SARMs or Selective Androgen Receptor Modulators have become increasingly common in the bodybuilding and recreationally lifting world.
But much like driving with your drunk uncle Larry, there are concerns about safety. Some use these research chemicals to enhance muscle mass, enhance athletic performance, or even enhanced fat loss. But how safe are they exactly?
SARMs were originally developed to replace Anabolic Steroids in the medical world, as they do have fewer androgenic adverse effects. This doesn’t mean they are “good”, however.
We’re going to take a deep dive into what the Safest SARMs are, which the most potent SARMs are, and see just why these cannot be coined as “for human consumption”.
What Are the Safest SARMs?
SARMs were developed in the late 1990s, as a means to replace Anabolic Androgenic Steroids in the medical world. See, Steroids are used as a treatment for muscle wastage diseases such as HIV/AIDS.
The reason for this is that even though Steroids have been developed more and more over the 1900s, they still had adverse effects, especially on women and children. SARMs were developed as a safer Steroid alternative, as they could be used without causing as many adverse effects.
That said, clinical trials are still not 100% sure about the safety of SARMs. Even though there are multiple people who have used SARMs for sport enhancement, the FIA has still not approved SARMs for human use.
While a Selective Androgen Receptor Modulator has the potential to be safe, there are still some that are less safe than others. The safest SARMs would have to be MK-677 [Not a SARM but a Growth Hormone Secretagogue , Ostarine MK 2866, Stenabolic, Andarine S4, and LGD 4033.
You have to run compounds that will obviously increase muscle mass or at least stop muscle loss when cutting, but you would want to avoid the worst side effects. Let’s look at these compounds in greater detail.
What are SARMs?
Simply put, SARMs or Selective Androgen Receptor Modulators were developed to replace Anabolic Steroids in the medical world. See, Steroids were given as a treatment method for individuals who suffered from illnesses that cause atrophy of skeletal muscle.
Unfortunately, Steroids will cause quite a bit of side effects while increasing muscle mass, so doctors wanted something new, something better.
The scientists over at Ligand Pharmaceuticals were the first to identify such a compound, that had both anabolic activity while also portraying some selectiveness in tissue . Thus, SARMs were developed to act like Anabolic Steroids, without adverse effects.
How Do Selective Androgen Receptor Modulators Work?
The human body has Androgen Receptors throughout that are meant to be bound by ligands. In particular, these ligands include human hormones such as Testosterone. This is completely normal and healthy, and can even be exploited.
By massively increasing the number of certain ligands in the body, we can see massive biological changes, particularly in metabolism, body fat levels, bone density, and muscle mass. We know from a study published in the New England Journal of Medicine that Testosterone alone will build muscle mass  – no exercise is needed! Just look at the graph!
SARMs will do something similar to Steroids, just not quite as powerful. SARMs will bind to the Androgen Receptors in the body, causing muscle growth. Easy right? Let’s make it a bit harder. This is how SARMs work:
Step 1: Steroid Hormone or SARM binds to the Steroid Hormone Receptors
Step 2: Hormone/SARM-Receptor complex enters the Nucleus
Step 3: The complex will bind to the receptor sites on the chromatin
Step 4: This activates mRNA transcription
Step 5: mRNA leaves the nucleus
Step 6: Ribosomes translate mRNA into new proteins
This is the process in which SARMs will help you gaining muscle. These compounds will also not bind to all the receptors in the human body, unlike Anabolic Steroids, which will bind to everything.
Safest SARMs for Bulking
Bulking is a term usually used by individuals looking to gain quite a bit of muscle mass, and don’t actually mind gaining a bit of pudge as well. Not the “leanest” option available.
The safest SARM for bulking would have to be Ligandrol LGD 4033 because it’s actually got some potency. Yes, there are side effects, however, if your goal is bulking, you’re looking for something with significant benefits.
This means taking a few L’s, and choosing the appropriate Selective Androgen Receptor Modulator. Might be a wise idea to keep some PCT or anti aromatase products on hand.
Safest SARMs for Lean Muscle Mass
Conversely to “bulking”, trying to gain lean muscle mass usually means a more careful approach. Someone looking to improve muscle mass, someone looking to use some body building products to cause muscle growth without any fat gain or bloat.
The safest SARM for lean muscle mass would have to be Ostarine. Ostarine is known to be somewhat mild in its physical function, and that means that you simply won’t be experiencing the heavy sides. You can still experience a great amount of muscle growth, and you certainly will do less damage than any Anabolic Steroid.
Safest SARMs for Fat Loss
Fat loss differs ever so slightly from “cutting” because in my opinion, fat loss can apply to anyone and everyone. Only athletes (specifically physique athletes) will cut.
The safest SARM for Fat Loss would have to be MK-677 (again, not really a SARM). MK 677 is known as a Growth Hormone secretagogue that will increase the amount of Growth Hormone the pituitary produces.
Growth Hormone has few if any “real” side effects when used in normal doses. It can definitely lead to insulin resistance if you totally abuse the product in question, however, you have to be eating like an absolute pig (and using way too much for that to happen).
MK 677 will lead to increased levels of Lipase in the body, which in turn will greatly increase lipolysis – fat loss. It is pretty average at inducing muscle growth, however.
Safest SARMs for Cutting
Cutting is reserved for athletes mostly. Physical function plays a massive role in their progress, as they need to battle muscle wasting as much as they possibly can. Other SARMs like MK 677 would help, sure, but I think the safest SARM for cutting is Ligandrol.
It is going to do a better job at stopping muscle wasting when dieting than some other SARMs on this list, and in clinical trials it has been shown to aid slightly in the act of losing fat.
If you diet correctly, you even stand a change of increasing lean muscle mass! But, you have to be doing everything perfectly for that to happen.
Safest SARMs for Beginners
Beginners are often misinformed that they can take substances without any sides. There are always going to be some side effects, these are not dietary supplements after all. This is why these compounds are banned by the World Anti Doping Agency.
That said, if you are 100% sure about using a SARM, you could look at Ostarine. Typically not going to have a lot of side effects, and it is the SARM with the most amount of clinical trials supporting it.
Benefits of SARMs
SARMs are a term used to describe a massive amount of compounds that all have a different chemical structure, and they will have different effects based of that structure. That said, SARMs can have the following benefits:
- Increase in lean muscle tissue
- Decrease in body fat levels
- Improving your cardiovascular and muscular endurance
- Greater bone density
- Better sleep
- Certain SARMs can even increase libido and sexual function
While SARMs do have a host of benefits, it’s important to remember that SARMs can still have side effects. No official regulatory body has approved SARMs for human use, and that will only happen when all the side effects have been fully studied, etc.
SARMs vs Anabolic Steroids
The first thing you need to know is that SARMs and Steroids do exactly the same thing, just in different manners.
Both SARMs and Steroids will bind to the Androgen Receptor Cells, and cause a biological change from there. The process is explained in a paragraph higher in this article, however, it is important to remember that these substances do the same thing.
The only difference is that Steroids have the potential to be way more impactful on your body. Steroid users have a greater risk of developing prostate cancer, worse cholesterol readings, and Testosterone suppression. This is because Steroids are a lot stronger than SARMs.
SARMs do, however, need a lot more research done on them before we have a grasp as to how these compounds act on a long term scale.
Safest Place to Buy SARMs
Finding a reputable SARM supplier online is pretty hard, and for good reason. These guys can label their products as anything and since the dietary supplement industry doesn’t regulate these compounds, they aren’t tested.
That said, we have made use of Amino Asylum for a long while now, and they have never disappointed us. They have everything from RAD 140 to even other products, like a Selective Estrogen Receptor Modulator.
They have a large number of great reviews on their site and on Reddit, and if you spend some time online, you’ll soon realize that Amino Asylum is the leading SARM supplier in the States.
Safest Way to take SARMs
Don’t. SARMs are experimental, they are literally sold as research chemicals! So, if you are terrified of any side effects at all, maybe don’t use these substances, there are plenty of other dietary supplements such as Creatine that can help you.
If you are actually sure you want to use a SARM, here are some tips on how to use SARMs safely:
- Don’t use too much, follow the recommended dosing
- Don’t use the strongest SARMs, start off with lighter ones and move up
- Do not run cycles that are longer than recommended
- Have your bloodwork done to see how your hormones change, like with LetsGetChecked
- Use other substances like a Selective Estrogen Receptor Modulator (SERM) and aromatase inhibitors as needed
- Make use of a PCT once you have completed your cycle
Are SARMs Legal?
The use of a Selective Androgen Receptor Modulator or SARM is technically illegal. These are classified as “not for human use” and they may not be sold as dietary supplements. That said, SARMs are legal to purchase under the term “research chemicals”, as are some other compounds like Peptides. SARMs are however banned by the World Anti Doping Agency in professional sports.
Safest SARMs companies?
The safest SARM companies we could recommend would have to be Amino Asylum and Chemyo, and Sports Technology Labs. They have been in the industry for a while, and they have a lot of good reviews. They frequently test their products and have amazing quality.
Best and Safest SARMs?
The “best” and “safest” do not always go together, as they are not the same. The best SARMs for one person might not be the best SARMs for someone else. The safest SARMs would have to be MK 677, Ostarine, and Stenabolic as they have the least amount of side effects.
Are SARMs Safe for Females?
SARMs can be safe for females, but only if they use the correct ones. YK-11 is not safe for females, but females could use Ostarine. Female SARM usage is rising rapidly, and a lot of females have great success with them.
Are SARMs Safe?
Anything can be dangerous if used incorrectly. SARMs can be safe, yes, however it depends on you. If you already have kidney damage and you use way too much LGD 4033 and RAD 140 at the same time, you’re going to get hurt.
Hair Safe SARMs?
While there is no clinical research to show that SARMs will cause hair loss, there are some who will experience hair loss regardless. The safest SARMs for hair loss would be Ostarine and MK 677.
Is 1 Cycle of SARMs Safe?
It could be, yes. You will determine the safety of the situation, however, based on your dosage, the SARM used, and the time of the cycle.