130 In the index

Argireline ARGI

A cosmetic ingredient applied to skin that relaxes the tiny facial muscles that cause wrinkles, marketed as a topical alternative to Botox. Cosmetic studies show it modestly reduces wrinkle depth when applied to skin; it isn't meant to work anywhere else in the body.

Also known as Acetyl hexapeptide-3, Acetyl Hexapeptide-8, Argireline NP, Hexapeptide 3, L4EL31FWIL, Acetyl hexapeptide 3, Acetyl-glu-glu-met-gln-arg-arg-amide, RefChem:552452

Effects Skin and hair

Routes Topical

Legal status Dietary supplement

WADA Not listed

Molecular Structure of C₃₅H₆₂N₁₄O₁₁S

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PubChem has no 3D conformer for this molecule, so this is the flat structure.

Chemistry

Formula: C35H62N14O11S
Molar mass: 887.0
CAS: 616204-22-9
PubChem CID: 71587772
IUPAC name: (4S)-4-acetamido-5-[[(2S)-1-[[(2S)-1-[[(2S)-5-amino-1-[[(2S)-1-[[(2S)-1-amino-5-(diaminomethylideneamino)-1-oxopentan-2-yl]amino]-5-(diaminomethylideneamino)-1-oxopentan-2-yl]amino]-1,5-dioxopentan-2-yl]amino]-4-methylsulfanyl-1-oxobutan-2-yl]amino]-4-carboxy-1-oxobutan-2-yl]amino]hex-5-enoic acid
InChIKey: AJLNZWYOJAWBCR-OOPVGHQCSA-N

Reported dosing

Limited data

What has been reported in the literature and by users. This is a record of what is done, not a recommendation.

Typical dose Topical concentration of roughly 5-10% in serum

Reported range Manufacturer formulations vary

Route Topical

Frequency Once or twice daily

Duration Ongoing (cosmetic use)

Marketed as a cosmetic 'Botox-like' peptide ingredient; independent evidence for meaningful wrinkle reduction is limited.

Where this comes from Manufacturer-sponsored cosmetic studies

Human data for this compound is limited. Read the figures above as a record of reported use rather than established dosing.