Mechanism of Action

Kisspeptin-10 stimulates the release of GnRH. It is synthesized in the arcuate and anteroventral paraventricular nucleus of the hypothalamus. It binds to the KISS1R receptor via activation of the KISS1 gene when it triggers the phospholipase C pathway involving the hypothalamic cells.

Class of Compound

Peptide

Street Names

Metastin, KP-10

Effects

Increases LH levels, sexual arousal, increases testosterone levels in men.

Side Effects and Dangers

Overdose may result in hypersecretion of the gonadotropic hormones, precocious puberty

Top Studies

• Kisspeptin/GPR54 System: What Do We Know About Its Role in Human Reproduction?

• Pubertal development and regulation

• Kisspeptin-10 (KP-10) stimulates osteoblast differentiation through GPR54-mediated regulation of BMP2 expression and activation