26 In the index

Cortisol CORT

The body's own natural stress hormone, one of the most thoroughly studied hormones in medicine. Its normal roles in metabolism, immunity, and stress response are well understood, and so are the harms of having too much of it for too long, like muscle loss, belly fat gain, and blood sugar problems.

Also known as Hydrocortisone (endogenous), hydrocortisone, Acticort, Cetacort, Hydrocortisyl, Cobadex, Hytone, Cortenema

Effects Hormonal

Routes Oral

Legal status Prescription drug

WADA Banned in-competition

Molecular Structure of C₂₁H₃₀O₅

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Chemistry

Formula: C21H30O5
Molar mass: 362.5
CAS: 50-23-7
PubChem CID: 5754
IUPAC name: (8S,9S,10R,11S,13S,14S,17R)-11,17-dihydroxy-17-(2-hydroxyacetyl)-10,13-dimethyl-2,6,7,8,9,11,12,14,15,16-decahydro-1H-cyclopenta[a]phenanthren-3-one
InChIKey: JYGXADMDTFJGBT-VWUMJDOOSA-N

Reported dosing

Approved label

What has been reported in the literature and by users. This is a record of what is done, not a recommendation.

Typical dose 20-25 mg/day (physiologic replacement, as hydrocortisone)

Reported range 15-30 mg/day, divided doses

Route Oral (as hydrocortisone) or IV in acute settings

Frequency 2-3 times daily, mimicking natural circadian rhythm

Duration Chronic/ongoing (as prescribed, for diagnosed adrenal insufficiency)

This entry refers to therapeutic replacement dosing for diagnosed adrenal insufficiency, not supplementation in healthy individuals, which is not indicated.

Where this comes from FDA prescribing information (hydrocortisone)

These figures are recorded for reference and are not a recommendation. Dosing is a decision for you and a clinician.