric microstructures improves cardiac function following myocardial infarction. Biomaterials, 46, 26–34. https://doi.org/10.1016/j.biomaterials.2014.12.050

6) Mechano-growth factor regulated cyclic stretch-induced osteogenic differentiation and MMP-1, MMP-2 expression in human periodontal ligament cells by activating the MEK/ERK1/2 pathway]. (2019, February 1). PubMed. https://pubmed.ncbi.nlm.nih.gov/31080992/

7)Dłużniewska, J., Sarnowska, A., Beręsewicz, M., Johnson, I. T., Srai, S. K. S., Ramesh, B., Goldspink, G., Górecki, D. C., & Zabłocka, B. (2005). A strong neuroprotective effect of the autonomous C‐terminal peptide of IGF‐1 Ec (MGF) in brain ischemia. The FASEB Journal, 19(13), 1896–1898. https://doi.org/10.1096/fj.05-3786fje

8)Goldspink, G. (2005). Research on mechano growth factor: its potential for optimising physical training as well as misuse in doping. British Journal of Sports Medicine, 39(11), 787–788. https://doi.org/10.1136/bjsm.2004.015826

9)Jing, X., Ye, Y., Bao, Y., Zhang, J., Huang, J., Wang, R., Guo, J., & Guo, F. (2018). Mechano-growth factor protects against mechanical overload induced damage and promotes migration of growth plate chondrocytes through RhoA/YAP pathway. Experimental Cell Research, 366(2), 81–91. https://doi.org/10.1016/j.yexcr.2018.02.021

10)Walker, A. (2017, July 20). Hearts and Minds of Mice and Men: Mechano Growth Factor a new tool in the battle against age-related neuron loss? https://blogs.biomedcentral.com/on-biology/2017/07/20/hearts-minds-mice-men-mechano-growth-factor-new-tool-battle-age-related-neuron-loss/

Contributors

Kumar Rathi

Kumar Rathi | Writer

Kartik is a medical student with a passion for anatomy and physiology. He writes research papers, articles and blogs to raise awareness and also has a strong interest in teaching and public speaking. Aspiring to be a successful cardiologist, Kartik believes in connecting with people on a personal level and is an expert in peptides.

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Chemical Structure

Mechanism of Action

PEG MGF is a peptide that is derived from Insulin like growth factor (IGF-1) and thus has a lot of functional similarities to IGF-1. It can stimulate the IGF-1 receptors, through which it increases fat metabolism in the body and promotes lean muscle mass. PEG MGF can increase the proliferation of skeletal muscle stem cells which allows for the increase in muscle mass. It also has the ability to prevent apoptosis in cardiomyocytes that have undergone ischemic damage and therefore employed cardio-protective functions. Similarly in the case of neurodegenerative diseases, PEG MGF can regenerate neurons and help people in retaining their cognitive abilities.

Class of Compound

Peptide

Street Names

PEG MGF, Pegylated MGF, Pegylated Mechano Growth Factor

Effects

Increases skeletal muscle growth ,Anti-inflammatory ,Cardio-protective

Side Effects and Dangers

Low blood sugar level , Inflammation in legs ,Slowing down of heartbeat

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