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Peptides / Gonadotropins and GnRH

140 In the index

Gonadorelin GNRH

A synthetic version of a natural fertility hormone, approved for testing how well the pituitary gland works, and used off-label during testosterone therapy to keep the testicles working and preserve fertility. Human studies support both uses.

Also known as GnRH, Factrel, Gonadorelina, GnRH-I, Gonadorelinum, Fertagyl, LH-Releasing factor, Luforan, Lutrefact

Effects Hormonal
Routes Subcutaneous
Legal status Prescription drug
WADA Banned at all times

Molecular Structure of C55H75N17O13

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  • Carbon
  • Hydrogen
  • Nitrogen
  • Oxygen

PubChem has no 3D conformer for this molecule, so this is the flat structure.

Chemistry

Formula
C55H75N17O13
Molar mass
1182.3
CAS
33515-09-2
PubChem CID
638793
IUPAC name
(2S)-N-[(2S)-1-[[(2S)-1-[[(2S)-1-[[(2S)-1-[[2-[[(2S)-1-[[(2S)-1-[(2S)-2-[(2-amino-2-oxoethyl)carbamoyl]pyrrolidin-1-yl]-5-(diaminomethylideneamino)-1-oxopentan-2-yl]amino]-4-methyl-1-oxopentan-2-yl]amino]-2-oxoethyl]amino]-3-(4-hydroxyphenyl)-1-oxopropan-2-yl]amino]-3-hydroxy-1-oxopropan-2-yl]amino]-3-(1H-indol-3-yl)-1-oxopropan-2-yl]amino]-3-(1H-imidazol-5-yl)-1-oxopropan-2-yl]-5-oxopyrrolidine-2-carboxamide
InChIKey
XLXSAKCOAKORKW-AQJXLSMYSA-N

Reported dosing

Approved label

What has been reported in the literature and by users. This is a record of what is done, not a recommendation.

Typical dose 100 mcg, 2-3 times weekly (off-label fertility-preserving use during TRT)
Reported range 100 mcg every other day to twice daily depending on protocol
Route Subcutaneous injection
Frequency 2-3 times weekly to twice daily depending on protocol
Duration Ongoing, alongside TRT (off-label use)

FDA-approved for diagnostic use and, historically, fertility indications; off-label use to maintain testicular function during testosterone therapy is common in telehealth TRT clinics but not a formally approved use for that purpose.

Where this comes from FDA prescribing information; off-label telehealth-prescribing patterns

These figures are recorded for reference and are not a recommendation. Dosing is a decision for you and a clinician.