5 Best Peptides for Fat Loss

The use of peptides to promote fat loss has risen quite alot in the recent past. This is because peptides follow a natural pathway to trigger fat loss such as altering the hormonal levels. However, not all peptides trigger fat loss. Read through the end to known about the top 5 peptides promoting fat loss!
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Numerous supplements have been introduced in the market to manage nutritional imbalances, enhance fitness, or combat diseases. Despite all the advancements, there are always some side effects associated with supplements. 

One such supplement is peptides which are relatively new as compared to SARMs or prohormones. 

All of these supplements are used among athletes and fitness freaks to gain healthy muscle mass and a speedy recovery. 

On the other hand, one of the major effects of peptides is fat loss. Their role in fat loss is more likely due to an increase in the secretion of human growth hormone leading to enhanced lipolysis, inhibited lipogenesis, and much more. 

This review is about the top 5 peptides that can promote fat loss with maximum potency and triggering minimal side effects. 

Warning: The content on Muscleandbrawn.com and the information included in this article is intended for entertainment and informational purposes only. It is not intended nor implied to be a substitute for professional medical advice. Prior to buying anything, check that it is compliant where you live with your current government laws. We frequently mention research chemicals that are not made for human consumption. Therefore, before purchasing any product for personal use, consult with your doctor or healthcare provider first.

Key Takeaways  

  • AOD 9604 is one of the top fat loss peptides. It is a fragment of human growth hormone and thereby functions through an increase in lipolysis in conjunction with decreased lipogenesis. 
  • CJC 1295 is the second leading peptide for fat loss. The peptide is an analog of growth hormone stimulating hormone, favoring subcutaneous fat loss and increase in lean muscle mass
  • Mimicking the action of growth hormone, Tesamorelin works by increasing IGF-1 levels and prompting lipolysis. 
  • 5-Amino-1Q is another potent anti-obesity drug leading to greater metabolism via block blocking the activation of NNMT enzymes. 
  • Ipamorelin is a growth hormone secretagogue leading to greater stimulation of GH from the anterior pituitary gland. Through this peptide, your body gets rid of unnecessary fat.

How do Peptides work?

Each peptide has a distinct mechanism of action from that of the others. However, most peptides result in the release of increased levels of growth hormone from the anterior pituitary gland. Growth hormone (GH), a peptide hormone, works by targeting different organs and causing systemic effects. 

It binds to receptors found in skeletal muscles, adipose tissue, and hepatocytes. With subsequent binding, it leads to increased fat metabolism. 

Human growth hormone increases the process of lipolysis alongside decreasing the occurrence of lipogenesis (1). That said, your body starts utilizing already stored fat reserves and prevents the formation of new lipids. 

This mechanism accelerates fat loss, especially in central regions such as the abdomen. Few other peptides are seen to work by modifying the levels of other hormones, such as insulin and glucagon, responsible for glucose regulation (2). 

How to take Peptides?

Most peptides are available in various forms, such as capsules, tablets, and injections. Therefore, the intake of peptides is very convenient due to their multiple forms. 

However, as far as efficacy and bioavailability are concerned, taking the peptides via injections is recommended. 

1) best injectable peptide for weight loss

Semagutide Sources

Semaglutide (GLP-1) for Sale

Semaglutide gets grouped with other Peptides but is more commonly known as a GLP-1 receptor agonist. It mimics the action of human incretin glucagon-like peptide-1 (GLP-1).

This is something that you would want when trying to lose weight, and this is why Semaglutide is being used as an anti-obesity medication (combined with a good diet and training plan). It is simply a method of glycemic control. [1,2]

When trying to lose weight or even trying to increase weight dramatically (bulking), glycemic control could help a tremendous amount.

Semaglutide will help your pancreas release the right amount of insulin when your blood sugar is high. So, it helps your body produce the correct amount of insulin needed.

This can help you avoid chronically high levels of blood sugar, which can have some severe impacts on your health. Fitness fanatics will also know that elevated blood sugar levels are one of the major causes of inflammation, fat gain, and heart disease.

Semaglutide Overview

⭐️ Top Benefits: Increases glycaemic control and decreases hunger
🧪 Form: Injectable liquid
⌛️ Max Time Used: 6 – 8 Weeks
💰 Average Cost: $119.99
❤️‍🩹 Side Effects: Allergic reaction
☢️ Dangers: Allergic reaction
📚 Best Peptide Stack: HGH / IGF-1 / HGH-Frag
Men/Women: Men and women
➡️ Go to the Full review

  • Increases insulin control
  • Decreases hunger
  • Pain at the injection site
  • Allergic reaction

2) AOD 9604

AOD9604 is a synthetic fragment of the human growth hormone (HGH) C-terminus (3). The peptide gained immense popularity after a successful clinical trial in 2004. 

AOD9604 works via two common mechanisms. It is known to increase lipolysis by many folds and inhibit lipogenesis from taking place (4). 

With increased lipolysis, your body utilizes the already present fat reserves, converting them to fatty acids and glycerol. These by-products are then eventually used in the production of ATP. On the other hand, new fat synthesis via lipogenesis is reduced to marked levels with AOD9604. 

ADO 9604 Summary

AOD 9604

Losing excessive body weight and getting rid of obesity has just become much easier with the introduction of AOD9604 in the market.

AOD9604 is a synthetic fragment of the human growth hormone (HGH) C-terminus (176-191). This hexadecapeptide has shown remarkable effects on fat metabolism by upregulating lipolysis and inhibiting lipogenesis.

AOD9604 targets fat-rich areas and promotes fat breakdown without disturbing the overall metabolic profile.

AOD9604 was well advocated as an anti-obesity medication in the past as it cuts down fat deposition. Perhaps this was confirmed in one of the clinical trials taking place in Australia, where nearly 300 obese individuals experienced weight loss.

Besides, AOD9604 doesn’t affect IGF-1 and insulin levels, thus ensuring minimal risk of developing glucose intolerance and diabetes mellitus. With AOD9604, you don’t have to worry about hypercholesterolemia as well!

The good news is that AOD9604 is an FDA-approved drug as an anti-obesity drug, so you don’t have to worry about adverse effects at all. All you can expect is mild headaches, indigestion, nausea, swelling, etc.

AOD9604 can really be your go-to therapy for weight loss but make sure to use it at the proper dosages, or else a disturbed metabolic profile awaits you!

Features

💉 Forms: Powders, Spray
🕑 Cycle Length: 20 Days
💊 Dosage: 300 mcg/day
Benefits: Weightless, Prevents Hypercholesterolemia
💸 Cost: $79.99
⚠️ Side Effects: Headache, Indigestion
Stacks: AOD 9604/Semaglutide

  • Marked fat loss
  • It can help prevent cardiovascular and metabolic disorders away
  • Pain, redness, and flushing of the face can be experienced after the injection

3) CJC 1295

Comprising approximately 30 amino acids, CJC 1295 is a synthetic analog of growth hormone stimulating hormone (GHRH). With increased GHRH levels, the anterior pituitary gland is stimulated. This leads to peak growth hormone (GH) levels and, consequently, insulin-like growth factor-1 (IGF-1) (5). 

With high GH and IGF-1, you have a better chance of reducing excess subcutaneous fat and an increased lean muscle mass due to enhanced protein synthesis. CJC 1295 is also reported to improve the lipid profile of many. 

Interestingly, CJC 1295 works best with maximized benefits when stacked with Ipamorelin. When dosed appropriately, both can boost fat loss, improve protein synthesis, lead to lean muscle mass, strengthen the immune system, and rapid healing. 

#1 Best Overall

CJC 1295 + Ipamorelin Stack

This is the quintessential combination for Growth Hormone secretion. CJC-1295 is a Growth Hormone Releasing Hormone while Ipamorelin is one of the Growth Hormone Releasing Peptides.

Some studies are showing that using a GHRH and GHRP together will yield better results [2].

As this will massively increase your endogenous Growth Hormone release, you can expect similar results to taking pure HGH. Benefits include weight loss, muscle growth, and better body composition, and various human studies found that people just feel better on HGH therapy.

This is a very common peptide stack and is going to result in a better life, and potentially, your desired physique.

Stack Overview

⭐️ Top Benefits: Increase in Lean Muscle Mass, Enhanced Endurance, Improved Fat Loss, Better Sleep Quality, Enhanced Recovery, Strengthening of Joints and Connective Tissue.
🧪 Form: Injectable.
💉 Typical Dosage: CJC-1295: 1000 mcg to 2000 mcg per week; Ipamorelin: 200 mcg to 300 mcg per day.
⌛️ Typical Cycle Duration: 8 to 12 weeks (60 to 90 days).
💰 Average Cost: Approximately $49 (Prices may vary depending on the supplier and product concentration).
✅ Availability: Easily available through various online peptide suppliers, but a prescription may be required in some regions.
❤️‍🩹 Side Effects and Dangers: Vertigo, Increased Body Temperature, Water Retention, Headaches, Injection Site Reactions, Increased Hunger, Lowered Blood Sugar Levels.
🔄 See before and after
➡️ Go to the Full review

4) Medical Peptide

Tesamorelin is considered to be one of the best peptides for fat loss. With several clinical trials reporting its efficacy, Tesamorelin can be revolutionary in cases of severe fat deposition such as central obesity. 
Tesamorelin Acetate is a synthetic peptide consisting of 44 amino acids. The peptide is seen to mimic the action of the human growth hormone (HGH). It is seen to increase the production of IGF-1, leading to lipolysis and reduced adipose tissue (7). 

Tesamorelin, through clinical trials, helps reduce the visceral adipose tissue as in cases of HIV-induced lipodystrophy (abnormal fat deposition in certain body parts). 

It is reported that Tesamorelin works best in individuals over 30 years since the production of HGH naturally starts declining. Therefore the effects of Tesamorelin are more prominent in such people. 

Tesamorelin Summary

Tesamorelin

Tesamorelin is a Peptide that is prescribed to individuals that have too much adipose tissue around their stomach, typically those who suffer from HIV.

Certain illnesses and lifestyle choices will store fat more around the abdomen, which is actually pretty unhealthy.

Losing weight will mostly be determined by training and diet, however, Tesamorelin combined with professional medical advice can help you lose a lot of fat.

Tesamoreline is a GHRH, so you will see an increase in plasma Growth Hormone levels. You can expect an increase in insulin-like growth factor (IGF-1) following injections, which has other benefits such as cell growth in skin and hair.

Tesamorelin Overview

⭐️ Top Benefits: Increases natural HGH production
🧪 Form: Injectable liquid
⌛️ Max Time Used: 14 weeks
💰 Average Cost: $91.99
❤️‍🩹 Side Effects: Insulin resistance
☢️ Dangers: Not really
📚 Best Peptide Stack: GHRP / HGH / IGF-1
Men/Women: Men and women
➡️ Go to the Full review

  • Muscle gain
  • Fat Loss
  • Increased bone density
  • Injection site pain
  • Insulin resistance

5) Growth Hormone Secretagogue

Ipamorelin is a potential growth hormone secretagogue, causing the release of Growth hormone from the anterior pituitary gland (8). A surge in endogenous GH release causes several physiological processes like lipolysis and energy production to alter. 

With improved lipid metabolism, your body gets rid of unnecessary subcutaneous fat (9). Even after a single cycle, individuals report higher levels of HGH than normal. 

Fortunately, unlike other GH secretagogues, Ipamorelin doesn’t cause unpleasant effects such as increased cortisol levels or appetite changes. 

In conjunction with CJC 1295, Ipamorelin can cause a prolonged rise in Growth hormone production and, consequently, wider benefits. 

Ipamorelin Summary

Ipamorelin

Ipamorelin stands out as a potent pentapeptide (Aib-His-D-2-Nal-D-Phe-Lys-NH2) with remarkable growth hormone (GH)-releasing properties, both in vitro and in vivo. This selective growth hormone-releasing peptide has garnered attention as a promising solution for female fat loss.

Scientific investigations reveal that Ipamorelin has the potential to elevate the body’s natural growth hormone production by an impressive 30%. Given the pivotal role of growth hormone in fat metabolism, this elevation becomes crucial for achieving effective fat loss.

As women, especially those aged 40 and above, experience a decline in natural growth hormone levels, their metabolism tends to slow down, leading to increased fat storage. Ipamorelin’s capacity to boost these levels can counteract this decline, potentially accelerating fat loss by up to 20%.

What sets Ipamorelin apart is its unique characteristic of not stimulating appetite, distinguishing it from other growth hormone stimulants. This feature allows women to harness its fat-burning properties without the counterproductive urge to consume more calories.

Furthermore, a compelling study demonstrated that individuals incorporating Ipamorelin into their regimen experienced a notable 14% reduction in visceral fat over a 12-week period. Visceral fat, often deemed “dangerous fat,” is associated with various health risks, underscoring the importance of its reduction for overall well-being.

In summary, Ipamorelin presents a scientifically backed approach to female fat loss by elevating growth hormone levels, hastening metabolism, and reducing detrimental visceral fat—all achieved without triggering an increased appetite. This makes Ipamorelin a promising avenue for those seeking an effective and well-rounded solution to enhance their overall body composition.

Ipamorelin Overview

⭐️ Top Benefits: Increases natural HGH production
🧪 Form: Injectable liquid
⌛️ Max Time Used: Up to 3 months
💰 Average Cost: $52.99
❤️‍🩹 Side Effects: Insulin resistance
☢️ Dangers: Not really
📚 Best Peptide Stack: HGH / IGF-1 / GHRP / CJC-1295
Men/Women: Men and women
➡️ Go to the Full review

  • Muscle gain
  • Fat Loss
  • Increased bone density
  • Injection site pain
  • Insulin resistance

How do Peptides work?

Each peptide has a distinct mechanism of action from that of the others. However, most peptides result in the release of increased levels of growth hormone from the anterior pituitary gland. Growth hormone (GH), a peptide hormone, works by targeting different organs and causing systemic effects. 

It binds to receptors found in skeletal muscles, adipose tissue, and hepatocytes. With subsequent binding, it leads to increased fat metabolism. 

Human growth hormone increases the process of lipolysis alongside decreasing the occurrence of lipogenesis (1). That said, your body starts utilizing already stored fat reserves and prevents the formation of new lipids. 

This mechanism accelerates fat loss, especially in central regions such as the abdomen. Few other peptides are seen to work by modifying the levels of other hormones, such as insulin and glucagon, responsible for glucose regulation (2). 

How to take Peptides?

Most peptides are available in various forms, such as capsules, tablets, and injections. Therefore, the intake of peptides is very convenient due to their multiple forms. 

However, as far as efficacy and bioavailability are concerned, taking the peptides via injections is recommended. 

AOD9604 is a synthetic fragment of the human growth hormone (HGH) C-terminus (3). The peptide gained immense popularity after a successful clinical trial in 2004. 

AOD9604 works via two common mechanisms. It is known to increase lipolysis by many folds and inhibit lipogenesis from taking place (4). 

With increased lipolysis, your body utilizes the already present fat reserves, converting them to fatty acids and glycerol. These by-products are then eventually used in the production of ATP. On the other hand, new fat synthesis via lipogenesis is reduced to marked levels with AOD9604. 

Comprising approximately 30 amino acids, CJC 1295 is a synthetic analog of growth hormone stimulating hormone (GHRH). With increased GHRH levels, the anterior pituitary gland is stimulated. This leads to peak growth hormone (GH) levels and, consequently, insulin-like growth factor-1 (IGF-1) (5). 

With high GH and IGF-1, you have a better chance of reducing excess subcutaneous fat and an increased lean muscle mass due to enhanced protein synthesis. CJC 1295 is also reported to improve the lipid profile of many. 

Interestingly, CJC 1295 works best with maximized benefits when stacked with Ipamorelin. When dosed appropriately, both can boost fat loss, improve protein synthesis, lead to lean muscle mass, strengthen the immune system, and rapid healing. 

How to reconstitute Peptides?

Peptides usually require reconstitution before administering. It is due to most peptides being manufactured in powder/lyophilized form when in a container/vial. 

Therefore, to efficiently use the drug, you must mix the powdered peptide with bacteriostatic water. Make sure you add drops of water with the right dosage in consideration. 

After mixing, make sure there is maximum interaction between the bacteriostatic water and powdered peptide in the vial. 

How to inject Peptides?

Most peptides are supposed to be injected into the body via a needle since very few come in the form of capsules. Intravenous, intramuscular and subcutaneous are the three most common methods of administering peptides. 

The Intravenous method requires a professional for the administration. In contrast, for intramuscular, all it takes is a direct jab on the muscles. In the end, subcutaneous administration is perhaps the easiest route. All one needs to do is prick the needle underneath the skin. 

However, under all circumstances, it is recommended to have a professional or an experienced individual do the procedure. 

Are Peptides Safe for Fat Loss?

Starting new supplements can be daunting at times because of their potential side effects. However, with peptides, you’ve got nothing to worry about. Peptides are generally considered very safe and fall within the safety profile. It is due to most peptides mimicking the actions of endogenous hormones. 

However, peptides are contraindicated in cases of pregnancy and cancer.

Additional benefits of using Peptides

While fat loss is one of the most prominent benefits associated with peptides, it would be naive to limit it to that only. Peptides are multi-oriented supplements that are being used by the masses. 

They’ve reported causing enhanced angiogenesis, leading to better recovery and wound healing. Growth hormone analogs/secretagogues are reported to increase lean muscle mass, making these peptides popular among athletes and fitness freaks. 

With improved fat loss, peptides also help in reducing the risk of developing potential cardiovascular disorders such as atherosclerosis. Certain peptides also have anti-inflammatory properties. 

💉Become a Peptide Expert (Protect your Health) 💉

Take our FREE 25-email course to learn everything you need to know about the scientific application of peptides. Discover how to protect your health, avoid sketchy peptide vendors, and stop wasting your hard-earned money. 🔥 🧪 💊 💪 💉 🩸🏥 🥎

Alternatives for Weight Loss

Although peptides are quite efficient and potent regarding fat loss properties, they aren’t the only ones to do so. Certain compounds have been developed, especially in the past decade, that cater to fat loss attributes besides other benefits. 

As alternatives, certain Selective Androgen Receptor modulators (SARMs) such as Cardarine and Ostarine are best when it comes to fat loss.

However, strong SARMs are also known for nastier side effects. Besides this, fat loss supplements can also be used with Peptides. 

Are Fat Loss Peptides Legit?

Using peptides is surely the safest way to reduce excess fat. With little to no side effects, peptides can provide long-term benefits such as increased fat loss, cholesterol and triglyceride regulation, and an overall healthy physical being.  

These peptides, besides fat loss, also provide a wide range of other benefits such as rapid wound healing, recovery, and an increase in lean muscle mass. 

Therefore, with peptides, you’re in for a multi-beneficial effect all at once. The ball’s in your court! 

What peptide is best for fat loss?

Tesamorelin is reportedly more potent than CJC 1295 and Ipamorelin combined. It is considered effective in individuals with a greater amount of fat to lose.

Do peptides burn belly fat?

Yes, some peptides have been reported to work directly on the abdominal fat through increased lipolysis and inhibition of lipogenesis.

Who should not take peptides?

Generally, peptides are well tolerated with rare side effects. However, if you’re pregnant or have/had cancer, peptide supplementation is contraindicated as it can interfere with hormone balance.

How fast do you see results from peptides?

It generally takes a couple of months for results to show up. However, after 4 to 6 months, they should be highly apparent.

How long should you cycle peptides?

It is recommended to cycle for approximately 6 to 12 weeks.

How to reconstitute Peptides?

Peptides usually require reconstitution before administering. It is due to most peptides being manufactured in powder/lyophilized form when in a container/vial. 

Therefore, to efficiently use the drug, you must mix the powdered peptide with bacteriostatic water. Make sure you add drops of water with the right dosage in consideration. 

After mixing, make sure there is maximum interaction between the bacteriostatic water and powdered peptide in the vial. 

How to inject Peptides?

Most peptides are supposed to be injected into the body via a needle since very few come in the form of capsules. Intravenous, intramuscular and subcutaneous are the three most common methods of administering peptides. 

The Intravenous method requires a professional for the administration. In contrast, for intramuscular, all it takes is a direct jab on the muscles. In the end, subcutaneous administration is perhaps the easiest route. All one needs to do is prick the needle underneath the skin. 

However, under all circumstances, it is recommended to have a professional or an experienced individual do the procedure. 

Are Peptides Safe for Fat Loss?

Starting new supplements can be daunting at times because of their potential side effects. However, with peptides, you’ve got nothing to worry about. Peptides are generally considered very safe and fall within the safety profile. It is due to most peptides mimicking the actions of endogenous hormones. 

However, peptides are contraindicated in cases of pregnancy and cancer.

Additional benefits of using Peptides

While fat loss is one of the most prominent benefits associated with peptides, it would be naive to limit it to that only. Peptides are multi-oriented supplements that are being used by the masses. 

They’ve reported causing enhanced angiogenesis, leading to better recovery and wound healing. Growth hormone analogs/secretagogues are reported to increase lean muscle mass, making these peptides popular among athletes and fitness freaks. 

With improved fat loss, peptides also help in reducing the risk of developing potential cardiovascular disorders such as atherosclerosis. Certain peptides also have anti-inflammatory properties. 

Alternatives for Weight Loss

Although peptides are quite efficient and potent regarding fat loss properties, they aren’t the only ones to do so. Certain compounds have been developed, especially in the past decade, that cater to fat loss attributes besides other benefits. 

As alternatives, certain Selective Androgen Receptor modulators (SARMs) such as Cardarine and Ostarine are best when it comes to fat loss.

However, strong SARMs are also known for nastier side effects. Besides this, fat loss supplements can also be used with Peptides. 

Are Fat Loss Peptides Legit?

Using peptides is surely the safest way to reduce excess fat. With little to no side effects, peptides can provide long-term benefits such as increased fat loss, cholesterol and triglyceride regulation, and an overall healthy physical being.  

These peptides, besides fat loss, also provide a wide range of other benefits such as rapid wound healing, recovery, and an increase in lean muscle mass. 

Therefore, with peptides, you’re in for a multi-beneficial effect all at once. The ball’s in your court! 

What peptide is best for fat loss?

Tesamorelin is reportedly more potent than CJC 1295 and Ipamorelin combined. It is considered effective in individuals with a greater amount of fat to lose.

Do peptides burn belly fat?

Yes, some peptides have been reported to work directly on the abdominal fat through increased lipolysis and inhibition of lipogenesis.

Who should not take peptides?

Generally, peptides are well tolerated with rare side effects. However, if you’re pregnant or have/had cancer, peptide supplementation is contraindicated as it can interfere with hormone balance.

How fast do you see results from peptides?

It generally takes a couple of months for results to show up. However, after 4 to 6 months, they should be highly apparent.

How long should you cycle peptides?

It is recommended to cycle for approximately 6 to 12 weeks.

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1)https://pubmed.ncbi.nlm.nih.gov/30885833/
2)https://pubmed.ncbi.nlm.nih.gov/32416957/
3)https://pubmed.ncbi.nlm.nih.gov/25208511/
4)https://pubmed.ncbi.nlm.nih.gov/11146367/
5)https://pubmed.ncbi.nlm.nih.gov/16352683/
6)https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5826726/
7)https://pubmed.ncbi.nlm.nih.gov/20101189/
8)https://pubmed.ncbi.nlm.nih.gov/9849822/
9)https://pubmed.ncbi.nlm.nih.gov/10373343/

Contributors

Kumar Rathi

Kumar Rathi | Writer

Kartik is a medical student with a passion for anatomy and physiology. He writes research papers, articles and blogs to raise awareness and also has a strong interest in teaching and public speaking. Aspiring to be a successful cardiologist, Kartik believes in connecting with people on a personal level and is an expert in peptides.

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