Best NAC Supplements (N-Acetyl Cysteine)

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With Amazons banning of NAC (N-Acetyl Cysteine) supplements suppliers have been running dry all over, we’ve seen most brands stop selling outright but have found a few still supplying NAC, either in pure powder form or in a more popular form as an addition to Immunity and Vision supplements.

We’re going to keep updating this list with brands as we find them being sold online, but one thing is clear: The government doesn’t want you to have this.

NAC is one of the most popular supplements used for antioxidant support and to reduce inflammation.

Here, we’ll review exactly what you need to know about the leading NAC supplements and discuss why they’re far superior to competing brands.

TL;DR: What is NAC?

  • NAC supplements provide the body with an additional supply of l-cysteine, which in turn produces glutathione. Glutathione is an antioxidant that defends the body from oxidative stress and free radical damage.
  • NAC is extremely helpful for those who have liver damage or suffer from severe physical or mental illness. People who consume alcohol regularly or who frequently use acetaminophen have an increased need for glutathione.
  • NAC is more soluble and stable than cysteine and also has a far greater potential to supply the body with sulfur.
  • Bulk Supplements offers the best NAC overall. This product is available in both gelatin or vegetarian capsules.
  • Life Extension offers the best NAC capsules. This product is easily absorbed and can be taken up to 3 times daily.
  • Nuzena offers the best vision support supplement. It contains NAC within its vision support blend along with essential vitamins and minerals that optimize vision and eye health.
  • 1MD offers the best natural cough suppressant. It contains 9 ingredients, including NAC, that work synergistically to boost the immune system and promote respiratory system performance.

Comparison of the 4 Best NAC Supplements

Best NAC Supplement
Bulk Supplements
1
Best NAC Supplements (N-Acetyl Cysteine)Best NAC Supplements (N-Acetyl Cysteine)Best NAC Supplements (N-Acetyl Cysteine)Best NAC Supplements (N-Acetyl Cysteine)Best NAC Supplements (N-Acetyl Cysteine)
Best NAC Supplement
Bulk Supplements

This supplement contains 100% pure NAC and is completely free of any filler ingredients.

1 Scoop Daily
600mg per Serving
$0.10 per Serving
Best NAC Capsules
Life Extension
2
Best NAC Supplements (N-Acetyl Cysteine)Best NAC Supplements (N-Acetyl Cysteine)Best NAC Supplements (N-Acetyl Cysteine)Best NAC Supplements (N-Acetyl Cysteine)Best NAC Supplements (N-Acetyl Cysteine)
Best NAC Capsules
Life Extension

This easily-absorbed, capsule version of NAC contains 600 mg per serving.

1-3 Capsules Daily
600mg per Serving
$0.18 per Serving
Best Eye Health Supplement
Nuzena
3
Best NAC Supplements (N-Acetyl Cysteine)Best NAC Supplements (N-Acetyl Cysteine)Best NAC Supplements (N-Acetyl Cysteine)Best NAC Supplements (N-Acetyl Cysteine)Best NAC Supplements (N-Acetyl Cysteine)
Best Eye Health Supplement
Nuzena

This multivitamin and supplement combo contains NAC within its vision support blend.

2 Capsules Daily
505mg Supplement Blend
$1.17 per Serving
Best Cough Suppressant
1MD
4
Best NAC Supplements (N-Acetyl Cysteine)Best NAC Supplements (N-Acetyl Cysteine)Best NAC Supplements (N-Acetyl Cysteine)Best NAC Supplements (N-Acetyl Cysteine)Best NAC Supplements (N-Acetyl Cysteine)
Best Cough Suppressant
1MD

This immunity and respiratory supplement contains NAC along with key antioxidants and herbs.

2 Capsules Daily
600mg per Serving
$1.10 per Serving

Best NAC Supplement: Bulk Supplements 

Best NAC Supplements

Bulk Supplements offers the best NAC capsules available and provides customers with the option to select from standard gelatin capsules or vegetarian-friendly capsules.

This product contains pure N-Acetyl L-Cysteine that is free of additional ingredients or additives of any kind. Customers can order either 100 or 300 capsules of NAC or may choose to purchase it in powder form of varying quantities as well.

It is recommended for adults to take 1-3 servings of 600mg daily, depending on their health needs.

 

Pros
  • Capsule or powder form

  • Gelatin or vegetarian capsules

  • 100% pure NAC

Cons
  • Vegetarian capsules sell out often and may have limited availability 

Best NAC Capsules – Life Extension

Best NAC Supplements

NAC by Life Extension is available in an easily absorbed, capsule form that provides 600mg of N-Acetyl-L-Cysteine per serving.

This is the perfect product for customers who can’t stand the somewhat bitter taste of NAC in its standard powder form as it doesn’t leave an aftertaste whatsoever.

Additionally, there’s no hassle with having to measure out dosages exactly and this product provides an easy way to gradually increase or lower servings as needed.

This 100% pure NAC supplement provides systemic benefits, especially for bronchial, respiratory, liver, and immune health.

It is recommended for adults to take 1-3 capsules daily.

Pros
  • Easy to take capsules
  • 600mg of NAC per serving
  • 100% pure NAC

Cons
  • Powder version is less expensive per serving than capsules

Best Vision Support Supplement: Vision Support + by Nuzena

Best NAC Supplements

This multivitamin and supplement-based product contains NAC within its vision support supplement blend.

Altogether, it comes packed with 14 essential nutrients and 11 different supplements to support the health and functionality of your macula lens and eyesight.

In addition to NAC, some of Vision Support +’s most noteworthy ingredients include:

  • Lutein
  • Zeaxanthin
  • Magnesium
  • Quercetin
  • Zinc
  • Alpha Lipoic Acid

 

It is recommended for adults to take 2 capsules of Vision Support + daily, once during the middle of the day and once at night.

Pros
  • 25 vitamins, minerals, and antioxidants
  • Contained in veggie capsules
  • 505mg Vision Support Blend
Cons
  • Does not disclose concentration of NAC

Best Cough Suppressant: ImmunityMD® Plus by 1MD

Best NAC Supplements

This product contains 9 ingredients which consist of essential vitamins, minerals, and supplements that support respiratory function and help relieve cough-related chest discomfort.

Each serving provides 600 mg of NAC along with the following immune-boosting herbs and supplements that accelerate healing and alleviate irritation of the respiratory tract:

  • Pelargonium sidoides 10:1 Extract
  • Elderberry 10:1 Extract
  • Marshmallow Root Extract

 

It is recommended for adults to take 1 capsule twice daily with food.

Pros
  • Immune-boosting vitamins and minerals
  • Herbs and supplements that reduce mucus build-up
  • 600mg of NAC per serving

Cons
  • Contains vegetable oil powder

NAC Antioxidant

NAC exhibits extremely powerful antioxidant properties due to its ability to enhance glutathione production, promote full-body detoxification, and remove free radicals. [1]

Its role as an antioxidant allows it to be an effective option in the treatment of disorders that result directly from free oxygen radical formation and damage. Some of the most common disorders that are caused or heavily affected by free radical damage include infertility in men and PCOS in women.

Men and women affected by these disorders who have used NAC in conjunction with standard forms of treatment have displayed incredible improvements in fertility parameters, such as sperm morphology and function, and have improved women’s chances of conceiving due to improvements in ovulation. [5]

Additionally, NAC has provided substantial support for diabetics in the prevention of further complications related to oxidative stress. Studies have shown that NAC reduces the risk of myocardial infarction in those who suffer from diabetes and may play a critical role in the prevention of both ischemia and non-ischemic-associated cardiac damage. [3]

Best Time to Take NAC

NAC can be taken throughout the day as needed. However, it is generally recommended to take NAC after eating to prevent potential side effects such as nausea or gastrointestinal discomfort.

Most people take their first dose of NAC upon waking with breakfast and take additional servings as needed, such as mid-day or before bed.

NAC for Anxiety

NAC has been used for the treatment of anxiety, depression, and similar disorders. [2]  NAC is successful in the treatment of psychiatric and neurological disorders due to its role in reducing cellular damage related to oxidative stress and inflammation, its ability to prevent apoptosis, and its assistance in mitochondrial function and dopamine regulation. [4]

Studies have displayed that servings of 2,400-3,000 mg/day of NAC used over the course of at least 3 months help to drastically reduce the severity of the most common symptoms associated with mental health disorders. [6]
[7]

NAC provides people of all ages with an over-the-counter, affordable form of treatment that is easily accessible and poses minimal adverse effects.

Best NAC Supplement

We recommend N-Acetyl L-Cysteine (NAC) by Bulk Supplements as the best NAC supplement. Bulk goes above and beyond in offering its customers numerous options for how to take their NAC and its products are incredibly pure and affordable when compared to other leading brands.

The company offers both powder and capsule form for its NAC and it also provides both gelatin and vegetarian options for its capsules.

Take-Home Message

If you’re looking for the best NAC capsules, we highly recommend taking pure NAC by Bulk Supplements. However, if you want to include NAC as an add-in option along with taking additional supplements, we recommend Persona. Finally, those who are searching for the best NAC powder should use Science Bio.

References

See all references

[1] Mokhtari, V., Afsharian, P., Shahhoseini, M., Kalantar, S. M., & Moini, A. (2017). A Review on Various Uses of N-Acetyl Cysteine. Cell journal, 19(1), 11–17. https://doi.org/10.22074/cellj.2016.4872

[2] Rapado-Castro, M., Dodd, S., Bush, A. I., Malhi, G. S., Skvarc, D. R., On, Z. X., … & Dean, O. M. (2017). Cognitive effects of adjunctive N-acetyl cysteine in psychosis.

[3] Dludla, P. V., Dias, S. C., Obonye, N., Johnson, R., Louw, J., & Nkambule, B. B. (2018). A systematic review on the protective effect of N-acetyl cysteine against diabetes-associated cardiovascular complications. American Journal of Cardiovascular Drugs, 18(4), 283-298.

[4] Oliver, G., Dean, O., Camfield, D., Blair-West, S., Ng, C., Berk, M., & Sarris, J. (2015). N-acetyl cysteine in the treatment of obsessive compulsive and related disorders: a systematic review. Clinical psychopharmacology and neuroscience : the official scientific journal of the Korean College of Neuropsychopharmacology, 13(1), 12–24. https://doi.org/10.9758/cpn.2015.13.1.12

[5] Jannatifar, R., Parivar, K., Roodbari, N. H., & Nasr-Esfahani, M. H. (2019). Effects of N-acetyl-cysteine supplementation on sperm quality, chromatin integrity and level of oxidative stress in infertile men. Reproductive Biology and Endocrinology, 17(1), 1-9.

[6] Slattery, J., Kumar, N., Delhey, L., Berk, M., Dean, O., Spielholz, C., & Frye, R. (2015). Clinical trials of N-acetylcysteine in psychiatry and neurology: a systematic review. Neuroscience & Biobehavioral Reviews, 55, 294-321.

[7] Fernandes, B. S., Dean, O. M., Dodd, S., Malhi, G. S., & Berk, M. (2016). N-Acetylcysteine in depressive symptoms and functionality: a systematic review and meta-analysis. The Journal of clinical psychiatry, 77(4), 457-466.

 

Kathryn Giuffrida MPH

Kathryn obtained a MPH in Toxicology & Risk Assessment from the University of South Florida in 2018. She's also a year-round swimmer who qualified to compete in the 2020 TYR Pro Series.

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