Best NAC Supplements

Best NAC Supplements (N-Acetyl Cysteine)

This is our review of the 3 best NAC (N-Acetyl Cysteine) supplements for 2021. Here, we’ll review exactly what you need to know about the leading NAC supplements and why they’re far superior to competing brands.

Check out our top picks below for NAC in both powder and capsule form!

Best NAC Supplements

TL;DR: What is NAC?

  • NAC supplements provide the body with an additional supply of l-cysteine, which in turn produces glutathione. Glutathione is an antioxidant that defends the body from oxidative stress and free radical damage.
  • NAC is extremely helpful for those who have liver damage or suffer from severe physical or mental illness. People who consume alcohol regularly or who frequently use acetaminophen have an increased need for glutathione.
  • NAC is more soluble and stable than cysteine and also has a far greater potential to supply the body with sulfur.

Comparison of the 3 Best NAC Supplements

Best NAC Capsules
Bulk Supplements
Best NAC Supplements (N-Acetyl Cysteine)Best NAC Supplements (N-Acetyl Cysteine)Best NAC Supplements (N-Acetyl Cysteine)Best NAC Supplements (N-Acetyl Cysteine)Best NAC Supplements (N-Acetyl Cysteine)
Best NAC Capsules
Bulk Supplements

Pure NAC is a clean and pure product without any form of filler content. It is tested in the lab and verified for guaranteed quality.

100 or 300 Capsules
600mg per Serving
1-3 Servings Daily
Best NAC Powder
Science Bio
Best NAC Supplements (N-Acetyl Cysteine)Best NAC Supplements (N-Acetyl Cysteine)Best NAC Supplements (N-Acetyl Cysteine)Best NAC Supplements (N-Acetyl Cysteine)Best NAC Supplements (N-Acetyl Cysteine)
Best NAC Powder
Science Bio

Science Bio NAC comes in powder form and is free of adulterants, excipients and flow agents to ensure purity.

Powder Form
500mg per Serving
1-3 Servings Daily
Best Custom NAC Supplement
Best NAC Supplements (N-Acetyl Cysteine)Best NAC Supplements (N-Acetyl Cysteine)Best NAC Supplements (N-Acetyl Cysteine)Best NAC Supplements (N-Acetyl Cysteine)Best NAC Supplements (N-Acetyl Cysteine)
Best Custom NAC Supplement

Persona's vitamin pack is custom-tailored to each customer's unique health needs through the use of a highly-detailed online questionnaire. NAC is available as an add-in option.

Capsule Form
600mg per Serving
Vegetarian Friendly
Individual Ingredients $0.12-$1.57 Daily

Best NAC Capsules: Bulk Supplements 

BulkSupplements NAC Bulk Supplements offers the best NAC capsules available and provides customers with the option to select from standard gelatin capsules or vegetarian-friendly capsules.

This product contains pure N-Acetyl L-Cysteine that is free of additional ingredients or additives of any kind. Customers can order either 100 or 300 capsules of NAC or may choose to purchase it in powder form of varying quantities as well.

It is recommended for adults to take 1-3 servings of 600mg daily, depending on their health needs.


  • Capsule or powder form

  • Gelatin or vegetarian capsules

  • 100% pure NAC

  • Vegetarian capsules sell out often and may have limited availability 

Best NAC Powder: Science Bio

Best NAC Supplements (N-Acetyl Cysteine)

N-Acetyl L-Cysteine (NAC) by Science Bio is one of the purest and best tested NAC powders available on the market today. This product is manufactured by Botany Biosciences and each container comes with 100 g of pure NAC.

This NAC powder contains no additional ingredients and is free of adulterants, excipients, and flow agents. Additionally, it is contained within a PET single-wall jar that protects the product from UV damage that may lead to degradation.

It is recommended for adults to take 1-3 servings of 500mg daily when using this product. For best results, consumers should take NAC with food.

  • 100% pure NAC
  • Lab reports provided for each batch
  • 200 servings per container

  • Some consumers may not feel comfortable purchasing from a brand that sells research chemicals
  • Only available in powder form

custom multivitamin pack

Best Custom NAC Supplement: Persona Nutrition

Best Prenatal Vitamins

Persona Nutrition provides customers with their own personalized, monthly subscription vitamin pack to best meet their specific health needs.

In order to best customize individual vitamin packs, each customer should initially complete a quick assessment on Persona’s website to receive personalized, science-backed supplement
recommendations. Specific questions on this assessment gather information on specific types of diets, allergies and food sensitivities, health conditions, medication use, and more.

Alternatively, individuals may also use the option to filter vitamins by certain health needs on the products page.

Persona offers NAC as an add-in option that contains 600 mg of free-form n-acetyl cysteine.

  • Highly Detailed Online Assessment
  • Live Nutritionist Support
  • 80 Different Ingredients Available
  • Not All Ingredients are Trademarked
  • Uses Proprietary Blends
  • Does Not Rely on Blood Test or DNA Test

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NAC Antioxidant

NAC exhibits extremely powerful antioxidant properties due to its ability to enhance glutathione production, promote full-body detoxification, and remove free radicals. [1]

Its role as an antioxidant allows it to be an effective option in the treatment of disorders that result directly from free oxygen radical formation and damage. Some of the most common disorders that are caused or heavily affected by free radical damage include infertility in men and PCOS in women.

Men and women affected by these disorders who have used NAC in conjunction with standard forms of treatment have displayed incredible improvements in fertility parameters, such as sperm morphology and function, and have improved women’s chances of conceiving due to improvements in ovulation. [5]

Additionally, NAC has provided substantial support for diabetics in the prevention of further complications related to oxidative stress. Studies have shown that NAC reduces the risk of myocardial infarction in those who suffer from diabetes and may play a critical role in the prevention of both ischemia and non-ischemic-associated cardiac damage. [3]

Best Time to Take NAC

NAC can be taken throughout the day as needed. However, it is generally recommended to take NAC after eating to prevent potential side effects such as nausea or gastrointestinal discomfort.

Most people take their first dose of NAC upon waking with breakfast and take additional servings as needed, such as mid-day or before bed.

NAC for Anxiety

NAC has been used for the treatment of anxiety, depression, and similar disorders. [2]  NAC is successful in the treatment of psychiatric and neurological disorders due to its role in reducing cellular damage related to oxidative stress and inflammation, its ability to prevent apoptosis, and its assistance in mitochondrial function and dopamine regulation. [4]

Studies have displayed that servings of 2,400-3,000 mg/day of NAC used over the course of at least 3 months help to drastically reduce the severity of the most common symptoms associated with mental health disorders. [6]

NAC provides people of all ages with an over-the-counter, affordable form of treatment that is easily accessible and poses minimal adverse effects.

Best NAC Supplement

We recommend N-Acetyl L-Cysteine (NAC) by Bulk Supplements as the best NAC supplement. Bulk goes above and beyond in offering its customers numerous options for how to take their NAC and its products are incredibly pure and affordable when compared to other leading brands.

The company offers both powder and capsule form for its NAC and it also provides both gelatin and vegetarian options for its capsules.

custom multivitamin pack

Take-Home Message

If you’re looking for the best NAC capsules, we highly recommend taking pure NAC by Bulk Supplements. However, if you want to include NAC as an add-in option along with taking additional supplements, we recommend Persona. Finally, those who are searching for the best NAC powder should use Science Bio.


See all references

[1] Mokhtari, V., Afsharian, P., Shahhoseini, M., Kalantar, S. M., & Moini, A. (2017). A Review on Various Uses of N-Acetyl Cysteine. Cell journal, 19(1), 11–17.

[2] Rapado-Castro, M., Dodd, S., Bush, A. I., Malhi, G. S., Skvarc, D. R., On, Z. X., … & Dean, O. M. (2017). Cognitive effects of adjunctive N-acetyl cysteine in psychosis.

[3] Dludla, P. V., Dias, S. C., Obonye, N., Johnson, R., Louw, J., & Nkambule, B. B. (2018). A systematic review on the protective effect of N-acetyl cysteine against diabetes-associated cardiovascular complications. American Journal of Cardiovascular Drugs, 18(4), 283-298.

[4] Oliver, G., Dean, O., Camfield, D., Blair-West, S., Ng, C., Berk, M., & Sarris, J. (2015). N-acetyl cysteine in the treatment of obsessive compulsive and related disorders: a systematic review. Clinical psychopharmacology and neuroscience : the official scientific journal of the Korean College of Neuropsychopharmacology, 13(1), 12–24.

[5] Jannatifar, R., Parivar, K., Roodbari, N. H., & Nasr-Esfahani, M. H. (2019). Effects of N-acetyl-cysteine supplementation on sperm quality, chromatin integrity and level of oxidative stress in infertile men. Reproductive Biology and Endocrinology, 17(1), 1-9.

[6] Slattery, J., Kumar, N., Delhey, L., Berk, M., Dean, O., Spielholz, C., & Frye, R. (2015). Clinical trials of N-acetylcysteine in psychiatry and neurology: a systematic review. Neuroscience & Biobehavioral Reviews, 55, 294-321.

[7] Fernandes, B. S., Dean, O. M., Dodd, S., Malhi, G. S., & Berk, M. (2016). N-Acetylcysteine in depressive symptoms and functionality: a systematic review and meta-analysis. The Journal of clinical psychiatry, 77(4), 457-466.



The author

Kathryn Giuffrida MPH
Kathryn trains full-time in year-round swimming and qualified to compete in the 2020 TYR Pro Series. Kathryn has also competed in bodybuilding within the women’s figure division and plans to return to the stage in the near future.

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