119 In the index

Semax SEMAX

A brain-protective peptide developed in Russia and approved there as a nasal-spray medication for stroke recovery and cognitive problems. Russian studies support benefits for thinking and brain protection in those situations, though it lacks FDA approval or independent Western confirmation.

Also known as ACTH 4-10 analogue, ACTH (4-7), Pro-Gly-Pro-, I5FAL2585H, ACTH (4-7), prolyl-glycyl-proline-, Pro-gly-pro-acth (4-7), RefChem:56007, MEHFPGP, Met-Glu-His-Phe-Pro-Gly-Pro

Effects Focus Mood

Routes Nasal

Legal status Research chemical

WADA Not listed

Molecular Structure of C₃₇H₅₁N₉O₁₀S

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PubChem has no 3D conformer for this molecule, so this is the flat structure.

Chemistry

Formula: C37H51N9O10S
Molar mass: 813.9
CAS: 80714-61-0
PubChem CID: 9811102
IUPAC name: (2S)-1-[2-[[(2S)-1-[(2S)-2-[[(2S)-2-[[(2S)-2-[[(2S)-2-amino-4-methylsulfanylbutanoyl]amino]-4-carboxybutanoyl]amino]-3-(1H-imidazol-5-yl)propanoyl]amino]-3-phenylpropanoyl]pyrrolidine-2-carbonyl]amino]acetyl]pyrrolidine-2-carboxylic acid
InChIKey: AFEHBIGDWIGTEH-AQRCPPRCSA-N

Reported dosing

Limited data

What has been reported in the literature and by users. This is a record of what is done, not a recommendation.

Typical dose 250-500 mcg/day

Reported range 250-1500 mcg/day

Route Intranasal

Frequency Once or twice daily

Duration 2-4 week course, often cycled

Approved and sold in Russia as a nootropic/neuroprotective peptide; not FDA-approved, and independent Western confirmation of its effects is limited.

Where this comes from Russian-language clinical studies

Human data for this compound is limited. Read the figures above as a record of reported use rather than established dosing.