Online TRT Cost: What You’ll Pay, Who It Suits and What Happens First

A monthly price is the first thing most online TRT pages show you, and it’s easy to misread.

Testosterone is a controlled substance, and its FDA label calls for blood work before treatment starts. This guide lays out the full bill at Yes Clinic, who TRT suits, what happens before anything ships, and what it can mean for your fertility.

Online TRT cost has two parts: the testosterone, and the blood work a clinician needs before prescribing it. At Yes Clinic, three months of testosterone cypionate is $329 (about $110 a month), with the consultation and shipping included. First labs are priced separately, from $129 in most states. So your first three months start at $458, or at $329 if you already have labs from the last 90 days and the clinician accepts them.

Three recent rule changes shape online TRT:

• DEA · 2026: A temporary DEA and HHS rule lets DEA-registered clinicians prescribe controlled medications by telemedicine, with no in-person visit first, through 31 December 2026. Testosterone is a Schedule III controlled substance.
• FDA · 2025: On 28 February 2025, FDA recommended adding TRAVERSE heart-safety results to every testosterone label and required a blood pressure warning where one was missing.
• SPORT: USADA’s guide to WADA’s 2026 Prohibited List gives testosterone cypionate as an example of a prohibited ester.

By the numbers:

• 300 ng/dL: the American Urological Association’s cut-off for low total testosterone
• $329: three months of TRT at Yes Clinic, about $110 a month
• 7: states where Yes Clinic can’t offer TRT

Sources: Federal Register, 31 December 2025; FDA, 28 February 2025; USADA, 16 October 2025; AUA guideline (2018, validity confirmed 2024).

See the $329 plan and lab prices →

Online TRT cost: the whole bill, line by line

A monthly number is easy to misread. Your real TRT cost per month depends on the labs around the medication, before you start and while you’re on it. Here’s every line at Yes Clinic, and what to ask anywhere else.

Add up the first quarter:

• Walk-in lab, most states: $329 plus $129 is $458, about $153 a month.
• Phlebotomist at home: $329 plus $249 is $578, about $193 a month.
• Labs you already have: $329, if the clinician decides they’re enough. (A screenshot of a 2023 result won’t be.)

After that, each three-month plan is $329, plus a follow-up panel when your clinician orders one. Expect a first follow-up level after you start, then testing “every 6-12 months,” per the AUA. That’s TRT without insurance at Yes Clinic: each line priced on the page.

What happens to the money if the answer is no. If the clinician decides TRT isn’t right for you, you aren’t charged for medication. Lab fees follow a different rule. Yes Clinic’s refund policy says lab orders can be refunded before the sample is collected or the kit is used. “Once testing has been performed, the cost cannot be refunded.” Dispensed medication can’t be returned or refunded either.

See the TRT plan and lab options →

To compare programs, get the same five numbers from each: three months of medication, first labs, the consultation, shipping and one follow-up panel. A page that won’t show all five before you pay has told you something. Muscle & Brawn’s online TRT clinic comparisons line programs up, and our seven checks for any online clinic cover the rest.

Who TRT suits, according to the label

TRT is a prescription treatment for men whose bodies don’t make enough testosterone. The FDA label for testosterone cypionate covers “replacement therapy in the male in conditions associated with symptoms of deficiency or absence of endogenous testosterone,” such as testicular failure or pituitary injury. It also sets a limit: safety and efficacy in men with “age-related hypogonadism,” meaning low testosterone from aging alone, “have not been established.”

Proof comes first. Before starting, the label says to confirm the diagnosis “by ensuring that serum testosterone concentrations have been measured in the morning on at least two separate days and that these serum testosterone concentrations are below the normal range.”

The American Urological Association (AUA) guideline on testosterone deficiency uses “a total testosterone level below 300 ng/dL as a reasonable cut-off,” and makes the diagnosis only when low levels are “combined with symptoms and/or signs.” One low afternoon result proves little.

Good fit if you:

• Have two low morning testosterone results, or will get them, plus symptoms
• Aren’t trying to have children now, or have talked fertility through first
• Will do follow-up blood work when your clinician asks
• Are comfortable giving yourself an injection at home

Skip it if you:

• Are trying to conceive now. The fertility section below explains why.
• Have breast cancer, or known or suspected prostate cancer. The label lists both as contraindications.
• Want it for performance. The label says it “has not been shown to be safe and effective for the enhancement of athletic performance.”
• Live in Alabama, Arkansas, Connecticut, Louisiana, Minnesota, Pennsylvania or Rhode Island, where Yes Clinic can’t offer TRT as of October 2026.
• Want a promised result. No honest clinic will give you one.

If libido or erections are the main complaint, our sildenafil vs tadalafil guide and what FDA keeps finding in gas station sex pills cover the ED side.

What happens first: blood work, a live visit, then a decision

At Yes Clinic the order is fixed, and nothing ships until a clinician says yes.

1. Enter your state. The page stops you in the seven states above.
2. Choose your TRT blood work.
   • Walk-in lab, or a phlebotomist (a certified blood-draw technician) at your home: testosterone (free and total), estradiol, SHBG, DHEA-S, PSA, a blood count, and metabolic and lipid panels.
   • Home kit: testosterone, estradiol, SHBG, DHEA-S, LH, prolactin, PSA and cortisol. Its list has no blood count, which the AUA wants before testosterone starts, so your clinician decides what else you need drawn.
   • Or upload labs from the last 90 days.
3. Check out and complete the intake, plus a live visit with a licensed clinician. Testosterone is a controlled substance, so this isn’t a questionnaire-only service.
4. The clinician decides. They may prescribe, ask for more (say, a letter from your own doctor or a urologist if a result needs a second look) or say no. Payment doesn’t guarantee a prescription.
5. If it’s a yes, a licensed US pharmacy prepares testosterone cypionate, 200 mg/mL, in your name and ships it. Your clinician sets the dose and gives the injection directions.

Start with your state →

That TRT blood work does a safety job. The label says hemoglobin and hematocrit “should be checked periodically” to catch polycythemia, a rise in red blood cells, and a newer testosterone cypionate label adds that more red cell mass “may increase the risk of thromboembolic events,” meaning blood clots.

For hematocrit, the AUA tells clinicians to consider holding off if it’s above 50% before you start, and says 54% or higher on treatment “warrants intervention.” It also wants a PSA, a prostate blood test, before starting in men over 40.

One more thing, and on this site it matters. Tell the clinician about any anabolic steroids, SARMs or other compounds you’ve used, now or in the past. Testosterone levels “may be in the normal or subnormal range in men abusing synthetic testosterone derivatives,” the label notes, so a result can mislead a clinician who doesn’t know your history.

TRT and fertility: read this before you start

Testosterone from outside the body tells your brain to stop sending the signals your testes run on. In the label’s words, your own “testosterone release is inhibited through feedback inhibition of pituitary luteinizing hormone (LH),” and at large doses “spermatogenesis may also be suppressed.” Spermatogenesis is sperm production.

The newer testosterone cypionate label goes further: “Reduced fertility is observed in some men taking testosterone replacement therapy. The impact on fertility may be irreversible.”

On timing, the AUA is blunt: testosterone “should not be prescribed to men who are currently trying to conceive,” and it wants men interested in fertility evaluated before treatment starts. Writing about men who’d used testosterone or anabolic steroids, the guideline says return of sperm “can be highly variable, taking up to two years after cessation of exogenous testosterone in some cases, with some men never experiencing return of sperm.”

If kids are anywhere in your plans, say so before the visit. The AUA lists other routes clinicians may use “in men with testosterone deficiency desiring to maintain fertility,” including selective estrogen receptor modulators (SERMs), which work on the brain’s feedback signals instead of supplying testosterone.

Ask your clinician whether a route that doesn’t supply testosterone fits you. Nobody can promise what any option will do for your fertility, and a clinician decides.

Honest limits of TRT, and of us

Start with what TRT may not do. The AUA tells clinicians to explain that “the evidence is inconclusive whether testosterone therapy improves cognitive function, measures of diabetes, energy, fatigue, lipid profiles, and quality of life measures,” and to talk about stopping if your levels come up but your symptoms don’t.

Blood pressure is on the label: “Testosterone can increase blood pressure which can increase cardiovascular (CV) risk over time,” and testosterone isn’t recommended with uncontrolled high blood pressure. TRAVERSE, the trial whose results FDA recommended adding to every testosterone label, gave men with heart disease or several risk factors a testosterone gel or a placebo. Major heart events were similar (7% vs 7.3%), while blood clots in the legs or lungs were numerically higher on testosterone (1.7% vs 1.2%). It tested a gel, not injections.

Ours is compounded. Yes Clinic’s TRT page labels its testosterone cypionate a compounded medication. Compounded medications are not FDA-approved, and FDA does not review them for safety, effectiveness or quality before marketing. The AUA puts its preference in writing: “Commercially manufactured testosterone products should be prescribed rather than compounded testosterone, when possible.” California orders are filled with a commercially manufactured product. Outside California we don’t offer a manufactured option; if that matters to you, an in-person clinic may suit you.

The online rules have an end date, too. Federal law normally lets a clinician prescribe a controlled substance remotely “only after conducting at least one in-person medical evaluation.” The temporary rule that waives this runs through 31 December 2026, so an online TRT prescription from a clinician you’ve never met in person relies on it. What replaces it wasn’t final when we checked on 13 October 2026. If nothing replaces it, new patients may need an in-person visit first. A final rule has reportedly been under federal review since August.

Compete in a tested sport? USADA’s 2026 guide names testosterone cypionate as a prohibited ester, and a prescription doesn’t change your federation’s rules. USADA has a therapeutic use exemption (TUE) pre-check form; start there.

Where we’re weak TRT isn’t available in seven states. Labs cost extra, and once testing is done, the lab fee isn’t refunded. There’s no phone line: you reach the care team through the patient portal or support@yesclinic.com, which isn’t monitored around the clock. Don’t email health details. In an emergency, call 911.

Our walk-through of fine print in GLP-1 programs shows the same price-page method.

Online TRT cost, in one line: $329 for three months, plus labs you can see priced before you book them.

See the TRT plan →

Important safety information. Testosterone cypionate is a Schedule III controlled substance: use it only as prescribed, store it securely, and never sell or share it. Do not use it if you have breast cancer or known or suspected prostate cancer; one label also lists serious heart, liver or kidney disease. It is not for women, and it can harm an unborn baby. Testosterone can raise blood pressure, which can increase the risk of heart attack and stroke over time, and it is not recommended with uncontrolled high blood pressure. It can raise red blood cell counts (hematocrit), which your clinician checks with blood work. Blood clots in the legs or lungs have been reported: get care for leg pain, swelling or warmth, or sudden shortness of breath. It can suppress sperm production, and the effect on fertility may be irreversible. It may worsen sleep apnea and enlarged-prostate symptoms, and can cause fluid retention, breast enlargement and acne. Misuse at higher doses than prescribed can cause serious heart and mental health problems. In an emergency, call 911. Full information: yesclinic.com/important-safety-information.

Yes Clinic is a LegitScript certified telehealth company. It is not a pharmacy and does not make or compound medication; a licensed US pharmacy prepares your prescription. Outside California, Yes Clinic’s testosterone cypionate is a compounded medication (California orders are filled with a commercially manufactured product); compounded medications are not FDA-approved, and FDA does not review them for safety, effectiveness or quality before marketing. A prescription is issued only if a licensed clinician decides treatment is appropriate; availability varies by state, and TRT is not available in Alabama, Arkansas, Connecticut, Louisiana, Minnesota, Pennsylvania or Rhode Island. FDA, DEA, HHS, the American Urological Association, USADA and WADA, all named in this article, have no connection to Yes Clinic and do not endorse it.