When you hear the word ‘peptides,’ what instantly pops up in your mind are big and bulky muscles, enhanced stamina as well as endurance, fat loss, and improved metabolism.
Rarely has a peptide been developed, which heavily offers a potential treatment for conditions like anxiety and depression.
One such peptide-cum-nootropic that we are talking about today is Selank. Research on this synthetic peptide Selank shows its multitasking effects on the body, including cognitive and immunological benefits.
This article will include everything you should know about Selank, such as how it works in the body, the promising benefits it offers, the typical dosages, and, importantly, any possible side effects.
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What is Selank?
Selank is a synthetic peptide, which works as an adrenocorticotropic/melanocyte-stimulating hormone (ACTH-MSH). It is analogous to the endogenously occurring tetrapeptide called Tuftsin (1).
The amino acid sequence of Tuftsin is, Thr-Lys-Pro-Arg and is predominantly found in the IgG class of antibodies (2). The structure of Selank is an elongated version of Tuftsin with 3 additional amino acids, Pro-Gly-Pro (3). This adds to the stability of the molecule along with a longer half-life.
This relatively small peptide was originally designed and developed in Russia at the Institute of Molecular Genetics. Since then, scientists have constantly been researching Selank to explore its prospective benefits.
How Does Selank Work?
Selank is one of the regulatory peptides, and it modulates different reactions in the body.
Because Selank is well-known for treating symptoms related to anxiety and depression, it was believed that Selank directly influences GABA receptors and the subsequent binding of GABA. But the clinical trials suggest that Selank rather acts as an allosteric effector of GABA receptors (4).
Some evidence also suggests that Selank triggers the metabolism of neurotransmitters, such as serotonin and dopamine (5). Thus, Selank modifies the genes expressing the neuro-transmitting properties in the neuronal cells.
Selank is also known to promote the expression of Brain-derived neurotrophic factor (BDNF).
As Selank is analogous to Tuftsin, which plays a key structural role in the IgG antibodies, it is quite self-explanatory that Selank modulates many immunological reactions.
Selank regulates the expression of factors, such as Interleukin-6 (IL-6) (6). This subsequently influences the immunocompetent cells, such as T-helper cytokines.
Benefits Of Selank
Because Selank influences the working of neurochemicals, it effectively treats anxiety. The anxiolytic effects of Selank were confirmed by one of the studies involving 60 patients who were administered Selank (7).
Selank has also been used as an antidepressant drug as well as an antistress drug. Antistress effects result from the natural release of enkephalins in the body. Clinical trials also demonstrated a marked decrease in mood behaviors, such as aggression, fear, and restlessness.
Individuals given Selank report a better mood and calm state with renewed energy levels. Although insignificant, some evidence suggests that Selank promotes a deep sleep state.
Selank also enhances the cognitive performance of individuals and influences traits like learning and memory (8). It improves the focus and concentration in individuals and gives mental clarity.
It is observed that long-term treatment with Selank improves the cardiometabolic parameters, such as blood glucose levels as well as blood pressure (9). It is also seen that Selank therapy reduces cholesterol levels, which minimizes the chances of weight gain by fat accumulation (10).
Because Selank influences the immunoregulatory factors, such as Interleukin-6 (IL-6), it plays a critical role in combating infections.
A mice-based study also observed that Selank increased the antioxidant effects in the liver (11).
Is Selank Legal?
As Selank was originally developed in Russia, it is legal to buy Selank there as it potentially treats General Anxiety disorder (GAD).
But, it is important to note that the FDA hasn’t authorized the use of Selank for any medical purposes.
Who Should Use Selank?
Anyone suffering from conditions such as anxiety and depression can use Selank because of its promising effects so far on the patients. While one may be inclined to use other drugs, such as benzodiazepines, Selank offers similar effects with nearly no sedation or side effects.
It stabilizes mood significantly by regulating the levels of important neurochemicals, such as serotonin and dopamine, etc.
Selank can potentially be also used as a peptide therapy to strengthen the immune system.
Forms Of Selank
Selank is predominantly available in the form of Nasal spray. Recently, injections have also been developed as an alternative to users who find sprays uncomfortable.
It is important to note that Selank is not available in oral forms. Beware of any scams!
How To Use Selank?
Selank is usually taken intranasally as well as in injection form because of its effectiveness. It quickly travels to the blood and brain in these methods of intake.
While it is easier to use nasal sprays and drops, the injectable form of Selank should only be administered intramuscularly (IM) and subcutaneously (under the skin). Preferable areas are the thigh, shoulder, buttocks, and stomach.
It is important to note that the injectable form of Selank is relatively less effective.
To prolong the shelf-life of the nasal sprays, read the precise instructions on the bottle, and keep it in accurate temperature conditions.
The recommended dosage guidelines are 1-2 nasal sprays in each nostril regularly.
If you are using the injectable form of Selank, then you can achieve the optimal benefits by administering 250-300mcg of Selank per day.
While there is not much information available on the Selank cycle, the trials performed so far show that subjects experienced anxiolytic effects for a week.
Therefore, it can be seen that the cycling duration depends on your purpose of intake. You may use it in alternative weeks and experience effects.
Selank is famously stacked with Semax. Both of them have been used as therapeutic for individuals with brain disorders. Selank/Semax stack has been proved effective in improving learning and memory.
Research also suggests that Selank/Semax stack plays a key role in cognitive health by triggering the process of regeneration and development as well as improved neuromuscular performance.
Selank is seen to alleviate symptoms of anxiety and depression. An enhanced immune system is also seen in subjects using Selank/Semax stack.
I tried to find the personal experiences of individuals using Selank to establish the credibility of the peptide. Let’s read some of the honest reviews now.
One of the Reddit users said,
“This stuff is incredible.”
One of the Amazon customers left a review saying,
“After taking it for about 2 months I felt noticeably positive mood changes whereas usually I fall into a depressive pattern. It’s very worth it, I can’t recommend it enough”
“Exactly what I was looking for”
There were also some mixed reviews by Selank users as well. A few anonymous users also reported no significant effects after using Selank.
One of them said,
“I’ve tried lower dosages of regular Selank, if that counts. You can’t feel it as much.
There was no sedation to speak of, just a lack of anxiety.”
Selank Side Effects
Perhaps what distinguishes Selank from other drugs used to treat anxiety is that it doesn’t cause any sedative or adverse effects.
The clinical trials involving the administration of Selank demonstrated no toxicity in the subjects. There is also no incidence of experiencing withdrawal symptoms, making it an ideal use.
Where Can I Buy Selank?
Because it is not approved by the FDA to buy Selank, you might not be able to find it very commonly out in the market. And this is why it is easier to fall into the trap of buying unauthentic Selank nasal spray or injectable forms.
I would recommend stores like Amino Asylum, which not only specialize in selling 100% original peptides but also offer supreme customer services in a competitive price range.
Selank vs. Other Compounds
Selank vs. Semax
While both are developed in Russia, Semax is a nootropic that is particularly used to enhance cognitive functions. It assists the individuals to achieve more mental clarity and optimal concentration levels. It is a neuroprotective as well as a neurostimulating peptide.
Selank, as you know now, is more commonly used for its anxiolytic effects. While it also offers similar benefits to Semax, the medical/therapeutic use of Selank is more pronounced.
The mechanism of action of both the nootropics seems quite similar.
It is important to note that there are structural differences as well. Semax is a derivative of the endogenous peptide ACTH, while Selank is an elongated version of Tuftsin, a naturally occurring peptide found in IgG immunoglobulins.
Selank/Semax stack is more commonly used to avail maximum synergistic benefits.
Is Selank Legit?
While one can argue that there is not much extensive research done on Selank so far, the little already done, does prove Selank to possess anxiolytic, antidepressant, and nootropic effects.
I would recommend Selank if you are planning to manage your symptoms of anxiety and depression, but as far as nootropic effects are concerned, I might be a bit hesitant in advocating for it!
FAQs on Selank
1. Does Selank help you sleep?
Yes, it promotes deep, restful sleep.
2. Why is inhaling Selank effective?
Inhaling Selank is more efficient in reaching the bloodstream and brain.
3. What does Selank peptide do?
Selank has pronounced anxiolytic activity and acts as a stable neuropsychotropic, antidepressant, and antistress drug that relieves aggression and fear reaction in different animal species.
4. Is Selank the same as Semax?
Both of them are closely related but not the same.
5. Can you take Semax and Selank together?
The Selank/Semax combination works for patients interested in improving mental clarity, memory, and focus and alleviates anxiety and depression.
Kartik, thanks for this information. I used Selank from a lab with virtually no customer service, so had trouble figuring how to take it. I wound up using one spray per nostril each day and it was amazing. I had developed anxiety from MCAS which I gather was due to dysregulation from a mold exposure.
I’d like to buy more and use a lab with someone to talk to and am willing to try Swiss Chems, but I see that you have to mix it yourself and while that’s not a deal breaker, I still don’t get the ratios of mg to dilution to mcg per spray. I gather I want around 200 mcg per spray. Is it the Selank that is 5mg or the Selank and water weight 5 mg? What is the volume of the vial, and is the 5mg per 10 (I’m guessing) ml bottle what give you the concentration that delivers the 200 mcg/spray? Sorry to sound kind of dumb, but I am just not well-educated enough and hope you can help me get over my anxiety(!) enough to make a purchase. Thanks for any direction with this. Greatly appreciated. Peptides are pretty amazing, I’m finding out. Any direction to ed materials about peptides also appreciated.