We all have experienced sleep issues at some point in our lives and for, of course, different reasons.
Some of us have trouble sleeping owing to our mental and emotional stress. On the other hand, some of us may have been clinically diagnosed with chronic insomnia. For whatever reason, sleep deprivation or even disturbed sleep patterns can take a big toll on our personal and professional life.
Sleep research has been one of the most concerning areas for scientists and doctors. One of the peptides introduced in the market that can induce sleep by improving objective sleep quality is Delta-sleep inducing peptide, more commonly known as DSIP.
This naturally occurring substance is disrupting the market, and with more clinical research, DSIP’s usage can grow exponentially, considering its precise mechanism of action inside the body.
Stay with me through the end to know everything about this sleep-inducing peptide (DSIP) and decide for yourself!
Key Takaways on DSIP
- DSIP acts as a potent neuromodulator and can cross the BBB, thus initiating the sleep onset mechanism.
- It improves sleep patterns as well as circadian rhythm and proves to be beneficial in treating chronic insomnia.
- DSIP can also induce antinociceptive effects and improve pain perceptions drastically.
- Although little evidence is available, some data advocates DSIP’s tremendous effects on treating depression.
What is DSIP?
Delta sleep-inducing peptide, aka DSIP, is a naturally occurring neuropeptide and was first extracted somewhere between the 1970s and 1980s from the cerebral venous blood of rabbit brain during slow-wave sleep.
DSIP is synthesized in the hypothalamus of the rabbits and then travels down to different target sites inside the central nervous system (1).
Upon further investigation, scientists were able to locate the areas of the brain, such as the thalamus, cerebral cortex, and cerebellum, for having a maximum concentration of DSIP.
Biochemically, DSIP constitutes 9 amino acids with the following sequence (Trp-Ala-Gly-Gly-Asp-Ala-Ser-Gly-Glu and is known to easily cross the blood-brain barrier to initiating its sleep onset mechanism.
How Does DSIP Work?
While the exact mechanism of action is still not fully understood, and it is difficult to frame appropriately, limited studies suggest that DSIP acts as a potent neuromodulation compound by affecting different neuronal systems involving GABA and glutamate. This is interesting because most medications often act as sedatives to promote sleep, but DSIP acts as a neuromodulator.
While there are a lot of mixed findings, one thing is for sure DSIP primarily works to initiate the sleep onset mechanism. Some studies suggest that DSIP promotes slow-wave sleep patterns and ensures shorter sleep latency periods in individuals (2).
DSIP also reduces the intensity of withdrawal symptoms experienced post-long-term analgesic medications.
DSIP has the ability to alter the serum levels of some hormones, such as corticotropin, somatostatin, serotonin, etc.
Rat-based studies also suggest that DSIP may trigger strong anti-oxidant effects and strengthen the immune system.
Besides, some evidence highlights the efficacious role of DSIP in improving blood supply to certain areas of the brain, thus promoting healing and therapeutic effects.
While many of these mechanisms are just hypothesized from limited clinical trials performed on animal models, more extrapolation is required to know the exact pharmacodynamics of DSIP.
Benefits of DSIP
As the name suggests, DSIP promotes sleep and causes triggers sleep onset, as clinically seen in several studies. DSIP helps to regulate circadian rhythms in individuals with continuous sleep disturbance.
The most groundbreaking benefit of DSIP is its role in improving sleep patterns and maintaining a shorter sleep latency in individuals diagnosed with severe chronic insomnia. In one of the studies, subjects reported an improvement in subjective sleep quality after a DSIP dose (3).
Besides DSIP’s diverse effects on sleep, it has many other nonsleep effects on humans.
One of the small studies reported a considerable reduction in pain episodes and improved mood quality. This was also indicated in a rat-based study, as DSIP can have a potent antinociceptive effect. This can be augmented by the fact that DSIP can also reverse withdrawal symptoms, particularly from alcohol and opioid (4).
While the role of DSIP in muscle building and bulking is not widely studied, a small study observed a decrease in somatostatin levels after DSIP intake, which can contribute to long-term protein anabolism in skeletal muscles.
DSIP has also been seen to regulate metabolic disturbances induced by stress and act as a stress limiter. DSIP acts as a potent antioxidant compound as well as ensures a sufficient supply of oxygen to maintain oxidative phosphorylation (5). These effects were seen in rat-brain mitochondria, and scientists believe that DSIP could potentially be used in settings of MI and strokes.
DSIP may also normalize blood pressure in hypertensive patients, as some of the small-scale studies suggested.
DSIP is also been studied for its effects on patients suffering from major depressive disorder. Importantly, chemical imbalance, specifically lower serotonin levels, has a strong association with causing depression.
Biochemical analysis of cerebrospinal fluid of depressed patients also shows lower levels of DSIP. Interestingly, it has been found that DSIP can modulate the levels of serotonin and its metabolites, thus playing a potential role in treating depression (6).
Although a hypothesis, DSIP may also strengthen the immune system and mitigate the risk of dysplasia, and decrease spontaneous tumor incidence.
Is DSIP Legal?
While DSIP is generally advocated as one of the safe sleep-promoting substances, the legality of this neuropeptide is still debatable.
At the moment, you can only buy DSIP without restrictions in only a handful of countries. I suggest you check your country’s legal requirements before making the purchase.
Who Should Use DSIP?
Anyone with a disturbed circadian rhythm and irregular sleep pattern can opt for DSIP for the above reasons. Chronic insomniac patients can also try this DSIP because the results are pretty promising.
It is imperative to mention that although DSIP can be used for medicinal and major therapeutic benefits such as stroke, MI, and major depressive disorder, more research is required to prove that!
Forms of DSIP
You will only find the powder form of DSIP, which would need to be reconstituted before you can really inject it.
While there is a possibility that you may find other forms of DSIP in some local online stores, I would highly suggest you use the injectable forms owing to the greater bioavailability.
How To Use DSIP
You will need to buy the lyophilized powder, reconstituted with the bacteriostatic water before being ready for use.
The best way to inject is subcutaneously, but there are other ways of injection as well.
To know the exact procedure of reconstitution, please follow the link and get a detailed guide in front of you!
The dosage really depends on your purpose of intake. And there are no authoritative studies done as of yet that can really highlight the optimal DSIP dosage.
A handful of people only suggest using anywhere between 100mcg to 250mcg every alternate day. On top of that, my advice would be to start slow, with around 50mcg once a week, and then gradually move your way up once your body gets accustomed to it.
DSIP is generally used alone, and there are not many popular stacks to think of. However, considering my peptide knowledge and experience, DSIP can be stacked with CJC 1295 and Ipamorelin.
CJC 1295 and Ipamorelin stack of often used to induce the release of growth hormone (GH). Higher GH levels promote slow-wave sleep and improve sleep quality in a lot of ways. With that being said, both of these peptides can form a solid stack and optimize your sleep perfectly!
To learn more about Ipamorelin, you may follow the link.
Now it’s time to go through some Reddit reviews and discussions on DSIP to really get an insight into what’s going on!
One of the users said,
“DSIP works but if you take it too often though it can also cause insomnia without it.”– Reddit User…
Another one said,
“Used it and effects were noticeable. At higher doses the sleepiness would last way into the next day. A friend of mine accidentally dosed it too high and was groggy for two days straight.”– Reddit User…
Best Time to Take DSIP
The ideal time to use DSIP is 1 to 3 hours prior to sleep to ensure maximum efficacy after kicking in!
Side Effects of DSIP
The good news is that DSIP is an overall safe peptide that offers nearly no long-term adverse effects!
While there have been limited long-term studies to really define the long-term safety profile of DSIP, a few people have only reported occasional headaches, but that’s really it.
You are pretty much safe to go with DSIP!
Where To Buy DSIP?
It is extremely important to choose the right vendor to buy DSIP or any peptide in fact.
DSIP vs. Other Compounds
Honestly speaking, there are no similar peptides available in the market that could be compared with DSIP.
DSIP is one unique sleep-promoting substance in the peptide category that works its way naturally unlike other artificially sleep-promoting substances.
Is DSIP Legit?
If you were to take my opinion, DSIP is surely legit and has got great potential to increase sleep as well as regulate sleep cycles by modulating sleep wave cycles and not causing any sedation.
While the sleep aspect is promising, more research is needed to assess DSIP’s effects on other medicinal and therapeutic purposes.
You can anyways start using a low dose if you really feel the need and then work your way up!
FAQs on DSIP
How quickly does DSIP work?
DSIP significantly lowered the pain levels of 6 out of 7 patients after intravenous administration on 5 consecutive days followed by 5 injections every 48-72 hours.
Does Delta sleep-inducing peptide work?
Only one study has investigated the effects of DSIP on sleep EEG in normal men and found only minor effects. Studies on the efficiency of DSIP in the treatment of insomnia produced conflicting results.
What is DSIP used for?
This agent has been used for treating alcohol and opioid withdrawal. Clinical symptoms and signs may disappear after the injection of DSIP.
What does Delta sleep mean?
Muscle tone, pulse, and breathing rate decrease in N3 sleep as the body relax even further. The brain activity during this period has an identifiable pattern of what is known as delta waves. For this reason, stage 3 may also be called delta sleep or slow-wave sleep (SWS).
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