Chemical Structure

Mechanism of Action

Kisspeptin-10 stimulates the release of GnRH. It is synthesized in the arcuate and anteroventral paraventricular nucleus of the hypothalamus. It binds to the KISS1R receptor via activation of the KISS1 gene when it triggers the phospholipase C pathway involving the hypothalamic cells.

Class of Compound


Street Names

Metastin, KP-10


Increases LH levels, sexual arousal, increases testosterone levels in men.

Side Effects and Dangers

Overdose may result in hypersecretion of the gonadotropic hormones, precocious puberty

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