Yes Clinic is a legitimate, LegitScript-certified telehealth platform that prescribes TRT, GLP-1 weight-loss medication, ED treatment, hair-loss prescriptions, and longevity injections through licensed U.S. clinicians. TRT costs $329 for a three-month plan, with the telehealth visit, medication, and shipping included in that price and bloodwork billed separately from $99.

Quick Verdict

Yes Clinic is a U.S.-based telehealth platform offering testosterone replacement therapy (TRT), GLP-1 weight-loss medications, sexual wellness treatments, hair-loss prescriptions, and longevity care, all through licensed U.S. clinicians, with lab work built into its hormone programs. TRT is $329 for a three-month plan (about $110/month), with the telehealth consultation, medication, and shipping all included in that price. The platform holds LegitScript certification, works with licensed U.S. pharmacies, and does not require long-term contracts.

What stands out: All-in TRT pricing with no separate consultation charge, lab-guided hormone care, and one account for TRT, weight loss, ED, hair loss, and longevity treatments.

Where it falls short: Newer platform with limited independent review data, some medications are compounded (not FDA-approved branded drugs), and bloodwork is priced separately from medication plans.

Bottom line: A solid option for anyone who wants clinician-supervised hormone or weight-loss care delivered through telehealth, especially if transparent pricing and lab-guided care are priorities.

What Is Yes Clinic?

Yes Clinic is a direct-to-consumer telehealth platform that connects patients with licensed U.S. clinicians for prescription treatments in five categories: hormone optimization, medical weight loss, sexual wellness, hair loss, and longevity. The entire process, from intake questionnaire to prescription delivery, happens online, with medications shipped from licensed U.S. pharmacies.

Unlike the growing list of telehealth startups that focus exclusively on TRT or exclusively on GLP-1s, Yes Clinic bundles multiple treatment categories under one account. That means a single patient portal for a guy managing both a testosterone protocol and a semaglutide prescription, without bouncing between two different platforms.

The platform serves both men and women, which separates it from male-only TRT clinics. Women can access weight-loss, sexual wellness, and longevity treatments, plus female hormone lab testing, through the same intake flow.

Treatments Available at Yes Clinic

Here is a full breakdown of what Yes Clinic currently offers, organized by treatment category.

Hormone Optimization (TRT & Enclomiphene)

The TRT program is built around lab work, which matters more than most people realize. Running testosterone without checking your levels is one of the most common mistakes in self-managed hormone protocols. Yes Clinic builds that oversight into the treatment plan: TRT starts with a telehealth visit and a review of recent bloodwork (recent labs you already have can be used), and follow-up panels covering testosterone, estradiol, and a blood count start at $59. Your clinician reviews your lab results before setting your protocol.

Weight Loss (GLP-1s & Metabolic Support)

The semaglutide and tirzepatide formulations are compounded, not the FDA-approved brand-name versions (Ozempic/Wegovy and Mounjaro/Zepbound). That is something to understand before starting. Compounded drugs are prepared by licensed pharmacies, but the FDA does not review them for safety, effectiveness, or quality the way it reviews their branded counterparts.

Sexual Wellness (ED Treatment)

Tadalafil starts at $99 for 30 tablets, with a 90-tablet option available at $199, and sildenafil starts at $89 for 30 tablets. That is competitive for telehealth ED pricing.

Hair Loss

Both are combination formulas rather than plain generics: each pairs the base prescription with oral minoxidil, biotin, and vitamins D3 and K2 in a single fast-dissolve tablet.

Longevity & Peptides

Each longevity plan is cleared by a licensed clinician before anything ships.

Yes Clinic Pricing Breakdown

One of the stronger points of this platform is how pricing is structured. Yes Clinic does not charge membership fees or lock patients into long-term contracts, and its TRT plan includes the telehealth consultation, medication, and shipping in one price, with no separate consultation charge at checkout.

TRT Pricing

Enclomiphene Pricing

Weight Loss Pricing

ED Treatment Pricing

Hair Loss Pricing

Longevity Pricing

Lab Pricing

Bloodwork is priced separately. Unlike clinics that hide lab costs inside an inflated medication price, Yes Clinic lists bloodwork as its own line item. That transparency cuts both ways: you see exactly what you’re paying for, but you should factor lab costs into your total when comparing platforms.

How the Yes Clinic Process Works

The signup-to-treatment flow follows the standard telehealth model, but with a few details worth noting.

Step 1: Online Health Questionnaire. You fill out a medical intake form covering your symptoms, health history, goals, and any current medications. It only takes a few minutes.

Step 2: Licensed Clinician Review. A licensed U.S. clinician reviews your questionnaire. For TRT and enclomiphene, that includes a telehealth visit and a review of your recent bloodwork, and for TRT the visit is included in the plan price. The clinician decides whether a prescription is appropriate based on your individual case; not every submission gets approved.

Step 3: Prescription & Shipping. If approved, your prescription is filled by a licensed U.S. pharmacy and shipped directly to your door.

Step 4: Ongoing Monitoring. For TRT protocols specifically, follow-up lab panels (from $59) track key markers including testosterone, estradiol, and your blood count, so your clinician can keep an eye on your protocol over time. This is the difference between a protocol that is actively managed and one that is left to guesswork.

Credentials and Trust Signals

Before signing up with any telehealth platform that ships prescription medication to your house, these are the boxes that need checking:

LegitScript Certification. Yes Clinic is LegitScript certified, and the seal in its site footer links straight to LegitScript’s own verification page. LegitScript is the certification body Google and Meta use to vet online pharmacies and telehealth advertisers.

Licensed U.S. Pharmacies. Medications are dispensed by licensed U.S. pharmacies.

Clinician Supervision. Every prescription is reviewed and issued by a licensed U.S. clinician. This is not a “select your medication and check out” model.

Lab-Guided Hormone Care. TRT and enclomiphene start with a telehealth visit and recent bloodwork, and patients can order their labs directly through Yes Clinic, starting at $99, instead of arranging them somewhere else.

Pros and Cons

What Works Well

• Transparent, all-in TRT pricing: no membership fees, no separate consultation charge, no long-term contracts
• Lab-guided TRT: a telehealth visit and bloodwork review before you start, with follow-up panels from $59
• Broad treatment menu: TRT, GLP-1 weight loss, ED, hair loss, and longevity under one platform
• Serves both men and women: weight-loss, sexual wellness, and longevity care for women, not just male hormone therapy
• LegitScript certified: verified by the standard certification body for online healthcare
• No long-term contracts: multi-month plans are paid up front

Where It Could Be Better

• Newer platform: limited track record on independent review sites like Trustpilot compared to established competitors
• Compounded medications: semaglutide and tirzepatide are compounded formulations, not FDA-approved branded versions
• Bloodwork priced separately: some competing clinics bundle labs into the treatment cost
• No in-person option: telehealth only, which may not suit patients who prefer hands-on clinical relationships

How Yes Clinic Compares to Other Online TRT Clinics

If you’re evaluating Yes Clinic against other telehealth TRT providers, here is how the key differentiators line up.

The broadest comparison takeaway: Yes Clinic competes on breadth. Most TRT-focused clinics do not also offer GLP-1 weight-loss medications, ED treatment, hair-loss prescriptions, and longevity care in one platform. If you only need TRT, a testosterone-only clinic might offer a lower monthly rate. But if you want to manage multiple treatments from one provider, that consolidation has real value.

Who Is Yes Clinic Best For?

Ideal fit:

• Men looking for clinician-supervised TRT with lab work built into the process
• Patients who want transparent pricing without membership fees or contracts
• Anyone managing multiple needs, say, testosterone optimization alongside a GLP-1 weight-loss protocol, who does not want to juggle separate platforms
• Women looking for weight-loss, sexual wellness, or longevity care
• People in areas with limited access to local hormone or weight-loss clinics
• Guys who want the TRT + ED combo handled under one roof

Not the best fit:

• Patients who specifically want FDA-approved branded semaglutide (Wegovy) or tirzepatide (Zepbound) rather than compounded versions
• Anyone who needs in-person care or prefers a face-to-face clinical relationship
• Patients seeking the absolute lowest per-month TRT cost, since some competitors undercut on price

The Fine Print

A few things worth reading twice before you sign up:

Compounded medications are not FDA-approved drugs. Yes Clinic explicitly states that some of its treatments are compounded by licensed pharmacies and have not been evaluated by the FDA for safety or effectiveness. That includes its GLP-1 medications, both enclomiphene options, the hair-loss and gum formulas, and the longevity injections, so you should understand what that means before starting treatment.

Lab work is separate from medication pricing. When comparing total cost against competitors who bundle labs, add the bloodwork line item (from $99 for a starting TRT panel) to your medication cost for an apples-to-apples comparison.

This is telehealth, not a replacement for a PCP. As with any prescription protocol (TRT, GLP-1s, ED medication, or hair loss treatment), the right move is a conversation with a qualified clinician who understands your full health picture. Yes Clinic’s clinicians handle that within the platform, but if you have complex medical history, your primary care doctor should be in the loop.

Final Verdict

Yes Clinic is a legitimate, well-structured telehealth platform that delivers clinician-supervised access to TRT, weight-loss medications, ED treatment, hair-loss prescriptions, and longevity care, with transparent pricing and lab-guided hormone care at the center of its approach.

It is not the cheapest option for testosterone-only patients, and its compounded GLP-1 formulations carry the same caveats as any compounded medication. But for someone who values consolidated care, all-in TRT pricing, and a clinician who actually reviews your labs before you start, Yes Clinic checks the boxes that matter most.

If you are currently managing your hormones without medical oversight, or considering starting TRT and want a legitimate, LegitScript-certified place to start, this platform deserves a look.

Frequently Asked Questions