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Fisetin FISE

A plant compound being studied for its ability to help clear out old, damaged cells linked to aging. Human trials are just getting underway, with early safety data looking okay, but there's not yet solid proof it delivers real anti-aging benefits in people.

Also known as Fisetin, 5-Desoxyquercetin, 3,3',4',7-Tetrahydroxyflavone, 3,7,3',4'-Tetrahydroxyflavone, Fustel, Viset, Fisetholz, Superfustel

Effects Longevity

Routes Oral

Legal status Dietary supplement

WADA Not listed

3D Molecular Structure of C₁₅H₁₀O₆

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Chemistry

Formula: C15H10O6
Molar mass: 286.24
CAS: 528-48-3
PubChem CID: 5281614
IUPAC name: 2-(3,4-dihydroxyphenyl)-3,7-dihydroxychromen-4-one
InChIKey: XHEFDIBZLJXQHF-UHFFFAOYSA-N

Reported dosing

Clinical data

What has been reported in the literature and by users. This is a record of what is done, not a recommendation.

Typical dose 100 mg/day (chronic) or 20 mg/kg for 2 consecutive days per month (senolytic protocol)

Reported range 100-1500 mg/day depending on protocol

Route Oral

Frequency Once daily (chronic) or short intermittent pulses (senolytic)

Duration Ongoing (chronic) or a few days per month (senolytic 'hit-and-run' dosing)

Sold as a dietary supplement; senolytic dosing protocols are extrapolated from early-phase human trials, not an approved indication.

Where this comes from Early-phase senolytic clinical trials; supplement-industry dosing

These figures are recorded for reference and are not a recommendation. Dosing is a decision for you and a clinician.