If you are an athlete or into fitness, I am pretty sure that you must have at least once tried to look for a peptide that could optimize your exercise regimens most naturally by working at the micro level rather than the macro level.
With new research popping up every day on different peptides, we now have a peptide in the market that works to revamp your metabolism in such a way that leads to stronger stamina and enhanced athletic activity.
While most of the existing peptides available in the market trigger the release of growth hormone from the anterior pituitary gland, Mots-c is unique in its mechanism of action and this is a peptide that we are talking about today.
Read through the end of this MOTS-C Peptide Guide to know everything about Mots-c and make a decision as an athlete whether it should be your go-to peptide or not.
- MOTS-C is a 16 amino acid peptide, transcribed particularly from mitochondrial DNA.
- The peptide increases insulin sensitivity, optimizing glucose utilization and overall body metabolism.
- MOTS-C peptide can also increase cell differentiation, leading to osteoporosis management or prevention.
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What is Mots-c?
Several mitochondrial-derived peptides have been studied for their therapeutic applications in the past few years. And, Mots-c is one of them!
Mots-c is a peptide consisting of 16 amino acids transcribed specifically from the mitochondrial genome (1).
Detailed studies and thorough analysis confirm that mots-c helps regulate several metabolic pathways in energy production.
The peptide assists in weight regulation, exercise, longevity, and glucose metabolism (2).
Due to its widespread systemic effects, mots-c is a therapeutic peptide that can be used for recreational purposes.
How Does Mots-c Work?
Unlike several other peptides, Mots-c doesn’t work by inducing the release of growth hormone. Instead, it works by enhancing glucose metabolism via various pathways.
With an improved glucose metabolism, the body can produce more significant amounts of energy, allowing different ways to function smoothly.
Metabolic dysfunction, such as surplus food intake with no physical activity, can lead to diabetes, obesity, and metabolic syndrome (3).
It is also reported that excess food can cause mitochondrial dysfunction in specific ways.
This is where mots-c comes into play. Okay, before going ahead, let me first explain to you what functional metabolism is.
Available metabolism consists of proper intake and utilization of glucose reservoirs and optimal insulin function alongside well-functioning mitochondria.
One of the prime functions of Mots-c is to increase insulin sensitivity manifolds, particularly in the skeletal muscles.
They do so by enhancing the AMPK pathway (4). This allows the body to use more storage biomolecules and increase energy expenditure to run other metabolic pathways.
Research also reports that Mots-c can help increase glucose clearance instead of lowering its production inside the liver.
It is seen to reduce non-fasting glucose levels and improve glucose tolerance tests.
Besides this, mots-c is known to increase bone cell differentiation and alleviate osteoporosis symptoms. However, the exact mechanism is unknown!
Benefits of Mots-c
This is the most exciting part!
MOTS-C is one of those peptides with a wide array of systemic benefits. The peptide assists in numerous body functions with minimal to no side effects.
Researchers report a significant decrease in obesity in rats that were fed a high-fat diet and supplemented with Mots-c.
Due to its ability to enhance insulin sensitivity and energy production, one can use Mots-c to optimize exercise regimens. The peptide can increase endurance and energy levels for cardio exercises.
Research trials also suggest a rather protective action of Mots-c in mitochondrial health. The peptide can help protect mitochondrial DNA against free radicals and oxidative stresses.
Besides this, it is believed that low MOTS-c can cause endothelial dysfunction.
Therefore, rats supplemented with MOTS-c peptide improved endothelial and epicardial blood vasculature, leading to advanced heart functions (6).
Lastly, its cell differentiation ability can help cease excessive inflammation and osteoporosis of bones. This is one of the ways of slowing down the aging process (7).
Dosage & Cycling
Peptides need to be dosed very carefully to mitigate the risk of developing any adverse effects.
For proper dosage and cycling recommendations, it is suggested that you contact a healthcare specialist to figure out the optimum dose for you.
For mots-c, it is recommended to use 10 mg of it subcutaneously once a week. As far as cycling is concerned, you can run the peptide for four weeks straight!
To know more about dosage and cycling guidelines, you may view the detailed chart available on Muscle and Brawn.
Side Effects of Mots-c
Mots-c is one of those peptides that rarely cause any major side effects.
The peptide is believed to be very safe for human consumption; however, limited research trials have been performed so far involving human subjects.
Therefore, you may need to be pretty careful before deciding to use Mots-c.
Nevertheless, Mots-c can cause redness and rashes at the administration site, so a little icing after a Mots-c injection can be helpful.
Furthermore, if you do end up experiencing a side effect that you are not familiar with, report it to a healthcare specialist.
User Reviews and Experiences
Because there is pretty limited research done on Mots-c, digging into some of the user reviews and experiences can give us some real insights.
One of the users at Reddit said,
“The typical protocol for MOTS-c is 10mg 3X weekly for four weeks, then 10mg weekly for four weeks. I also use 5mg instead of the 10mg dosing with good results.
When it comes to mitochondrial dysfunction, this peptide is great. I have used it personally without much result, but I’m a conditioned athlete who exercises 2-3 hours daily. I find that this is a great adjunct to treatment in my patients with any mitochondrial dysfunction.”
Another one said,
“I’m using MOTS-C currently. I’m doing 5mg three times a week. It appears beneficial, but it’s hard to attribute my results to MOTS-C specifically because I’m also just training a ton on TRT and CJC1295/ipamorelin.
That said, after my first dose I swim a record distance for myself (2100 yards continuously whereas my max was 400 yards).”
|Stack Combination||Key Components||Benefits||Recommended Dosage|
|MOTS-c + IGF1-LR3 + PEG MGF||– MOTS-C – IGF1-LR3 – PEG MGF||– Increased fatty acid oxidation – Enhanced muscle repair – Inhibition of myostatin – Similar effects with PEG-MGF||– MOTS-C: 10 mg thrice a week for 6 weeks – IGF1-LR3: 25-75 mcg per day for 6 weeks – PEG MGF: 200-300 mcg 2-3 times per week|
|MOTS-c + CJC 1295/Ipamorelin||– MOTS-C – CJC 1295 – Ipamorelin||– Increased growth hormone production – Fat burning – Protein production – Stabilized insulin function||– MOTS-C: 10 mg thrice a week for 6 weeks – CJC 1295 and Ipamorelin dosages as per recommended guidelines|
Stacking peptides is one of the best ways to enjoy synergistic effects in one go with maximal optimization. While Mots-c is not popularly stacked, there are still some experiences and studies that could be helpful for us to understand the stacking of Mots-c.
MOTS-c + IGF1-LR3 + PEG MGF
It is now becoming a standard regimen to stack Mots-c with IGF1-LR3 and PEG MGF and use it as a monotherapy.
IGF1-LR3 increases fatty acid oxidation and enhances muscle repair by inhibiting myostatin. Additionally, you can supplement with PEG-MGF due to similar effects.
For this monotherapy to be effective, it is fundamental to increase 25-75 mcg per day for six weeks; for Mots-c, use 10 mg thrice a week for six weeks.
If you want to include PEG MGF in the stack, 200-300 mcg 2-3 times per week should be enough!
MOTS-c +CJC 1295/Ipamorelin
This one is quite a new combination of peptide stack.
CJC 1295 and Ipamorelin work via increasing growth hormone production from the anterior pituitary gland.
This, in turn, facilitates the burning of fat and protein production and, like Mots-c, stabilizes insulin function.
There are only a few vendors that sell the best quality MOTS-c peptide; Biotech Peptides and Sports Technology Labs are two of the leading ones.
Hence, if you’re thinking about where to buy MOTS-C, make sure to choose one of these two vendors.
Is MOTS-C Peptide Legal?
The legal status of MOTS-C Peptide is a subject of importance for individuals considering its use, particularly athletes, fitness enthusiasts, and those interested in its potential benefits.
In the United States, for example, peptides like MOTS-C were not approved by the Food and Drug Administration (FDA) for human consumption or for use as drugs.
This means that, under federal law, peptides like MOTS-C are generally not considered legal for human use without specific FDA approval.
The sale and distribution of these peptides for human use, particularly as a performance-enhancing or therapeutic substance, may be subject to regulatory scrutiny.
However, the regulation of peptides like MOTS-C can be complex and varies from state to state, making the legal landscape even more convoluted.
Some states may have stricter regulations in place, while others may not specifically address these substances.
Furthermore, the availability of peptides like MOTS-C can be influenced by their intended use.
While they may not be approved for human consumption, some suppliers may sell these substances for research purposes only.
It’s crucial to carefully read the product labeling and descriptions to ensure compliance with the intended use.
It’s also important to note that legal opinions and regulations surrounding these substances can be subject to change, and legal interpretations may vary.
Therefore, individuals interested in using MOTS-C should consult with legal experts or regulatory authorities in their region to ensure they are in compliance with current laws and regulations.
In summary, the legality of MOTS-C Peptide and similar substances can be complex and subject to regional variations.
It’s crucial for individuals considering its use to conduct thorough research and seek legal advice to ensure they are compliant with the latest regulations and requirements in their area.
MOTS-C Peptide Guide: Is Mots-c Legit?
Mots-c is definitely one of the legit peptides available in the market.
The peptide, with its beneficial effects such as enhanced exercise tolerance, functional metabolism, weight loss, and prevention of osteoporosis, makes mots-c one of the effective therapeutic peptides.
Although there is pretty limited research available involving humans as subjects, it shows promising results in all other clinical trials ever conducted.
Due to its positive impact on insulin sensitivity, it is hypothesized that mots-c can also be used to treat diabetes mellitus type 2.
FAQs about Mots-c
Is MOTS-c FDA approved?
No, for now, MOTS-c is not yet approved by the FDA for human consumption. However, one can indeed use it for research purposes.
Does MOTS-c work?
YES! Mots-c works quite well when optimum exercise is concerned. Studies propose that subjects treated with Mots-c could run faster than the non-treated ones.
Can MOTS-c help you lose weight?
MOTS-c promotes functional metabolism, thereby enhancing and optimizing exercise ability, glucose metabolism, and losing weight simultaneously.
How to inject MOTS-c peptide?
Mots-c is one of the few injectable peptides available. For this peptide, subcutaneous administration is recommended and considered safe