5 Best NAC Supplements and Brands (Powder and Pills)

Best NAC Supplements

Earlier this year, Amazon sent customers scrambling to find NAC supplements when they removed them from their platform. Although this may have seemed sudden it has been a long battle between the FDA and supplement companies manufacturing and distributing NAC supplements.

Whilst this battle rages on, a lot of us have been stranded and are unable to purchase NAC. NAC is one of the most popular supplements used for antioxidant support and to reduce inflammation.

In this review we will review NAC products that are still manufactured and distributed and why they are superior to competing brands.

FeaturesThorneBulk SupplementsDoublewood supplementsLife Extension
βœ”οΈ FDA approvedβœ…οΈβœ…οΈβœ…οΈβœ…οΈ
βœ”οΈ Third Party Testedβœ…οΈβœ…οΈβœ…οΈβœ…οΈ
Shipping cost$11.95Depends on LocationsDepends on LocationsFree within USA
πŸ’Έ NAC price$26/90 capsules$43.96$29.95/210 capsules$11.25/60 capsules
πŸ“ LocationNewYork, USAHenderson, NevadaPennsylvania, USAFlorida, USA
Variety of NAC500 mg600 mg500 mg600 mg
πŸ“‹ Personalizationβœ…οΈπŸš«πŸš«βœ…οΈ
πŸ’Έ Payment optionsCredit cardAmerican Express, Visa, Master Card, Discover, PaypalCredit cardAmerican Express, Visa, Master Card, Discover
⭐ Best forAntioxidant, Anti Anxiety, Fertility
πŸ“¦ Product typesPowder and pill form
πŸ€‘ Pricing$0.10 – $0.27 per serving
βœ… Discounts10% off with Bulk Supplements with code brawn10
1Best Small Pills
Thorne 500mg Capsules
  • Easy to take capsules
  • 500mg of NAC per serving
  • 100% pure NAC
Buy Now (20% off)
2Best Powder
Bulk Supplements Powder (Back in Stock)
  • Best priced
  • 10% off with brawn10 at checkout
  • Multiple sizes available
  • Powder form
3Best Large Pills
Doublewood Supplements 1000mg Capsules
  • Trusted brand
  • Larger 1000mg capsules

Warning: The content on Muscleandbrawn.com and the information included in this article is intended for entertainment and informational purposes only. It is not intended nor implied to be a substitute for professional medical advice. Prior to buying anything, check that it is compliant where you live with your current government laws. We frequently mention research chemicals that are not made for human consumption. Therefore, before purchasing any product for personal use, consult with your doctor or healthcare provider first.

NAC Banned On Amazon

In July 2020, the FDA sent advisory letters to seven supplement brands warning them against selling NAC supplements, even though the FDA has not done a final determination on NAC supplements. However, even though it’s an open issue, Amazon has jumped the gun and banned the sale of all supplements that contain this ingredient.

Don’t worry though! We found the leading retailers that still sell NAC, but be aware that they might sell out at any moment.

Best Sized Pills

Thorne 500mg Capsules

NAC by Thorne is available in capsule form and each serving (1 capsule) provides 500mg of N-Acetyl-L-Cysteine.

This product is ideal for customers who are completely new to using NAC and want to gradually increase their dosage over time.
Thorne provides one of the best-tested and most easily absorbed low-dose NAC capsules on the market today.

It is recommended for adults to take 2-3 capsules daily.

20% off by using our link


  • Easy to take capsules
  • 500mg of NAC per serving
  • 100% pure NAC


  • Powder version is less expensive per serving than capsules
  • Other capsules contain higher dosages (better for more experienced users)
Best Large Capsules

Best NAC Supplement for Covid – Doublewood Supplements 1000mg Capsules

Double Wood offers one of the most potent NAC supplements available today.  Each capsule contains 500mg of NAC, but the recommended daily serving is 2 capsules (1,000mg).

Thankfully, Double Wood’s NAC capsules are made with naturally derived ingredients only and are free from synthetic materials that are often contained in lower-quality, generic products.

Whether you’re new to using NAC or have used it for a while, this product can be easily dosed according to one’s preferences and tolerability.

Full Brand Review


  • 2 capsules daily
  • 1000mg of NAC per serving
  • 100% pure NAC


  • Powder version is more cost-effective
Best Powder and Most Affordable

Bulk Supplements Powder (Back in Stock)

Bulk Supplements offers the best NAC capsules available. It provides customers with the option to select from standard gelatin capsules or vegetarian-friendly capsules and there is also a powder version available as well.
This product contains pure N-Acetyl L-Cysteine that is free of additional ingredients or additives of any kind. Customers can order either 100 or 300 capsules of NAC or may choose to purchase it in powder form of varying quantities as well.
It is recommended for adults to take 1-3 servings of 600mg daily, depending on their health needs.

Full Brand Review

10% off with code brawn10


  • Capsule or powder form
  • Gelatin or vegetarian capsules
  • 100% pure NAC
  • Best valie


  • Vegetarian capsules sell out often and may have limited availability
Best Medium Capsules

Life Extension

NAC by Life Extension is available in an easily absorbed capsule form that provides 600mg of N-Acetyl-L-Cysteine per serving.

This is the perfect product for customers who can’t stand the somewhat bitter taste of NAC in its standard powder form as it doesn’t leave an aftertaste whatsoever.

Additionally, there’s no hassle with having to measure out dosages exactly and this product provides an easy way to gradually increase or lower servings as needed.
This 100% pure NAC supplement provides systemic benefits, especially for bronchial, respiratory, liver, and immune health.

It is recommended for adults to take 1-3 capsules daily.


  • Easy to take capsules
  • 600mg of NAC per serving
  • 100% pure NAC


  • Powder version is more cost-effective

NAC Antioxidant

NAC exhibits extremely powerful antioxidant properties due to its ability to enhance glutathione production, promote full-body detoxification, and remove free radicals. [1]

Its role as an antioxidant allows it to be an effective option in the treatment of disorders that result directly from free oxygen radical formation and damage. Some of the most common disorders that are caused or heavily affected by free radical damage include infertility in men and PCOS in women.

Men and women affected by these disorders who have used NAC in conjunction with standard forms of treatment have displayed incredible improvements in fertility parameters, such as sperm morphology and function, and have improved women’s chances of conceiving due to improvements in ovulation. [5]

Additionally, NAC has provided substantial support for diabetics in the prevention of further complications related to oxidative stress. Studies have shown that NAC reduces the risk of myocardial infarction in those who suffer from diabetes and may play a critical role in the prevention of both ischemia and non-ischemic-associated cardiac damage. [3]

NAC for Anxiety

NAC has been used for the treatment of anxiety, depression, and similar disorders. [2]  NAC is successful in the treatment of psychiatric and neurological disorders due to its role in reducing cellular damage related to oxidative stress and inflammation, its ability to prevent apoptosis, and its assistance in mitochondrial function and dopamine regulation. [4]

Studies have displayed that servings of 2,400-3,000 mg/day of NAC used over the course of at least 3 months help to drastically reduce the severity of the most common symptoms associated with mental health disorders. [6]

NAC provides people of all ages with an over-the-counter, affordable form of treatment that is easily accessible and poses minimal adverse effects. As far as what the best is? Just get pure.

NAC for Covid-19

NAC has multiple properties that have been shown useful in treating critically ill patients and now Covid-19.

These properties are:

  • Antioxidant
  • Anti Inflammatory
  • Immune modulating characteristics 

Research has shown that administration of NAC may suppress Covid-19 replication and improve outcomes if used timely.

The administration of NAC in combination with other antiviral agents may reduce the hospital admission rate, mechanical ventilation and mortality [8].

Dosage for Covid-19

Research has proposed a dose of 600mg as an effective and economical measure to prevent Covid-19 in healthy patients.

If symptoms of Covid-19 start developing a dose of 1200mg is recommended to help alleviate symptoms and accelerate recovery from the infection.

For patients in ICU healthcare practitioners can administer NAC via IV form [8].

Before taking NAC, it is important to chat to your healthcare provider.

NAC and Lung Health

Chronic obstructive pulmonary diseases (COPD), Asthma and chronic bronchitis are  common lung disorders that are estimated to affect  millions of Americans. COPD causes long term oxidative damage and inflammation of the lungs. This causes the airways to constrict and results in shortness of breath and coughing. 

NAC can help relieve symptoms for individuals affected by COPD and other lung conditions.  The main way it helps is by acting as an antioxidant and expectorant. 

NAC helps replenish glutathione levels in the lungs which helps reduce inflammation in the airways, it also helps to thin the mucus in the lungs. This reduces the frequency and severity of coughing, wheezing and shortness of breath.

NAC supplements have been used to improve COPD symptoms, exacerbations and lung function decline. In a one-year study, 600mg of NAC twice a day significantly improved lung functions and symptoms in those with stable COPD [8].

NAC for Depression, Anxiety, OCD and trichotillomania

Addictive and compulsive disorders affect millions of Americans and include depression, bipolar disorder, anxiety, trichotillomania, skin picking, nail biting and OCD.

Glutamate is an important neurotransmitter in the brain however when it is in excess paired with a depletion of glutathione it can contribute to OCD and other addictive behaviors. Research has shown that NAC can benefit these disorders by replenishing NAC and regulating the levels of Glutamate in the brain. This makes it easier for patients to reduce unwanted behavior [9].

The recommended dose for NAC with these disorders is 1200mg to be taken twice a day, one in the morning and one in the evening [10].

Best NAC Supplement?

We recommend N-Acetyl L-Cysteine (NAC) by Bulk Supplements as the best NAC supplement. Bulk goes above and beyond in offering its customers numerous options for how to take their NAC and its products are incredibly pure and affordable when compared to other leading brands.

The company offers both powder and capsule form for its NAC and it also provides both gelatin and vegetarian options for its capsules. They’re also the most affordable option!

Should I take NAC in the Morning or Evening?

NAC can be taken throughout the day as needed. However, it is generally recommended to take NAC after eating to prevent potential side effects such as nausea or gastrointestinal discomfort.
Most people take their first dose of NAC upon waking with breakfast and take additional servings as needed, such as mid-day or before bed.
If you are taking it for lung conditions it may be best to take a dose in the evening as lung function can decline in the evening.

How long does it take for NAC to work?

For NAC to function at its best it needs to be converted to L-Glutathione first, this takes about an hour after you take it. Some conditions such as trichotillomania, skin picking  may require you to take it for a longer period of time until you start seeing improvement.

Take-Home Message

NAC is a powerful supplement with many health benefits. If you’re looking for the best NAC capsules, we highly recommend taking pure NAC by Bulk Supplements.

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[1] Mokhtari, V., Afsharian, P., Shahhoseini, M., Kalantar, S. M., & Moini, A. (2017). A Review on Various Uses of N-Acetyl Cysteine. Cell journal, 19(1), 11–17. https://doi.org/10.22074/cellj.2016.4872

[2] Rapado-Castro, M., Dodd, S., Bush, A. I., Malhi, G. S., Skvarc, D. R., On, Z. X., … & Dean, O. M. (2017). Cognitive effects of adjunctive N-acetyl cysteine in psychosis.

[3] Dludla, P. V., Dias, S. C., Obonye, N., Johnson, R., Louw, J., & Nkambule, B. B. (2018). A systematic review on the protective effect of N-acetyl cysteine against diabetes-associated cardiovascular complications. American Journal of Cardiovascular Drugs, 18(4), 283-298.

[4] Oliver, G., Dean, O., Camfield, D., Blair-West, S., Ng, C., Berk, M., & Sarris, J. (2015). N-acetyl cysteine in the treatment of obsessive compulsive and related disorders: a systematic review. Clinical psychopharmacology and neuroscience : the official scientific journal of the Korean College of Neuropsychopharmacology, 13(1), 12–24. https://doi.org/10.9758/cpn.2015.13.1.12

[5] Jannatifar, R., Parivar, K., Roodbari, N. H., & Nasr-Esfahani, M. H. (2019). Effects of N-acetyl-cysteine supplementation on sperm quality, chromatin integrity and level of oxidative stress in infertile men. Reproductive Biology and Endocrinology, 17(1), 1-9.

[6] Slattery, J., Kumar, N., Delhey, L., Berk, M., Dean, O., Spielholz, C., & Frye, R. (2015). Clinical trials of N-acetylcysteine in psychiatry and neurology: a systematic review. Neuroscience & Biobehavioral Reviews, 55, 294-321.

[7] Fernandes, B. S., Dean, O. M., Dodd, S., Malhi, G. S., & Berk, M. (2016). N-Acetylcysteine in depressive symptoms and functionality: a systematic review and meta-analysis. The Journal of clinical psychiatry, 77(4), 457-466.

[8] Shi Z, Puyo C, 2020, N-Acetylcysteine to Combat Covid-19: An Evidence Review, Therapeutics and Clinical Risk,16: 1047-55. https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7649937/

[9] Goodson A, 2018, Top 9 Benefits of NAC (N-Acetyl Cysteine), Healthline, viewed 30th November 2021, https://www.healthline.com/nutrition/nac-benefits

[10] Grant JE, 2017, N-Acetylcysteine for Trichotillomania, Skin Picking, and Nail Biting, The TLC Foundation, viewed 30th November 2021, https://www.bfrb.org/learn-about-bfrbs/123-n-acetylcysteine-for-trichotillomania-skin-picking-and-nail-biting


Kathryn Giuffrida MPH

Kathryn Giuffrida MPH | Writer

Kathryn is a Florida native with a Bachelor of Science in Biology and a Master of Public Health in Environmental and Occupational Health. She is an accomplished digital marketer, having contributed to websites like Muscle and Brawn, and an avid swimmer who qualified to compete in the 2020 TYR Pro Series. Kathryn's passion for science, health, and fitness make her an asset to any platform seeking engaging and scientifically sound content.

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2 years ago

ALERT … Science Bio states on its info that you refer to for more info …
NOT FOR HUMAN CONSUMPTION !!!!! you really need to remove this product for sale… unless i am missing something .. IT CLEARLY SAYS THIS !!!
‘This material is sold for laboratory research use only. Terms of sale apply.
“Not for human consumption, nor medical, veterinary, or household uses. Please familiarize yourself with our Terms & Conditions prior to ordering”
“This material is sold for laboratory research use only. Terms of sale apply. Not for human consumption, nor medical, veterinary, or household uses. Please familiarize yourself with our Terms & Conditions prior to ordering.”

Muscle and Brawn Team
2 years ago
Reply to  lee

Hi Lee, this is necessary because the FDA is cracking down on NAC. This means that companies cannot advertise them for human consumption even though NAC has been in use for decades and is known to be a safe supplement. Science.bio is an approved vendor and known to have extremely high quality controls.

Take a look at studies covering NAC: https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6562654/#:~:text=Although%20NAC%20is%20considered%20a,our%20understanding%20of%20NAC%20applicability.

miranda priestley
miranda priestley
2 years ago

is nac made from corn

1 year ago

No, NAC is not derived from corn.

2 years ago

I take AC Glutathione. Is it safe for me to take NAC with it since NAC raises glutathione levels?

1 year ago

Am confused i buy NAC on Amazon most of the time..no probs at all
No where does is say..not for human consumption

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