273 In the index

Trazodone TRAZ

An FDA-approved antidepressant now used mostly off-label, at lower doses, as a sleep aid because of its drowsiness-causing side effect. Human studies support both its antidepressant effect at higher doses and its practical use for sleep at lower doses, with a good safety record compared to many sleep medications.

Also known as Desyrel, Trazodon, Beneficat, Trazalon, Trazodil, Trazodona, Trazonil, Trittico

Effects Sleep

Routes Oral

Legal status Prescription drug

WADA Not listed

3D Molecular Structure of C₁₉H₂₂ClN₅O

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Chemistry

Formula: C19H22ClN5O
Molar mass: 371.9
CAS: 19794-93-5
PubChem CID: 5533
IUPAC name: 2-[3-[4-(3-chlorophenyl)piperazin-1-yl]propyl]-[1,2,4]triazolo[4,3-a]pyridin-3-one
InChIKey: PHLBKPHSAVXXEF-UHFFFAOYSA-N

Reported dosing

Approved label

What has been reported in the literature and by users. This is a record of what is done, not a recommendation.

Typical dose 25-100 mg at bedtime (off-label sleep use) or 150-300 mg/day divided (approved antidepressant use)

Reported range 25-400 mg/day depending on indication

Route Oral

Frequency Once daily (sleep use) or 2-3 times daily (antidepressant use)

Duration Chronic/ongoing (as prescribed)

FDA-approved antidepressant now used mostly off-label, at lower doses, as a sleep aid due to its sedating side effect.

Where this comes from FDA prescribing information; off-label clinical use patterns

These figures are recorded for reference and are not a recommendation. Dosing is a decision for you and a clinician.