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Nootropics / Neuroprotective

76 In the index

Methylene blue MB

An old medical dye, FDA-approved for a rare blood disorder, with a history of treating malaria and current off-label interest for brain and cellular energy. Its approved emergency use is well proven; the brain-boosting claims rest on smaller, less conclusive human studies.

Also known as Methylthioninium chloride

Effects Focus Longevity
Routes Oral
Legal status Prescription drug
WADA Not listed

Molecular Structure of C16H18ClN3S

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  • Carbon
  • Hydrogen
  • Chlorine
  • Nitrogen
  • Sulfur

PubChem has no 3D conformer for this molecule, so this is the flat structure.

Chemistry

Formula
C16H18ClN3S
Molar mass
319.9
CAS
61-73-4
PubChem CID
6099

Reported dosing

User-reported

What has been reported in the literature and by users. This is a record of what is done, not a recommendation.

Typical dose 0.5-2 mg/kg (low-dose, off-label cognitive/mitochondrial use)
Reported range 0.5-4 mg/kg depending on indication; much higher doses (1-2 mg/kg IV) used clinically for methemoglobinemia
Route Oral or IV
Frequency Once daily (low-dose oral use) or single IV dose (emergency medical use)
Duration Ongoing (off-label low-dose use) or single administration (emergency use)

FDA-approved IV treatment for methemoglobinemia; low-dose oral use for cognition/mitochondrial support is off-label and unregulated. Can cause dangerous serotonin syndrome if combined with SSRIs/SNRIs or other serotonergic drugs.

Where this comes from FDA prescribing information (approved indication); off-label user-reported dosing

There is no approved human dosing for this compound. The figures above are what users and vendors report, not what has been established as safe or effective. Treat them as a record of what is done, not as guidance.