84 In the index

Tianeptine TIAN

An antidepressant approved in some countries outside the U.S., unusual because it also acts on opioid receptors in the brain in addition to its main effect. It works well for depression where it's approved, but that opioid-like activity has led to real, documented cases of dependence and difficult withdrawal with regular high-dose use.

Also known as Stablon, Coaxil, Tianeptina, 0T493YFU8O, CHEBI:91749, S-1574, Tianeptinum, RefChem:898102

Effects Mood

Routes Oral

Legal status Prescription drug

WADA Not listed

3D Molecular Structure of C₂₁H₂₅ClN₂O₄S

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Chemistry

Formula: C21H25ClN2O4S
Molar mass: 437.0
CAS: 72797-41-2
PubChem CID: 68870
IUPAC name: 7-[(3-chloro-6-methyl-5,5-dioxo-11H-benzo[c][2,1]benzothiazepin-11-yl)amino]heptanoic acid
InChIKey: JICJBGPOMZQUBB-UHFFFAOYSA-N

Reported dosing

Approved label

What has been reported in the literature and by users. This is a record of what is done, not a recommendation.

Typical dose 12.5 mg, 3 times daily

Reported range 12.5-50 mg/day

Route Oral

Frequency 3 times daily (standard); higher, more frequent unsupervised dosing reported with misuse

Duration Chronic/ongoing (as prescribed, where approved)

An antidepressant approved in some countries outside the US (not FDA-approved); unusual for also acting on opioid receptors, which has led to real, documented cases of dependence and difficult withdrawal at high, unsupervised doses — a pattern that has drawn increasing US regulatory attention to unapproved 'tianeptine' supplement products.

Where this comes from International prescribing information; case reports of misuse/dependence

These figures are recorded for reference and are not a recommendation. Dosing is a decision for you and a clinician.