Mechanism of Action

GW0742 is also known as PPAR (peroxisome proliferator-activated receptor) agonist. GW0742 binds to the delta PPAR which increases the expression of genes responsible for fat metabolism. As particular effects are shown in muscles, heart and liver, it mostly controls the triglyceride levels as well as glucose metabolism in these organs.

Class of Compound

PPAR Delta Agonist

Street Names

GW072, PPAR Delta Agonist

Effects

• Lowers cholesterol levels
• Minimizes gut inflammation
• Improves lipid profile

Side Effects and Dangers

• Increased heart size (cardiomegaly)
• Enlargement of heart in mice in just 24 hours
• No human-based clinical trials

Top Studies

• GW0742 activates peroxisome proliferator-activated receptor δ to reduce free radicals and alleviate cardiac hypertrophy induced by hyperglycemia in cultured H9c2 cells
• Development of PPAR-agonist GW0742 as antidiabetic drug: study in animals