22 In the index

Progesterone P4

A key natural sex hormone, FDA-approved for hormone therapy and fertility support. Extensive human research backs its approved uses, with effects and risks depending on the specific formulation and how it's taken.

Also known as Prometrium, Pregn-4-ene-3,20-dione, Agolutin, Progestin, Crinone, Utrogestan, Luteol, Gestormone

Effects Hormonal Sleep

Routes Oral Topical

Legal status Prescription drug

WADA Not listed

3D Molecular Structure of C₂₁H₃₀O₂

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Chemistry

Formula: C21H30O2
Molar mass: 314.5
CAS: 57-83-0
PubChem CID: 5994
IUPAC name: (8S,9S,10R,13S,14S,17S)-17-acetyl-10,13-dimethyl-1,2,6,7,8,9,11,12,14,15,16,17-dodecahydrocyclopenta[a]phenanthren-3-one
InChIKey: RJKFOVLPORLFTN-LEKSSAKUSA-N

Reported dosing

Approved label

What has been reported in the literature and by users. This is a record of what is done, not a recommendation.

Typical dose 100-200 mg/day (oral) or 45-90 mg vaginal gel every other day, depending on indication

Reported range Varies widely by formulation, route, and indication (menopause, fertility support, gender-affirming care)

Route Oral, vaginal, topical, or injection

Frequency Once daily to every other day, depending on formulation and indication

Duration Chronic/ongoing or per fertility-treatment cycle, as prescribed

FDA-approved in multiple formulations (e.g., Prometrium, Crinone); dosing is highly individualized and monitored via bloodwork and symptoms.

Where this comes from FDA prescribing information

These figures are recorded for reference and are not a recommendation. Dosing is a decision for you and a clinician.