Gonadorelin Peptide Guide – Effects, Dosage, Side Effects

Gonadorelin was originally introduced as a replacement of HCG, but is it actually a fine and effective replacement? Read more to find about it!

In all honesty, most of us really think that strict workout regimens and consistent physical fitness via gym-ing is all it takes to have a stable physical and emotional well-being. While you may be right about most part of it, but there is more to it! 

The physical and emotional well-being of both men and women is not only dependent upon physical workouts but also on the internal hormonal balance. 

If this balance is disrupted, people may suffer from a variety of consequences which include infertility, amenorrhea, lack of muscle mass, and mood swings. One such class of regulators in the body are sex hormones, and their disturbed levels can lead to various problems.

In such cases, peptides like Gonadorelin have proven to be most effective in the regulation of sex hormones. These sex hormones then modulate sexual drive and mood, which is a big confidence booster! 

Gonadorelin is primarily used to treat infertility in both men and women, while some of its other effects have also been studied recently.

We will explore the many benefits of Gonadorelin in this review, and I am pretty sure that you will be able to make a decision for yourself whether Gonadorelin should be your go-to peptide or not! 

Warning: The content on Muscleandbrawn.com and the information included in this article is intended for entertainment and informational purposes only. It is not intended nor implied to be a substitute for professional medical advice. Prior to buying anything, check that it is compliant where you live with your current government laws. We frequently mention research chemicals that are not made for human consumption. Therefore, before purchasing any product for personal use, consult with your doctor or healthcare provider first.

Key Takeaways: 

  1. Gonadorelin mimics the role of gonadotropin-releasing hormone (GRH), and stimulates the release of FSH and LH. 
  2. Gonadorelin regulates your hormonal balance and ensures healthy sex life in both men and women. 
  3. While research may seem promising, anecdotal evidence on Gonadorelin doesn’t sound convincing! 
  4. BioTech peptides are one of the premium places to buy authentic Gonadorelin!

What is Gonadorelin?

Gonadorelin is a synthetic decapeptide that resembles the gonadotropin-releasing hormone. It stimulates the pituitary gland to release other hormones, including luteinizing hormone (LH) and follicle-stimulating hormone (FSH). This is why Gonadorelin is also called a luteinizing hormone-releasing hormone.  

LH and FSH are both hormones that are responsible for regulating reproductive activity in humans and thereby ensuring fertility.  

How does Gonadorelin work?

Gonadorelin is an analogue of gonadotropin-releasing hormone, therefore its mechanism of action is similar to it. It is also pretty straightforward to understand!

Gonadorelin primarily acts on the gonadotropin receptors in the hypothalamus and stimulates the hypothalamic-pituitary-gonadal axis. (1) This axis comprises of the hypothalamus, pituitary gland and the gonadal glands that are linked by the way of interdependent hormones. 

Once the hypothalamus is activated, it will stimulate the anterior pituitary to release the sex hormones FSH and LH. Since these hormones are directly released into the bloodstream, the anterior pituitary is considered to be a part of the endocrine system.

Fig 1. Effects of Gonadorelin products on LH release

In females, FSH is then primarily responsible for the growth of the ovarian follicle inside the ovaries whereas LH causes ovulation which is the release of eggs from the ovaries. The ovaries in turn also produce estrogen and progesterone for the development of the uterine tissue. (2

On the other hand, in males, FSH is primarily responsible for stimulating spermatogenesis and thereby the production of sperm cells. LH stimulates the Leydig cells of the testes to produce testosterone which is responsible for the typical features of puberty. (3

Benefits of Gonadorelin

While the most significant benefit of Gonadorelin is evident from its use in fertility medicine, its effects can be observed in various other functions of the body.

Gonadorelin causes the maturation and release of the ovum from the ovary into the fallopian tube. This allows for fertilization to take place and helps a woman get pregnant in the presence of a sperm which otherwise wouldn’t have been possible in an anovulatory cycle. 

(4

If the released ovum is not fertilized, the thickened endometrium lining is shed and this process is known as menstruation. Amenorrhea is the condition in which this process is absent. Gonadorelin however has proven effective in regulating the monthly menstrual cycle and thereby inducing menstruation. (5)

It is important to note that the release of FSH and LH from the pituitary further stimulates the release of estrogen and progesterone from the ovaries. Estrogen is an important sex hormone that not only repairs the endometrium lining of the uterus for implantation but also affects many other processes in the body.

One such effect is on the bone cells of the body. Estrogen ensures healthy bone by modulating the activity of osteoclasts and osteoblasts, thereby preventing osteoporosis in women. (6) Thus, Gonadorelin prevents the weakening of bones by indirectly elevating estrogen levels.

In men, the effects of this peptide are widely distributed. Primarily, by the way of increasing testosterone levels, Gonadorelin has been proven to restore sperm production and thereby fertility in men who may have testosterone deficiency. (7

Testosterone then also develops secondary sexual features in the body that include increased muscle mass and strength. 

One important use of this peptide is seen in men who are currently undergoing testosterone therapy. The direct intake of testosterone without the involvement of the brain through the hypothalamic gonadal axis leads to testicular atrophy over time. Gonadorelin prevents this by maintaining the size of the testes. (8

In a study done on animals, Gonadorelin significantly improved libido which supports the hypothesis that by regulating the levels of sex hormones in the body, this peptide also improves low sex drive and mood in both men and women. (9)

Moreover, a study done on mice showed that Gonadorelin also has potent anti-cancer properties as it suppressed intestinal and colonic tumor growth. (10)

Is Gonadorelin Legal?

Studies have proven that Gonadorelin can treat infertility in both men and women. 

While this is an established fact, more research is required to establish its efficacy in human subjects and therefore it is not approved by the FDA as of yet. 

Who Should Use Gonadorelin?

Gonadorelin should be used by women who are experiencing amenorrhea and anovulatory menstrual cycles. It can also help alleviate the risk of osteoporosis in such women.

It can be safely administered by men as well who are undergoing testosterone therapy and are looking to avoid testicular atrophy and shrinkage. It will also help men in attaining a bulky body mass as well as strength.

Generally, it can be used by both men and women who are struggling with infertility, decreased sexual drive, mood swing and gonadotropin deficiency.

Forms of Gonadorelin

Gonadorelin is available in very limited forms amongst which, injectable is the widely used one since it has greater potency.

The other form is the intranasal spray that is easier to administer with minimal side effects.

How to Use Gonadorelin? 

Gonadorelin can be injected easily like any other injectable! 

The site must be first cleaned with alcohol and then it can be administered subcutaneously or intravenously as recommended by healthcare professionals. 

Before using the intranasal sprays, it is recommended that the nose is blown out and cleaned for substantial effects.

Gonadorelin Dosage

For the treatment of Amenorrhea, the recommended dosage is 5 mcg which must be delivered intravenously over 1 minute.

In case of gonadotropin deficiency in adults, 0.1 mg can be injected subcutaneously or intravenously

Gonadorelin Cycling

5 mcg of Gonadorelin can be safely administered every 90 minutes for a period of 21 days for Amenorrhea. 

0.1 mg is usually injected as a single dose while nasal sprays are used 2 to 3 times a week.

Gonadorelin Stacks

Due to its notable effects in the treatment of infertility alone, Gonadorelin is not frequently stacked with other peptides.

Some professionals however have recommended the stacking of Gonadorelin with other peptides which are similarly used for infertility treatments such as human chorionic gonadotropin (hCG). This may amplify the treatment by producing additive effects.

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Gonadorelin User Reviews

It is very important to know the experiences of people because that’s the most honest level of insight, right?

Let’s dig into some of the Reddit reviews and see what people have to say about Gonadorelin.

One of the users said,

“I took it for months, and my nuts went from golf balls to grapes. Even my doctor said it’s not as effective as hCG for testicular atrophy”.

Another one said,

I’ve spoke with 4 different clinics and everyone of them said that gonaderllin as a low success rate and the only reason they was offering it was cause at this time, it’s all they really got to replace HCG, even though they know it isn’t comparable. It’s sad. HCG has very low risk and side effects and works amazingly.”

Yet another user was dissatisfied with Gonadorelin as he said,

“Gonadorelin is a waste of time honestly. It has a half life of around 40 minutes so you would need to inject 3-4 times a day minimum to even see any results if you see any. I used it for 3 months and it basically did nothing. Started hcg and started seeing results within a week.”

Damn!!

It seems like Gonadorelin is absolutely not what the research otherwise suggests. At least that’s what anecdotal evidence suggests, right?

Make SURE you make a wise decision! 

Gonadorelin Side Effects 

The side effects pertaining to the use of this peptide are minimal with headache and nausea as the most common cited ones. 

Since Gonadorelin regulates the menstrual cycle, some level of abdominal pain can also be experienced by women who are menstruating.

Other side effects include redness, pain and swelling at the site of injection which are not related to the peptide itself. 

Where can I buy Gonadorelin?

Just like every time, we have BioTech Peptides for our rescue!

Gonadorelin By BioTech Peptides

Biotech peptides offer almost all kinds of peptides available in the market. As far as Gonadorelin or GnRH is concerned, it is also available in one of the variants. 

Biotech peptides commonly offer 10mg of Gonadorelin, costing $77.00, which is a pretty reasonable price, unlike other vendors in the market. 

BioTech peptides are at the top, with 99% product purity. They also offer 5%-10% discounts for customer retention depending on your purchase. 

Surprisingly, they also have a same-day shipping facility with a 30-day money-back guarantee. 

  • 99% pure and authentic 
  • Same-day shipping policy 
  • Excellent customer reviews 
  • Relatively expensive

Gonadorelin vs. Other Peptides

Gonadorelin vs. HCG

Both these peptides have the ability to increase sperm production by elevating the levels of testosterone in the body and thereby treating infertility in men. They also work on the same gonadotropin receptors in the hypothalamus.

The one main difference between them is their site of origin. While HCG is a natural peptide produced in the body, Gonadorelin is synthetically made. Gonadorelin also has the ability to act as an anti-tumor peptide whereas the effects of HCG are limited. 

Is Gonadorelin Legit?

The existing literature on Gonadorelin proves that this peptide has crucial effects on the endocrine system of the body. It not only regulates the production of sex hormones but also modulates their effects in the body.

However, it is imperative to mention that research done on human subjects is limited, and anecdotal evidence, as we saw earlier, is pretty hard to swallow, no?

While the decision to use Gonadorelin or not lies onto you, all I would say is make a safe pick for yourself! 

FAQs about Gonadorelin

What happens if you take too much gonadorelin?

An overdose of gonadorelin is unlikely to threaten life. Notify your doctor immediately or call an emergency room or poison control center for advice if an overdose is suspected. Symptoms of a gonadorelin overdose are not known.

How often should you take gonadorelin?

Adultsβ€”5 micrograms (mcg) injected by the pump into a vein or under the skin slowly over 1 minute, every ninety minutes for twenty-one days.

Does gonadorelin cause weight gain?

Ovarian hyperstimulation syndrome (OHSS) is a severe side effect that may happen in some women who use gonadorelin. Call your doctor right away if you have severe stomach pain or bloating; a very upset stomach, throwing up, or diarrhea; a big weight gain; shortness of breath, or a change in how much urine is passed.

Does gonadorelin prevent testicular shrinkage?

We generally prescribe gonadorelin for men who are on testosterone replacement therapy (TRT) and who don’t want to experience further gradual testicular shrinkage and decreased testicular functional capacity while they’re on TRT than they’re already experiencing.

Does gonadotropin increase testicle size?

They showed that the serum level of testosterone, positive sperm count, and testicular volume were increased significantly in the gonadotropin-injected group.

Is gonadorelin effective?

For cosmetic purposes (to counteract testicular atrophy), Gonadorelin is best used in intermittent phases, but it’s also extremely effective when the additional sperm count is desirable, such as if a man has been on TRT for years but still wants to have children.

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1)Dattani, M. T., & Gevers, E. F. (2016). Endocrinology of Fetal Development. Elsevier EBooks, 849–892. https://doi.org/10.1016/b978-0-323-29738-7.00022-8

2)Carroll, R. (2007, January 1). Female Reproductive System. https://doi.org/10.1016/b978-0-323-04318-2.50020-0

3)Finkelstein, J. S., Lee, H., Burnett-Bowie, S. M., Pallais, J. C., Yu, E. W., Borges, L. F., Jones, B. M., Barry, C. T., Wulczyn, K. E., Thomas, B. J., & Leder, B. Z. (2013). Gonadal Steroids and Body Composition, Strength, and Sexual Function in Men. The New England Journal of Medicine, 369(11), 1011–1022. https://doi.org/10.1056/nejmoa1206168

4)Merkison, J., Malcom, C., & DeCherney, A. H. (2022). Use of gonadotropin-releasing hormone (GnRH) agonist trigger in fertility preservation for patients with inherited genetic disorders. Frontiers in Endocrinology, 13. https://doi.org/10.3389/fendo.2022.826419

5)Santoro, N. (1990). Efficacy and safety of intravenous pulsatile gonadotropin-releasing hormone: Lutrepulse for Injection. American Journal of Obstetrics and Gynecology. https://doi.org/10.1016/0002-9378(90)91441-e

6)Ji, M., & Yu, Q. (2015). Primary osteoporosis in postmenopausal women. Chronic Diseases and Translational Medicine, 1(1), 9–13. https://doi.org/10.1016/j.cdtm.2015.02.006

7)McBride, J. W., & Coward, R. M. (2016). Recovery of spermatogenesis following testosterone replacement therapy or anabolic-androgenic steroid use. Asian Journal of Andrology, 18(3), 373. https://doi.org/10.4103/1008-682x.173938

8)Palacios, A., McClure, R. D., Campfield, A., & Swerdloff, R. S. (1981). Effect of Testosterone Enanthate on Testis Size. The Journal of Urology, 126(1), 46–48. https://doi.org/10.1016/s0022-5347(17)54372-4

9)Monaco, D., Fatnassi, M., Padalino, B., AubΓ©, L., Khorchani, T., Hammadi, M., & Lacalandra, G. M. (2015). Effects of a GnRH administration on testosterone profile, libido and semen parameters of dromedary camel bulls. Research in Veterinary Science, 102, 212–216. https://doi.org/10.1016/j.rvsc.2015.08.011

10)Janakiram, N. B., Mohammed, A., Brewer, M., Bryant, T., Biddick, L., Lightfoot, S., Pathuri, G., Gali, H., & Rao, C. V. (2014). Raloxifene and Antiestrogenic Gonadorelin Inhibits Intestinal Tumorigenesis by Modulating Immune Cells and Decreasing Stem-like Cells. Cancer Prevention Research, 7(3), 300–309. https://doi.org/10.1158/1940-6207.capr-13-0345

Contributors

Kumar Rathi

Kumar Rathi | Writer

Kartik is a medical student with a passion for anatomy and physiology. He writes research papers, articles and blogs to raise awareness and also has a strong interest in teaching and public speaking. Aspiring to be a successful cardiologist, Kartik believes in connecting with people on a personal level and is an expert in peptides.

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Gonadorelin

Chemical Structure

Mechanism of Action

Gonadorelin is a synthetic decapeptide which primarily acts on the hypothalamus and induces the release of follicle stimulating hormone (FSH) and luteinizing hormone (LH) from the anterior pituitary. These hormones then regulate a number of endocrine processes in the body, including the release of ovum from the ovaries in order for fertilization to take place. It also regulates the menstrual cycle in women and treats amenorrhea. In men, LH stimulates the Leydig cells of the testes to produce testosterone which ultimately aids in the maturation of sperms and is responsible for increasing muscle mass and strength.

Class of Compound

Peptide

Street Names

Gonadorelin, Gonadotropin releasing hormone, Factrel

Effects

Treatment for infertility , Regulates menstrual cycle ,Improves muscle mass

Side Effects and Dangers

Abdominal pain , Headache ,Redness at injection site

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