Epiandrosterone Review

Epiandrosterone is a metabolic derivative of DHEA and testosterone and is known to increase lean muscle mass significantly. It causes a boost in your energy levels pre-workout and may also enhance libido.

Class of Compound

Steroid

Mechanism of Action

Epiandrosterone is converted to DHT and promotes protein anabolism. It dilates blood vessels by inhibiting the pentose phosphate pathway and binds to the gamma-aminobutyric acid (GABA)/benzodiazepine-receptor complex (GABA-RC), acting as a negative non-competitive modulator. It also inhibits thromboxane A2 while promoting the synthesis of insulin-like growth factor 1 (4), cyclic guanosine monophosphate, and nitric oxide (NO), improving circulation. Epiandrosterone influences hypolipidemic pathways promoting fat loss.

Street Names

Isoandrosterone

Effects

Increases muscle mass, fat loss, lower blood cholesterol, vasodilation, improves libido

Side Effects and Dangers

Liver and kidney damage, hair loss, prostatic hyperplasia

Chemical Structure

If you are an aspiring bodybuilder, I am sure that you will be curious enough to find out about different anabolic and androgenic steroids that could help you build and bulk up muscles.

But, often, what withholds the users from starting any steroid cycle is the way these steroids work and the potential risk factors associated with them.

So without further ado let me introduce you to the class of steroids, called prohormones. This class of steroid integrates themselves in the natural biochemical pathways in the body and increases the synthesis of the end-product so that bodybuilders and fitness pros can experience optimal benefits organically.

Today, we are looking at Epiandrosterone in-depth, a steroidal prohormone that immediately converts into the sex hormones found in the body.

What is Epiandrosterone?

Epiandrosterone, more popularly known as Epi Andro or 3β-androsterone, is a metabolic derivative of Dehydroepiandrosterone (DHEA) and testosterone (1).

DHEA, an adrenal hormone produced in the body, is converted into Epiandrosterone by the activity of an enzyme called 5α-reductase.

When you take Epiandrosterone, it immediately converts itself into Dihydrotestosterone (DHT). And, for this reason, it is also referred to as a prohormone.

Because it is a prohormone, Epi Andro has weak androgenic activity compared to its biochemical products.

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How Does Epiandrosterone Work?

By this time, I am sure that you must have a rough idea as to how Epiandrosterone must be working.

Epiandrosterone is converted into Dihydrotestosterone (DHT), which possesses far more anabolic and androgenic properties than testosterone (2).

Because of the anabolic and androgenic properties of DHT, Epiandrosterone indirectly promotes the uptake of amino acids by the cells and its consequent conversion to protein building. It also minimizes the catabolism of muscle proteins.

Epiandrosterone acts as a precursor of estradiol, a female sex hormone.

Research suggests that Epiandrosterone also seems to promote fat loss by influencing the hypolipidemic pathways.

A shred of weak evidence suggests that Epiandrosterone acts as a negative non-competitive modulator of gamma-aminobutyric acid (GABA)/benzodiazepine-receptor complex (GABA-RC)(3).

Although still unclear, Epiandrosterone is hypothesized to suppress the production of factors like thromboxane A2 while promoting the synthesis of insulin-like growth factor 1 (4), cyclic guanosine monophosphate, and nitric oxide (NO).

Benefits of Epiandrosterone

Epi Andro will help you build and bulk up muscles in a short span of time. Because of its anabolic potency, it will help in building muscle proteins and consequently increase muscle mass.

Besides, it can have hypolipidemic effects on your body. This means that you can expect fat loss at the same time. This will result in an overall improvement in lean muscle mass.

Because Epi Andro is hypolipidemic, it lowers the blood cholesterol levels, which in turn minimizes the risk of developing any cardiovascular conditions.

Epiandrosterone also seems to influence your energy and aggression levels pre-workout. It can mentally as well as physically prepare you to smash the gym hard and experience intense training sessions.

Therefore, you can expect to experience enhancement in overall energy, stamina, and endurance levels after cycling yourself with Epiandrosterone.

As stated above, Epi Andro increases the release of nitric oxide (NO). Nitric oxide plays a major role in vasodilation, thus improving the blood circulation in your body. In other words, it improves microcirculation in your body.

Because Epiandrosterone is a precursor to estradiol, the end result is an increase in sperm count as well as improved sexual performance (libido).

One of the indirect benefits of consuming Epi Andro is increased hair growth on the chest and pubic areas.

Perhaps you can expect faster recovery as a result of the Epiandrosterone cycle.

Is Epiandrosterone Legal?

Because it is a prohormone, Epi Andro is legal as well as safe to buy at any stores.

Who Should Use Epiandrosterone?

If you are aiming to build muscles and improve your overall strength, endurance, stamina, and athleticism, Epiandrosterone can be one of the compounds you can consider.

One of the benefits that Epiandrosterone offers is that it sparks aggression in you before workout sessions and gears you up to that level, you can also use Epiandrosterone to enhance your fitness regimes.

Forms of Epiandrosterone

Epi Andro is predominantly available to be taken orally, which means you can find it in the form of capsules as well as tablets.

Besides, there is also Epi Andro powder available in the market, so if you are not a fan of capsules/tablets, there you go!

How do I use Epiandrosterone?

Because there is no injectable form of Epi Andro at the moment, there is not much that needs to be explained related to its usage.

One thing that I would like to highlight is that post-cycle therapy is mandatory. Once you are done with the Epi Andro cycle with whatever dosage was recommended, a month long post-cycle therapy is recommended so that your hormones get back to their normal levels.

Epiandrosterone Dosage

While there are no set dosage guidelines available, most users so far have been taking somewhere between 250mg-500mg of Epi Ando per day.

With that being said, if you are a beginner, start with a lower dosage of just 250mg first. This will let you know how your body is going to react to this prohormone. Once your body gets hold of the lower dose of Epi Andro, then maybe you can double it.

Going regularly beyond 500mg might make you experience adverse effects typical of androgenic steroids.

Also, make sure to split your daily dose into two halves across the day.

Where to buy Epiandrosterone?

Huge Supplements based in the States provides a nifty little product called Sapogenix. This is one of their best selling products, containing 250mg of the following:

Epiandrosterone Review

Dioscorea Makino 50-67:1 Extract (Rhizome and aerial parts) (standardized to 6-keto-diosgenin, Spirosanol saponins, Furastanolic saponins, 5R-Spirost-4-ene-3, 6-diol), Progenin III, Psuedoprotodioscin, Methyl Protodioscin, Dioscin, Protodioscin, Iridoid Glycosides.

With more than 250 reviews on their site, and a grand score of 4.6 Stars, you know this product isn’t all bark.

Epiandrosterone Cycle

Typical Epi Andro cycles are for anywhere between 6-8 weeks. The reason behind the longer cycling duration of Epi Andro is its relatively weak androgenic capability.

If you are a beginner, I would highly suggest limiting your first few cycles to 6 weeks only.

One complete cycle of Epi Andro must be followed by a 4 week long post-cycle therapy, as stated above. Then, maybe you should start a new cycle of Epi Andro.

After reading about the personal experiences of people, one thing I really would like to highlight to the potential users of Epi Andro is that you may not experience any results within the first cycle. You may, when you begin your second cycle, start seeing effects in your body, such as muscle building and fat loss.

The crux of all this is to not have high expectations of the Epi Andro due to pretty obvious reasons.

Epiandrosterone Stack

There are not many typical Epi Andro stacks that people are using at the moment.

Very selected brands offer Epiandrosterone with Dymethazine, another anabolic steroid (5).

Some people also seem to stack Epi Andro with other related supplements, such as Epicatechin (6). Epicatechin offers improved vascularity, lower cholesterol levels, enhanced muscle protein synthesis, and natural antioxidant effects.

Amongst the two possible stacks, I would suggest the latter.

Epiandrosterone Reviews

Honestly, there are a lot of mixed reviews of Epi Andro. Some users seem to be heavily influenced by the prohormone, while others offer a considerable degree of critique.

Well, let’s dig into some of the reviews to get a real idea.

Stimosarausrex says,

“Personally I’m a huge fan of epi-androsterone. Always add it to my cycle as it protects against gyno, frees SHGB and works synergistically with all compounds.”

One of the anonymous users said,

“In my opinion, I think compounds like Epiandrosterone are overrated. They do work, but it really isn’t anything special, especially at the prices they are selling these products.”

Another user said,

“When I look at my own cycle experience and results, I wouldn’t run epiandrosterone again.”

TheHunterZolomon said,

“Watch out for hair loss. I experienced some. It’s not a strong muscle builder, and depending on the dosage, may not even be that great for your goals.”

Best Time To Take Epiandrosterone

The ideal time to consume Epi Andro seems to be pre-workout. Epi Andro demonstrates a considerable effect on energy levels that one might need before intense gym/training sessions.

Epiandrosterone Side Effects

Keeping aside the very mild and not so usual side effects, Epi Andro can be generally considered safe from all the adverse effects that synthetic androgenic anabolic steroids cause, such as liver and kidney damage.

One of the studies suggests that Epi Andro is observed to promote baldness (7). After some cycles, you might experience hair loss, which I am sure is not something you would want

Another study suggests that Epiandrosterone offers prostatic hyperplasia, which in easy language means that it may cause an over development of the prostate organ (8).

Where Can I Buy Epiandrosterone?

Because people do not so commonly use Epiandrosterone, you will find it really tough to come across brands/stores offering original and authentic Epi Andro.

If you know a trusted seller, or come across any nearest supplement store, make the purchase right away!

Epiandrosterone Pricing

A typical cycle of Epi Andro will cost you between $200 to $300.

Yes, I know that the price range seems to be a bit high, which is often a reason why most users look for other cheaper yet effective alternatives.

Epiandrosterone vs. Other Compounds

Epiandrosterone vs. Androsterone

While both compounds are isomers of each other, Androsterone is a metabolite of Dihydrotestosterone (DHT) and testosterone, but Epiandrosterone is a derivative of Dehydroepiandrosterone (DHEA) and testosterone.

Androsterone acts as a positive modulator of GABA receptors. On the other hand, Epi Andro acts as a negative modulator (9).

Epiandrosterone and Androsterone are very similar in their offerings in terms of the benefits. It offers improved muscle building, enhanced sexual characteristics, and high endurance.

Is Epiandrosterone Legit?

Okay, so if you were to take my opinion, I would not whole-heartedly recommend Epiandrosterone. I will surely back my opinion with reasons, don’t worry!

There is not much human-based research/clinical trials that prove the efficiency and efficacy of Epi Andro. There are much better alternatives in the form of steroids, peptides, SARMs, and supplements available in the market that could help you achieve your fitness goals. Considering the above, as well as the personal reviews of users, I wouldn’t recommend Epi Andro to users.

Maybe try out some other effective androgenic and anabolic steroids as well as SARMs, such as Turkesterone, GW0742, Ostarine MK 2866, and Andarine S4, etc.

FAQs on Epiandrosterone

Is Epiandrosterone the same as DHEA?

DHEA is the 5-dehydro analog of epiandrosterone (5α-androstane-3β-ol-17-one) and is also known as 5-dehydroepiandrosterone or as δ5-epiandrosterone.

What is Androsterone used for?

Androsterone is used for weight loss, improving athletic performance, reducing sexual problems, and for many other uses, but there is no good scientific evidence to support its use. Androsterone might also be unsafe.

What are the benefits of prohormones?

Supplement manufacturers often claim that Andro use improves serum testosterone concentrations, increases muscular strength and muscle mass, helps to reduce body fatness, enhances mood, and improves sexual performance.

Is there substantial human-based research available on Epi Andro?

The answer is No! There is not much research conducted on Epi Andro.

Pros
  • Enhanced muscle building
  • Hypolipidemic properties
  • Improved vascularity/microcirculation
Cons
  • Lack of human-based research
  • Baldness
  • Prostate hyperplasia
 

1. https://www.ebi.ac.uk/chebi/searchId.do?chebiId=CHEBI:541975
2. https://analyticalsciencejournals.onlinelibrary.wiley.com/doi/full/10.1002/dta.2291
3. https://pubchem.ncbi.nlm.nih.gov/compound/Epiandrosterone
4. https://academic.oup.com/endo/article/137/8/3375/3037721
5. https://pubmed.ncbi.nlm.nih.gov/26663462/
6. https://pubmed.ncbi.nlm.nih.gov/29355598/
7. https://pubmed.ncbi.nlm.nih.gov/14757277/
8. https://pubmed.ncbi.nlm.nih.gov/12657354/
9. https://pubchem.ncbi.nlm.nih.gov/compound/Androsterone

Daniel Louwrens CPT

Hi there! My name is Daniel Louwrens, and I have more than 10 years of experience in the bodybuilding & fitness world. I have graduated with a degree in Chemistry, and my aim with helping people is to educate people who have questions about anything and everything fitness: Training, Nutrition, Recovery, and PED's.

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