Spironolactone SPIRO

An FDA-approved medication for high blood pressure, heart failure, acne, and excess hair growth from hormone imbalances, also used in some gender-affirming care. Extensive research supports all these uses, with regular blood tests needed to watch potassium levels.

Also known as Aldactone, Verospirone, Spirolactone, Spiresis, Uractone, Xenalon, spironolattone

Effects Hormonal

Routes Oral

Legal status Prescription drug

WADA Banned at all times

3D Molecular Structure of C₂₄H₃₂O₄S

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Chemistry

Formula: C24H32O4S
Molar mass: 416.6
CAS: 52-01-7
PubChem CID: 5833
IUPAC name: S-[(7R,8R,9S,10R,13S,14S,17R)-10,13-dimethyl-3,5'-dioxospiro[2,6,7,8,9,11,12,14,15,16-decahydro-1H-cyclopenta[a]phenanthrene-17,2'-oxolane]-7-yl] ethanethioate
InChIKey: LXMSZDCAJNLERA-ZHYRCANASA-N

Reported dosing

Approved label

What has been reported in the literature and by users. This is a record of what is done, not a recommendation.

Typical dose 25-100 mg/day

Reported range 25-400 mg/day depending on indication

Route Oral

Frequency Once or twice daily

Duration Chronic/ongoing (as prescribed)

FDA-approved potassium-sparing diuretic/antiandrogen (Aldactone) for hypertension, heart failure, acne, and (off-label) hormone therapy; banned by WADA as a masking diuretic in sport.

Where this comes from FDA prescribing information

These figures are recorded for reference and are not a recommendation. Dosing is a decision for you and a clinician.