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Peptides / Melanocortin peptides

134 In the index

Melanotan II MT-II

An unapproved tanning peptide popular in gray-market circles, also used off-label for its effect on libido. A small original study showed it really did darken skin and boost libido, but also caused nausea, flushing, and unwanted erections, and it was never developed into an approved product.

Also known as MT2, Melanotan-II, UPF5CJ93X7, RefChem:925444, MT-II, Melanotan (MT)-II, Melatonan, Melanotan II acetate salt

Effects Libido Skin and hair
Routes Subcutaneous
Legal status Research chemical
WADA Not listed

Molecular Structure of C50H69N15O9

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  • Carbon
  • Hydrogen
  • Nitrogen
  • Oxygen

PubChem has no 3D conformer for this molecule, so this is the flat structure.

Chemistry

Formula
C50H69N15O9
Molar mass
1024.2
CAS
121062-08-6
PubChem CID
92432
IUPAC name
(3S,6S,9R,12S,15S,23S)-15-[[(2S)-2-acetamidohexanoyl]amino]-9-benzyl-6-[3-(diaminomethylideneamino)propyl]-12-(1H-imidazol-5-ylmethyl)-3-(1H-indol-3-ylmethyl)-2,5,8,11,14,17-hexaoxo-1,4,7,10,13,18-hexazacyclotricosane-23-carboxamide
InChIKey
JDKLPDJLXHXHNV-MFVUMRCOSA-N

Reported dosing

User-reported

What has been reported in the literature and by users. This is a record of what is done, not a recommendation.

Typical dose 250-500 mcg/day (loading), then reduced maintenance dosing
Reported range 250 mcg-1 mg/day
Route Subcutaneous injection
Frequency Once daily during loading, then less frequently
Duration Ongoing/cyclical (unregulated use)

Not FDA-approved for any use. Widely used off-label for tanning and libido; associated with nausea, facial flushing, darkening of moles (with case reports of melanoma requiring closer monitoring), and priapism at higher doses.

Where this comes from Early discontinued clinical trials (as a libido drug precursor to bremelanotide); user-reported/research-chemical vendor literature

There is no approved human dosing for this compound. The figures above are what users and vendors report, not what has been established as safe or effective. Treat them as a record of what is done, not as guidance.

Variants

Name Abbr Route Notes
Melanotan II injectable MT2-I Subcutaneous The standard subcutaneous form.