So, you’re looking at potentially getting the better version of Clomid… I don’t blame you! Enclomiphene citrate, also known by its brand names Androxal and Rextoro, is a selective estrogen receptor modulator (SERM). It is chemically related to clomiphene citrate, which is commonly prescribed as a fertility treatment for women under the brand name Clomid. However, enclomiphene citrate is specifically designed for use in men.

But finding Enclomiphene might be easier said than done. The internet is riddled with stories of GPs being very hostile to the idea of this new medication, and so, many men have turned to online clinics for help. Not only can you get Testosterone replacement therapy (testosterone treatment) online, but you can specifically also get Enclomiphene.

So, if you’re looking to improve your quality of life in a legit and legal way, you’re at the right place.

Key Takeaways

• Enclomiphene citrate works by increasing the production of testosterone in men with low testosterone levels, a condition known as hypogonadism
• The best clinic to get Enclomiphene citrate from is FountainTRT, a company that specializes in Testosterone Replacement Therapy
• Enclomiphene citrate is usually taken orally, and dosages vary depending on the individual’s condition and response to treatment
• It’s important to note that enclomiphene citrate should only be used under the supervision of a healthcare professional

What is Enclomiphene Citrate?

Enclomiphene citrate is a medication developed as a treatment for hypogonadism in men. Hypogonadism is a condition characterized by low levels of testosterone, which can lead to various symptoms including fatigue, low libido, erectile dysfunction, and reduced muscle mass.

Enclomiphene citrate belongs to a class of medications known as selective estrogen receptor modulators (SERMs). SERMs like enclomiphene citrate bind to estrogen receptors in certain tissues, effectively blocking the action of estrogen. By doing so, enclomiphene citrate increases the release of gonadotropins from the pituitary gland, which in turn stimulates the testes to produce more testosterone.

The development of enclomiphene citrate involved both preclinical and clinical research studies to evaluate its efficacy and safety in treating hypogonadism in men. Clinical trials typically involve phases of testing to assess different aspects of the medication, including its pharmacokinetics (how the body absorbs, distributes, metabolizes, and excretes the drug), dosing regimens, efficacy in increasing testosterone levels, and safety profile.

Enclomiphene citrate was developed as an alternative to traditional testosterone replacement therapy (TRT), which involves administering exogenous testosterone. While TRT effectively raises testosterone levels, it can also suppress the body’s natural production of testosterone, potentially leading to infertility and other side effects.

Studies have shown that Enclomiphene does increase serum total testosterone levels, and this increase in serum testosterone levels will lead to a relief of primary hypogonadism. This is most basic form of testosterone therapy, and can help millions of men worldwide.

The Best Enclomiphene Clinic: FountainTRT

FountainTRT Summary

#1 Best Online TRT Clinic: FountainTRT

FountainTRT has legitimately built a cutting edge TRT service. When you go to their website and take their quiz you realize that other TRT providers are stuck in 2015.

FountainTRT feels a lot closer to a startup than a TRT clinic. They provide a seamless quiz, evaluation, and then give you an option to do blood work locally at a LabCorp location, or alternatively have some COME TO YOUR HOUSE.

They are a premium concierge service that is on call 24/7 for any questions and urgent labs required.

While other companies hire freelance professionals, their medical team is comprised of full time doctors that will monitor you on a 1:1 basis. Tadalafil, HCG, Anastrozole and Enclomiphene.

TAKE THE QUIZ

FountainTRT Overview

🧪 Treatments: Injectable and topical TRT, HGC, Tadalifil, Anastrozole, and Enclomiphene (more coming).
💰 Average Cost for TRT: $199/month
👨‍🔬 Membership required: Included in price
❤️‍🩹 Insurance accepted: FSA and HSA cards
⌚ Periodic blood work: Varies by patient
✨ Trustpilot Reviews: ‎4.8 Stars | 111 reviews
⭐️ Muscle and Brawn Rating: 4.5 Stars
➡️ Go to the Full review

• $35 for blood work (best in industry)
• World class doctors (Not outsourced freelancers)
• Offers local and at home blood draw
• Premium concierge available 24/7
• Offers TRT cream, Injections, and oral (Coming soon)
• Offers HCG, Arimidex, and other compounds to help you stay optimized and manage Estradiol
• Available in the following states: AL, AZ, CA, CO, CT, FL, GA, IL, IN, MI, NJ, NY, NC, OH, PA, TN, TX, VA, WA, WI, KY and MO.

• More pricey than alternatives (not by much)
• Currently not available in AK, AR, DE, HI, IA, ID, KS, LA, ME, MD, MA, MN, MS, MT, NE.

You might have heard or even read about FountainTRT before. This revolutionary company is happy to provide Testosterone Therapy to the masses, helping you increase your natural testosterone production, natural testosterone levels, and, of course, free testosterone.

FountainTRT is an online TRT clinic that focuses on providing TRT to those who are in need. Led by a team of experienced physicians deeply committed to promoting long-term wellness, FountainTRT places a strong emphasis on balancing hormone levels crucial for vitality, mood, and energy.

One of FountainTRT’s standout features is its innovative sign-up process, which begins with an interactive quiz designed to engage and inform potential clients about TRT. Following the quiz, individuals undergo a consultation to further tailor their treatment plan to their specific needs. This approach ensures that entry into TRT treatment is not only informative but also engaging.

Moreover, FountainTRT prioritizes accessibility by offering affordable lab work as part of the initial assessment, thus reducing barriers to treatment access. Despite offering a single membership plan, FountainTRT ensures that it meets the individual needs of each client through transparent pricing, thereby eliminating hidden costs and enabling straightforward financial planning.

Continuous monitoring and regular follow-ups are integral to FountainTRT’s approach, with home lab tests allowing for ongoing assessment of treatment efficacy and safety. Periodic blood work enables adjustments to treatment plans, highlighting FountainTRT’s commitment to personalized care.

With a focus on client satisfaction, FountainTRT provides responsive customer service and an intuitive online portal for seamless management of treatment and communication with healthcare providers. Positive client reviews attest to the exceptional service provided by FountainTRT.

Established in 2018 in San Francisco, California, FountainTRT is led by a team of scientists and biotech experts dedicated to advancing TRT and hormonal medicine. Beyond addressing low testosterone, FountainTRT offers innovative therapies for various hormonal challenges, reflecting their commitment to holistic health.

FountainTRT’s board-certified medical professionals specialize in tailoring treatment options to meet individual needs, empowering men to lead healthier and more fulfilling lives. Through their holistic approach and cutting-edge therapies, FountainTRT aims to propel the realm of TRT and hormonal medicine into the future, offering hope and solutions to those grappling with hormonal imbalances.

How does FountainTRT work?

Before you go about getting your fill of enclomiphene citrate or testosterone replacement therapy, you need to go through a little process. Fountain TRT operates through a streamlined three-step process, consistent with the approach taken by other companies offering testosterone treatments. Here’s how it works:

1. Initial Assessment: Prospective clients interested in Fountain TRT’s program begin by completing an online initial assessment. This involves answering a series of questions designed to determine eligibility for testosterone replacement therapy. Typically taking around 2 minutes, this assessment serves as the first step in the journey towards hormone optimization.
2. TRT Evaluation: Following the initial assessment, individuals proceed to provide additional health and personal information. This includes details such as full name, date of birth, state of residence, and responses to specific health-related queries. Once this step is completed, individuals are granted approval to advance to the checkout process, marking the progression towards initiating their TRT journey.
3. Check Out and Lab Tests: During the checkout process, individuals are prompted to select their preferred method for blood testing, which includes options for at-home testing or visiting a LabCorp facility. Additionally, individuals indicate their treatment preference, such as topical cream or injections. Upon completing the online checkout process, individuals receive a confirmation email from Fountain TRT detailing the subsequent steps. A temporary $300 hold is placed on the individual’s bank account during this stage, which is then replaced with a $35 charge within 1-2 days. Lab tests are scheduled either via text message or through direct contact from Fountain TRT, with LabCorp visits being a standard part of the process. Once blood test results are obtained, individuals have the opportunity to schedule a telehealth visit with a provider from Fountain TRT to discuss the next steps in their personalized treatment plan.

Can I trust FountainTRT?

Absolutely. FountainTRT has been around for quite some time, and in that time has gathered not only a sizable client base, but an equally sized ‘good review’ package. There are a couple on their site as well as other sites like Reddit.

In the end, it comes down to the quality of life they can provide. The quality of the products and the costs associated with these products. Now, your costs will be different depending on which package you take, however, there is no doubt that you’ll receive a quality product.

The company and medication is also controlled by medical professionals, who will take side effects into account. Sure, male hypogonadism is bad all around, however, there are side effects to the treatments. This is why they monitor elevated levels of estrogen and manage it with an aromatase inhibitor (if needed). They monitor lifestyle factors that might influence your progress. Nothing is left to the wayside, and everything is considered.

How does Enclomiphene Citrate Work?

Enclomiphene acts as an antagonist at estrogen receptors in the hypothalamus. By competitively binding to these receptors, enclomiphene prevents the inhibitory effects of estrogen, specifically estradiol, on gonadotropin-releasing hormone (GnRH) neurons.

With estrogen receptors blocked, the hypothalamus perceives reduced estrogen signaling. This leads to an upregulation of GnRH secretion from hypothalamic neurons. GnRH is a key regulator of the reproductive axis and stimulates the release of gonadotropins from the pituitary gland.

The increased GnRH secretion stimulates the anterior pituitary gland to release gonadotropins, namely luteinizing hormone (LH) and follicle-stimulating hormone (FSH). LH, in particular, plays a crucial role in the stimulation of Leydig cells in the testes.

LH binds to receptors on Leydig cells within the testes, triggering a cascade of intracellular events. This ultimately results in an increase in the production and secretion of testosterone.

Elevated LH levels, along with FSH, promote the synthesis and release of testosterone from Leydig cells into the bloodstream. Testosterone serves numerous physiological functions in males, including the maintenance of muscle mass, bone density, libido, and overall well-being.

As testosterone levels rise, there is a negative feedback loop exerted on the hypothalamus and pituitary gland. Elevated testosterone levels inhibit the release of GnRH and, consequently, LH and FSH. This helps maintain testosterone within a physiological range and prevents excessive production.

Effects on Testosterone Deficiency

A 2013 study was created as a randomized, single-blind, two-centre, phase II study to evaluate the effects of three different doses of enclomiphene citrate (6.25, 12.5 and 25 mg) vs transdermal testosterone on 24-h LH and total testosterone in otherwise normal healthy men with secondary hypogonadism.

After 6 weeks of continuous use, the mean (sd) concentration of total testosterone at day 42 was 604 (160) ng/dL for men taking the highest dose of enclomiphene citrate (enclomiphene citrate, 25 mg daily) and 500 (278) ng in those men treated with transdermal testosterone. These values were higher than day 1 values but not different from each other.

Treatment with enclomiphene citrate did not significantly affect levels of thyroid-stimulating hormone, adenocorticotropic hormone, cortisol, lipids or bone markers.

So, as you can see, Enclomiphene citrate is a citable testosterone treatment compared to transdermal testosterone gel. Both of these raised low testosterone, however, Enclo had far fewer side effects.

Does Enclomiphene count as Testosterone Replacement Therapy?

Yes. The function of Enclomiphene citrate is to function as a ‘testosterone supplementation’ or as TRT. It might not be pure testosterone replacement, but will increase serum testosterone levels naturally. This stands as one of the greatest treatments for male hypogonadism, since injectable testosterone replacement therapy does have side effects like influencing the quality of sperm counts, and sperm production, and can even elevate chances of prostate cancer.

Both, however, have the same positive effects namely weight loss, more red blood cells, less insulin resistance, more lean muscle mass, and hypogonadal men who undergo TRT all report better sex and mental values.

TRT plays a pivotal role in male health, and both Enclomiphene treatment and regular injectable

Side Effects of Enclomiphene Citrate

1. Hot Flashes: Hot flashes are a common side effect of enclomiphene citrate treatment. These sudden sensations of warmth, often accompanied by sweating and flushing of the skin, can occur intermittently throughout the day or night. Hot flashes are thought to be due to the medication’s impact on estrogen receptors in the hypothalamus, which disrupts the body’s temperature regulation.
2. Headaches: Headaches are another reported side effect of enclomiphene citrate. While the exact mechanism is not fully understood, it’s believed that changes in hormone levels, particularly fluctuations in testosterone and estrogen, may contribute to the development of headaches in some individuals. These headaches can range from mild to moderate in intensity and may occur during the initial stages of treatment.
3. Mood Changes: Some individuals may experience mood changes, including mood swings, irritability, or emotional lability, while taking enclomiphene citrate. These mood changes may be related to fluctuations in hormone levels, particularly testosterone, which can influence mood and behavior. It’s important for individuals experiencing significant mood changes to discuss them with their healthcare provider, as adjustments to the treatment plan may be necessary.

Enclomiphene Citrate vs Clomiphene Citrate TRT

Enclomiphene and Clomid (clomiphene citrate) are both medications classified as selective estrogen receptor modulators (SERMs) with similar mechanisms of action. They are primarily used in the treatment of hypogonadism and infertility, although they have distinct differences in their chemical structures, pharmacokinetics, and clinical applications.

Overall, most men report that Enclomiphene is far better than Clomid due to its lower side effects.

Let’s compare the differences of these various aspects:

1. Chemical Structure:
   • Enclomiphene: Enclomiphene is the trans isomer of clomiphene citrate. It is a single isomer formulation, containing only the active enantiomer of clomiphene.
   • Clomid: Clomiphene citrate is a racemic mixture of two isomers: enclomiphene (trans isomer) and zuclomiphene (cis isomer).
2. Pharmacokinetics:
   • Enclomiphene: Enclomiphene has a longer half-life compared to zuclomiphene, which is the inactive isomer found in Clomid. It is typically administered as a single isomer formulation.
   • Clomid: Clomid contains both enclomiphene and zuclomiphene isomers. Zuclomiphene has a longer half-life compared to enclomiphene and can accumulate in the body with repeated doses.
3. Clinical Applications:
   • Enclomiphene: Enclomiphene is specifically formulated for use in men with hypogonadism to increase testosterone levels. It is not approved for use in women.
   • Clomid: Clomid is primarily used in women to induce ovulation in cases of infertility. It may also be used off-label in men with hypogonadism, but enclomiphene is considered more suitable for this purpose due to its single isomer formulation and potentially reduced side effects.
4. Side Effects:
   • Enclomiphene: Common side effects of enclomiphene in men include hot flashes, headaches, and mood changes. It is generally well-tolerated, with fewer estrogenic side effects compared to Clomid.
   • Clomid: Common side effects of Clomid in women include hot flashes, ovarian enlargement, abdominal discomfort, and mood swings. In men, Clomid may cause estrogenic side effects due to the presence of zuclomiphene, including gynecomastia and fluid retention.
5. Efficacy:
   • Enclomiphene: Enclomiphene has been shown to effectively increase testosterone levels in men with hypogonadism while minimizing estrogenic side effects.
   • Clomid: Clomid has been used off-label in men with hypogonadism, but its efficacy may be limited by the presence of zuclomiphene, which can contribute to estrogenic side effects.
6. Cost and Availability:
   • Enclomiphene: Enclomiphene may be more expensive than Clomid due to its single isomer formulation and specific indication for hypogonadism in men.
   • Clomid: Clomid is a more widely available medication and may be more cost-effective, but its use in men with hypogonadism is off-label.

Conclusion

In conclusion, the utilization of enclomiphene citrate necessitates prudent oversight by healthcare professionals. Its efficacy and safety hinge upon appropriate supervision, ensuring optimal outcomes while minimizing potential risks.

The best Clinic to get Enclomiphene from is FountainTRT, hands down. They specialize in TRT, helping men of all ages improve their hormonal health, including but not limited to the use of Enclomiphene. They also offer other treatments as well. Prices are reasonable, quality control is excellent, and the reviews speak for themselves.