GW0742 SARM: Benefits, Uses, Dosage

GW0742 is a PPAR delta agonist that improves both energy and endurance, which means you can work out harder and longer while also getting leaner.
Medically reviewed by Dr. Mohammed Fouda
Dr. Fouda uses his extensive knowledge and expertise as an academic scholar to medically review articles for scientific accuracy and credibility, ensuring that the medical information presented is up-to-date and trustworthy. He is responsible for ensuring the quality of the medical information presented on our website.

There’s a new compound making waves in the SARMs marketplace. Although it’s technically not a SARM, GW0742 is being lauded as even better than Cardarine which happens to be one of the most popular fat-loss compounds.

In this article, we lift the lid on GW0742 to find out just how good it is and why top SARMs retailers sell this compound.

Warning: The content on and the information included in this article is intended for entertainment and informational purposes only. It is not intended nor implied to be a substitute for professional medical advice. Prior to buying anything, check that it is compliant where you live with your current government laws. We frequently mention research chemicals that are not made for human consumption. Therefore, before purchasing any product for personal use, consult with your doctor or healthcare provider first.

TL;DR: What is GW0742?

  • GW0742 was developed by Glaxo Smith Kline who is best known for making Cardarine.
  • GW0742 and Cardarine are very similar, having just a single atom’s difference in their molecular makeup.
  • Although it’s grouped with SARMs, GW0742 is a PPAR agonist. Its key function is to break down the fatty acids in your stored energy reserves to provide your body with extra energy.
  • The method of action of GW7042 is almost identical to that of Cardarine, however, it is more powerful in its fat-burning action.

PPAR Agonist

GW0742 is a PPAR (peroxisome proliferator-activated receptor) agonist. PPAR agonists are a group of nuclear receptor proteins that regulate gene expression.

There are three main classes of PPAR agonists:

  • PPAR alpha agonists
  • PPAR gamma agonist
  • PPAR delta agonists

The main function of PPAR alpha agonists is to lower cholesterol and triglyceride levels.

PPAR gamma agonists mainly work to control blood glucose levels. This drug is mainly developed for use with diabetics.

PPAR delta agonists are designed to switch over the body’s preferred fuel energy system from carbohydrate-derived glucose to lipids from stored body fat.

PPAR Delta Agonist

GW0742 Review
Image sourced from PPARΞ΄ Promotes Running Endurance by Preserving Glucose. doi:10.1016/j.cmet.2017.04.006

GW0742 is a PPAR delta agonist. Delta is also known as NR1C2 and it turns on the genes that are responsible for fat metabolism. These proteins are found all over the body but are most prolific in the muscles, heart, and liver.

In addition to increasing lipid uptake for energy, the delta agonist also affects the way that your body responds to exercise. In improving stored fat utilization, this protein also helps to protect you from fatty liver disease.

The PPAR delta agonist can control your energy use during endurance-type exercise. It will prioritize fat burning during the workout and preserve your glucose supplies.

The effect of this is that you have a longer-lasting supply of energy and, therefore, more endurance. Studies have shown that supplementation with a PPAR delta agonist (GW0742) improves running endurance significantly.


GW0742 is a PPAR delta agonist designed to affect the peroxisome proliferator-activated receptor protein to improve its ability to burn stored body fat. This, in turn, improves training energy and endurance so that you can work out harder and longer while also getting leaner.

How Does Gw0742 Work?

Even though there is quite limited research on GW0742 at this date, we know that it acts in a very similar way to Cardarine. We know that it acts as a PPAR agonist of the delta variant to enhance the fat-oxidizing activity of the protein.

By the very fact that it improves the body’s fat-burning ability, GW0742 will significantly boost your energy output and improve your endurance levels. That is because the compound encourages the preferential burning of fat, which contains 9 calories per gram.

This compares with glucose, which contains four calories per gram. That means that you get more than double the energy output for every gram of fat burned.

Where to Buy GW0742

GW0742 Summary


GW0742 is a synthetic peroxisome proliferator-activated receptor Ξ΄ (PPARΞ΄) agonist that has been extensively studied in the field of pharmacology and biochemistry. PPARΞ΄ is a nuclear receptor that plays a crucial role in various metabolic processes, including lipid metabolism, glucose homeostasis, and inflammation. Activation of PPARΞ΄ by agonists like GW0742 has been investigated for its potential therapeutic applications in several diseases, particularly metabolic disorders such as obesity, diabetes, and cardiovascular diseases.

One intriguing aspect of GW0742 is its ability to mimic some of the effects of exercise. Studies in animal models have demonstrated that treatment with GW0742 can increase endurance and enhance skeletal muscle oxidative capacity, similar to the effects observed with physical exercise.

GW0742 has been widely used as a research tool in both in vitro and in vivo studies to elucidate the role of PPARΞ΄ in various physiological and pathological processes.

GW0742 Overview

⭐️ Top Benefits: Fat Loss, Endurance
πŸ§ͺ Form: Liquid, Powder
βŒ›οΈ Cycle Length: 8-12 weeks
πŸ’° Average Cost: $79.99
β€οΈβ€πŸ©Ή Side Effects: Cardiovascular damage
☒️ Dangers: Cardiovascular damage
πŸ“š Best Stack: Cardarine / MK-677
PCT Required: No
πŸ§β€β™‚οΈπŸ§β€β™€οΈMen/Women: Men and Women
➑️ Go to the Full review

  • Improves metabolic health.
  • Offers potential cardiovascular benefits.
  • Mimics some effects of exercise.
  • Safety profile not fully understood.
  • Potential side effects unclear.

Why Use GW0742?

GW0742 is a new and exciting compound that is worth experimenting with. If you have had any experience with Cardarine and have been impressed by its fast-cutting abilities, you can have every confidence that GW0742 will give you even better results.

Some users even claim that it is up to 200 times more effective than Cardarine! At this stage, however, there are no comparative studies between the two compounds.

GW0742 vs Cardarine

GW7042 and Cardarine are both produced by Glaxo Smith Kline. The company has stated that this new compound is significantly more powerful in terms of its fat-burning ability than Cardarine.

GW0742 Bodybuilding

When it comes to using it for bodybuilding, GW0742’s main benefit is as a cutting agent. By switching the body’s preferential energy system from glucose to stored body fat, it will get you ripped faster.

A secondary benefit of GW0742 is that it will increase your training energy as a result of enhanced fat burning.

GW0742 Dosage

The ideal dosage of GW0742 is unclear at this stage.

The majority of users follow a Cardarine dosage protocol. That would have you taking 10 mg per day as a beginner user and stepping it up to 25 mg per day as an advanced user.

You should not go beyond 25 mg per day.

GW0742 Cycle

GW0742 should be cycled for between 8-12 weeks. You do not have to go on a PCT cycle after a cycle as the compound does not affect testosterone levels.

GW0742 Stack

GW0742 can be stacked with SARMs to improve cutting results or to achieve muscle gains while you are cutting. We recommend stacking GW0742 with Ostarine, which will help preserve your muscle mass as you get ripped.

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GW0742 Results

The results that people are getting with GW0742 are truly impressive. Some people have reported losing up to 20 pounds of body fat over an 8-week cycle!

GW0742 Side Effects

The side effects of GW0742 are almost identical to those of Cardarine. The main one is an enlargement of the heart.

This is a condition known as cardiomegaly. This effect has, to date, only been seen in studies with rats. There have been no reported cases of enlarged hearts by people using the compound.

GW0742 Reddit

Reddit has an active channel that discusses all things SARMs, including G0742. There you can have your questions answered by fellow SARMs users.

Check it out here!

Should I Take GW0742?

If you have any experience taking Cardarine and were impressed by its fat-cutting abilities, you can have full confidence that GW0742 will give you even better results. However, before using this compound, you should assess the potential major risk associated with its use as demonstrated in animal studies – an enlarged heart. If this is not a concern for you, then you may want to consider experimenting with GW0742 as a fat-loss agent.

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Steve Theunissen

Steve Theunissen | Writer

Steve Theunissen is a seasoned fitness professional with 25+ years of experience. He has multiple certifications from the International Sports Sciences Association, including Certified Personal Trainer, Fitness Nutrition Certification, and Strength and Conditioning Certification. He's a knowledgeable and experienced bodybuilding coach, combining his passion for fitness with his writing skills to educate and inspire. Whether starting out or looking to take training to the next level, Steve Theunissen is the ideal coach to help reach fitness goals.

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Dr. Mohammed Fouda

Dr. Mohammed Fouda | Reviewer

Dr. Fouda uses his extensive knowledge and expertise as an academic scholar to medically review articles for scientific accuracy and credibility, ensuring that the medical information presented is up-to-date and trustworthy. He is responsible for ensuring the quality of the medical information presented on our website.

Read all articles
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Micheal chapman
Micheal chapman
2 years ago

Hey bro can you email me back? I need some advice on this compound just safe dosage etc

Chemical Structure

Mechanism of Action

GW0742 is also known as PPAR (peroxisome proliferator-activated receptor) agonist. GW0742 binds to the delta PPAR which increases the expression of genes responsible for fat metabolism. As particular effects are shown in muscles, heart and liver, it mostly controls the triglyceride levels as well as glucose metabolism in these organs.

Class of Compound

PPAR Delta Agonist

Street Names

GW072, PPAR Delta Agonist


  • Lowers cholesterol levels
  • Minimizes gut inflammation
  • Improves lipid profile

Side Effects and Dangers

  • Increased heart size (cardiomegaly)
  • Enlargement of heart in mice in just 24 hours
  • No human-based clinical trials

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